• Proceedings of the Optical Society of Korea Conference
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• 2004.02a
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• pp.354-355
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• 2004

• Current Optics and Photonics
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• v.1 no.2
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• pp.132-137
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• 2017

To investigate the usefulness of optical coherence tomography (OCT) for imaging lymphedema, we directly compared it to other histological methods in a mouse model of lymphedema. We performed detailed imaging of the lymphedema lesion on a mouse tail. We imaged the mouse tail in vivo with OCT and created histopathological samples. We constructed a spectrometer-based OCT system using a fiber-optic Michelson interferometer. The light was directed to 50:50 couplers that split the light into reference and sample arms. Backscattered light from a reference mirror and the sample produced an interference fringe. An OCT image of the lymphedema model revealed an inflammatory reaction of the skin that was accompanied by edema, leading to an increase in the light attenuation in the dermal and subcutaneous layers. Similar to OCT image findings, histological biopsy showed an inflammatory response that involved edema, increased neutrophils in epidermis and subdermis, and lymphatic microvascular dilatation. Furthermore, the lymphedema model showed an increase in thickness of the dermis in both diagnostic studies. In the mouse tail model of lymphedema, OCT imaging showed very similar results to other histological examinations. OCT provides a quick and useful diagnostic imaging technique for lymphedema and is a valuable addition or complement to other noninvasive imaging tools.

• Korean Journal of Optics and Photonics
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• v.6 no.4
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• pp.288-295
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• 1995

We have studied about spatial wavefront analysis of a pulsed laser output beam by means of an imaging unstable ring resonator with an infinite Fresnel number. We have constructed a Newtonian telescope type NBUR (Negative Branch Unstable Ring) Nd:YAG laser with 4 plane mirrors. Provided that the NBUR resonator is under self imaging condition, the resonator could be reduced diffraction effects which were occuring to the beam transmitting through the circular aperture of scraper mirror in the resonator. We have observed enhancement in the spatial coherence of wavefronts of laser beam due to the iterative round trips of the self imaging beam inside the ring resonator. The information on the spatial wavefronts was determined by the fringe patterns from Mach-Zehnder interferometer and the fringe analysis by means of the Fourier transform method showed the distortion of wavefronts of less than 0.2), In comparison with a standing wave type resonator, we have confirmed that the spatial coherence of the NBUR Nd:YAG laser output beam was enhanced as much as 75%. s 75%.

• Journal of Biomedical Engineering Research
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• v.34 no.2
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• pp.91-96
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• 2013

In this study, we developed an integrated optical coherence tomography - photoacoustic microscopy (OCT-PAM) system to simultaneously provide optical absorption and scattering information. Two different laser sources, such as a pulsed laser for PAM and a superluminescent diode for OCT, were employed to implement the integrated OCT-PAM system. The performance of the OCT-PAM system was measured by imaging carbon fibers. We then imaged black and white hairs to demonstrate the simultaneous OCT-PAM imaging capabilities. As a result, OCT can produce 3-D images of both black and white hairs, whereas PAM is only able to image the black hair due to strong optical absorption of black hair.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.37-42
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• 2005

We construct and test the polarization-sensitive optical coherence tomography (PS-OCT) system for imaging porcine and human articular cartilages. PS-OCT is a new imaging technology that provides information regarding not only the tissue structures but tissue components that show birefringence such as collagen. In this study, we measure the cartilage thickness of the porcine joint and the phase retardation due to collagen birefringence. Also, we demonstrate that changes of the collagen fiber orientation could be detected by the PS-OCT system. Finally, differences between normal and damaged human articular cartilage are observed using the PS-OCT system, which is then compared with the regular histology pictures. As a result, the PS-OCT system is proven to be effective for diagnosis of the pathology related to the cartilage. In the future, this technology may be used for discrimination of the collagen types. When combined with endoscope technologies, the PS-OCT images may become a useful tool for in vivo tissue testing.

• Current Optics and Photonics
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• v.7 no.2
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• pp.176-182
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• 2023

Optical coherence tomography (OCT) is being developed to guide various ophthalmic surgical procedures. However, the high cost of the intraoperative OCT system limits its availability mostly to the largest hospitals and healthcare systems. In this paper, we present a design and evaluation of a low-cost intraoperative common-path free-hand scanning OCT system. The lensed fiber imaging probe is designed and fabricated for intraocular use and the free-hand scanning algorithm that could operate at a low scanning speed was developed. Since the system operates at low frequencies, the cost of the overall system is significantly lower than other commercial intraoperative OCT systems. The assembled system is characterized and shows that it meets the design specifications. The handheld OCT imaging probe is tested on multilayer tape phantom and ex-vivo porcine eyes. The results show that the system could be used as an intraoperative intraocular OCT imaging device.

• Journal of the Optical Society of Korea
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• v.15 no.4
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• pp.352-356
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• 2011

Dual-wavelength holography has a better axial range than single-wavelength holography, allowing unambiguous phase imaging. Partial coherence sources reduce coherent noise, resulting in improved reconstructed images. We measured a ball-grid array using dual-wavelength holography with partial coherence sources. This holography method is useful for measurement samples that exhibit coherence noise and have a step height larger than the single wavelength used in holography.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2459-2463
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• 2005

Optical coherence tomography (OCT) is high resolution medical imaging system which is obtaining image inside biological objects with non-destructive method. OCT system is based on Michelson interferometer with a reciprocating mirror in the reference arm and a biological object in the sample arm. The obtained OCT image suffers from a granular or mottled image, called speckle. Speckle is caused by random interferences between reflected coherence waves. In this paper, we propose effective speckle reduction method that uses wavelet transform. With wavelet domain image, sub-windowing and thresholding are performed. Finally, speckle reduction experiments for Misgurnus mizolepis skin and rat eye images are shown.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05b
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• pp.804-806
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• 2004

As a noninvasive imaging meathod, optical coherence tomography system has been extensively studied because it has some advantage such as imaging of high resolution, low cost, and compace size configuration. The optical power of the sample signal reflected from an object is usually very small in optical coherence tomography(OCT) due to absorption and scattering in a sample material. Furthermore, there happens a serious loss of sample signal power in a fiber coupler because it does not transfer to a photodetector but return to the optical source. In order to improve the SNR of OCT system, basic Michelson and Mach-Zehnder interferometer types were configured then, we compared simulation with measurement of reference sample Therefore, an On in configuration of Math-Zehnder interferometer was demonstrated in order to improve the signal to noise ratio

• Journal of the Optical Society of Korea
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• v.18 no.2
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• pp.151-155
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• 2014

Although various ophthalmic imaging methods, including fundus photography and optical coherence tomography, have been applied for effective diagnosis of ocular diseases with high spatial resolution, most of them are limited by shallow imaging penetration depth and a narrow field of view. Also, many of those imaging modalities are optimized to provide microscopic anatomical information, while functional or cellular information is lacking. Compared to other ocular imaging modalities, photoacoustic imaging can achieve relatively deep penetration depth and provide more detailed functional and cellular data based on photoacoustic signal generation from endogenous contrast agents such as hemoglobin and melanin. In this paper, array-based ultrasound and photoacoustic imaging was demonstrated to visualize pigmentation in the eye as well as overall ocular structure. Fresh porcine eyes were visualized using a real-time ultrasound micro-imaging system and an imaging probe supporting laser pulse delivery. In addition, limited photoacoustic imaging field of view was improved by an imaging probe tilting method, enabling visualization of most regions of the retina covered in the ultrasound imaging.