• Molecules and Cells
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• v.39 no.11
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• pp.783-789
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• 2016

Afflicted neurons in various neurodegenerative diseases generally display diverse and complex pathological features before catastrophic occurrence of massive neuronal loss at the late stages of the diseases. This complex nature of neuronal pathophysiology inevitably implicates systemwide changes in basic cellular activities such as transcriptional controls and signal cascades, and so on, as a cause. Recently, as one of these systemwide cellular changes associated with neurodegenerative diseases, epigenetic changes caused by protein toxicity have begun to be highlighted. Notably, recent advances in related techniques including next-generation sequencing (NGS) and mass spectrometry enable us to monitor changes in the post-translational modifications (PTMs) of histone proteins and to link these changes in histone PTMs to the specific transcriptional changes. Indeed, epigenetic alterations and consequent changes in neuronal transcriptome are now begun to be extensively studied in neurodegenerative diseases including Alzheimer's disease (AD). In this review, we will discuss details of our current understandings on epigenetic changes associated with two representative neurodegenerative diseases [AD and polyglutamine (polyQ) diseases] and further discuss possible future development of pharmaceutical treatment of the diseases through modulating these epigenetic changes.

• Journal of The Korean Association For Science Education
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• v.33 no.3
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• pp.650-663
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• 2013

Multidimensional scaling can be used to identify relationships among concepts, revealing the structure of the cognitive framework by measuring distances within perceptual maps. The current study sought to examine the relationships among concepts related to photosynthesis in 2,844 $3^{rd}-11^{th}$ grade science students. The questionnaire included items on 'location,' 'products,' 'reactants,' and 'environmental factors', presenting images related to each theme. Students provided responses corresponding to particular topics, and reported the extent to which the concept was related to the topic on a scale from 1 to 30. The survey results were as follows: first, students were not able to clearly distinguish between or understand the four main topics. Second, students organized their cognitive structures by closely associating related concepts after learning. Third, the presented concepts revealed a mixture of scientific and non-scientific concepts, suggesting that students needed to clearly distinguish the preconceptions through which they organized concepts, so that they are suitable for cognitive structures based on learning. Furthermore, non-scientific concepts within perceptions were consistently maintained throughout learning, affecting the proximity of scientific concepts.

• Journal of electromagnetic engineering and science
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• v.9 no.4
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• pp.194-201
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• 2009

In this paper, a new spectrum sensing method based on energy detection is proposed and analyzed in a cognitive radio(CR) system. We employ a delay diversity receiver for sensing the primary user's spectrum with reasonable cost and complexity. Conventional CR with the receiver equipping multiple antennas requires additional hardware and space for installing multiple antennas in accordance with increase in the number of antennas. If the number of antennas increases, detection probability as well as hardware complexity and cost rise. Then, it is difficult to make a primary user detector practically. Therefore, we adopt a delay diversity receiver for solving problems of the conventional spectrum detector utilizing multiple antennas. We derive analytical expressions for the spectrum sensing performance of the proposed system. From the simulation results, it is demonstrated that the primary user detector with the delay diversity receiver has almost half the complexity and shows similar or improved performance as compared with that employing multiple antennas. Therefore, the proposed spectrum sensing structure can be a practical solution for enhancing the detection capacity in CR system operations. The results of this paper can be applied to legacy CR systems with simple modifications.

• Cartoon and Animation Studies
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• s.45
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• pp.299-320
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• 2016

The interests of education methods using Serious games have been increasing recently. But resu,lt-oriented game design framework have not been reflected intrinsic motivation. To increase usage of educational serious game as resource, it is needed game design framework for providing the immersion and collaborative active learning that cognitive Psychologic theories recommend. By outlining the background of the serious game design framework and exemplifying its use, a constructive structure to examine purposed based games is introduced.

• Korean Institute of Interior Design Journal
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• v.15 no.4 s.57
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• pp.138-146
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• 2006

Main elements in definition of space value were physical, formal, and reasonable characteristics in the past. Howener recently, definition of space value is changing by being advanced about study concerned with human's cognition and thinking way in definition and analysis of space. As you see, cognitive psychologists have emphasized the importance of human's cognitive structure and process and studied diverse aspects of human's thinking ; consciousness, perception, memory, image, language, decision-making, inference, and so on. Therefore main elements in definition of space value are five-dimensional, psychological, symbolic, mental, emotional characteristics above physical, formal, and reasonable characteristics. As mentioned above, the conversion of thinking focused on reason to thinking focused on human's spirit and emotion is achieved in contemporary architecture and 'human's experience' in space becomes a very important factor. For that reason, the purpose of this study is consideration of human's cognitive process in space by conversion of thinking and gives a definition about experience. And, I would like to define 'experience design' whose main attribute is experience in space and establish theoretical basis of experience design through theoretical researches about experience. This study on experience design that induces users to participate in space and stimulate human's spirit is a important point in definition of space value not only contemporary interior architecture but also prospective generation.

• Smart Media Journal
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• v.5 no.1
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• pp.30-37
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• 2016

In recent decades, the study of human brain function has dramatically increased thanks to the advent of Functional Magnetic Resonance Imaging. This is a powerful tool which provides a deep view of the activities of the brain. From fMRI data, the neuroscientists analyze which parts of the brain have responsibility for a particular action and finding the common pattern representing each state involved in these tasks. This is one of the most challenges in neuroscience area because of noisy, sparsity of data as well as the differences of anatomical brain structure of each person. In this paper, we propose the use of appropriate discriminant methods, such as Fisher Discriminant Ratio and hypothesis testing, together with strong boosting ability of Adaboost classifier. We prove that discriminant methods are effective in classifying cognitive states. The experiment results show significant better accuracy than previous works. We also show that it is possible to train a successful classifier without prior anatomical knowledge and use only a small number of features.

• Journal of Advanced Navigation Technology
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• v.17 no.5
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• pp.506-515
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• 2013

In cognitive radio networks, several research works typically address the framework which consists of a spectrum sensing period and a data transmission period. When the frame period is short, there is the problem that the throughput of secondary users decrease. In this paper, aggregated data slot structure is considered to increase the throughput of secondary users. Chapman-Kolmogorov equation is used for the modeling of the transmission probability of primary users and formulation of an optimization problem to maximize the throughput of secondary users. Solution of the optimization problem results in the optimal spectrum sensing time, the length of data slot and the number of data slots governed by a spectrum sensing.

• Sleep Medicine and Psychophysiology
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• v.9 no.1
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• pp.9-13
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• 2002

Alzheimer's disease (AD) is one of the most common and devastating dementing disorders of old age. Most AD patients showed significant alternation of sleep structure as well as cognitive deficit. Typical findings of sleep architecture in AD patients include lower sleep efficiency, higher stage 1 percentage, and greater frequency of arousals. The slowing of EEG activity is also noted. Abnormalities in REM sleep are of particular interest in AD because the cholinergic system is related to both REM sleep and AD. Several parameters representing REM sleep structure such as REM latency, the amount of REM sleep, and REM density are change in patients with AD. Especially, measurements of EEG slowing during tonic REM sleep can be used as an EEG marker for early detection of possible AD. In addition, a structural defect in the suprachiasmatic nucleus is suggested to cause various chronobiological alternations in AD. Most of alternations related to sleep make sleep disturbances common and disruptive symptoms of AD. In this article, the author reviewed the alternation of sleep structure and circadian rhythm in AD patients.

• Journal of Elementary Mathematics Education in Korea
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• v.16 no.3
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• pp.321-336
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• 2012

Cognitive subject imposes structures on an object to shape it into a structured thing. Structures that the subject imposes on an object in a given problem context can be diverse horizontally and vertically. In view of the horizontal diversity of structure, problem-solving activities focusing on various structures may enrich the present problem-solving education which emphasizes applying and comparing a couple of problem-solving strategies. Finding an algebraic formula for a figural pattern should be regarded as a new starting point of searching for more various structures. In view of the vertical diversity of structure, it should be aware that students may see different structures from the structure that their teacher expect them to see. The vertical diversity of structure enables us to provide students with experience of progress.

• The Journal of the Korea Contents Association
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• v.11 no.8
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• pp.187-197
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• 2011

There are many researches about effects of consumer innovativeness on the new product adoption behavior. However most of these studies regard this construct as one dimensional concept so that the extant studies suggest very ambiguous results about the relationship between consumer innovativeness and adoption behavior. This study subdivides the construct as cognitive innovativeness and sensory one and suggest these two types of consumer innovativeness affect on the risk perception of the potential adopter differently when the consumer adopt new product. In the empirical research through regression analysis and structure equation model with 217 samples, the study shows the consumer who have high level of cognitive innovativeness are more sensitive to functional risk of new products compared to one who have high level of sensory innovativeness. On the other side, sensory innovative consumer perceive social risk more when they adopt new products than cognitive innovator who have higher level of cognitive innovativeness. The result means there are dual paths on the relationship between consumer innovativeness and new products adoption behavior. Unlike the early studies, this study shows that there's dual path in relationship between the consumer's innovativeness and new product adoption. That is the consumer who have higher sensory innovativeness perceive the social risk of new products more sensitively than functional risk but the consumer who have cognitive innovativeness perceive functional risk more. So, new product adoption behavior would be different depending on the sensory or cognitive innovativeness.