Classifying Instantaneous Cognitive States from fMRI using Discriminant based Feature Selection and Adaboost

  • Vu, Tien Duong (Dept. of Electronics and Computer Engineering, Chonnam National University) ;
  • Yang, Hyung-Jeong (Dept. of Electronics and Computer Engineering, Chonnam National University) ;
  • Do, Luu Ngoc (Dept. of Electronics and Computer Engineering, Chonnam National University) ;
  • Thieu, Thao Nguyen (Dept. of Electronics and Computer Engineering, Chonnam National University)
  • Received : 2015.11.25
  • Accepted : 2016.03.23
  • Published : 2016.03.31

Abstract

In recent decades, the study of human brain function has dramatically increased thanks to the advent of Functional Magnetic Resonance Imaging. This is a powerful tool which provides a deep view of the activities of the brain. From fMRI data, the neuroscientists analyze which parts of the brain have responsibility for a particular action and finding the common pattern representing each state involved in these tasks. This is one of the most challenges in neuroscience area because of noisy, sparsity of data as well as the differences of anatomical brain structure of each person. In this paper, we propose the use of appropriate discriminant methods, such as Fisher Discriminant Ratio and hypothesis testing, together with strong boosting ability of Adaboost classifier. We prove that discriminant methods are effective in classifying cognitive states. The experiment results show significant better accuracy than previous works. We also show that it is possible to train a successful classifier without prior anatomical knowledge and use only a small number of features.

Keywords

References

  1. T. Mitchell, R. Hutchinson, M. Just, R.S. Niculescu, F. Pereira, X. Wang. "Classifying Instantaneous Cognitive States from fMRI Data", American Medical Informatics Association Symposium, October 2003.
  2. B.M. Bly, "When you have a General Linear Hammer, every fMRI time-series looks like independent identically distributed nails", Concepts and Methods in NeuroImaging Workshop, 2001
  3. Hojen-Sorensen, L.K. Hansen and C.E. Rasmussen, "Bayesian modeling of fMRI time series", Proc. Conf. Advances in Neural Information Processing Systems, NIPS, 1999, pp 754-760
  4. Cox, D.D., Savoy, R.L.: "Functional magnetic resonance imaging (fMRI) "brain reading": detecting and classifying distributed patterns of fMRI activity in human visual cortex." NeuroImage 19, 2003, pp 261-270 https://doi.org/10.1016/S1053-8119(03)00049-1
  5. Wagner, A. D. et al. "Building memories: Remembering and forgetting of verbal experiences as predicted by brain activity." Science, 281, 1998, pp 1188-1191. https://doi.org/10.1126/science.281.5380.1188
  6. T.M. Mitchell, R. Hutchinson, R.S. Niculescu, F.Pereira, X. Wang, M. Just, and S. Newman "Learning to Decode Cognitive States from Brain Images" Machine Learning, Vol. 57, Issue 1-2, October 2004. pp. 145-175. https://doi.org/10.1023/B:MACH.0000035475.85309.1b
  7. M.T.T.Hoang, Y.G.Won and H.J.Yang, "Cognitive States Detection in fMRI Data Analysis using incremental PCA", ICCSA, 2007. pp.335-341.
  8. Luu-Ngoc Do, Hyung-Jeong Yang, "Classification of Cognitive States from fMRI data using Fisher Discriminant Ratio and Regions of Interest" International Journal of Contents, Vol.8, No.4, pp.55-62, 2012.12 https://doi.org/10.5392/IJoC.2012.8.1.055
  9. Michael Collins, Robert E. Schapire, Yoram Singer. "Logistic regression, AdaBoost and Bregman distances" Machine Learning, Vol.48 July 2002 Issue 1, pp 253-265 https://doi.org/10.1023/A:1013912006537
  10. Freund, Y. and R. E. Schapire. "A Decision -Theoretic Generalization of On-Line Learning and an Application to Boosting." Journal of Computer and System Sciences, Vol. 55, pp. 119-139, 1997. https://doi.org/10.1006/jcss.1997.1504
  11. Rademacher, J., Galaburda, A.M., Kennedy, D.N., Filipek, P.A., Caviness, V.S.: Human celebral cortex: localization, parcellation, and morphometry with magnetic resonance imaging. J. Cogn. Neurosci. 4, 352-374 (1992) https://doi.org/10.1162/jocn.1992.4.4.352
  12. Etzel, J.A., Gazzola, V., Keysers, C.: An introduction to anatomical ROI-based fMRI classification analysis. Brain Res. 1282, 114-125 (2009) https://doi.org/10.1016/j.brainres.2009.05.090
  13. Sergios Theodoridis, Konstantinos Koutroumbas: Pattern Recognition, 273-274 (2009)