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Enhanced Drug Carriage Efficiency of Curcumin-Loaded PLGA Nanoparticles in Combating Diabetic Nephropathy via Mitigation of Renal Apoptosis

  • Asmita Samadder;Banani Bhattacharjee;Sudatta Dey;Arnob Chakrovorty;Rishita Dey;Priyanka Sow;Debojyoti Tarafdar;Maharaj Biswas;Sisir Nandi
    • Journal of Pharmacopuncture
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    • v.27 no.1
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    • pp.1-13
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    • 2024
  • Background: Diabetic nephropathy (DN) is one of the major complications of chronic hyperglycaemia affecting normal kidney functioning. The ayurvedic medicine curcumin (CUR) is pharmaceutically accepted for its vast biological effects. Objectives: The Curcuma-derived diferuloylmethane compound CUR, loaded on Poly (lactide-co-glycolic) acid (PLGA) nanoparticles was utilized to combat DN-induced renal apoptosis by selectively targeting and modulating Bcl2. Methods: Upon in silico molecular docking and screening study CUR was selected as the core phytocompound for nanoparticle formulation. PLGA-nano-encapsulated-curcumin (NCUR) were synthesized following standard solvent displacement method. The NCUR were characterized for shape, size and other physico-chemical properties by Atomic Force Microscopy (AFM), Dynamic Light Scattering (DLS) and Fourier-Transform Infrared (FTIR) Spectroscopy studies. For in vivo validation of nephro-protective effects, Mus musculus were pre-treated with CUR at a dose of 50 mg/kg b.w. and NCUR at a dose of 25 mg/kg b.w. (dose 1), 12.5 mg/kg b.w (dose 2) followed by alloxan administration (100 mg/kg b.w) and serum glucose levels, histopathology and immunofluorescence study were conducted. Results: The in silico study revealed a strong affinity of CUR towards Bcl2 (dock score -10.94 Kcal/mol). The synthesized NCUR were of even shape, devoid of cracks and holes with mean size of ~80 nm having -7.53 mV zeta potential. Dose 1 efficiently improved serum glucose levels, tissue-specific expression of Bcl2 and reduced glomerular space and glomerular sclerosis in comparison to hyperglycaemic group. Conclusion: This study essentially validates the potential of NCUR to inhibit DN by reducing blood glucose level and mitigating glomerular apoptosis by selectively promoting Bcl2 protein expression in kidney tissue.

Effect of Mixture Rate of Used Media and Perlite on Physico-Chemical of Properties Root Media and Seedling Quality in Fruit Vegetables Plug Nursery System (공정육묘시 재활용 상토에 신규상토 및 펄라이트의 혼합비율이 상토의 이화학적 특성과 과채류 묘소질에 미치는 영향)

  • Byun, Hyo-Jeung;Kim, Young Shik;Kang, Ho-Min;Kim, Il Seop
    • Journal of Bio-Environment Control
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    • v.21 no.3
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    • pp.213-219
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    • 2012
  • Improving the physico-chemical properties of used media by mixing ratio of new plug media (NPM), used plug media (UPM) and perlite is necessary to improve seedling quality. In this study, five treatments were designed to investigate mixing ratio of UPM and NPM by ratio of volume 0 : 100, 25 : 75, 50 : 50, 75 : 25, 100 : 0, respectively. On the other hand, nine treatments were designed to investigate of perlite volumes were added to UPM and mixed media (UPM : NPM (50 : 50)) with 0, 5, 10, and 20% of ratio volume. The physicochemical properties of all mediums and their effect on growth response of tomato and cucumber seedlings were determined. The result indicates that physical properties was improved when NPM was mixed with UPM and at mixed ratio of volume 50 : 50 (v : v) has similar pore spare, bulk density and water retention to NPM. Seedling quality of tomato and cucumber in mixed media (50 : 50) are better than other mixed ratio and similar to NPM. Addition perlite to UPM and mixed media 50 : 50 (v : v) increased the pore space and water retention. Physical properties such as particle density, pore space and bulk density were increased when perlite volume increased. However, the best of seedling quality was observed by the addition at 10% volume of perlite. These results suggested that optimum of mixed ratio for recycled used media is new media and used media 1 : 1 mixed.

Unfair Restrain on Competition in Air Cargo Fuel Surcharge Case (공정거래법상 부당한 경쟁제한의 의미 - 항공화물 유류할증료 담합사건을 중심으로 -)

  • Lee, Chang Jae
    • The Korean Journal of Air & Space Law and Policy
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    • v.30 no.1
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    • pp.117-149
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    • 2015
  • On May 16, 2014 the Supreme Court of Korea rendered its decision with respect to litigation filed by All Nippon Airways Co., Ltd. ("ANA") for revocation of an order of correction and payment of a penalty imposed by the Korea Fair Trade Commission ("KFTC"). On or around September 2002, ANA and various airlines operating air cargo service from Japan to Korea were allegedly to have agree to introduce of fuel surcharge into their rates on cargo fares in an attempt to recoup falling profits from rising of oil price. As this hard core cartel was per se prohibited under Korean competition law (The Monopoly Regulation And Fair Trade Act), KFTC began an investigation and consequently with fruitful results imposed an amount of penalty and issued an order of prohibition. ANA protested against this imposition by filing suit against KFTC under the reasons that (1) their agreement was simply pursuant to the relevant laws and regulations including Air Transport Agreement between Korea and Japan, (2) there was an administrative guidance from Japanese government to allow this agreement, (3) extraterritorial application of Korean competition law to the agreement in this matter was improper as it was made within Japan and targeted only for the shipment from Japan to Korea: accordingly there is not a direct and serious effect between the agreement and any result of anti-competitive. This article aims to review ANA's allegation and the judgement delivered by Korean court under some issues respectively; (1) whether there is an effectively actual anti-competitive cartel between airlines including plaintiff, (2) whether filed rate doctrine is reasonable and applicable in this case for precluding wrongfulness, (3) what is the reasonable limitation of boundaries in extraterritorial application of Korean competition law. Additionally, this article also suggests to concern particular features of air transport business as an regulated industry in judging the unfair restrain on competition.

The Legal Nature and Problems of Air Mileage (항공마일리지의 법적 성격과 약관해석)

  • Kim, Dae-Kyu
    • The Korean Journal of Air & Space Law and Policy
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    • v.25 no.2
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    • pp.163-199
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    • 2010
  • A frequent flyer program is a loyalty program offered by many airlines. Typically, airline customers enrolled in the program accumulate frequent flyer miles corresponding to the distance flown on that airline or its partners. There are other ways to accumulate miles. In recent years, more miles were awarded for using co-branded credit and debit cards than for air travel. Acquired miles can be redeemed for free air travel; for other goods or services, such as travel class upgrades, airport lounge access or priority bookings. The first modern frequent flyer program was created Texas International Airlines in 1979. This program was also adopted in Korean Air in 1984. Since then, the mileage programs have grown enormously. As of June 2009, the total member of two national airlines in Korea had been over thirty million. However, accumulated miles could be burden of airlines, because the korean corporations should record the annual financial report the accumulate mileage on a liability account by 'the international financial report standards(IFRS)' next year. The korean airlines need to minimize the accumulated miles, so that for instance Korean Airlines SKYPASS-miles expire 5 years after being earned. It means that miles earned on or after July 2008 will expire after five years if unredeemed. Thus, this paper attempt to analyze the unfairness of the mileage rules of korean airlines by examining a specific portion of the conditions relating to consumer protection, because many mileage users has difficulties using mileage programs and complained the amendment of the mileage rules. In conclusion, the contemporary mileage rules in Korea are rather unsatisfactory, because airlines is not only recognizing a mileage into a kind of benefit but also denying inheritance of mileage and the legal nature of mileage as a property right. It is necessary to amend relevant mileage rules in view of consumer protection, because air mileage is not simple benefit but a right of mileage user.

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Analysis of User Behavior for the Revitalization of Small Parks near Stations by the Location Types in Influential Subway Area (역세권내 역 인접 소공원의 유형별 이용행태분석을 통한 활성화 방안 연구)

  • Lee, Joo-Hee;Park, Jin-A.
    • Journal of the Korean Institute of Landscape Architecture
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    • v.36 no.3
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    • pp.9-20
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    • 2008
  • The government is planning to link a small park with the soon to be ready subway line 9 as a part of Seoul's policy, "The standard or plan for making a water-friendly space by water use" (2007). However, the specified concepts and instructions of the small parks need further work. Therefore, the policy is expected to expand to neighboring small parks near the subway station, but these are not supported by research or data which suggests the needs or actual user behavior and utilization of small parks. our country added the specified concept of small parks and theme parks to the classification of urban parks in the Urban Park Act Revision (2005.3.31), but the concept of small parks is not clearly settled in the law in the scopes of its function, scale, promotion nor particularly defined plans for small park projects. This study examines as small park near a subway station. The characteristics of there region and users vary from the characteristics of the station and region. In the "directions for concrete standards under the types of urban parks and green zones" (2007.2) the types of small parks are classified by "regional characteristics" and "user characteristics". Therefore, this study classifies the subject of neighboring small parks near subway stations as the neighborhood and small urban parks according to the Urban Park Act. The study was paralleled with observation and questionnaires on the analysis of the neighborhood and small urban parks. The actual conditions of park utilization and user behavioral characteristics were deducted by observation, while the questionnaire determined actual user utilization, importance and satisfaction level as well as the small park environment. This study largely focused on three aspects: park facility, design of this sentence isn't even complete. The second aspect isn't finished and the third isn't here.

Measurement of Radiation Using Tissue Equivalent Phantom in ICR Treatment (자궁강내 근접방사선조사시 인체조직등가 팬톰을 이용한 방사선량 측정)

  • Jang, Hong-Seok;Suh, Tae-Suk;Yoon, Sei-Chul;Ryu, Mi-Ryeong;Bahk, Yong-Whee;Shinn, Kyung-Sub
    • Journal of Radiation Protection and Research
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    • v.20 no.1
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    • pp.45-52
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    • 1995
  • This study is to compare A point doses in human pelvic phantom by film dosimetry, computer planning and manual calculation by using of along-away table. We developed tissue equivalent human pelvic phantom composed of four pieces of cylindrical acryl tubes with water, to simulate intracavitary radiation (ICR) in patients with cervix cancer. When the phantom assembled from 4 pieces, it has a small space for inserting Fletcher-Suit-Delclos applicator like a human vagina. Fletcher-Suit-Delclos applicator inserted into the space was packed tightly with furacin gauzes, and three $^{137}Cs$ sources with radioactivity of $15.7mg\;Ra-eq$ were inserted into the tandem. For the film dosimetry, two pieces of X-OMAT V film (Kodak Co.) of which planes include point A, were arranged orthogonally in the slits between phantoms. A point dose and iso-dose curves were measured by means of optical densitometer. A point doses by film dosimetry, RTP system and manual calculation by using of along-away table were compared, and iso-dose curves by film dosimetry and computer planning were also compared. The dose of A point was 51.2cGy/hr by film dosimetry, 46.7cGy/hr by RTP system and 47.9 cGy/hr by along-away table. A point dose by computer planning was similar to the dose by calculation using of along-away table with acceptable accuracy $({\pm}3%)$, however, the dose by film dosimetry was different from two others with about 10% error. Since most clinical beams contains a scatter component of low energy photons, the correlation between optical density and dose becomes tenuous. In addition, film suffers from several potential errors such as changes in processing conditions, interfilm emulsion differences, and artifacts caused by air pockets adjacent to the film. For these reasons, absolute dosimetry with film is impractical, however, it is very useful for checking qualitative patterns of a radiation distribution. In future, solid state dosimeter such as TLD must be used for the dosimetry of ionizing radiation. When considerable care is used, precision of approximately 3% may be obtained using TLD.

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Particulate Matter Removal of Indoor Plants, Dieffenbachia amoena 'Marianne' and Spathiphyllum spp. according to Light Intensity (광량에 따른 실내식물 디펜바키아와 스파티필럼의 미세먼지 제거능)

  • Kwon, Kei-Jung;Park, Bong-Ju
    • Journal of the Korean Institute of Landscape Architecture
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    • v.46 no.2
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    • pp.62-68
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    • 2018
  • This study investigated the effect of light intensity on the removal of particulate matter by Dieffenbachia amoena 'Marianne' and Spathiphyllum spp.. An acrylic chamber ($600{\times}800{\times}1200mm$, $L{\times}W{\times}H$) modeled as an indoor space and a green bio-filter ($495{\times}495{\times}1000mm$, $L{\times}W{\times}H$) as an air purification device were made of acrylic. The removal of particulate matter PM10 and PM1, the photosynthetic rate, stomatal conductance, and number of stomata of Dieffenbachia amoena 'Marianne' and Spathiphyllum spp. were measured according to three different levels of light intensity (0, 30 and $60{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$). Regarding the length of time taken for PM10 to reach $1{\mu}g$, the Dieffenbachia amoena 'Marianne' showed a significant difference according to the presence or absence of light, and there was no significant difference shown between light intensity of 30 and $60{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$. As for the Spathiphyllum spp., there was no significant difference between 0 and $30{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$, while a significant difference was shown at $60{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$. After 90 minutes, the PM1, PM10, and $CO_2$ residuals of the Spathiphyllum spp. were lowest at $60{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$. The remaining amount of PM1 and PM10 was lower with the Spathiphyllum spp. than with the Dieffenbachia amoena 'Marianne', even at $0{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}PPFD$. With both plants, the higher the light intensity, the higher the photosynthetic rate, while the stomatal conductance did not show any significant difference. Spathiphyllum spp. showed a higher photosynthetic rate and stomatal conductance and a greater number of stomata than Dieffenbachia amoena 'Marianne', and stomata were observed in both the front and back sides of the leaves. The air purification effect of Spathiphyllum spp. is considered to be better than Dieffenbachia amoena 'Marianne' at the same light intensity due to such plant characteristics. Therefore, in order to select effective indoor plants for the removal of particulate contamination in an indoor space, the characteristics of plants such as the photosynthetic rate and the number and arrangement of stomata according to indoor light intensity should be considered.

Some New Problems of International Aviation Security- Considerations Forcused on its Legal Aspects (최근국제항공보안대책(最近國際航空保安対策)의 제간제(諸間題) -특히 법적측면(法的測面)을 중심(中心)으로-)

  • Choi, Wan-Sik
    • The Korean Journal of Air & Space Law and Policy
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    • v.5
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    • pp.53-75
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    • 1993
  • This article is concerned with the comment on "Some New Problems of International Aviation Security-Considerations Forcused on its Legal Aspects". Ever since 1970, in addition to the problem of failure to accept the Tokyo, Hague and Montreal Conventions, there has been also the problem of parties to them, failing to comply with their obligations under the respective treaties, in the form especially of nominal penalties or the lack of any effort to prosecute after blank refusals to extradite. There have also been cases of prolonged detention of aircraft, passengers and hostages. In this regard, all three conventions contain identical clauses which submit disputes between two or more contracting States concerning the interpretation or application of the respective conventions to arbitration or failing agreement on the organization of the arbitration, to the International Court of Justice. To the extent to which contracting States have not contracted out of this undertaking, as I fear they are expressly allowed to do, this promision can be used by contracting States to ensure compliance. But to date, this avenue does not appear to have been used. From this point of view, it may be worth mentioning that there appears to be an alarming trend towards the view that the defeat of terrorism is such an overriding imperative that all means of doing so become, in international law, automatically lawful. In addition, in as far as aviation security is concerned, as in fact it has long been suggested, what is required is the "application of the strictest security measures by all concerned."In this regard, mention should be made of Annex 17 to the Chicago Convention on Security-Safeguarding International Civil Aviation against Acts of Unlawful Intereference. ICAO has, moreover, compiled, for restricted distribution, a Security Manual for Safeguarding Civil Aviation Against Acts of Unlawful Interference, which is highly useful. In this regard, it may well be argued that, unless States members of ICAO notify the ICAO Council of their inability to comply with opecific standards in Annex 17 or any of the related Annexes in accordance with Article 38 of the 1944 Chicago Convention on International Civil Aviation, their failure to do so can involve State responsibility and, if damage were to insure, their liability. The same applies to breaches of any other treaty obligation. I hope to demonstrate that although modes of international violence may change, their underlying characteristics remain broadly similar, necessitating not simply the adoption of an adequate body of domestic legislation, firm in its content and fairly administered, but also an international network of communication, of cooperation and of coordination of policies. Afurther legal instrument is now being developed by the Legal Committee of ICAO with respect to unlawful acts at International airports. These instruments, however, are not very effective, because of the absence of universal acceptance and the deficiency I have already pointed out. Therefore, States, airports and international airlines have to concentrate on prevention. If the development of policies is important at the international level, it is equally important in the domestic setting. For example, the recent experiences of France have prompted many changes in the State's legislation and in its policies towards terrorism, with higher penalties for terrorist offences and incentives which encourage accused terrorists to pass informations to the authorities. And our government has to tighten furthermore security measures. Particularly, in the case an unarmed hijacker who boards having no instrument in his possession with which to promote the hoax, a plaintiff-passenger would be hard-pressed to show that the airline was negligent in screening the hijacker prior to boarding. In light of the airline's duty to exercise a high degree of care to provide for the safety of all the passengers on board, an acquiescence to a hijacker's demands on the part of the air carrier could constitute a breach of duty only when it is clearly shown that the carrier's employees knew or plainly should have known that the hijacker was unarmed. The general opinion is that the legal oystem could be sufficient, provided that the political will is there to use and apply it effectively. All agreed that the main responsibility for security has to be borne by the governments. A state that supports aviation terrorism is responsible for violation of International Aviation Law. Generally speaking, terrorism is a violation of international law. It violates the sovereign rights of states, and the human rights of the individuals. We have to contribute more to the creation of a general consensus amongst all states about the need to combat the threat of aviation terrorism. I think that aviation terrorism as becoming an ever more serious issue, has to be solved by internationally agreed and closely co - ordinated measures.

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Overall risk analysis of shield TBM tunnelling using Bayesian Networks (BN) and Analytic Hierarchy Process (AHP) (베이지안 네트워크와 AHP (Analytic Hierarchy Process)를 활용한 쉴드 TBM 터널 리스크 분석)

  • Park, Jeongjun;Chung, Heeyoung;Moon, Joon-Bai;Choi, Hangseok;Lee, In-Mo
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.18 no.5
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    • pp.453-467
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    • 2016
  • Overall risks that can occur in a shield TBM tunnelling are studied in this paper. Both the potential risk events that may occur during tunnel construction and their causes are identified, and the causal relationship between causes and events is obtained in a systematic way. Risk impact analysis is performed for the potential risk events and ways to mitigate the risks are summarized. Literature surveys as well as interviews with experts were made for this purpose. The potential risk events are classified into eight categories: cuttability reduction, collapse of a tunnel face, ground surface settlement and upheaval, spurts of slurry on the ground, incapability of mucking and excavation, and water leakage. The causes of these risks are categorized into three areas: geological, design and construction management factors. Bayesian Networks (BN) were established to systematically assess a causal relationship between causes and events. The risk impact analysis was performed to evaluate a risk response level by adopting an Analytic Hierarchy Process (AHP) with the consideration of the downtime and cost of measures. Based on the result of the risk impact analysis, the risk events are divided into four risk response levels and these levels are verified by comparing with the actual occurrences of risk events. Measures to mitigate the potential risk events during the design and/or construction stages are also proposed. Result of this research will be of the help to the designers and contractors of TBM tunnelling projects in identifying the potential risks and for preparing a systematic risk management through the evaluation of the risk response level and the migration methods in the design and construction stage.

Can Lufthansa Successfully Limit its Liability to the Families of the Victims of Germanwings flight 9525 Under the Montreal Convention?

  • Gipson, Ronnie R. Jr.
    • The Korean Journal of Air & Space Law and Policy
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    • v.30 no.2
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    • pp.279-310
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    • 2015
  • The Montreal Convention is an agreement that governs the liability of air carriers for injury and death to passengers travelling internationally by air. The Montreal Convention serves as the exclusive legal framework for victims and survivors seeking compensation for injuries or death arising from accidents involving international air travel. The Montreal Convention sets monetary liability caps on damages in order to promote the financial stability of the international airline transport industry and protect the industry from exorbitant damages awards in courts that would inevitably bankrupt an airline. The Convention allows a litigant suing under the Convention to avoid the liability caps in instances where the airline's culpability for the injury or death is the direct result of negligence, another wrongful act, or an omission of the airline or its agents. The Montreal Convention identifies specific locations as appropriate venues to advance claims for litigants seeking compensation. These venues are closely tied to either the carrier's business operations or the passenger's domicile. In March 2015, in an act of suicide stemming from reactive depression, the co-pilot of Germanwings flight 9525 intentionally crashed the aircraft into the French Alps killing the passengers and the remaining crew. Subsequent to the crash, there were media reports that Lufthansa made varying settlement offers to families of the passengers who died aboard the flight ranging from $8,300 USD to $4.5 Million USD depending on the passengers' citizenship. The unverified offers by Lufthansa prompted outcries from the families of the decedent passengers that they would institute suit against the airline in a more plaintiff friendly jurisdiction such as the United States. The first part of this article accomplishes two goals. First, it examines the Montreal Convention's venue requirement along with an overview of the recoverable damages from countries comprising the citizenship of the passengers who were not American. The intentional crash of Germanwings flight 9525 by its First Officer encompasses the possibility that Lufthansa may be exposed to unlimited compensatory damages beyond the liability caps contained in the Convention. The second part of this article explores the application of the Convention's liability limits to the Germanwings flight to demonstrate that the likelihood of escaping the liability limits is slim.