• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• International Journal of Internet, Broadcasting and Communication
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• 제7권2호
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• pp.96-104
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• 2015

Fischer Tropsch reaction is one of the interesting topic for renewable and clean energy. Polymerization of carbon monoxide or carbon dioxide with hydrogen over metal supported catalyst can produce long chain hydrocarbons. Synthetic liquid hydrocarbons are promising alternative to fossil fuels. This research work has been focused on the synthesis of Fe based catalyst for Fischer Tropsch reaction. Mesoporous silica (MS) support prepared by a precipitation method using two different washing solution, distilled water (DW) and acid in ethanol solution (ET), and different calcination temperature. Then, Fe/MS was prepared by an incipient wetness impregnation method. All of samples were systematically characterized using various physical and chemical techniques. TEM and XRD analysis were used to ensure that the cubic Ia3d mesostructure is stable after calcination. FTIR spectra are useful to ascertain the existence of template in the support. TPR studies were also used to understand the nature of Fe species and their reducibility. The results reveal that washing the support with distilled water and calcination at $550^{\circ}C$ can efficiently remove the triblock copolymer templates. The existence of template in the support affects the textural properties of all catalyst investigated.

• International Journal of Advanced Culture Technology
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• 제4권4호
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• pp.45-50
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• 2016

This is a humanistic study to trace phenomena logically the comprehensive therapeutic mechanism of the human body which is coded by the smart emotion of the rated signal conveyed by the Rated Sijo. The Gestalt, which is structured in the form of therapeutic metastasis conveyed by sentences, is intended to embody the principle of human response. So, this researcher explored the metastatic structure toward Gestalt of original human being through the passage of foreground and background by ergonomic and chemical structure. In the meantime, this researcher focused on revealing the structure of the field of existence by the symbol system in which the therapeutic mechanism of the human body is embodied. As a result, the basic framework of Gestalt literary therapy, which contributes to the improvement of the Quality of Life metaphorized as a mechanism of the symbol system by the metastasis of literary therapy or the electrical operation of the human body. As a result, the human body as a conductor through literature has turned out to be an original Gestalt structure pursued by literature. In addition, it was analyzed that the human body would accept signals such as emotions and Rated Emotions planted in the sentence, and synapse them into the human physiological psycho analytical symbol system. Therefore, it has been confirmed possibility that human existent environment and trauma are separated from the whole universe can push fully implement therapeutic techniques toward totalization by a combination of literary devices, especially appropriate electric signal combination of the Rated Sijo.

• Composites Research
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• 제17권6호
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• pp.58-66
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• 2004

페놀 컴포지트(PC)의 실용화에 관하여 $\ulcorner$영국의 경우 $\lrcorner$ 에 대한 사례를, 지금까지 5회 본지에 보고했다. 이 이야기는 1987년 11원 18일 런던 지하철의 화재사고의 대책 끝에 채택한 $\ulcorner$착화ㆍ연소 방지와 화재의 검은 연기ㆍ유해가스 발생 방지$\lrcorner$ 에 관한 규정을 강화 시행함으로써 위험으로부터 시민을 지키는 혁신 정책이였다. 런던 지하철 당국의 $\ulcorner$단호한 실행$\lrcorner$ 은 영국시민의 지지를 얻어 런던지하철, 영국 국철을 시작으로 지하철 역구내, 선박, 학교, 병원 등 $\ulcorner$인간 생명 제일의 장소$\lrcorner$ 에 PC를 차례로 적용해 가는 상황을 보고했다. 이 $\ulcorner$PC의 적용$\lrcorner$ 에는 많은 $\ulcorner$검증$\lrcorner$ 이 필요했지만 필자의 한사람인 Ken L. Forsdyke 씨는 프로젝트 리더로써 약 10인의 협력자와 함께 $\ulcorner$기초 테마의 축적$\lrcorner$ 을 행했다. 이번 회는 그 일부를 소개하고 $\ulcorner$영국의 경우$\lrcorner$ 를 최종 정리했다. 그 후 그는 협력한 사람들과 미국으로 옮겨 PC에 따른 $\ulcorner$안전한 사회$\lrcorner$ 의 실현에 노력하고 있다. 그의 협력으로 英ㆍ美ㆍ日의 정보 교환은 더욱 진전되고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6595-6597
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• 2015

Objective: To investigate short- and long-term treatment effects and side reactions of lobaplatin plus 5-Fu combined and concurrent radiotherapy in treating patients with inoperable middle-advanced stage esophageal cancer. Methods: Sixty patients with middle-advanced stage esophageal squamous cell cancer were retrospectively analyzed. All patients were administered lobaplatin (50 mg intravenously) for 2 h on day 1, and 5-Fu ($500mg/m^2$) injected intravenously from day 1 to 5 for 1 cycle, in an interval of 21 days for totally 4 cycles. At the same time, late-course accelerated hyperfractionated three-dimensional conformal radiotherapy was performed. Patients were firstly treated with conventional fractionated irradiation (1.8 Gy/d, 5 times/week, a total of 23 treatments, and DT41.4 Gy), and then treated with accelerated hyperfractionated irradiation (1.5 Gy, 2 times/d, a total of 27 Gy in 9 days, an entire course of 6-7 weeks, and DT 68.4Gy). Results: All patients completed treatment, including 10 complete response (CR), 41 partial response (PR), 7 stable disease (SD), and 2 progressive disease (PD). The total effective rate was 85.0% (51/60). Thirty-nine patients had an increased KPS score. One-, 2-, and 3-year survival rates were 85.3%, 57.5%, and 41.7%, respectively. The median survival time was 27 months. The adverse reactions included myelosuppression, which was mainly degree I and II. The occurrence rate of radiation esophagitis was 17.5%. No significant hepatic or renal toxicity was observed. Conclusion: Lobaplatin plus 5-Fu combined with concurrent radiotherapy is safe and effective in treating patients with middle-advanced stage esophageal cancer. However, this result warrants further evaluation by randomized clinical studies.

• 식물병연구
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• 제24권1호
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• pp.59-65
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• 2018

Pyraclostrobin은 광범위한 스펙트럼의 항진균 활성이 있는 퀴논외부저해제(Quinone outside inhibitor, QoI)로 작용하는 살균제이다. 기존 보고에 의하면 pyraclostrobin이 일부 세균병과 바이러스병에 대해 병 저항성을 유도한다고 알려져 있다. 본 연구는 pyraclostrobin 항진균제를 활용하여 고추 세균점무늬병(Xanthomonas euvesicatoria)의 예방 가능성을 검토하였다. Pyraclostrobin은 in vitro 상에서 X. euvesicatoria에 대해 항균활성이 없었지만, 고추에 pyraclostrobin 단독(방제가 69%) 또는 streptomycin과 혼합 살포(방제가 90%) 하였을 때, 고추 세균점무늬병 예방 효과를 나타냈다. Pyraclostrobin의 고추 세균점무늬병 예방 효과는 병원균 접종 1-3일전이 효과적이었다. 이상의 결과로 pyraclostrobin 살진균제를 활용하여 고추 세균점무늬병을 효과적으로 예방할 수 있을 것을 사료된다.

• 한국산업보건학회지
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• 제4권1호
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• pp.117-126
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• 1994

Some of the important and vital roles performed by the Health Care Center of Pohang Iron & Steel Co., Ltd.(POSCO) are the periodic monitoring of the work sites as well as regular medical check-ups for each workers to ensure both pleasant and safe working conditions and to protect employees' health. Pohang Steel Works, which has 42 plants, 26 facilities and 12,000 employees, has an annual crude steel production capacity of 9,670,000 using 24,500,000 ton of raw materials. We have measured lots of areal and personal working environment according to Occupational Safety and Health Law semiannually. All data collected on industrial hygiene is stored and managed by personal computer. The developed of a computerized industrial hygiene control system linked to the company's main computer system will provide efficient evaluation of the working environment as well as critical informations on employees' health. Development of this system had begun in May, 1992 and was completed in March, 1994. The computerized industrial hygiene control system can; 1. store industrial hygiene data, providing key pertinent to the diagnosis of occupational related illnesses, and if necessary, the basis for improving the working environment, 2. decide type and time of medical examination of each work for exposure to specific agents, and supply proper protection periodically, 3. prevent occupational related illnesses through evaluation of environmental and biological monitoring, and performance of epidemiological surveillance, 4. facilitate proper job placement through linking of industrial hygiene control and personnel information systems, 5. monitor job processes. levels of chemical agents used, and new agents introduced, 6. and increase productivity by saving time resulting from the implementation of the computerized sysyte,

• 한국산업보건학회지
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• 제18권1호
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• pp.32-40
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• 2008

Methyl bromide has been used as a representative fumigant for quarantine, and several poisoning cases have occurred recently by this chemical in Korea. The purpose of this study is to evaluate workers' exposures to airborne methyl bromide in the importing and exporting plant products quarantine companies. Air samples were collected 400/200 mg Anasorb 747TM and were analyzed by gas chromatograph /flame ionization detector according to the Occupational Safety and Health Agency (OSHA) Method PV2040. Geometric mean (GM) and arithmetic mean (AM) of total 27 workers' exposure concentrations to airborne methyl bromide were 1.12 ppm and 0.24 ppm, respectively. Two exposures(12.1 ppm and 12 ppm as 8hr-TWA) of total 27 workers' exposures exceeded the Korean standard (5 ppm) of Ministry Labor, while 4 exposures (15%) exceeded the Threshold Limit Value (TLV) (1 ppm) of American Conference of Governmental Industrial Hygienists (ACGIH). Seven samples (11%) of total 63 short-term air samples exceeded the OSHA Permissible Exposure Limit (PEL) 20 ppm (Ceiling). The opening (management) task in wood fumigation by tent showed the highest short-term exposure concentrations (AM: 18.6 ppm, GM: 0.58 ppm, maximum: 340.7 ppm). The maximum level in treatment task of the same process was 2.01 ppm. Methyl bromide concentrations in opening operation was significantly higher than that in treatment operation (p<0.05). In conclusion, the GM of workers' 8hr-TWA exposures to airborne methyl chloride in the importing/exporting plant quarantine industry was estimated below the ACGIH TLV (1 ppm). However, opening task in the fumigation of wood being covered with tent or fumigation of pant products in container showed the levels exceeding ACGIH TLV (1 ppm), and opening task in the fumigation of wood being covered with tent showed the level exceeding the Korean standard of Ministry of Labor (5 ppm).

• 한국건축시공학회지
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• 제18권5호
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• pp.463-469
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• 2018

기존의 다층으로 구성되어 시공성이 낮은 옥상녹화 공법의 개선을 위해 개발한 방수 방근 시트 일체화 옥상녹화박스 유닛공법의 일체화를 위해 사용하는 전자기 유도가열방식의 금속 고정구와 콘 형상 고정구의 부착성능을 평가하기 위해 엔지니어링 PE, TPO, PVC 시트 등 3종류의 시트에 가열온도에 따른 부착성능 및 동일한 시험체로 냉열반복 후 부착성능을 측정하였다, 그 결과는 엔지니어링 PE시트에 부착한 고정구의 부착성능이 가장 우수하게 나타났으며, 금속고정구는 가열온도가 올라갈수록, 콘 형상 고정구는 가열온도가 낮을수록 우수한 부착성능을 보여주었고, 냉열 반복 후 부착시험 결과는 상온 부착시험 결과와 동일하게 나타났다. 기존의 양면 부틸테이프 고정방식의 콘 형상 고정구는 낮은 부착하중과 냉열반복에 의한 뚜렷한 성능저하가 발생하는데 비하여 전자기 유도가열방식의 고정구는 우수한 성능을 유지하였다.

• 펄프종이기술
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• 제34권5호
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• pp.39-48
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• 2002

The water retention of coating colors can be accurately measured by devices such as an AA-GWR water retention meter whose principle of measurement Is based on pressure filtration of coatings under an externally applied air pressure over a certain period of time. It was hypothesized that such devices could be also used to determine the immobilization solids (IMS) of coating colors by determining a sudden drop in the rate of dewatering, that is, a sudden change in the drainage curves. To test this hypothesis, the immobilization solids of coating colors containing various thickeners and water retention additives at different levels were first accurately measured by a modified immobilization tester based on the well-known gloss drop method, and then their values were compared with those obtained by an AA-GWR water retention tester. They agreed very well and showed that the standard deviation is only 0.14% in the IMS points between both methods. This good agreement was not surprising because both test methods are based on the same end-point, that is, the immobilization solids point at which menisci begin to form at the coating surface. Theoretical considerations supporting this new method for measuring the immobilization solids of coating colors are presented and some recommendations for the test method are discussed. Also, the effect of various thickeners and water retention additives on the properties and printability of coated papers is discussed.