• Journal of Computing Science and Engineering
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• 제10권3호
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• pp.75-84
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• 2016

Medical cyber-physical systems (MCPS) integrate sensors, actuators, and software to improve patient safety and quality of healthcare. These systems introduce major challenges to safety analysis because the patient's physiology is complex, nonlinear, unobservable, and uncertain. To cope with the challenge that unidentified physiological parameters may exhibit short-term variances in certain clinical scenarios, we propose a novel run-time predictive safety monitoring technique that leverages a maximal model coupled with online training of a computational virtual subject (CVS) set. The proposed monitor predicts safety-critical events at run-time using only clinically available measurements. We apply the technique to a surgical glucose control case study. Evaluation on retrospective real clinical data shows that the algorithm achieves 96% sensitivity with a low average false alarm rate of 0.5 false alarm per surgery.

• 지식경영연구
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• 제16권4호
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• pp.17-34
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• 2015

본 연구는 모바일 캐주얼 게임의 이용자가 모바일 캐주얼 게임에 몰입할 때 주로 어떠한 특성들에 의해 영향을 받는지 파악하고, 그 결과 이용자의 만족도와 충성도에 어떤 영향을 미치는지 실증적으로 검증하였다. 선행연구를 바탕으로 재미, 기술 숙련도, 이용 용이성, 즉시접속성, 도전감을 몰입의 중요 특성으로 선정하였으며, 몰입이 이용자의 만족도와 충성도에 미치는 영향을 설문조사를 통해 실증 분석하였다. 분석 결과, 재미, 이용 용이성, 도전감이 몰입에 영향을 미쳤고, 몰입은 만족도에만 영향을 미쳤으며, 만족도는 충성도에 영향을 미쳤다.

• 정보관리학회지
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• 제19권4호
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• pp.185-208
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• 2002

노인들을 위한 정보서비스는 우리나라 공공도서관의 새로운 도전이다. 공공도서관을 주체로 하는 인터넷기반 노인정보서비스를 개발하기 위하여 노인들의 정보원 정보요구 그리고 정보이용 현황을 조사하였다. 1060명의 노인에 대한 면접조사를 수행하여 분석한 결과, 노인들은 대중매체와 비공식 구두 커뮤니케이션을 선호하며, 요구정보는 건강의료, 뉴스, 취미, 종교, 레저여행의 순서로 나타났다. 23%에 해당하는 인터넷 이용 노인들의 활용현황과 인터넷 비이용자들의 장애요인을 식별하였다. 분석결과와 선행연구를 기초로 하여, 정보개발 참고봉사 인터페이스 교육 등으로 구성된 서비스 개발 모델과 협동운영방식을 제안하였고 향후 발전을 위한 문제점과 개선방안을 제시하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제22권1호
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• pp.81-89
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• 2018

This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues. DBHP significantly inhibited the increased sRaw and improved the decreased TV on IAR and LAR, and also inhibited recruitment of eosinophils and neutrophils into the lung, and release of biochemical inflammatory mediators such as histamine and phospholipase $A_2$ from these infiltrated leukocytes, and improved pathological changes. However, anti-asthmatic activities of DBHP at oral doses of 12.5 to 50 mg/kg was less than those of dexamethasone (5 mg/kg, p.o.) and cromoglycate (10 mg/kg, p.o.), but more potent or similar to that of salbutamol (5 mg/kg, p.o.). These results in the present study suggest that anti-asthmatic effects of DBHP in the guinea pigs model of OVA-induced asthmatic responses principally are mediated by inhibiting the recruitments of the leukocytes and the release of biochemical inflammatory mediators from these infiltrated leukocytes.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.36-44
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• 2011

Objective : Propolis (PP) has been used in oriental medicine. PP has various biological activities. However, its immunoregulatory and anti-inflammatory activities have not been well studied. In this study, I investigated these activities of PP by using ovalbumin-induced allergic asthma in mice. Methods : To examine the effect of PP on allergic asthma, mice were sensitized with $100{\mu}g$ of OVA and 1mg of aluminum potasssium sulfate (Alum; Sigma) intraperitoneally on day 0 and 7. On day 14, mice were challenged on consecutive 3 days with 5% OVA and AHR was assessed 24 hours after the last challenge. To examine severity of AHR, I examined the population of eosinophiles and T cells in spleen and lung and cytokine production in T cells. Futhermore, I examined histological changes during the OVA-induced allergic asthma. Results and Conclusion : PP reduced the population of eosinophil and CD4+ T cells on the OVA-induced AHR mice model. PP also inhibited IL-4 production but increased INF-g production in T cells. These results suggest that PP may be beneficial material for allergic asthma.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1833-1840
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• 2013

Metastasis is one of the hallmarks of malignant neoplasms and is the leading cause of death in many cancer patients. A major challenge in cancer treatment is to find better ways to specifically target tumor metastasis. In this study, the anti-metastatic potential of the methanolic extract of Rhizophora apiculata (R.apiculata) was evaluated using the B16F-10 melanoma induced lung metastasis model in C57BL/6 mice. Metastasis was induced in C57BL/6 mice by injecting highly metastatic B16F-10 melanoma cells through the lateral tail vein. Simultaneous treatment with R.apiculata extract (10 mg/kg b.wt (intraperitoneal) significantly (p<0.01) inhibited pulmonary tumor nodule formation (41.1 %) and also increased the life span (survival rate) 107.3 % of metastatic tumor bearing animals. The administration of R.apiculata extract significantly (p<0.01) reduced biochemical parameters such as lung collagen hydroxyproline, hexosamine, uronic acid content, serum nitric oxide (NO), ${\gamma}$-glutamyl transpeptidase (GGT) and sialic acid levels when compared to metastasis controls. These results correlated with lung histopathology analysis of R.apiculata extract treated mice showing reduction in lung metastasis and tumor masses. Taken together, our findings support that R.apiculata extract could be used as a potential anti-metastasis agent against lung cancer.

• IMMUNE NETWORK
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• 제9권2호
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• pp.46-52
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• 2009

Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS) are important in innate immune responses to various intracellular bacterial infections, including mycobacterial infections. It is generally recognized that reactive nitrogen intermediates play an effective role in host defense mechanisms against tuberculosis. In a murine model of tuberculosis, NO plays a crucial role in antimycobacterial activity; however, it is controversial whether NO is critically involved in host defense against Mycobacterium tuberculosis in humans. Here, we review the roles of NO in host defense against murine and human tuberculosis. We also discuss the specific roles of NO in the central nervous system and lung epithelial cells during mycobacterial infection. A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease.

• 한국컴퓨터그래픽스학회논문지
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• 제16권2호
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• pp.1-7
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• 2010

본 논문에서는 큰 회전 변형이 일어나는 가는 막대를 실시간에 시뮬레이션하는 기법을 제안한다. 가는 막대는 로프나 머리카락과 같이 일차원적인 구조를 표현하는데 널리 사용될 수 있다. 시각적으로 사실적인 가는 막대의 애니메이션을 실시간에 생성하는 것은 컴퓨터 그래픽스분야에서 오랫동안 주요한 도전 과제였다. 본 논문에서는 연속체 역학에 기반한 지배방정식을 세우고 이를 실시간에 적분하는 가는 막대구조를 위한 모달와핑기법을 개발한다. 이와같은 새로운 시뮬레이션 기법은 삼차원 솔리드를 위해 개발된 종전의 모달 와핑 기법을 확장한 것이다. 본 논문에서 제안한 방법은 매우 많은 정점으로 이루어진 가는 막대 구조의 큰 휨과 꼬임변형도 실시간에 사실적으로 생성할 수 있다.

• BMB Reports
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• 제53권8호
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• pp.442-447
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• 2020

The non-viral delivery of genes into macrophages, known as hard-to-transfect cells, is a challenge. In this study, the microporation of a CpG-free and small plasmid (pCGfd-GFP) showed high transfection efficiency, sustainable transgene expression, and good cell viability in the transfections of Raw 264.7 and primary bone marrow-derived macrophages. The non-viral method using the pCGfd vector encoding anti-EGFR single-chain Fv fused with Fc (scFv-Fc) generated the macrophages secreting anti-EGFR scFv-Fc. These macrophages effectively phagocytized tumor cells expressing EGFR through the antibody-dependent mechanism, as was proved by experiments using EGFR-knockout tumor cells. Finally, peri-tumoral injections of anti-EGFR scFv-Fc-secreting macrophages were shown to inhibit tumor growth in the xenograft mouse model.

• Wind and Structures
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• 제12권6호
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• pp.505-517
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• 2009

Synchronous wind-induced pressures, measured in wind-tunnel tests on model buildings instrumented with hundreds of pressure taps, are an invaluable resource for designing safe buildings efficiently. They enable a much more detailed, accurate representation of the forces and moments that drive engineering design than conventional tables and graphs do. However, the very large volumes of data that such tests typically generate pose a challenge to their widespread use in practice. This paper explains how a wavelet representation for the time series of pressure measurements acquired at each tap can be used to compress the data drastically while preserving those features that are most influential for design, and also how it enables incremental data transmission, adaptable to the accuracy needs of each particular application. The loss incurred in such compression is tunable and known. Compression rates as high as 90% induce distortions that are statistically indistinguishable from the intrinsic variability of wind-tunnel testing, which we gauge based on an unusually large collection of replicated tests done under the same wind-tunnel conditions.