• 대한한방내과학회지
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• 제22권1호
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• pp.13-20
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• 2001

Object : This study was carried out to examine the effects of Shogunjungtang-ga-younggol morea on gastric ulcers. Methods : In order to study the effects of Shogunjungtang-ga-younggol morea on gastric ulcers. Gastric ulcers were induced in HCI-aspirin in rats. The experiments were done by oral administration and measured by anatohistological features of ulcer lesions, and the changes of the number of parietal cells, chief cells, gastrin and somatostatin- immunoreactive cells. Results : In the Shogunjungtang-ga-younggol morea administrated groups, no gross lesions of ulcer and anatohistologically, just minor injury of gastric mucosa were detected. The number of parietal cells were significantly decreased, and the number of chief cells were significantly increased, in administrated groups. The number of gastrin-immunoreactive cells and somatostatin-immunoreactive cells was significantly increased in administrated groups. Conclusion : According to the results, it is considered that the administration of Shogunjungtang-ga-younggol morea seems to be applicable to the treatment of gastric ulcers.

• 한국멀티미디어학회논문지
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• 제4권2호
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• pp.108-115
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• 2001

본 연구에서는 RGB칼라영상에서 세 칼라 객체의 색상에 따라 정량적으로 분류하기 위하여 ML(Maximum Likelihood) 분류법 을 개선 시도하여 보았다. RGB 칼라 영상이라 하면 빨강, 초록, 파랑의 세 밴드로 이루어진다. 스펙트룸과 공간상의 요소를 고려한다면 3차원적인 구조를 갖게 된다. 이러한 3차원 구조의 voxel를 RGB cube에 투사하여 이로부터 ML분류법의 개선 방법론을 적용하여 보았다. 전례적으로 쉽게 사용되어지는 Box 분류법과 비교 검토하여 보았으며 Bayesian decision 이론을 기반으로한 통계학적인 ML 분류법을 사용하였다. 유방암 항체조직영상에 이 방법론을 응용하며 양성 세포핵 음성 세포핵 그리고 배경을 분류하는데 좋은 결과를 얻어 임상에서 유방암 환자의 예후 및 진단에 사용할 수 있도록 연구하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.80-80
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• 1997

The object of this study was to develop a gene therapy strategy for ovarian cancer. We have previously shown that AV with a L-plastin (LP) promoter infects breast and ovarian cancer cells and expressed ${\beta}$-galactosidase cDNA in preference to normal fibroblast cells and hematopoietic cells. We now report on the cytotoxicity of Ad.LP.CD, an AV carrying a CD cDNA which converts the pro-drug, 5-Fluorocytosine (5-FC) into the toxic drug 5-Fluorouracil (5-FU). Infection of Ad.LP.CD into either 293 cells or ovarian cancer cells generated the functional CD as measured by HPLC analysis. Using a ratio of AV to OVCAR3 cell of 100 and a 5-FC concentration of 100 ${\mu}$M, we achieve an over 95 % of cell growth inhibition. We are using flow cytometry analysis for ${\beta}$ -galactosidase and ovarian cancer associated folate receptor to screen primary ascites samples for infectivity after infection with an adenoviral vector, i.e., Ad.LP.LacZ. This vector system may be of value in the treatment of microscopic disease of ovarian cancer in the peritoneal cavity.

• 한국추진공학회지
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• 제11권4호
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• pp.26-37
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• 2007

통합 가상 엔진의 "Numerical Test Cell" 시험은 다분야 연계 해석을 통하여 하드웨어의 개발에 필요한 시간과 비용을 줄일 수 있다. 본 논문에서는 미국과 유럽에서의 전체 엔진 시뮬레이션 프로그램의 개발 활동과 NPSS를 바탕으로 관련 기술(공학 모델, 시뮬레이션 환경, 고성능 컴퓨팅)을 소개한다. 미국의 NASA Glenn 연구소는 기존의 코드들을 결합하고 기능을 개선하여 NPSS 개발 연구를 이끌고 있으며, 유럽에서는 대학, 연구소, 기업체로 구성된 VIVACE 컨소시움이 각 기관의 프로그램을 통합하여 PROOSIS를 개발하고 있다. 아울러 현재의 상황에 대한 고찰을 통하여 국내 개발의 가능성을 살펴보았다.

• 대한한방종양학회지
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• 제4권1호
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• pp.199-209
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• 1998

In order to find antiviral effect against Human immunodeficiency virus(HIV), Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, publicated 29 paters on anti-viral effect of herbal medicines and a convenient virus-induced cytopathic effect (CEP) inhibition assay was introduced. The major virus on experiment are HIV, Hepatitis B virus and HSV-1,2. Those of other studies showed inhibition of infected virus DNA replication and screening test of herbal medicines. More than 15 extractions were prepared by pure water boiling from herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC) of the $H_2O$ extracts of Padoo against HIV was <4.0, Hyungbangpaedoksan against HIV was 9.3, Whangyonhaedoktang against HIV-1 and HSV-2 was 15.3. These are high level cytotoxic concentration compared with the contrast. But antiviral effect was unable to figure out for selective $index(SI)=CC_{50}/EC_{50}$. The other herbal medicines were unable to showed potent anti-HIV and anti-HSV activity. The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

• 센서학회지
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• 제13권3호
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• pp.188-194
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• 2004

With a remarkable advance in CMOS (complimentary metal-oxide-semiconductor) process technology, a variety of vision sensors with signal processing circuits for complicated functions are actively being developed. Especially, as the principles of signal processing in human retina have been revealed, a series of vision chips imitating human retina have been reported. Human retina is able to detect the edge and motion of an object effectively. The edge detection among the several functions of the retina is accomplished by the cells called photoreceptor, horizontal cell and bipolar cell. We designed a CMOS vision chip by modeling cells of the retina as hardwares involved in edge and motion detection. The designed vision chip was fabricated using $0.6{\mu}m$ CMOS process and the characteristics were measured. Having reliable output characteristics, this chip can be used at the input stage for many applications, like targe tracking system, fingerprint recognition system, human-friendly robot system and etc.

• 한국통신학회논문지
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• 제27권7C호
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• pp.670-676
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• 2002

ATM 망에는 서비스 품질을 보장하기 위한 여러 가지 트래픽 관리 기법이 있다. 이 중 호 수락 제어는 실시간 서비스를 위해 매우 중요한 관리 기법이며 단일 소스 모델로 ON-OFF 모델이 사용되어졌다. 그러나 ON-OFF 모델의 트래픽과 ATM 망에서 실시간 서비스를 위해 이중 GCRA로 제어된 트래픽은 차이가 있다. 따라서 본 논문에서는 이중 GCRA로 제어된 트래픽을 분석하여 삼 상태 최악의 경우 모델(Three-state Worst-case Model: TWM)을 제안하고 최대 지연 변이를 보장해 줄 수 있는 호 수락 제어 방안을 제시한다. 기존의 ON-OFF 모델과 TWM을 실험적으로 비교하고 TWM이 서비스 품질 보장면에서 우수함을 보인다.

• 대한한방부인과학회지
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• 제25권3호
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• pp.40-60
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• 2012

Objectives: The object of this study was to observe antitumor, anticachexia and immunomodulatory effects of Shipyeukmiyeugi-eum(SYM) on human breast cancer cell, MCF-7, xenograft Balb/c nu-nu nude mice. Methods: Three different dosages of SYM-125, 250 and 500 mg/kg were orally administered once a day for 28 days from 11 days after tumor cell inoculation, and the changes on the body weights, tumor volume and weights, weights of spleen and popliteal lymph node and epididymal fat, serum IL-6 and IFN-${\gamma}$ levels, NK cell and peritoneal macrophage activities, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents were observed. In addition, histopathological observations of apoptotic cell, spleen, popliteal lymph node and cervical brown adipose were also detected. The results were compared with a potent cytotoxic estrogen receptor antagonist, Tamoxifen 20 mg/kg treated mice. Results: Tumor volumes and weights were decreased without cytotoxic effects on the both MCF-7 and MCF-10A cells as results of all three different dosages of SYM treatment. And weights of body, spleen, popliteal lymph node, epididymal fat, serum IFN-${\gamma}$, NK cell, peritoneal macrophage activities, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents were increased with decrease of serum IL-6. At histopathological observations, apoptotic tumor cells, spleen, popliteal lymph node and cervical brown adipose tissue were increased. That means tumor-related immunosuppress and cachexia were markedly inhibited by SYM treatment as compared with tumor-bearing mice. On the other hand, Tamoxifen showed marked cytotoxic effects against MCF-7 and MCF-10A, decreases of tumor volume and weights, and increases of apoptotic tumor cells and related decreases of tumor cell volumes, but tamoxifen markedly deteriorated the tumor-related immune-suppress and cachexia. Conclusions: The results obtained in this study suggest that SYM showed favorable anticancer effects and anticachexic effects on the MCF-7 cell xenograft through immunomodulatory effects. SYM did not induce any cytotoxic effects against both normal and cancer cells.

• 대한한의학회지
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• 제23권3호
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• pp.188-199
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• 2002

Objectives : Banhasasim-tang has been clinically used to treat upper gastric intestinal discomfort. The object of this study is to examine the defense effect of Banhasasim-tang for acute duodenal injury of the mouse. Methods and Materials : Twenty-one rats were divided into 3 groups and treated as follows: the control group was untreated mice. The ADE group was acute duodenal-damage-elicited mice. The BST group was Banhasasim-tang treated mice before acute duodenal damage elicitation. The groups were examined with common morphology, paneth cells in intestinal crypt, absorptive cells and goblet cells in epithelium, cell division in mucose, COX-l as mucosal protector, COX-2 (which appears to play an important role in inflammation), IL-2R-inducing cellular immuno-chainreaction, and the distribution of apoptotic cells. Results : 1. Common morphology: the ADE group was observed with duodenal injury - loss of villi, infiltration of cells concerned to inflammation (lymphocytes, granular leukocytes) to submucosal layer - by hemorrhagic erosions, while the BST group was seen the same as normal in proportion to increasing treatment time before injury. 2. Histochemical change: the ADE group was observed with noticeable decreased distribution of absorptive cells with microvilli, acid mucin secreted goblet cell, neutral mucin secreted goblet cell, paneth cells compared to the normal group. The BST group was seen to have distribution of epithelium cells resembling normal in proportion to increasing treatment time before injury. 3. Imnunohistochemical change: the ADE group showed a change of factors leading to duodenal injury as reduce of cytokinesis, COX-1, increase of COX-2, IL-2R-. In contrast, the BST group tended to reduction of cytokinesis, COX-1, increase of COX-2, IL-2R- in proportion to increasing taking time before injury. 4. Apoptosis change: the ADE group showed increasing apoptosis cells, in contrast to the BST group which was the same as normal in proportion to increasing treatment time before injury. Conclusions : According to the above results, by increasing the defense system of mucosal epithelium, Banhasasim-tang is thought to effectively protect tissue against ulcers resulting from acute duodenal injury.

• Journal of the Korean Wood Science and Technology
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• 제34권3호
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• pp.8-14
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• 2006

목재의 탄화기구를 이해하기 위하여 굴참나무재를 사용하여 $250{\sim}740^{\circ}C$의 온도조건에서 탄화하였다. 탄화온도가 높아질수록 시험체의 부피는 수축하였고, 방사 방향으로 할렬이 발생하였다. 탄화온도가 증가함에 따라 목탄의 중량감소율은 증가되었으며, 특히 탄화온도 $300{\sim}340^{\circ}C$에서 급격히 증가하는 경향이 나타났다. 목재의 도관은 탄화 시 방사방향보다 접선방향으로 매우 크게 수축하였다. 탄화온도 $250{\sim}300^{\circ}C$의 경우, 목섬유나 도관 주위의 유세포들이 탄화되지 않은 세포벽 형태를 보여주었다. 그러나 탄화온도 $340^{\circ}C$이상에서는 세포벽층이 매끄러운 비결정형인 목탄의 형태가 관찰되기 시작하였다. 탄화온도 $300^{\circ}C$까지는 목재 셀룰로오스의 결정성이 남아있었으나 $340^{\circ}C$ 이상에서는 비결정성으로 변화되고 있는 것이 관찰되었다.