• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.45-51
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• 2004

The number of development in educational software is currently decreasing despite rapid improvement in computer technology. This is partly due to the fact that the current software relies on the conventional hypermedia method or on the hierarchical method, both of which have inherent limitations. To compensate their limitations while keeping their merits, a hybrid method called the structured hypermedia link method has recently been proposed in the literature. It has been found that the structured hypermedia link method is far superior than the conventional methods in terms of educational effectiveness because it can help a learner to search various data by navigating between the study topics on his own while maintaining his level of cognitively overloaded stress to the minimum. The clinical microbiology laboratories were chosen as the candidate site for this study because its educational system has not been standardized and has been relying heavily on the personal experience. In this study, the hypermedia link method was applied to the development of an education system for the image analysis in clinical microbiology laboratories. For this purpose, a web-based computer aided instruction(CAI) program was designed to systematically organize the Gram stain method based on the standardized image data. In the future, CAI program must be intended to educate for beginner and developed to accept for variable knowledge. And it will be useful program for technicians in case of applying various examinations based Gram stain method of this study.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.118-122
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• 2016

Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.

• The Korean Journal of Nuclear Medicine
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• v.31 no.4
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• pp.427-432
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• 1997

Re-188 is useful candidate for therapeutic radionuclide because it has a physical half life of 17 hours, contains beta emissions suitable for therapy(maximum energy 2.12MeV) and emits a gamma ray that is suitable for quantitative diagnostic scanning(155keV). To use Re-188 as a radionuclide compound of angioplasty balloon radiotherapy, we investigated the labelling method and biodistribution of Re-188-DTPA We postulated that labeled Re-188-DTPA is preferable because it would be excreted via urinary system more easily than other compounds. To label Re-188 with DTPA, 1ml of 222MBq(6mCi) of Re-188 was added to DTPA solution(DTPA 20mg, $SnCl_2{\cdot}2H_2O$ 10mg, pH 3.5) and boiled at $100^{\circ}C$ for 120min in water bath. pH was adjusted to 5 with 2.3% sodium acetate. Labeling efficiency was measured using TLC-SG(acetone, saline). We evaluated biodistribution of Re-188-DTPA in sacrificed mice at 10 and 60 minutes after injection. We acquired images of kidneys, and drew time-activity curves in normal dogs and rats and calculated Tmax and Tl/2 in rats. The labelling efficiency was 95.7% on average. Labelling of Re-188-DTPA was.stable(90% after 5hours) in vitro at room temperature. According to time-activity curves of dogs and rats, it took 15 to 20 minutes after injection for Re-188-DTPA to be washed out through kidneys. In conclusion, Re-188-DTPA was successfully labeled, Re-188-DTPA was stable in vitro and was excreted early via kidneys in animals. We could recommend Re-188-DTPA as radionuclide of potential use in angioplasty balloon radiotherapy.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.8
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• pp.88-100
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• 1999

Detecting human face and facial landmarks automatically in an image is as essential step to a fully automatic face recognition system. In this paper, we present a new approach to detect automatically face and its eyes of input image with scale and rotation variations of faces by using an intensity based template matching with a single log-polar face template. In a template-based matching it is necessary to normalize the scale changes and rotations of an input image to a template ones. The log-polar mapping which simulates space-variant human visual system converts scale changes and rotations of input image into constant horizontal and cyclic vertical shifts in the output plane. Intelligent use of this property allows us to shift of the candidate log-polar faces mapped at various fixation points of an input image to be matched to a template over the log-polar plane. Thus, the proposed method eliminates the need of adapting multitemplate and multiresolution schemes, which inevitably give rise to intensive computation involved to cope with scale and rotation variations of faces. Through this scale and rotation involved to cope with scale and method can lead to detecting face and its eyes simultaneously. Experimental results on a database of 795 images show over 98% detection rate.

• Composites Research
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• v.23 no.3
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• pp.31-36
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• 2010

A new material, carbon-nanofiber/polypyrrole (CNF/PPy) composite films, with different CNF weight ratios were fabricated electrochemically. Compared to the fabrication process based on simple physical mixing, the flexibility of the new film has been improved much better than the previous similar material. Pure PPy films were also fabricated by the new electrochemical process for the comparison of difference. Several SEM images were taken at two locations (electrode-side and solution-side) and at the cross section of the samples. Electrical conductivity of the composite films was measured by the four-probe method. The conductivity of the pure PPy film 0.013cm thick was 79.33S/cm. The CNF/PPy composite film with 5% CNF showed a conductivity of 93S/cm. One with 10% CNF showed a conductivity of 126 S/cm. The conductivity of PPy improves, as the CNF weight ratio increases. The good conductivity of CNF/PPy composites makes them a candidate for a small bending actuator. A bending sensor consists of PPy and PVDF, which can be operated in the air, was designed and the bending deflection was calculated using FEM.

• Natural Product Sciences
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• v.26 no.1
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• pp.83-89
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• 2020

Osteoporosis is a worldwide disease leading to significant economic and societal burdens globally. Osteoporosis is caused by unbalanced bone remodeling between the rate of osteoclast bone resorption and osteoblast bone formation. Acer tegmentosum Maxim (AT) is a traditional herbal medicine containing multiple biological activities such as anti-oxidant and anti-inflammatory purposes. However, its role in osteoporosis has not been fully studied. Therefore, we investigated whether AT has a potent inhibitory effect on osteoporosis and its mechanism through a systemic evaluation in ovariectomized (OVX) mice. OVX mice were orally administrated with the AT at doses of 50, 100, and 200 mg/kg for 10 weeks. Histological images and histomorphometry analyses were performed by H&E and Toluidine blue satin, and the expression levels of receptor activator for nuclear factor-kB ligand (RANKL), nuclear factor of activated T cells cytoplasm 1 (NFATc1), c-Fos, and matrix metalloproteinase 9 (MMP9) related to the osteoclast differentiation were investigated using immunohistochemical analysis. Administration of AT prevented bone loss and the alternations of osteoporotic bone parameters at the distinct regions of the distal femur and spongiosa region in OVX mice. Further, administration of AT increased periosteal bone formation in a dose-dependent manner. Meanwhile, AT inhibited not only the expression of NFATc1 and c-Fos, which are two major regulators of osteoclastogenesis but also reduced bone resorbed encoding expression of MMP9 and RANKL. Our results indicated that administration of AT prevented bone loss and the alternations of osteoporotic bone parameters at the distinct regions of the distal femur and spongiosa region in OVX mice. Also AT has the bone protective effect through the suppression of osteoclast and promotion of osteoblast, suggesting that it could be a preventive and therapeutic candidate for anti-osteoporosis.

• Restorative Dentistry and Endodontics
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• v.36 no.5
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• pp.367-376
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• 2011

Early detection of carious lesions increases the possibility of treatment without the need for surgical intervention. Optical coherence tomography (OCT) is an emerging three-dimensional imaging technique that has been successfully used in other medical fields, such as ophthalmology for optical biopsy, and is a prospective candidate for early caries detection. The technique is based on low coherence interferometry and is advantageous in that it is non-invasive, does not use ionizing radiation, and can render threedimensional images. A brief history of the development of this technique and its principles are discussed in this paper. There have been numerous studies on caries detection, which were mostly in vitro or ex vivo experiments. Through these studies, the feasibility of OCT for caries detection was confirmed. However, further research should be performed, including in vivo studies of OCT applications, in order to prove the clinical usefulness of this technique. In addition, some technological problems must be resolved in the near future to allow for the use of OCT in everyday practice.

• Journal of Sasang Constitutional Medicine
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• v.22 no.1
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• pp.41-48
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• 2010

1. Objective There has been a few trials to diagnose Sasang Constitution by using EEG, but has not been studied intensively. For the purpose of practical diagnosis, the characteristics of EEG for each constitution should be studied first. Recently it has been shown that Sasang Constitution might be related to harm avoidance and novelty seeking in temperament and character profiles. Based on this finding, we propose a visual stimulation method to evoke a EEG response which may discriminate difference between constitutional groups. Through the experiment with this method, we tried to reveal the characteristics of EEG of each constitutional groups by the method of event-related potentials. 2. Methods: We used facial visual stimulation to verify the characteristics of EEG for each constitutional groups. To reveal characteristic in sensitivity and latency of response, we added several levels of noise to facial images. 6 male subjects(2 Taeeumin, 2 Soyangin, 2 Soeumin) participated in this study. All subjects are healthy 20's. To remove artifacts and slow modulation, we removed EOG contaminated data and renormalization is applied. To extract stimulation related components, normalized event-related potential method was used. 3. Results: From Oz channels, it is verified that facial image processing components are extracted. For lower level noise, components related to the visual stimulation were clearly shown in Oz, Pz, and Cz channels. Pz and Cz channels show differences among 3 constitutional groups in maximum around 200 msec. Especially moderate level of noise looks appropriate for diagnosis. 4. Conclusion: We verified that the visual stimulation with facial emotion might be a good candidate to evoke the differences between constitutional groups in EEG response. The differences shown in the experiment may imply that the process of emotion has distinct tendencies in latencies and sensitivity for each consitutional group. And this distinction might be related to the temperament profile of consitutional groups.

• Journal of the Korea Society of Computer and Information
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• v.16 no.7
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• pp.105-115
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• 2011

In Vision-based Intelligent Transportation System(ITS) the segmentation of road region is a very basic functionality. Accordingly, in this paper, we propose a region segmentation method using adaptive pattern extraction technique to segment road regions and sky regions from original images. The proposed method consists of three steps; firstly we perform the initial segmentation using Mean Shift algorithm, the second step is the candidate region selection based on a static-pattern matching technique and the third is the region growing step based on a dynamic-pattern matching technique. The proposed method is able to get more reliable results than the classic region segmentation methods which are based on existing split and merge strategy. The reason for the better results is because we use adaptive patterns extracted from neighboring regions of the current segmented regions to measure the region homogeneity. To evaluate advantages of the proposed method, we compared our method with the classical pattern matching method using static-patterns. In the experiments, the proposed method was proved that the better performance of 8.12% was achieved when we used adaptive patterns instead of static-patterns. We expect that the proposed method can segment road and sky areas in the various road condition in stable, and take an important role in the vision-based ITS applications.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.4 s.304
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• pp.79-86
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• 2005

In this paper, we propose a new LINF(Linear Independent Non-negative Factorization) algorithm for real-time face recognition systea This system greatly consists of the two parts: 1) face extraction part; 2) face recognition part. In the face extraction Part we applied subtraction image, the detection of eye and mouth region , and normalization method, and then in the face recognition Part we used LINF in extracted face candidate region images. The existing recognition system using only PCA(Principal Component Analysis) showed low recognition rates, and it was hard in the recognition system using only LDA(Linear Discriminants Analysis) to apply LDA directly when the training set is small. To overcome these shortcomings, we reduced dimension as the matrix that had non-negative value to be different from former eigenfaces and then applied LDA to the matrix in the proposed system We have experimented using self-organized DAIJFace database and ORL database offered by AT(')T laboratory in Cambridge, U.K. to evaluate the performance of the proposed system. The experimental results showed that the proposed method outperformed PCA, LDA, ICA(Independent Component Analysis) and PLMA(PCA-based LDA mixture algorithm) method within the framework of recognition accuracy.