• Title/Summary/Keyword: CCR5

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Effectiveness of endodontic retreatment using WaveOne Primary files in reciprocating and rotary motions

  • Patricia Marton Costa;Renata Maira de Souza Leal;Guilherme Hiroshi Yamanari;Bruno Cavalini Cavenago;Marco Antonio Hungaro Duarte
    • Restorative Dentistry and Endodontics
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    • v.48 no.2
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    • pp.15.1-15.7
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    • 2023
  • Objectives: This study evaluated the efficiency of WaveOne Primary files (Dentsply Sirona) for removing root canal fillings with 2 types of movement: reciprocating (RCP) and continuous counterclockwise rotation (CCR). Materials and Methods: Twenty mandibular incisors were prepared with a RCP instrument (25.08) and filled using the Tagger hybrid obturation technique. The teeth were retreated with a WaveOne Primary file and randomly allocated to 2 experimental retreatment groups (n = 10) according to movement type: RCP and CCR. The root canals were emptied of filling material in the first 3 steps of insertion, until reaching the working length. The timing of retreatment and procedure errors were recorded for all samples. The specimens were scanned before and after the retreatment procedure with micro-computed tomography to calculate the percentage and volume (mm3) of the residual filling material. The results were statistically evaluated using paired and independent t-tests, with a significance level set at 5%. Results: No significant difference was found in the timing of filling removal between the groups, with a mean of 322 seconds (RCP) and 327 seconds (CCR) (p < 0.05). There were 6 instrument fractures: 1 in a RCP motion file and 5 in continuous rotation files. The volumes of residual filling material were similar (9.94% for RCP and 15.94% for CCR; p > 0.05). Conclusions: The WaveOne Primary files used in retreatment performed similarly in both RCP and CCR movements. Neither movement type completely removed the obturation material, but the RCP movement provided greater safety.

Estimation of Glomerular Filtration Rate from Plasma Creatinine and Height in Children (소아에서 신장과 혈장 Creatinine 농도를 이용한 사구체여관율 측정)

  • Kim, Jeong-Lan;Park, Yong-Hoon;Hah, Jeong-Ok
    • Journal of Yeungnam Medical Science
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    • v.5 no.1
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    • pp.93-100
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    • 1988
  • In clinical practice, creatinine clearance(Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate(GFR) could be obtained from the simple determinations of plasma creatinine(Pcr) and body length(L) : GFR($m{\ell}/min/1.73m^2$=k L(cm)/Pcr(mg/$100m{\ell}$), (k=constant). The subject of this study were ill children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups; group I, from 1 to 5 years old, group II, from 6 to 10 years old, group III. from 11 to 15 years old. The results were as following ; 1) Measured creatinine clearance($Ccr_M$, $m{\ell}/min/1.73m^2$) were $109.73{\pm}9.97$ in group I, $108.26{\pm}9.02$ in group II, $96.20{\pm}4.72$ in group III and $105.48{\pm}5.23$ in all age group. 2) Measured k($k_M$) obtained from $Ccr_M=k$ Ht/Pcr were $0.49{\pm}0.03$ in group I, $0.48{\pm}0.02$ in group II, $0.43{\pm}0.02$ in group III, and $0.47{\pm}0.02$ in all age group.(Ht ; height) 3) Linear equations and correlation coefficients between Ht/Pcr(x) and Ccr(y) were y=0.822x-65.63(r=0.99) in group I, y=0.61x-23.46(r=0.72) in group II, y=0.18x+54.44(r=0.54) in group III and y=0.58x-22.13(r=0.81) in all age group. 4) $Ccr_E$ was again estiamted from linear equations between Ht/Pcr and $Ccr_M$ and $k_E$ was calculated with Ht/Pcr and $Ccr_E$ were $0.48{\pm}0.01$ in group I, $0.49{\pm}0.01$in group II, $0.43{\pm}0.01$ in group III and $0.47{\pm}0.00$ in all age group. 5) Consistant values of $k_E$ and $k_M$ were highly significant as 95~97.5% in group I and II, 90~95% in group III and 97.5~99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k($k_M$) according to the age in easy and rapid way.

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Expression of Chemokine Receptors Involved in Receptor-Mediated Endocytosis of Bone Marrow-Derived Stromal Stem Cells (골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구)

  • Jeong, Young-Sin;Byun, Hyang-Min;Shin, Jee-Young;Kim, Jung-Mogg;Chung, Hyung-Min;Oh, Yu-Kyoung
    • Journal of Pharmaceutical Investigation
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    • v.33 no.4
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    • pp.281-286
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    • 2003
  • To design gene deliver systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several culture conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells ad marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 ad CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression of chemokine receptors generally decreased in most chemokine receptors with the cultivaton of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher level of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased levels of receptor-mediated gene delivery into stromal stem cells.

A Study on the Mechanism of Urinary and Biliary Excretion of Chloramphenicol in the Dog (개에 있어서 Chloramphenicol의 뇨(尿) 및 담즙중(膽汁中) 배설기전(排泄機轉)에 관(關)한 연구(硏究))

  • Kim, Sung-Won
    • Journal of Pharmaceutical Investigation
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    • v.7 no.1_4
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    • pp.38-50
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    • 1977
  • A study on the mechanism of biliary and urinary excretion of chloramphenicol has been performed in the dog. 1) Chloramphenicol administered intravenously to dogs with ligated renal pedicle, readily appeared in bile greater than in plasma. 6.9% of a 50mg /kg i. v. dose of chloramphenicol were excreted into bile within 100 minutes. During the same periods of above experiment, the bile/plasma concentration ratios(B/P ratios) were 46 to 87. 2) Chloramphenicol injected into the vein of dog was rapidly excreted into urine. 18% of the administered dose were excreted into urine within 70 minutes. In the same periods of this experiment, Ccm/Ccr ratios were greater than 1.0 in most cases. 3) In experiment of simultaneous measurement of biliary and urinary excretion of chloramphenicol, Ccm/Ccr ratios were less than 1.0 and B/P ratios were 50 to 52. 4) In experiment measured simultaneously biliary and urinary excretion both Ccm/Ccr and $C^Hcm$(hepatic clearance) were significantly declined by probenecid, but not affected by 2,4-DNP and aminophylline although 2,4-DNP increased only bile flow and aminophylline both bile and urine volume. 5) Ccm/Ccr and $C^Hcm$ were increased in proportion to increment of plasma concentration ranging from 3.3 to 30 mg% of chloramphenicol. But when plasma concentration were increased to 70mg %, Ccm/Ccr were not increased and $C_Hcm$ were reduced about 30% in comparison with values obtajned at 30mg% of chloramphenicol. 6) Free/Bound(free to bouid from) ratios ranging from 1.0 to 90.0mg% of chloramphenicol were 76.2+3.72% $(mean{\pm}S.E.)$ Above results suggest that chloramphenicol is excreted into bile by a process of active trasport, that excretion of chloramphenicol into urine was made up with dual process, reabsorption and secretion, and that renal secretion was attained by active trasport process although renal reabsorption process could not understand.

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A Study on the Analysis of Relative Efficiency of Logistics Facilities in Korea (DEA기법을 이용한 한국 물류시설의 효율성 분석)

  • Lee, Kwangbae;Choi, Yongseok
    • Journal of Korea Port Economic Association
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    • v.29 no.2
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    • pp.159-171
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    • 2013
  • This paper aims to analyse the relative efficiency of logistics facilities and suggest the policy alternatives for exploring and activating them. This study also divides the logistics facilities into airport terminals, logistics complexes, container terminals, and trucking freight terminals. For this purpose, the CCR-DEA as well as the BCC-DEA techniques are employed to show which part explains the primary cause of inefficiencies of each DMU(Decision Making Unit). The empirical results indicate that the efficiency of logistics complex is the lowest of all, while freight trucking terminal has the highest efficiency. This study also reveals that operation inefficiency is greater than scale inefficiency in most of DMUs, showing that much more effort be done for alleviating the cost resulting from irrational management.

Analysis on the Difference in Efficiencies between Environmental Factors of Regional Public Hospitals in Korea using Super-Efficiency Model (초효율성 모형을 이용한 지방의료원의 환경요인별 효율성 차이 분석)

  • Yang, Dong-Hyun
    • The Journal of the Korea Contents Association
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    • v.12 no.7
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    • pp.284-294
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    • 2012
  • In the study, we estimate efficiencies using CCR model of DEA, Super efficiency(AP) model, and super-SBM model with the data of 32 regional public hospitals in Korea from 205 to 2009. With Wilcoxon-Mann-Whitney statistics, we analyze efficiency differences for environmental factors(regions, type of hospital, type of operations, type of education training, relative importance of madicaids) among regional public hospitals. The results can be summarized as follows. Firstly, technical inefficiencies of regional public hospitals range from 15% to 17% in CCR model, 13% to 15% in AP model, 7% to 12.6% in SuperSBM model. Second, we confirm that environmental factors of hospitals cause different inefficiencies among them. The implication of this study is that policy and institutional change may need to improve the efficiencies along with internal managerial reform.

Relative Efficiency and Productivity Change of the Korean Life Insurance Firms (국내 생명보험회사의 상대적 효율성 및 생산성 변화)

  • Kang, Ho-Jung
    • The Journal of the Korea Contents Association
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    • v.9 no.4
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    • pp.323-330
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    • 2009
  • This study measures the relative efficiency and productivity change of the Korean Life Insurance Firms using DEA model and Malmquist Index for 2004-2007. The main results of this study can by summarized as follows. First, in case of efficiency of CCR for 2004-2007, the number of efficient firms(CCR value is one) are six firms, five firms, four firms, seven firms respectively. Second, in case of efficiency of BCC for 2004-2007, the number of efficient firms(BCC value is one) are eight firms, nine firms, ten firms, twelve firms respectively. Third, In case of return to scale for 2004-2007, DRS are nine firms and IRS are two firms, DRS are five firms and IRS are five firms, DRS are five firms and IRS are four firms, DRS are five firms and IRS are two firms respectively, Fourth, Malmquist Index representing productivity change for 2004-2007 are 1.12 in 2004-2005, 0.97 in 2005-2006, 1.05 in 2006-2007.

Outcomes of Chronic Peritoneal Dialysis by Various Modalities in Korean Children - A Single Center Study (소아 환자에서 다양한 복막투석 방법간의 결과 비교-단일기관 연구)

  • Lee, Sung-Ha;Baek, Jae-Suk;Lee, Hyun-Kyung;Han, Kyoung-Hee;Choi, Hyun-Jin;Lee, Bum-Hee;Cho, Hee-Yeon;Cheong, Hae-Il;Choi, Yong;Ha, Il-Soo
    • Childhood Kidney Diseases
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    • v.11 no.2
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    • pp.255-263
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    • 2007
  • Purpose : A single center cross sectional retrospective study was performed to compare the outcomes of different peritoneal dialysis(PD) modalities in Korean children. Methods : Among children dialyzed with PD between the year 2004 and 2007, 35 children had reliable data on PD adequacy after 3 to 15 months of dialysis. Subjects were grouped by their modalities; 17, 13 and 5 children were on continuous ambulatory PD(CAPD), continuous cyclic PD(CCPD) and nightly intermittent PD(NIPD), respectively. Body weight and height, number of patients taking anti-hypertensives and laboratory data including biochemical and hemoglobin levels were compared. Dialysis adequacy including weekly Kt/Vurea, creatinine clearance (Ccr) and daily water removal were also compared. Patients were sub-grouped by their peritoneal permeability characteristics. Results : The percentage of patients taking anti-hypertensives, monthly change in Z-scores of body weight and height and laboratory data did not differ among the groups. Patients on CAPD and CCPD showed similar dialysis adequacies. Weekly dialytic Ccr was significantly lower in the NIPD group compared to the others. But total Ccr was not different when residual renal function was added. Weekly dialytic Ccr by CAPD was significantly higher than that of CCPD in low and low-average transporters. Conclusion : We propose that modality can be selected flexibly according to the patients' preferences. And peritoneal permeability characteristics provide valuable information for adjusting PD prescriptions in ultrafiltration failure or in inadequate dialysis. Further study of other clinical performance measures should be performed to clarify the comparable outcomes in different PD modalities.

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A Study on the Relative Operational Efficiency of Foreign Port Transportation Industry (외항운송업의 상대적 운영효율성 분석)

  • Kang, Da-Yeon;Lee, Ki-Se
    • The Journal of the Korea Contents Association
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    • v.21 no.4
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    • pp.88-95
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    • 2021
  • In Korea, which achieved economic growth due to export industries, the economic importance of the foreign port transportation industry is very great. The government took the initiative in fostering the foreign port transportation industry, and as a result, it developed into one of the top 10 foreign port transport countries in the world. However, due to the poor management of the small and medium-sized foreign port transport business and the trade dispute between countries, the foreign port transportation industry has faced a long-term invasion. Therefore, in order for these companies to recover again, they will, among other things, have to reorganize their operational inefficiency to carry out efficient production activities. In this study, we want to analyze the management efficiency of the top 10% companies in the unlisted domestic outbound shipping industry, present the project value of inefficient enterprises, and confirm the reference collection of companies that may be subject to benchmarking. For this purpose, a total of 10 foreign port transportation industry were analysed for efficiency and scale profitability (RTS) of the CCR and BCC models. The analysis showed that there were a total of six entities with BCC efficiency and five entities with CCR efficiency. In addition, there were a total of five entities with both BCC and CCR efficiency.

Development and fabrication of multi-filamentary Bi(2223)/Ag jointed tape (Bi(2223)/Ag 다심 초전도 접합선재의 제조)

  • 김규태;김정호;김호진;이동욱;주진호;나완수
    • Progress in Superconductivity
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    • v.4 no.2
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    • pp.172-175
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    • 2003
  • Critical current ratio and n-value of Bi(2223)/Ag superconducting joint tape were measured as a function of uniaxial pressure. In the superconducting joint method, MM and MSM joint were used ; MM joint is direct connection of two -multi filamentary tapes, and MSM is connection of them by using a single -filamentary tape. It was observed that the critical current ratio(CCR) for jointed tapes was not dependent on the uniaxial pressure but joining methods. The n-value of jointed tapes has similar trends with that of the CCR. Especially, double MSM joint showed the highest electrical properties as 63.4-76.0%(CCR) and 3.5-5.1 (n-value). It is considered that the improvements are due to the better inter connections of multifilaments by two single filamentary tapes on both sides.

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