Journal of Pharmaceutical Investigation
- Volume 7 Issue 1_4
- /
- Pages.38-50
- /
- 1977
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
A Study on the Mechanism of Urinary and Biliary Excretion of Chloramphenicol in the Dog
개에 있어서 Chloramphenicol의 뇨(尿) 및 담즙중(膽汁中) 배설기전(排泄機轉)에 관(關)한 연구(硏究)
Abstract
A study on the mechanism of biliary and urinary excretion of chloramphenicol has been performed in the dog. 1) Chloramphenicol administered intravenously to dogs with ligated renal pedicle, readily appeared in bile greater than in plasma. 6.9% of a 50mg /kg i. v. dose of chloramphenicol were excreted into bile within 100 minutes. During the same periods of above experiment, the bile/plasma concentration ratios(B/P ratios) were 46 to 87. 2) Chloramphenicol injected into the vein of dog was rapidly excreted into urine. 18% of the administered dose were excreted into urine within 70 minutes. In the same periods of this experiment, Ccm/Ccr ratios were greater than 1.0 in most cases. 3) In experiment of simultaneous measurement of biliary and urinary excretion of chloramphenicol, Ccm/Ccr ratios were less than 1.0 and B/P ratios were 50 to 52. 4) In experiment measured simultaneously biliary and urinary excretion both Ccm/Ccr and
Keywords