• Title/Summary/Keyword: Bioscience

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Neuronal Cell Protection Activity of Macrolactin A Produced by Actinomadura sp.

  • Kim, Hyeon-Ho;Kim, Won-Gon;Ryoo, In-Ja;Kim, Chang-Jin;Suk, Jae-Eun;Han, Kyou-Hoon;Hwang, Se-Young;Yoo, Ick-Dong
    • Journal of Microbiology and Biotechnology
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    • v.7 no.6
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    • pp.429-434
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    • 1997

  • Macrolactin A, 24-membered macrolide, was isolated from the culture broth of Actinomadura sp. as a neuronal cell protecting substance. In the cell assay, this compound inhibited glutamate toxicity in N18-RE-105 cells with an $EC_50$ value of 0.5 ${\mu}g/ml.

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Proteomic Analysis of Cytokine-Like Proteins Secreted from Human Bronchial Epithelial Cells in Response to Pathogenic Bacterial Infection

  • Park, Mi-Ja;Oh, Mi-Jung;Jo, Dong-Hwan;Chin, Mi-Reyoung;Lee, Ji-Yeon;Park, Ji-Woo;Lee, Na-Gyong;Kim, Dae-Kyong
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.111.1-111.1
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    • 2003

  • Bacterial infection is a very complex process in which both pathogens and host cells play crucial roles, and the host cells undergo drastic changes in their physiology, releasing various proteins in response to the pathogenic infection. Human airway epithelial surface serves as a first line of defense against microorganisms and the external environment. It is well known that bronchial epithelial cells secrete various chemokines and cytokines such as IL-6 and IL-8 to cope with various respiratory pathogens. (omitted)

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