• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.13-23
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• 2011

Objectives : The aim of this study was to develop the combined medical stimulus system consisted of the PEMFs (Pulsed electromagnetic fields) and LED which are able to stimulate local point such as acupoints and trigger points. Methods : To evaluate the therapeutic effect on the musculoskeletal disorders and the possibility of alternative method on manual acupuncture, we compared the fatigue recovery of two groups by analyzing the EMG and peak torque (non-stimulation and, stimulation group) after strenuous knee exercise. We chose the LR9 as a stimulation point. Results : The median frequency (MF) and fatigue index (F.I) of the stimulation group were recovered faster than those of the non-stimulation group. Also the peak torques of both groups were not restored until after 20 minutes. However, the peak torque of the stimulation group was regained higher than that of the non-stimulation group. Conclusions : We confirmed that the proposed combined stimulus system had useful effects as treatment instrument of musculoskeletal disorder using non-invasive method of PEMFs and LED.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.93-95
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• 1993

• Progress in Medical Physics
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• v.19 no.4
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• pp.285-290
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• 2008

In this study, we have fabricated a one-dimensional fiber-optic dosimeter for electron beam therapy dosimetry. Each fiber-optic dosimeter has an organic scintillator with a plastic optical fiber and it is embedded and arrayed in the plastic phantom to measure one-dimensional high energy electron beam profile of clinical linear accelerator. The scintillating lights generated from each sensor probe are guided by plastic optical fibers to the multi-channel photodiode amplifier system. We have measured one-dimensional electron beam profiles in a PMMA phantom according to different field sizes and energies of electron beam. Also, the isodose and three-dimensional percent depth dose curves in a PMMA phantom are obtained using a one-dimensional fiber-optic dosimeter with different electron beam energies.

• Molecules and Cells
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• v.38 no.10
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• pp.895-903
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• 2015

Non-coding microRNAs (miRNAs) regulate the translation of target messenger RNAs (mRNAs) involved in the growth and development of a variety of cells, including primordial germ cells (PGCs) which play an essential role in germ cell development. However, the target mRNAs and the regulatory networks influenced by miRNAs in PGCs remain unclear. Here, we demonstrate a novel miRNAs control PGC development through targeting mRNAs involved in various cellular pathways. We reveal the PGC-enriched expression patterns of nine miRNAs, including miR-10b, -18a, -93, -106b, -126-3p, -127, -181a, -181b, and -301, using miRNA expression analysis along with mRNA microarray analysis in PGCs, embryonic gonads, and postnatal testes. These miRNAs are highly expressed in PGCs, as demonstrated by Northern blotting, miRNA in situ hybridization assay, and miRNA qPCR analysis. This integrative study utilizing mRNA microarray analysis and miRNA target prediction demonstrates the regulatory networks through which these miRNAs regulate their potential target genes during PGC development. The elucidated networks of miRNAs disclose a coordinated molecular mechanism by which these miRNAs regulate distinct cellular pathways in PGCs that determine germ cell development.

• Journal of Biomedical Engineering Research
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• v.30 no.3
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• pp.185-190
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• 2009

Biomedical mobile devices for ubiquitous healthcare consist of biomedical sensors and communication terminal. They have two types of configuration. One is the sensor-network type device using wired or wireless communication with intelligent sensors to acquire biomedical data. The other is the sensor embedded type device, where the data can be acquired directly by itself. There are many examples of sensor network type, such as, fall detection sensor, blood glucose sensor, and ECG sensors networked with commercial PDA phone and commercial phone terminal for ubiquitous healthcare. On the other hand, sensor embedded type mounts blood glucose sensor, accelerometer, and etc. on commercial phone. However, to enable true ubiquitous healthcare, motion sensing is essential, because users go around anywhere and their signals should be measured and monitored, when they are affected by the motion. Therefore, in this paper, two biomedical mobile devices with motion monitoring function were addressed. One is sensor-network type with motion monitoring function, which uses Zigbee communication to measure the ECG, PPG and acceleration. The other is sensor-embedded type with motion monitoring function, which also can measure the data and uses the built-in cellular phone network modem for remote connection. These devices are expected to be useful for ubiquitous healthcare in coming aged society in Korea.

• Journal of Marine Bioscience and Biotechnology
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• v.13 no.1
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• pp.28-47
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• 2021

Pectin is a natural polysaccharide and biopolymer that serves as a structural component of plant tissues' primary cell walls. Pectin is primarily composed of D-galacturonic acid linked by α-1, 4-glycosidic linkage and is further classified by the ratio of esterified galacturonic acid groups known as degree of esterification (DE). Pectin that contains more than half of its carboxylate units as methyl esters is known as a high methyl (HM) ester. Conversely, pectin that has less than half of its carboxylate units as methyl esters is known as a low methyl (LM) ester. Pectin has various bioactive properties, including anticancer, anti-inflammatory, antioxidant, antidiabetic, anticholesterol, antitumoral, and chemopreventive properties. Moreover, pectin is a useful biopolymer in biomedical applications. Biomedical engineering, which is founded on research aimed to improve the quality of life using new materials and technologies, is typically classified according to the use of hydrogels, nanofiber mats, and nanoparticles. This paper reviews the progress of recent research into pectin-based biomedical applications and the potential future biomedical applications of marine-derived pectin.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.7-9
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• 1995

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.9
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• pp.1283-1289
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• 2013

The purpose of this study is to find the new method for estiming the spatial variations in a light source with utilizing the optical fiber sensory system. With this aim, firstly the asymmetry in the beam profile of a light source is evaluated by using the tipped optical fiber with 0, 10, 20, 30, 40, 45-degree angle. Secondly the variation of position in a light source is estimated by adjusting the relative position between the light source unit (XYZ stage, LED, Optical fiber) and the receiver unit (Photodiode, XYZ stage). Our experimental results show that the spatial variation of a light source can be resolved in terms of the variations in beam profile with varying the tip angle of an optical fiber and adjusting the relative distance between the light source unit and the receiver.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.23-26
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• 2009

During operations, neurosurgeons usually perform multiple temporary occlusions of parental artery, possibly resulting in the neuronal damage. It is generally thought that neuronal damage by cerebral ischemia is associated with extracellular concentrations of the excitatory amino acids. In this study, we measured the dynamics of extracellular glutamate release in 11 vessel occlusion(VO) model to compare between single occlusion and repeated transient occlusions within short interval. Changes in cerebral blood flow were monitored by laser-Doppler flowmetry simultaneously with cortical glutamate level measured by amperometric biosensor. From real time monitoring of glutamate release in 11 VO model, the change of extracellular glutamate level in repeated transient occlusion group was smaller than that of single occlusion group, and the onset time of glutamate release in the second ischemic episode of repeated occlusion group was delayed compared to the first ischemic episode which was similar to that of single 10 min ischemic episode. These results suggested that repeated transient occlusion induces less glutamate release from neuronal cell than single occlusion, and the delayed onset time of glutamate release is attributed to endogeneous protective mechanism of ischemic tolerance.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.128-131
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• 2002

Several FE models were developed based on micro-CT images of a mandibular specimen. A new dental implant model was suggested from parameter study for the relation between shape and interfacial stress of dental implants. It is found that the proposed model is highly beneficial.