• 한국컴퓨터정보학회논문지
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• 제16권1호
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• pp.117-124
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• 2011

본 논문은 생체 센서 시스템(bio-physical sensor system)을 이용하여 홈 네트워크 시스템을 구성하고, 생체 신호가 전달되도록 생체 신호 원격용 네트워크를 구현하였다. 측정 시스템의 구성조건은 시각(Vision), 체성감각(Somatosensory), 전정기관(Vestibular), 중추신경계통(CNS)의 변위점에서 평가하고, 맥박(Heart Rate), 체온(Temperature), 체중(Weight)을 기본 측정항목에 사용하였다. 주파수 변동에 따른 0.01 단위로 측정하여 평균값을 가지고 기준치에 비교하여 설정환경을 구성하고 측정값을 결정하였다. 생체 신호는 신체의 균형조절기능인 신경생리학적 감각처리 및 운동 출력기전으로 시각, 체성감각, 전정기관, 중추신경계통, 체질량지수(BMI)의 신체적 감각 기관의 수용체들 간의 운동에 대한 균형과 자세를 통한 기준으로 정상적인 균형 조절 상태와 균형의 크기 형태로 구분하고, 건강의 상태를 확인하도록 의미를 부여하였다. 본 연구의 결과로 제안한 홈 네트워크를 통해 헬스 센터 및 건강관리 중앙 시스템에 단말기를 통하여 전송됨으로 전문가을 통한 건강 관리시스템이 진행되는 결과를 얻을 수 있고, 다양한 신체적 파라메타를 통한 원격네트워크 모니터링 기능의 관리시스템이 형성 될 것으로 추론 할 수 있다.

• Toxicological Research
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• 제23권4호
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• pp.373-382
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• 2007

This study was conducted to obtain acute information of the oral dose toxicity of PGB-1, a novel polyglucosamine polymer produced from a new strain Enterobacter sp. BL-2 in male and female mice. In order to calculated 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250, 125 and 0 (vehicle control) ml/kg (body wt.). The mortality and changes on body weight, clinical signs, gross observation and organ weight and histopathology of principle organs were monitored 14 days after dosing with PGB-1. We could not find any mortalities, clinical signs, body weight changes and gross findings. In addition, significant changes in the organ weight and histopathology of principal organs were not observed except for some sporadic findings. The results obtained in this study suggest that PGB-1 may not be toxic in mice and may be therefore safe for clinical use. The $LD_{50}$ and approximate LD in mice after single oral dose of PGB-1 were considered over 2000 mg/kg in both female and male mice.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 학술대회 논문집 정보 및 제어부문
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• pp.484-485
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• 2008

초음파는 의학적 진단 및 치료의 목적으로 널리 사용되어 왔다. 일반적으로, 초음파 조사의 생물학적 무해성은 많은 연구를 통하여 보고되었으나, 최근 초음파 집속을 통한 강력 초음파의 사용에 대한 열적 안전성 평가가 중요한 요소로 대두되고 있다. 이에 본 연구에서는 강력 집속 초음파의 전달 에너지와 열적 분포를 측정하여 안전성 평가에 활용 가능한 초음파 열분포 팬텀을 제안하였다. 온도 분포 측정용 팬텀은 초음파 조직유사 팬텀 재료인 한천을 이용하였으며, 음향학적 특성의 유사성을 평가하였다. 온도 효과를 측정하기 위하여 $3{\times}3$의 형태로 온도 센서를 팬텀 내부에 배열하여 초음파 조사에 따른 온도 분포를 측정하였고 온도 측정을 위한 시스템을 개발하여, 초음파 가열 실험을 수행하였다. 본 연구에서 제안된 초음파 온도 분포 측정용 팬텀의 유용성을 확인하였으며, 온도 분포용 팬텀을 통한 강력 집속 초음파 장비의 열적 성능 평가에 적용 될 수 있을 것으로 사료되었다.

• 센서학회지
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• 제17권3호
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• pp.210-216
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• 2008

The propose of this study is evaluating which correlation of foot pressure distribution and scoliosis that happen by walking to 20'th Mens that have not experienced a scoliosis. The propose of this study is evaluating which correlation of foot pressure distribution and scoliosis that happen by walking to 20'th Mens that have not experienced a scoliosis. Measurement and analysis of Foot Pressure was executed by using by F-scan System. Degree of scoliosis was expressed as a angle used x-ray image of 5-lumbar from 4-thoracic vertebra The correlation between result of foot pressure and degree of scoliosis was evaluated under 0.05 interrelationship, and variables used for analysis were showed high correlation.

• Journal of Ginseng Research
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• 제42권3호
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• pp.356-360
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• 2018

The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speeding up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, and echocardiographic studies. The results exhibited that body weights were significantly reduced and the gain of different organ weights were partly eased by GBCK25 treatment. Echocardiography results proposed the amelioration of heart function through normalized levels of left ventricle systolic pressure, ejection fraction, and fractional shortening. These outcomes deliver straight confirmation that GBCK25 could be a potential nutraceutical source for the relief of HFD-induced obesity mediated cardiac dysfunctions.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.761-769
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• 2018

BACKGROUND: Bioprinting has recently appeared as a powerful tool for building complex tissue and organ structures. However, the application of bioprinting to regenerative medicine has limitations, due to the restricted choices of bio-ink for cytocompatible cell encapsulation and the integrity of the fabricated structures. METHODS: In this study, we developed hybrid bio-inks based on acrylated hyaluronic acid (HA) for immobilizing bio-active peptides and tyramine-conjugated hyaluronic acids for fast gelation. RESULTS: Conventional acrylated HA-based hydrogels have a gelation time of more than 30 min, whereas hybrid bio-ink has been rapidly gelated within 200 s. Fibroblast cells cultured in this hybrid bio-ink up to 7 days showed >90% viability. As a guidance cue for stem cell differentiation, we immobilized four different bio-active peptides: BMP-7-derived peptides (BMP-7D) and osteopontin for osteogenesis, and substance-P (SP) and Ac-SDKP (SDKP) for angiogenesis. Mesenchymal stem cells cultured in these hybrid bio-inks showed the highest angiogenic and osteogenic activity cultured in bio-ink immobilized with a SP or BMP-7D peptide. This bio-ink was loaded in a three-dimensional (3D) bioprinting device showing reproducible printing features. CONCLUSION: We have developed bio-inks that combine biochemical and mechanical cues. Biochemical cues were able to regulate differentiation of cells, and mechanical cues enabled printing structuring. This multi-functional bio-ink can be used for complex tissue engineering and regenerative medicine.

• Toxicological Research
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• 제9권2호
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• pp.233-240
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• 1993

Toxic effects of chronic adminstration of methamphetamine (MA) to SD rats were studied in respect to histopathological changes induced in each organ. In experimental groups liver weight decreased and brain weights increased markedly compared with controls in the 12th month after subcutaneous injection of 0.5 mg and 5mg/kg/BW MA. Serum alkaline phosphotase levels increased, but marked decrease of cholesterol, triglyceride, and BUN levels were checked depending on both the dose of MA and duration of treatment.

• Molecules and Cells
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• 제38권12호
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• pp.1071-1078
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• 2015

Superovulation induced by exogenous gonadotropin treatment (PMSG/hCG) increases the number of available oocytes in humans and animals. However, Superovulatory PMSG/hCG treatment is known to affect maternal environment, and these effects may result from PMSG/hCG treatment-induced oxidative stress. 2-Cys peroxiredoxins (2-Cys Prxs) act as antioxidant enzymes that protect cells from oxidative stress induced by various exogenous stimuli. Therefore, the objective of this study was to test the hypothesis that repeated PMSG/hCG treatment induces 2-Cys Prx expression and overoxidation in the reproductive tracts of female mice. Immunohistochemistry and western blotting analyses further demonstrated that, after PMSG/hCG treatment, the protein expression levels of 2-Cys Prxs increased most significantly in the ovaries, while that of Prx1 was most affected by PMSG/hCG stimulation in all tissues of the female reproductive tract. Repeated PMSG/hCG treatment eventually leads to 2-Cys Prxs overoxidation in all reproductive organs of female mice, and the abundance of the 2-Cys Prxs-$SO_{2/3}$ proteins reported here supports the hypothesis that repeated superovulation induces strong oxidative stress and damage to the female reproductive tract. Our data suggest that excessive oxidative stress caused by repeated PMSG/hCG stimulation increases 2-Cys Prxs expression and overoxidation in the female reproductive organs. Intracellular 2-Cys Prx therefore plays an important role in maintaining the reproductive organ environment of female mice upon exogenous gonadotropin treatment.

• Journal of Microbiology and Biotechnology
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• 제33권3호
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• pp.356-362
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• 2023

The 2'-fucosyllactose (2'-FL) is the richest components in a human milk oligosaccharide. Several studies have reported that 2'-FL has beneficial effects in infants. However, there are few studies on its immune-enhancing effects. This research aimed to examine the immune-enhancing effect of 2'-FL on immunosuppression by cyclophosphamide (CCP) in ICR mice. Mice were orally administered distilled water or 0.5 mg/kg B.W. 2'-FL for 14 days. An immunocompromised mouse model was induced using CCP 80 mg/kg B.W. at 12-14 days. Using the CCP had effects on reducing their body weight, organ weight, spleen index, natural killer (NK) cell activity, and cytokines concentration and expression. This study also used concanavalin A-mediated T-cell proliferation to verify the immune-enhancing effects in the sample. Body weight, spleen index, organ weight, and cytokine levels were measured to estimate the immune-enhancing effects. The body weight at 14 days tended to increase, and the spleen weight and index significantly increased in the 2'-FL group compared to the CCP group. The NK cell activity increased in the 2'-FL group compared to the CCP group, but there was no significant difference. The concentration of interleukin (IL)-2 tended to recover in the 2'-FL group compared to the CCP group. The 2'-FL group showed a significant increase of IL-10 and IFN-gamma concentration compared to the CCP group. In addition, there was a trend of increased IL-10 mRNA expression compared to the CCP group. These results revealed that 2'-FL improved CCP-induced immunosuppression, suggesting that 2'-FL may have the potential to enhance the immune system.

• 전자공학회논문지
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• 제53권12호
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• pp.147-151
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• 2016

Standing Whole Spine 검사는 많은 병원에서 자동노출제어장치 (automatic exposure control, AEC)를 사용하고 있어 체질량지수 (body mass index, BMI)에 따라 방사선량이 조절되는 특징이 있으며, 이를 통하여 환자 별 측정 DAP (dose area product) 값을 얻을 수 있다. 하지만, 검사 시 장기의 위치에 따른 흡수선량에 관한 연구는 크게 이루어지지 않고 있으며, 이에 본 연구에서는 Standing Whole Spine 검사 시 환자의 두께정보를 대표하는 BMI와 장기의 위치에 따른 흡수선량의 분포를 평가하고자 한다. 연구의 목적을 위하여 측정된 DAP값을 이용하여 PCXMC에서 환자의 5곳의 장기를 선정 (갑상샘, 유방, 심장, 콩팥, 이자)하여 선량을 계산하였다. 결과적으로, 측정된 DAP값은 BMI에 따라 증가하는 경향을 보였지만 전방 장기인 갑상샘, 유방, 그리고 심장에서는 BMI에 따라 장기선량이 감소하는 경향을 보였다. 또한 후방장기인 콩팥과 이자에서는 BMI와 아무런 상관관계를 가지지 않았다. 결론적으로, 본 연구결과를 통하여 Standing Whole Spine 검사 시 BMI와 장기의 위치에 따라 방사선의 영향이 다르게 나타남을 증명하였다.