Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PATHOLOGICAL STUDIES ON THE CHRONIC TOXICITY OF METHAMPHETAMINE ADMINISTRATION

  • Rim, Byung-Moo (Bio-safety Research Institute Chonbuk National University) ;
  • Cho, Gye-Myung (Bio-safety Research Institute Chonbuk National University) ;
  • Chang, Jae-Hong (Bio-safety Research Institute Chonbuk National University)
  • Published : 1993.12.01
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Abstract

Toxic effects of chronic adminstration of methamphetamine (MA) to SD rats were studied in respect to histopathological changes induced in each organ. In experimental groups liver weight decreased and brain weights increased markedly compared with controls in the 12th month after subcutaneous injection of 0.5 mg and 5mg/kg/BW MA. Serum alkaline phosphotase levels increased, but marked decrease of cholesterol, triglyceride, and BUN levels were checked depending on both the dose of MA and duration of treatment.

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References

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