• Molecules and Cells
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• v.41 no.5
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• pp.486-494
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• 2018

Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors-symptoms that mirror those observed in human autism spectrum disorders (ASD). Overexpression of TERT also alters the excitatory/inhibitory (E/I) ratio in the medial prefrontal cortex. However, the effects of TERT overexpression on hippocampal-dependent learning and synaptic efficacy have not been investigated. In the present study, we employed electrophysiological approaches in combination with behavioral analysis to examine hippocampal function of TERT transgenic (TERT-tg) mice and FVB controls. We found that TERT overexpression results in enhanced hippocampal excitation with no changes in inhibition and significantly impairs long-term synaptic plasticity. Interestingly, the expression levels of phosphorylated CREB and phosphorylated $CaMKII{\alpha}$ were significantly decreased while the expression level of $CaMKII{\alpha}$ was slightly increased in the hippocampus of TERT-overexpressing mice. Our observations highlight the importance of TERT in normal synaptic function and behavior and provide additional information on a novel animal model of ASD associated with TERT overexpression.

• Perspectives in Nursing Science
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• v.11 no.1
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• pp.10-17
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• 2014

Purpose: The aim of this study was to analyze health promotion programs utilizing forests by reviewing regional healthcare program plans in Korea. Methods: We analyzed 227 regional healthcare program plans from 2011 to 2014; seven health promotion programs of the 16 major healthcare programs were prescribed by public health law. Results: Our analysis revealed that only 35 health promotion programs from 29 sites were utilizing forests. Furthermore, of 21 known categories of health promotion programs, only nine incorporated the use of forests. Atopy-asthma healthcare programs were the most common forest health promotion programs, which also included specialized disease management programs (e.g., for atopy prevention and healing, patients with metabolic syndrome or cancer) and specialized mental health management programs (e.g., for addiction or dementia prevention). Others included programs on the development of forest roads or industrial development using forest products. Conclusion: Health programs using forests in Korea are still very limited and primarily comprise atopy-asthma prevention/management, health behavioral change, and mental health programs. This study provided useful information for developing health policies and forest health promotion programs further in Korea.

• Journal of Korean Public Health Nursing
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• v.26 no.1
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• pp.147-157
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• 2012

Purpose: The purpose of this study was to identify the related factors of change affecting the stages of change for exercise, on the assumption that there are various stages of change in the exercise behavior of women in nursing college. Methods: The subjects were 496 female college students in D city. The research instruments were stages of change for exercise behavior, the process of change, decisional balance, and self-efficacy. The dates were analyzed by descriptive statistics, ANOVA, and stepwise multiple regression using the SPSS 18.0 program. Results: The distribution of the subjects across the stages was: pre-contemplation, 17.7%; contemplation, 58.7%; preparation, 19.0%; action, 2.8%; maintenance, 1.8%. Analysis of variance showed that cognitive process (F=17.26, p<0.01), behavioral process (F=27.05, p<0.01), the pros of decisional-balance (F=7.07, p<0.01), the cons of decision-balance (F=5.82, p<0.01), and self efficacy (F=17.79, p<0.01) were significantly associated with the change of exercise behavior stages. The related factors of change affecting the change of exercise behavior stage were the cons of decision-making, counter conditioning, self re-evaluation, and body mass index, including 28.4% R-square. Conclusion: The transtheoretical model would be applicable to explain the exercise behavior of some women in nursing college. So, this study will be useful information for developing effective exercise behavior programs considering female students' stages of change.

• Journal of the Korean Society of Earth Science Education
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• v.9 no.2
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• pp.107-122
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• 2016

The purpose of this study is to review the literatures on the evolutionary perspective on education and to draw the educational implications for science education. This study addresses on several topics as follows: our common misunderstandings about the evolutionary perspective on education; children's inherent knowledge and abilities, their learning about the evolutionarily novel knowledge and abilities in school, their difficulties in academic learning, and the instructional strategies to cope with the difficulties; and the implications for science education from the evolutionary perspective. The evolutionary perspective on education has provided new insights how culturally important information is transmitted across generations in the past hunting-gathering societies and the modern societies, and how children's inherent motivational and behavioral dispositions affect their academic learning. In addition, the new perspective on education can be used to generate empirical hypotheses about children's science learning, and with the further research, could lead to useful implications and ultimately improve educational outcomes.

• The Korean Journal of Food And Nutrition
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• v.20 no.3
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• pp.325-333
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• 2007

This study was conducted to investigate the weight concerns of female university students living in Jeonju, as well as their control on behavior. Self-administered questionnaires were collected from 285 students. Statistical data analysis was completed using the SPSS v. 11.0 program. The results are summarized as follows: The average weight, height, and BMI of the subjects were 21.43 kg, 161.93 cm, and 19.8, respectively. With regard to body image, most were dissatisfied with their figures, especially the hips and thighs. About 42% of the students estimated their figures as 'slightly fat', while 5.4% stated 'very fat', even though their BMI classified as 'normal'. Four percent of the underweight students described themselves as being 'fatty'. Approximately 93% of the students had strongly pursued weight control, and 45.3% reported wanting to lose about $2{\sim}5$ kg. Almost 73% of the respondents had weight loss experience. The primary reason for weight control was to improve self-confidence. Only 19.6% had succeeded in losing weight, while nearly 48% had stopped dieting. To reduce weight, about two thirds of the students ate less(e.g. no snacks, no sweets). Fifty percent tried to reduce weight by more physical activity(e.g. sports). Television(50.9%), friends(48.4%), and newspapers/magazines(40.4%) were essential sources of pertinent information. In conclusion, the results show that female students in Jeonju have a great interest in weight reduction. Thus, the majority are willing to try several methods for weight reduction, which however, are not promising and not based on a lasting nutritional change. Therefore, it's necessary to increase cooperation among those concerned(e.g. dietitians, teachers, parents, media) and to develop weight-control programs that take into consideration lifestyle and daily habits, as well as combine physical activity, nutrition, and behavioral and personality training.

• Journal of Convergence for Information Technology
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• v.9 no.11
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• pp.241-246
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• 2019

The purpose of this study was to examine the effects of repetitive oral health education on oral health knowledge, attitudes and behaviors of elementary school students. A final analysis of 111 untested individuals was made. The oral health knowledge and oral health behavior scores according to the presence or absence of oral health education showed a higher level than the school that did not perform oral health education for 3 years (p <0.01). Repeated and continuous oral health education of elementary school students has a great influence on oral health knowledge and behavioral change, so if the dental hygienists can stay and manage oral health care, the effect will be increased.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.1-8
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• 2018

The purpose of this study is to investigate the interaction effects of organizational context, customer reaction, and job burnout in Senior Welfare organizations. In addition, we will analyze the moderating effects of demographic characteristics (personal characteristics, organizational characteristics). A total of 796 social workers engaged in Senior Welfare projects were analyzed. As a result, the following results were obtained. First. It was found that there was a significant difference between the variables in the sociodemographic characteristics, organizational context, customer reactions, and interaction effects on job burnout. Second, age, employment type, and Social Worker qualifications were the most important variables of control effect. The specific organizational behavioral factors between the employees and the users should be studied.

• Journal of Convergence for Information Technology
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• v.8 no.4
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• pp.213-217
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• 2018

The relationship between R&D investment and subsequent change has been mostly confirmed under additional influencing factors, with the form of innovation investments. The research assumes that a firm adjusts its R&D spending in accordance to performance feedback. It is argued that an increased fluctuation of a firm's R&D expense is related to a reduced performance. This hypothesis is tested on SME in World class 300 Projet by SMBA. Using panel data models, instability measured by SD is related to performance levels measured by ROA, ROE & PM. Results support the proposed relationship between R&D expense instability and the subsequent performance. Although a causal link cannot be clearly established, the results indicate that firms with a lower performance have higher R&D investment fluctuations, possibly being more responsive to performance feedback.

• International Journal of Oral Biology
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• v.46 no.3
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• pp.119-126
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• 2021

Activation of transient receptor potential vanilloid 1 (TRPV1), a calcium permeable channel expressed in primary sensory neurons, induces the release of glutamate from their central and peripheral afferents during normal acute and pathological pain. However, little information is available regarding the glutamate release mechanism associated with TRPV1 activation in primary sensory neurons. To address this issue, we investigated the expression of vesicular glutamate transporter (VGLUT) in TRPV1-immunopositive (+) neurons in the rat trigeminal ganglion (TG) under normal and complete Freund's adjuvant (CFA)-induced inflammatory pain conditions using behavioral testing as well as double immunofluorescence staining with antisera against TRPV1 and VGLUT1 or VGLUT2. TRPV1 was primarily expressed in small and medium-sized TG neurons. TRPV1+ neurons constituted approximately 27% of all TG neurons. Among all TRPV1+ neurons, the proportion of TRPV1+ neurons coexpressing VGLUT1 (VGLUT1+/TRPV1+ neurons) and VGLUT2 (VGLUT2+/TRPV1+ neurons) was 0.4% ± 0.2% and 22.4% ± 2.8%, respectively. The proportion of TRPV1+ and VGLUT2+ neurons was higher in the CFA group than in the control group (TRPV1+ neurons: 31.5% ± 2.5% vs. 26.5% ± 1.2%, VGLUT2+ neurons: 31.8% ± 1.1% vs. 24.6% ± 1.5%, p < 0.05), whereas the proportion of VGLUT1+, VGLUT1+/TRPV1+, and VGLUT2+/TRPV1+ neurons did not differ significantly between the CFA and control groups. These findings together suggest that VGLUT2, a major isoform of VGLUTs, is involved in TRPV1 activation-associated glutamate release during normal acute and inflammatory pain.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.250-257
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• 2021

The author tried to verify the mediating effect of the variable, perceived behavioral control, in the relationship between the independent variables(cosmetics-related variables, consumer's preference, advice & inducement), and the dependent variable(purchasing behavior), through AMOS structural equation modeling. As a result of analyzing the mediating effect in the impact relationship between latent variables, it was found that PBC(perceived behavior control) plays a mediating role in the impact relationship between CQ(cosmetics quality) and PB(purchasing behavior). Author found that the higher the quality of cosmetics and the greater the perceived behavior control in domestic cosmetics purchasing behavior, the more likely it will lead to purchasing behavior. In this context, while efforts are being made to improve cosmetic quality, measures to increase perceived behavior control, which can be said to be autonomy in purchasing behavior, should be sought.