• Korea Journal of Cosmetic Science
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• v.1 no.1
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• pp.19-29
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• 2019

In this work, we fabricated liquid crystal (LC) emulsions with fatty alcohol in order to stabilize high content ceramide in cosmetic formulation. We investigated the role of fatty alcohol and surfactant in the formation of higher order structure. As a result, we found that they play a crucial role to form higher order structure. SAXS study shows that ceramide can be incorporated up to 3% in cosmetic formulation with higher order structure and its stability was maintained up to 12 weeks at room temperature. According to WAXS study, the higher order structure can suppress the re-crystallization of ceramide in cosmetic formulation. Finally, we performed in vivo skin barrier recovery test for the damaged skin. LC emulsions with ceramide and O/W emulsions show significant effect in skin barrier recovery at D 1, D 2 and D 6 compared to the untreated condition. While only LC emulsions show significant skin recovery effect at D 14. We expect that LC emulsions are the promising skin carrier to stabilize ceramide and LC emulsions with ceramide can improve the skin barrier function.

• Journal of Advanced Marine Engineering and Technology
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• v.28 no.5
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• pp.801-810
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• 2004

The Primal-Dual Interior-Point (PDIP) method is currently one of the fastest emerging topics in optimization. This method has become an effective solution algorithm for large scale nonlinear optimization problems. such as the electric Optimal Power Flow (OPF) and natural gas and electricity OPF. This study describes major theoretical developments of the PDIP method as well as practical issues related to implementation of the method. A simple quadratic problem with linear equality and inequality constraints

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2007.10a
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• pp.560-560
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• 2007

• East Asian mathematical journal
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• v.35 no.5
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• pp.597-612
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• 2019

In this study, we propose a new logarithmic barrier approach to solve linear programming problem using the projective method of Karmarkar. We are interested in computation of the direction by Newton's method and of the step-size using minorant functions instead of line search methods in order to reduce the computation cost. Our new approach is even more beneficial than classical line search methods. We reinforce our purpose by many interesting numerical simulations proved the effectiveness of the algorithm developed in this work.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.32 no.2
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• pp.104-109
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• 2019

An analytical threshold voltage model is proposed to analyze the threshold voltage roll-off and drain-induced barrier lowering (DIBL) for a junction-based double-gate (JBDG) MOSFET and a junction-less double-gate (JLDG) MOSFET. We used the series-type potential distribution function derived from the Poisson equation, and observed that it is sufficient to use n=1 due to the drastic decrease in eigenvalues when increasing the n of the series-type potential function. The threshold voltage derived from this threshold voltage model was in good agreement with the result of TCAD simulation. The threshold voltage roll-off of the JBDG MOSFET was about 57% better than that of the JLDG MOSFET for a channel length of 25 nm, channel thickness of 10 nm, and oxide thickness of 2 nm. The DIBL of the JBDG MOSFET was about 12% better than that of the JLDG MOSFET, at a gate metal work-function of 5 eV. It was also found that decreasing the work-function of the gate metal significantly reduces the DIBL.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.674-681
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• 2020

The root of Codonopsis lanceolata has been used in traditional medicine. This study was conducted to confirm the comparative effect of ethanol solvent extraction (CLE) and supercritical carbon dioxide extraction (CLS) of C. lanceolata roots. CLS had higher antioxidant than CLE. For supercritical co-solvent modified carbon dioxide extraction (CLS), it were extracted at 250 bar 50℃ 150 min at a flow rate of ethyl alcohol 3 mL/min for 90min. In addition, CLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 ㎍/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. Also, the treatment by CLS (50 ㎍/mL) showed a significant increase of involucrin expression. These results indicate that supercritical carbon dioxide extract of C. lanceolatamay serve as a cosmeceutical agent for improving skin barrier function and the treatment of obesity.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2010.06a
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• pp.355-355
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• 2010

We studied the dependence of the performance of schottky barrier metal-oxide-field effect transistors(SB MOSFETs) on the work function of source/drain metals. A strong impact of the various work functions and the light wavelengths on the transistor characteristics is found and explained using experimental data. We used an insulator of a high thickness (100nm) and back gate issues in SOI substrate, subthreshold swing was measured to 300~400[mV/dec] comparing with a ideal subthreshold swing of 60[mV/dec]. Excellent characteristics of Al/Si was demonstrated higher on/off current ratios of ${\sim}10^7$ than others. In addition, extensive photoresponse analysis has been performed using halogen and deuterium light sources(200<$\lambda$<2000nm).

• Proceedings of the Korean Reliability Society Conference
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• 2002.06a
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• pp.211-216
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• 2002

실제적인 문제에서 신뢰성 기반 최적 설계(RBDO)를 구현하기 위해서는 유한요소 모델을 해석하기 위한 상용 프로그램과 설계한 것에 대한 신뢰성을 산정할 수 있는 프로그램을 통합하고 최적화 알고리듬을 적용하여야 최적화를 수행하여야만 한다. 또한 최적화 과정에서 최적상태에서 제약조건이 비활성 영역에서 놓이게 되는 것을 방지하기 위해서 제약조건 최적화 문제를 비제약 조건 최적화 문제로 바꾸어 주는 장애 함수를 사용하여 최적화를 수행하였다. 그리고 이 방법론을 기존의 신뢰성기반 최적화 방법론, 즉 신뢰도지수 접근방법과 목표성능치 접근방법과의 비교를 하였다.

• BMB Reports
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• v.49 no.5
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• pp.255-262
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• 2016

The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified 'loss of function' mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.10a
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• pp.115-119
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• 2011

Instead of very expensive sound record and professional measurement microphones the low cost Surface Mounted Device (SMD) microphones are proposed for practical barrier ANC system. FRF of the microphones and theirs sensitivity to the wind interferences are evaluated in semi anechoic chamber. The improvement of feedforward algorithm noise reduction index was evaluated based on measured coherence function between tested SMD and reference microphone. Test was performed at various wind speed from 1 m/s to 5 m/s.