• 대한예방한의학회지
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• 제12권1호
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• pp.73-87
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• 2008

In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasing clinical reports on the organ toxicities associated with consumption of herbal medicines. In general, most xenobiotics are metabolized by Phase I reaction(the main enzyme : cytochrome P450) and Phase II reaction. However, reactive oxygen species, free radicals and electrophils are produced inevitably during xenobiotics metabolism. These toxic species and metabolites are increased whenever the endogenous substances and enzymes for Phase II reaction not available. In addition, herbal-drug interactions are pharmacokinetic, with most actually or theoretically affecting the metabolism of the affected product by way of the cytochrome P450 enzymes. This review updated the knowledge on metabolic activation of herbal components and its clinical and toxicological implications. Also, the possible way for preventing the side-effects by herbal-medicine use was suggested.

• Geomechanics and Engineering
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• 제37권1호
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• pp.21-29
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• 2024

The effective management of damage in tunnels is crucial for ensuring their safety, longevity, and operational efficiency. In this paper, we propose an educational management model tailored specifically for addressing damage in tunnels, utilizing numerical solution techniques. By leveraging advanced computational methods, we aim to develop a comprehensive understanding of the factors contributing to tunnel damage and to establish proactive measures for mitigation and repair. The proposed model integrates principles of tunnel engineering, structural mechanics, and numerical analysis to facilitate a systematic approach to damage assessment, diagnosis, and management. Through the application of numerical solution techniques, such as finite element analysis, we demonstrate the efficacy of the proposed model in simulating various damage scenarios and predicting their impact on tunnel performance. Additionally, the educational component of the model provides valuable insights and training opportunities for tunnel management personnel, empowering them to make informed decisions and implement effective strategies for ensuring the structural integrity and safety of tunnel infrastructure. Overall, the proposed educational management model represents a significant advancement in tunnel management practices, offering a proactive and knowledge-driven approach to addressing damage and enhancing the resilience of tunnel systems.

• 대한안전경영과학회지
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• 제25권2호
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• pp.167-174
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• 2023

Currently, the budget for vocational competency development training has been expanded, but the number of participants has decreased. As the budget for the Vocational Competency Development Project increases, the participation of a large number of people becomes necessary. This study aims to derive factors that affect satisfaction by selecting factors related to respondent characteristics, training institutions, training types, and job performance for satisfaction with vocational competency development training, and to study ways to improve satisfaction. Data were collected through focus group interviews (FGI), and logistic regression analysis was conducted through feasibility review and reliability analysis. As a result, in the case of the model, it was confirmed that the degree of agreement between the case actually measured and the case predicted by the model was low in the Hosmer and Lemeshow test, but the overall classification accuracy was classified as 96.0% in the classification accuracy table. As for the influence of the factors, the result was derived that the application of knowledge technology, training institution facility equipment, Business Collaboration, long-term work plan, and satisfaction with work performed have an influence in the order.

• 한국간호교육학회지
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• 제18권3호
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• pp.474-485
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• 2012

Purpose: The Quality and Safety Education for Nurses [QSEN] initiative group has identified six competencies (patient-centered care, teamwork and collaboration, evidence-based practice, quality improvement, safety, and informatics) for pre-licensure nursing education along with related knowledge, skills, and attitudes for each competency. The purpose of this article is to illustrate a teaching strategy that uses films to demonstrate the QSEN competencies in undergraduate nursing students. Method: A literature review was conducted to define QSEN competencies, and six feature-length commercial movies were selected through a systematic process. We provided film titles and their synopses that can be useful in teaching the QSEN six competencies to undergraduate nursing students. Results: Patch Adams for patient-centered care, Wit for teamwork and collaboration, Lorenzo's Oil for evidence-based practice, Am$\acute{e}$lie for quality improvement, Blindness and The Island for informatics can be applied in nursing classroom practices. Conclusion: Establishing the connection between QSEN competencies and cinenurducation is novel, yet it would provide a unique opportunity for nurse educators seeking to overcome the challenge of better preparing future nurses. In future studies, additional films should be considered to enhance nursing educational strategies.

• 방사성폐기물학회지
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• 제21권4호
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• pp.489-502
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• 2023

This article presents the crucial role played by the French underground research laboratory (URL) in initiating the deep geological repository project Cigéo. In January 2023, Andra finalized the license application for the initial construction of Cigéo. Depending on Government's decision, the construction of Cigéo may be authorized around 2027. Cigéo is the result of a National program, launched in 1991, aiming to safely manage high-level and intermediate level long-lived radioactive wastes. This National program is based on four principles: 1) excellent science and technical knowledge, 2) safety and security as primary goals for waste management, 3) high requirements for environment protection, 4) transparent and open-public exchanges preceding the democratic decisions and orientations by the Parliament. The research and development (R&D) activities carried out in the URL supported the design and the safety demonstration of the Cigéo project. Moreover, running the URL has provided an opportunity to gain practical experience with regard to the security of underground operations, assessment of environmental impacts, and involvement of the public in the preparation of decisions. The practices implemented have helped gradually build confidence in the Cigéo project.

• 한국심리학회지 : 문화 및 사회문제
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• 제9권spc호
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• pp.35-55
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• 2003

최근까지 한국사회에서 각종 대규모 안전사고가 발생한 배경에는 국가에서 지난 30여년간 경제성장과 산업의 발전을 목표로 추구하면서 정책으로 안전체계를 구축하지 못한 문화의 특수성이 있다고 보았다. 이 관점에서 현재 한국사회의 안전체계를 구성하는 주체들의 심리와 행동 특성을 분석하고, 이어서 안전 분야에서 심리학이 기여할 수 있는 영역과 연구 과제를 논의하였다. 먼저 총체안전체계의 관점에서 체계를 구성하는 단위로서 안전관리의 책임을 맡은 정부, 안전상품과 써비스를 생산하여 판매하는 기업, 안전상품과 써비스를 소비하면서 한편으로 공동체의 안전생활 환경에 영향을 미치는 시민들, 그리고 안전을 위한 시민운동 단체를 구별하고 이 네 주체들이 각각 어떤 특징들을 보이는지 살펴보았다. 이 분석을 토대로 한국사회에서 심리학이 안전체계를 구성하는 네 주체들의 안전심리와 행동을 연구하여 개선하는데 응용하는 방안을 모색하였다. 안전에 관한 심리학 연구의 영역들로는 인지심리가 토대가 되어서 인간-기계체계를 다루는 인간공학 연구와 아울러 안전심리와 행동에 관한 사회행동 연구가 기초가 된다고 보았다. 이 연구들을 기초로 여러 전공의 심리학자들이 협력하여 안전체계를 구성하는 정부, 기업, 시민, 시민단체 및 언론에 전문지식과 정보를 만들어서 제공하여야 한다. 그리고 실제로 안전분야에 따라서 각종 기관에서 대중의 태도변화에 활용할 수 있는 홍보 계획과 아울러 각 주체들의 행동변화 계획을 만들어야 할 필요성도 지적하였다. 이 논문의 후반부에서는 도로교통 안전 분야에서 필자가 한국 운전자의 음주운전 행동을 연구한 결과를 예로 들어서 한국사회의 안전체계에 관한 심리학 연구의 전망과 장래 연구의 과제를 논의하였다.

• 한국멀티미디어학회논문지
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• 제13권12호
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• pp.1843-1854
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• 2010

The utilization of underground space has recently increased with the complication of road, the rise of the land price, and the development of green technology. Underground space ranges from classical excavations to subway, underground cities, and shopping malls where there are crowds of people. At this time, government has spent a lot of money in installing various types of safety facilities for preparations of increasing potential disasters. Therefore, an effective facility management system is required. In this paper, we propose an information retrieval process to effectively extract the facilities' information based on the ontology and spatial analysis in underground space. The ontology-based searching supports hierarchical and associated results as well as knowledge sharing with hierarchy concepts. The spatial analysis based searching has "Buffer" and "Near" functions to operate on a map without understanding any property of the facility information.

• Toxicological Research
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• 제17권
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• pp.17-24
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• 2001

Risk assessment is useful tool making good decisions on the risks of certain hazardous com-pound and suggests safe margin through scientific process using toxicological data, statistical tool, exposure value and relevant variants. The goal of risk management is to protect the public health from hazardous compound based on result of risk assessment having reality. For the suggestion of exact man-aging information, risk assessment must be designed to represent a "plausible estimate" of the exposure to the individuals and to minimize uncertainty. Risk assessment methodology and knowledge are expected to change more rapidly than before and up-to-date methodology should be applied in regulatory aspects through the Agency. For the useful application of risk assessment, the communication between the risk assessor and the risk manager is needed before the initiation of the risk assessment and upon its completion. Generally, the risk assessment itself as a practical tool in the regulatory decision making process would be regarded with social economic impact.ic impact.

• 한국동물위생학회지
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• 제39권1호
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• pp.41-49
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• 2016

In the present study, fast and robust methods for the next generation sequencing (NGS) were developed for analysis of PRRSV full genome sequences, which is a positive sensed RNA virus with a high degree of genetic variability among isolates. Two strains of PRRSVs (VR2332 and VR2332-R) which have been maintained in our laboratory were used to validate our methods and to compare with the sequence registered in GenBank (GenBank accession no. EF536003). The results suggested that both of strains had 100% coverage with the reference; the VR2332 had the coverage depth from minimum 3 to maximum 23,012, for the VR2332-R from minimum 3 to maximum 41,348, and 22,712 as an average depth. Genomic data produced from the massive sequencing capacities of the NGS have enabled the study of PRRSV at an unprecedented rate and details. Unlike conventional sequence methods which require the knowledge of conserved regions, the NGS allows de novo assembly of the full viral genomes. Therefore, our results suggested that these methods using the NGS massively facilitate the generation of more full genome PRRSV sequences locally as well as nationally in regard of saving time and cost.

• Journal of Veterinary Science
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• 제24권1호
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• pp.12.1-12.10
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• 2023

Background: Arthroscopic exploration of ventromedial part of canine coxofemoral joint is limited in conventional dorsal approach. Objectives: We evaluated the efficacy of a medial arthroscopic approach to the coxofemoral joint of dogs by analyzing the joint visible area and performing a safety analysis. Methods: Arthroscopic approaches to the coxofemoral joint were made in five cadavers using a traditional (dorsal) and novel (medial) approach. Three observers scored the visible area of images and videos of the acetabulum and femur. A safety analysis was performed via dissection of the medial hind limb. The distance between neurovascular structures and arthroscopic portals was measured. Results: The acetabulum was more visible in the dorsal than in the medial approach, with mean visualization scores of 16 ± 0.00 and 11.83 ± 1.26, respectively. The medioventral side of the femur was significantly more visible in the medial than in the dorsal approach, with mean visualization scores of 3.9 ± 0.99 and 6.93 ± 0.58, respectively. Safety analysis confirmed the medial portal site was safe, provided that the surgeon has comprehensive knowledge of the joint. The minimum distance from the arthroscopic medial portals to the nearest neurovascular structures was 2.5 mm. Conclusions: A medial arthroscopic approach to the canine coxofemoral joint has potential clinical application. Dorsal and medial approaches differ significantly and have distinct purposes. The medial approach is useful to access the ventromedial joint, making it an eligible diagnostic method for an arthroscopic evaluation of this area.