• Journal of KSNVE
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• v.2 no.4
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• pp.281-292
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• 1992

Two types of vibration problems are encountered in industrial field: active isolation and passive isolation. In a passive type of vibration isolation, a foundation of a delicated machinery such as TEM, SEM, inspection- probe test, photolithograph, etc. is designed to have a vibration amplitude lower than an acceptable limit. In an active type, the isolation is focused on the vibration reduction caused by the machine itself(pump, motor, press, compressor, etc.). The foundation for such a machine should be so designed as to reduce the transmitted vibration below the permissible level prescribed. At any case, a transmissibility and stability must to be considered. Since an active isolation type is aimed for a vibration source, it is useful to isolate the transmitted vibrations energy from a major vibration source at the specific location. In this paper, a designed methodology of double anti-vibration system has been examined in order to have low transmissibility and reliable stability. Also experiment of scale model behavior has been conducted. Finally, the experiment output of the transfer function is compared to the analytical data.

• Molecules and Cells
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• v.42 no.11
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• pp.755-762
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• 2019

Despite decades of research into colorectal cancer (CRC), there is an ongoing need for treatments that are more effective and safer than those currently available. Lactic acid bacteria (LAB) show beneficial effects in the context of several diseases, including CRC, and are generally regarded as safe. Here, we isolated a Lactobacillus rhamnosus (LR)-derived therapeutic protein, p8, which suppressed CRC proliferation. We found that p8 translocated specifically to the cytosol of DLD-1 cells. Moreover, p8 down-regulated expression of Cyclin B1 and Cdk1, both of which are required for cell cycle progression. We confirmed that p8 exerted strong anti-proliferative activity in a mouse CRC xenograft model. Intraperitoneal injection of recombinant p8 (r-p8) led to a significant reduction (up to 59%) in tumor mass when compared with controls. In recent years, bacterial drug delivery systems (DDSs) have proven to be effective therapeutic agents for acute colitis. Therefore, we aimed to use such systems, particularly LAB, to generate the valuable therapeutic proteins to treat CRC. To this end, we developed a gene expression cassette capable of inducing secretion of large amounts of p8 protein from Pediococcus pentosaceus SL4 (PP). We then confirmed that this protein (PP-p8) exerted anti-proliferative activity in a mouse CRC xenograft model. Oral administration of PP-p8 DDS led to a marked reduction in tumor mass (up to 64%) compared with controls. The PP-p8 DDS using LAB described herein has advantages over other therapeutics; these advantages include improved safety (the protein is a probiotic), cost-free purification, and specific targeting of CRC cells.

• Structural Engineering and Mechanics
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• v.24 no.3
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• pp.339-354
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• 2006

Hangzhou Bay Bridge spans the Hangzhou Bay and is located at Zhejiang province in the southeast seacoast of China. The total length of the bridge is 36 km. The bridge is composed of bridge approaches made up of multi-span prestressed concrete box girders and two cable-stayed bridges over the north and south navigable spans respectively. The seismic response analysis of the bridge model shows that if the navigable spans are designed as the routine earthquake-resistance system, the displacements and internal forces in pylons, piers and deckes are too large to satisfy the anti-seismic requirement of the structure. Therefore, the seismic reduction design was carried out by using viscous dampers to dissipate the kinetic energy of the structure both longitudinally and transversely. Using the vibration reduction system and aiming at the reasonable optimal goal, the purpose to reduce the seismic responses in south and north navigable spans has been achieved.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2011.06a
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• pp.192-192
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• 2011

For the safety of vessels sailing Marine Transport Facility announces sea route, reefs or shallow water. Photovoltaic, independent power system, installation in the general Marine Transport Facilities to be used in the marine lantern. Due to install of communications, controls, power consumption inceases. And the weather of cloudy day or rainy, generation of electricity is decrease. Recently, power system of marine facility using a hybrid generation system, photovoltaic generation system and wave power generation system. But increase of adhered shellfish inside the water column, is the cause of the reduction of efficiency. So study was conducted to Single channel AFS(Anti-Fouling system). In this paper we offer the Multi channel AFS for Marine Transport Facility and have simulated. Improve the accuracy of the research, we using the result of anode, in the experiment were actually in the buoy, is based on simulation. The experimental results is shown every anode's, in the Marine Transport Facility, ionization was conducted identically.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.5
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• pp.568-575
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• 2015

A hand-made vehicle with a formula (VF-1) was designed and manufactured with the aim of realizing a lightweight and high-performance vehicle. The driver's body weight and stiffness of the frame were considered. The vehicle was equipped with a one-cylinder Exiv 250 engine with intake manifold potting for realizing weight reduction, high performance, and low cost. The suspension system for the formula was designed through the analyses and tests of vehicle motion and equipment. In a steering system, anti-Ackerman geometry was introduced to increase the transverse force during cornering. A full electric paddle shift system was adopted to decrease the braking distance. For protection against the distortion and warping of the frame, tungsten inert gas (TIG) welding technology was used.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2009.10a
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• pp.185-189
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• 2009

It is very important to control the vibration transmitted from external utilities and the transient response due to the internal sources for the precision equipment, which is very sensitive to the vibration environment. The anti-vibration tables that use air springs have been widely used due to their excellent isolation performance, but the systems with high flexibility have the critical problem of large transient response by the impulsive force of the moving mass in operation of the equipment. In this paper, the hybrid vibration control system is proposed, which is combined the air springs with the semi-active MR dampers in order to satisfy the performances of isolation and vibration reduction simutaneously.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.4
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• pp.181-188
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• 2000

Input shaping is a method fur reducing residual vibration. Vibration is eliminated by convolving an input shaper, which is a sequence of impulses, with the desired system command. It has been applied to robot with a flexible manipulator. But it can be applied to the reduction of residual vibration far overhead crane. In this paper, input shaping shows good performance for anti-sway of overhead crane. In the z-domain, we designed an input shaper and calculated the sensitivity of it. If sensitivity is calculated in the z-domain, the shapes of sensitivity curves are expected easily. Accordingly, it is easy to design an input shaper in the z-domain. We compared the response of a system with shaper to it without that. Also, we compared El shaper to ZV shaper in view of robustness.

• Advances in Traditional Medicine
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• v.8 no.4
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• pp.423-429
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• 2008

Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

• Herbal Formula Science
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• v.13 no.2
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• pp.59-69
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• 2005

Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.5
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• pp.8-14
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• 2008

For nondestructive inspection of electron beam (EB) welding part in automotive power transmission assembly, a pulse-echo ultrasonic testing apparatus in water immersion has been applied using the ultrasonic waves with a frequency of 10MHz. However various problems have appeared during the ultrasonic inspection, which led to some significant mistakes in automatic quality evaluation of the welding parts. Experimental study showed that the state of water couplant medium containing some amount of contaminants, rusts and anti-corrosion agents had considerable influences on the reduction of ultrasonic amplitudes during wave propagation. The amplitude reduction depending on the coupling medium state could bring about some mis-diagnoses for defects in the welding parts. The results proposed that for a reliable inspection of defects in welds the state of water medium should be kept in about 15 volume fractions (vol.%) of anti-corrosion agents and in minimized contaminants.