Herbal Formula Science (대한한의학방제학회지)
- Volume 13 Issue 2
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- Pages.59-69
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- 2005
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
Effect of Samyoyongantang on Contact Hypersensitivity induced by Repeat Elicitation of DNCB.
사묘용안탕(四妙勇安湯) 물추출물이 DNCB로 유발된 접촉성피부염에 미치는 영향
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Byun, Sung-Hui
(College of Oriental Medicine, Daegu Haany University.)
;
- Lee, Byung-Wook (College of Oriental Medicine, Daegu Haany University.) ;
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Kim, Sang-Chan
(College of Oriental Medicine, Daegu Haany University.)
- Published : 2005.12.31
Abstract
Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.