• Journal of the Optical Society of Korea
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• v.15 no.1
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• pp.68-73
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• 2011

This study investigated, using the Orbscan II topography system, the influence of age and sex related changes on the corneal thickness and anterior corneal curvature, more specifically the fine structure of the cornea, in a Korean young population. The Orbscan II topography system is a computer-assisted slit-beam scanning technology that can map the anterior section of the cornea. The mean central corneal thickness of all subjects was $547.532{\pm}44.529\;{\mu}m$. There was no statistical difference (p>0.5) in the mean central corneal thickness between males and females. Sex and age related changes in the mean central corneal thickness had no specific statistical difference (P>0.5). There was a negative correlation between the anterior corneal curvature and the central corneal thickness in all subjects, except for the twenty year olds. However, the thickness relationship between the mean central corneal and the eight paracentral corneal thicknesses had strong statistical differences in all subjects. Also age and sex related changes in the central corneal thickness and the anterior corneal curvature in all subjects had no statistically significant difference, except from 20-26 years old (p>0.05). This information could be a suitable reference basis for future studies in the young population of Asia and for the development of examination tools for corneal refractive surgery.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.223-232
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• 2012

Purpose: Validating a new research method to determine posterior corneal curvature and asphericity(Q) in vivo, based on measurements of anterior corneal topography and corneal thickness. Methods: Anterior corneal topographic data, derived from the Medmont E300 corneal topographer, and total corneal thickness data measured along the horizontal corneal meridian using the Holden-Payor optical pachometer, were used to calculate the anterior and posterior corneal apical radii of curvature and Q. To calculate accurate total corneal thickness the local radius of anterior corneal curvature, and an exact solution for the relationship between real and apparent thickness were taken into consideration. This method differs from previous approach. An elliptical curve for anterior and posterior cornea were calculated by using best fit algorism of the anterior corneal topographic data and derived coordinates of the posterior cornea respectively. For validation of the calculations of the posterior corneal topography, ten polymethyl methacrylate (PMMA) lenses and right eyes of five adult subjects were examined. Results: The mean absolute accuracy (${\pm}$standard deviation(SD)) of calculated posterior apical radius and Q of ten PMMA lenses was $0.053{\pm}0.044mm$ (95% confidence interval (CI) -0.033 to 0.139), and $0.10{\pm}0.10$ (95% CI -0.10 to 0.31) respectively. The mean absolute repeatability coefficient (${\pm}SD$) of the calculated posterior apical radius and Q of five human eyes was $0.07{\pm}0.06mm$ (95% CI -0.05 to 0.19) and $0.09{\pm}0.07$ (95% CI -0.05 to 0.23), respectively. Conclusions: The result shows that acceptable accuracy in calculations of posterior apical radius and Q was achieved. This new method shows promise for application to the living human cornea.

• Journal of the Korea society of information convergence
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• v.6 no.1
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• pp.37-41
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• 2013

In this study, by using the Oculus Pentacam, we analyzed the relationship of corneal front astigmatism corneal and the radius of curvature of the rear face of the 20's to 40's. The vertical radius of curvature were man 7.94mm (${\pm}0.22$), women 7.87mm (${\pm}0.21$), the horizontal radius of the anterior corneal appeared man 7.69mm (${\pm}0.27$), women 7.63mm(${\pm}0.23$). And rear vertical radius of curvature were man 6.52mm(${\pm}0.23$), woman 6.55mm (${\pm}0.22$), the horizontal radius of the anterior corneal appeared man 6.06mm (${\pm}0.24$), woman 6.08mm(${\pm}0.24$). The results of correlation analysis between the radius of corneal posterior surface and the anterior corneal surface, it was found out that there is a significant correlation. In this study, similar results were obtained anterior surface of the cornea, the radius of curvature of the rear surface, the refractive power, and astigmatism, as other papers that have been reported. But in this paper, the cornea thickness was thicker than other previously reported paper.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.211-221
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• 2004

The purpose of this study is to evaluate the distribution and change of curvature of the anterior corneal surface with age in emmetropia. 504 subjects who have emmetroia with good naked vision of at least 0.6-1.0 (spherical equivalent: +0.75D- -0.75D) participated in this study. The 504 subjects into 8 groups with 10 year interval from 3-year to 83-year, and their corneal curvatures were analyzed using manual keratometry. The results are as follows. In individual analysis: First, regression analysis of corneal curvature radius with age has given an equation: Y = -0.003x + 7.796 (r = -0.26). The average corneal curvature radii was measured to be $7.68{\pm}0.25mm$ at 38.3-year and range was 6.98-8.54 mm. Second, frequency of corneal curvature radius were obtained in 36% between 7.61 and 7.80 mm, 78% between 7.41 and 8.00 mm, 96% between 7.21 and 8.20 mm, 100% between 6.98 and 8.54 mm. Third, as for the comparison of corneal curvature radius with respect to sex, The mean value of male (n = 304, mean: 37.6-year $7.72{\pm}0.24mm$, Range: 7.09-8.54 mm) is larger than that of female (n = 200, mean: 39.3-year $7.62{\pm}0.24mm$, Range: 6.98-8.42 mm) by 0.1mm (p<0.01). In groups analysis: First, regression analysis of corneal curvature radius with age has given an equation: $Y=-0.0066x^2+0.0227x+7.7282$ (r = -0.90). Second, vertical and horizontal curvature radius decreased with age (p < 0.01). Especially the decrease of horizontal curvature radius were more pronounced than the decrease of vertical (horizontal:10-70 age group: 0.38 mm decrease, vertical:10-70 age group: 0.20 mm decrease). Third, difference between steep and flat meridian (astigmatism) progressively decreased with age. (low age group:0.18 mm difference, high age group: 0.08 mm difference). Fourth, the corneal curvature radius of male was larger than female's in total groups(p < 0.01). Consequently, the change of corneal curvature radius with age progressively decreased in all conditions (mean, vertical, horizontal, male, and female) and this change was more outstanding in horizontal rather than in vertical.

• Journal of The Korean Ophthalmological Society
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• v.59 no.11
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• pp.1049-1055
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• 2018

Purpose: To investigate the factors associated with glaucoma in patients with pseudoexfoliation syndrome by comparing features of the anterior segments and ocular biometry according to the presence or absence of open-angle glaucoma in pseudoexfoliation syndrome. Methods: We analyzed 96 patients (115 eyes) diagnosed as having pseudoexfoliation syndrome in this study. The patients were divided into two groups of simple pseudoexfoliation syndrome (64 patients, 76 eyes) and pseudoexfoliation glaucoma (32 patients, 39 eyes). We compared the age, sex, underlying disease, location of pseudoexfoliative material, iris change, degree of nuclear cataract, pupil dilatation, corneal endothelial cell counts, central corneal thickness, anterior chamber depth, axial length, corneal curvature, and intraocular pressure (IOP). Results: There were no significant differences between the two groups in terms of age (p = 0.694), sex (p = 0.161), diabetes (p = 0.440), hypertension (p = 0.238), pseudoexfoliative material observed in anterior capsule (p = 0.700), pupillary margin (p = 0.210), iris depigmentation (p = 0.526), pupillary ruff loss (p = 0.708), degree of nuclear cataract (p = 0.617), pupil dilatation (p = 0.526), central corneal thickness (p = 0.097), anterior chamber depth (p = 0.283), axial length (p = 0.095), or horizontal and vertical corneal curvature (p = 0.066 and 0.306, respectively). In pseudoexfoliation glaucoma, significantly higher IOP (p = 0.026), a high frequency of membrane formation (p = 0.047), and decreased corneal endothelial cell counts (p = 0.048) were observed. Conclusions: Pseudoexfoliation syndrome with open-angle glaucoma was shown to be associated with high IOP, decreased corneal endothelial cell counts, and a high frequency of membrane formation. Therefore, when such changes are observed in pseudoexfoliation syndrome patients, a higher risk of open-angle glaucoma should be recognized, and careful attentionis required accordingly.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.2
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• pp.139-144
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• 2000

In this study, anterior corneal radius of curvature in korean subjects aged between 16 to 79 year-olds were measured using a keratometer. Refractive power was also measured without cyloplegia. A-mode Ultrasonography was used to measure anterior chamber depth, crystalline lens thickness, vitreous chamber depth & axial length. Measurements of anterior chamber depth of subjects in their 20s were between 3.0 mm & 4.0 mm, 70s age group were between 2 mm & 3.50 mm, showing a decrease with age. Crystalline lens thickness of 20s age group was 2.64 mm while 70s age group was 4.62 mm showing an increase with age. Vitreous chamber depth, unaffected by age, was about 17 mm. Axial length was 24.47 mm in subjects below 40s age groups decreasing to 24.11 mm in above 40s age groups. Corneal radius of curvature was 7.79 mm and 7.72 mm in younger and older age groups respectively, showing a decrease with age.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.2
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• pp.187-193
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• 2011

Purpose: This study was to compare differences between both eyes in corneal powers, axial lengths, anterior chamber depths in anisometropia and isometropia, and to investigate the relationship between anisometropia and refractive components. Methods: The subject was a total of 83 patients, anisometropia 45 patients (90 eyes) and isometropia 38 patients (76 eyes) from 2.7 to 15.3 years old, prescribed eyeglasses and contact lenses by refraction from July 2010 to August 2010 in Gwangju City B eye clinic. Axial length, anterior chamber depth, corneal curvature, and corneal refractive power were measured using IOL Master. Refractive error was measured using an Auto-refractometer. Results: Anisometropia was a statistically significant difference in axial length, binocular refractive components, refractive error, and axial length, Axial length/corneal radius (AL/CR) ratio showed a statistically significant difference in anisometropia and isometropia. The major cause of anisometropia all 45 subjects was the axial length. Among the refractive components axial length, AL/CR had a strong correlation, but corneal refractive power had no correlation. Anterior chamber depth had a weak correlation. Conclusions: This study found that refractive error was the most axial ametropia caused by the axial length. The main cause of anisometropia was the axial length, but refractive components had a weak correlation.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.1
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• pp.111-120
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• 2014

Purpose: This study was to investigate changes in the thickness of cornea, curvature of cornea, and aberration depending on the water contents, materials, and refractive power of contact lens. Methods: The differences in the corneal thickness between pre- and post-wearing the lenses were compared using 5 kinds of lenses. The changes in the corneal thickness, the curvatures of the anterior and posterior cornea, and high order aberration (HOA) before and after wearing the lenses were investigated at the center of the cornea, and the different distance and the direction away from the center of the cornea. For the equipments of measurement, ORB ScanII (Bausch & Lomb Inc, ver 3.14) was used to measure the corneal topography and thickness, and Zywave (Bausch & Lomb Inc, ver 5.20) was used to analyze the high order aberration. Results: Five (S1, S2, S3, T1, T2) of the lens was used for this study, excluding the lens T2 lens has four lenses and the thickness of the corneal shape, but the impact is minimal. In the case of the hydrogel soft contact lenses (T2 lens) with low oxygen permeability, the corneal thickness showed distinct increasing patterns. The high order aberration and coma aberration were most changed in the silicon hydrogel toric lens, while the depth of anterior was most changed in the hydrogel toric lens. Conclusion: Among the 5 kinds of contact lenses with different water contents, materials, and refractive power used for this study, the corneal shape change was small for the lenses with an oxygen permeability (Dk) of more than 28, and the largest for the lenses with a very low oxygen permeability.