• Annals of Geriatric Medicine and Research
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• v.22 no.4
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• pp.208-208
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• 2018

• Genomics & Informatics
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• v.21 no.2
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• Journal of Family Resource Management and Policy Review
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• v.14 no.4
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• pp.323-340
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• 2010

Many social and environmental changes have emerged due to the increasing size of the aging generation. This study explored the current status of the information leisure activity of the aging generation (computer use activity, internet service participation, social community participation and blogging, UCC, etc.) and the need for serious games among elderly consumers. It analyzed the current status of serious game and information leisure span as determined by experts on elderly care at the aging welfare institute. The research methods involved applying content analysis and focus group interviews. The results were as follows: The elderly are willing to enjoy the internet and economics networks. In particular, economic investment, economic news, health, meetings, and communication are the main internet search categories. The results for serious games are less interesting than those for IT participation. The components of usefulness in terms of serious games, as identified by care experts, are simplicity, a user-friendly interface, efficacy, and certainty in using the game device. Care experts recognize that serious games represent a supplementary device to traditional physical and emotional therapy.

• The Journal of the Convergence on Culture Technology
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• v.1 no.1
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• pp.69-72
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• 2015

Abstract Social pathologic phenomenon such as low fertility, nuclear family and one person households seems to be on the rise as Korea moves towards being an aging society. We think many trouble is expected to be exit as aging society progresses, but there were few studies about an aging society, especially funeral culture. Appearance of the aging society in Korea similarly follows the course of Japan. So we studied about similar funeral culture of aging society in Japan and prepared for the funeral culture in Korea. This study will suggest a gaze on realistic objective point of view, through the way to illustrate exactly the concept of "funeral for family (家族葬)" among Japanese funeral culture(Syukacheu(終活), Chyokusou(直葬) and funeral for family(家族葬)) and will be expected to be an important guide for leading the funeral culture in Korea occur due to aging in future. And this study will give a chance to ruminate on our's funeral attitude about the deceased's dignity.

• 한국노년학
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• v.27 no.2
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• pp.299-322
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• 2007

The purpose of this study is to critically review recent discourse on aging appeared in Korean newspapers. For this purpose, 1,725 articles on 'aging' or 'elderly' appeared on three major Korean newspapers during 1997- 2006 are analyzed. It is shown that there is a recent surge of articles portraying the positive images of aging in Korean newspapers emphasizing the importance of productive, successful aging and active life style of the elderly. This trend is a welcomed change from the negative images of elderly as dependent burden of society. However, it seems that over emphasis on positive aging and 'New Elderly' might have created another stereotype about the elderly and unintentionally marginalize the certain group of the elderly. By focusing on individual responsibility, it also overlooked the constraints imposed by social structure on disadvantaged elderly group, such as women, elderly in low socio-economic strata. Theoretical and policy implications of this trends are discussed.

• The Journal of Korean Academic Society of Nursing Education
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• v.27 no.4
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• pp.392-401
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• 2021

Purpose: This study was conducted to identify the relationship of health status, aging anxiety, social networking, generativity, and happiness and to investigate the main factors influencing happiness of late middle-aged adults. Methods: The study collected data from a total of 153 middle-aged men and women aged 50 to 64 years old from a consumer panel of Macromill-Embrain, the biggest online survey provider in Korea. The data were analyzed using descriptive statistics, Pearson's correlation coefficient and a stepwise multiple regression using the SPSS 22.0 program. Results: The subjects' happiness mean score was 16.17±9.29. Statistically significant differences in happiness were found according to education (F=4.38, p=.014), economic status (t=5.13, p<.001), and religion (t=2.18, p=.031). Happiness was correlated significantly with health status (r=.41, p<.001), aging anxiety (r=-.62, p<.001), family support (r=.43, p<.001), friend support (r=.36, p<.001) and generativity (r=.63, p<.001). The factors influencing happiness of late middle-aged adults were generativity (𝛽=.37, p<.001), aging anxiety (𝛽=-.35, p<.001), family support (𝛽=.20, p<.001), and economic status (𝛽=.13, p=.033). The explanatory power of the model was 58.0%. Conclusion: This study will be used as basic data when developing a nursing intervention program for successful aging by identifying factors that affect the happiness of late middle-aged adults.

• Korean Journal of Human Ecology
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• v.13 no.1
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• pp.17-27
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• 2004

The purpose of this study was to examine whether the intergenerational program affected the children's perceptions on the elderly and aging. This study also investigated how the children evaluated the program. The study methods was one group pretest-posttest design. The subjects were 30 elementary school children from 1st to 3rd grade. The intergenerational program was composed of 6 activities: recreation activity for rapport, making a kite, gardening, learning old customs, education of traditional manner, and making rice-cakes. It was executed for two weeks. Data for children's perceptions on the elderly and aging were collected by the interview using questionnaire at pretest-posttest. The results of the qualitative data analysis showed that the children's perception on the elderly and aging changed more positively after the program. There were significant differences between pre- and post-test on the children's perceptions of aging and intellectual aspects of the elderly. Most of the children evaluated the program very positively.

• Biomedical Science Letters
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• v.12 no.4
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• pp.337-341
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• 2006

Platelets clearly play an important role in inflammatory responses. In this study, we aimed to evaluate the relationship between aging and platelet activation. A total number of 799 persons (383 males and 416 females), who were apparently healthy and aged more than 20 years were recruited by a health promotion center in a community-based hospital in Seoul, Korea. We collected material data about their medical history and health behavior. Platelet parameters including mean platelet component (MPC), mean platelet volume (MPV), and platelet component distribution width (PCDW) were determined within 1 hour after blood collection using the ADVIA 120 automated hematology analyzer. The MPC of the women ($27.2{\pm}1.2$) was significantly love. than that of the men ($27.5{\pm}1.3$). The MPC of all participants was found to decrease with increasing age (P<0.01). Study participants in their twenties had the highest MPC ($27.7{\pm}1.1$), followed by those in their thirties ($27.6{\pm}1.1$), forties ($27.4{\pm}1.3$), fifties ($27.2{\pm}1.3$), sixties ($27.2{\pm}1.2$) and seventies ($27.1{\pm}1.2$). Multiple regression analysis showed that aging and gender were related with MPC after adjusting for confounding factors, including age, gender, smoking habit, hypertension, diabetes, body mass index and total cholesterol level. The this study shows that aging is related to platelet activation. Future research will need to determine the implications of increased platelet activation with aging, especially regarding the increased incidence of cardiovascular diseases and related mortalities that occur in older age groups.

• Child Health Nursing Research
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• v.5 no.3
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• pp.292-304
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• 1999

The lengthened average span of human life by virtue of recent developments in medicine has caused the Population of elders to increase. The development of modern industrial society has transformed family structure from the large family system to that of a nuclear family. Due to the shift in family structure, the problem of support for the aged has surfaced as a nursing problem as well as a social problem. With regard to this problem, this study aims to investigate the adolescent's understanding of elders and aging. By identifying their understanding and classifying their attitude patterns, this study will help the nursing assessment of the support of elders in the family. This study employed Q-methodology and the research was conducted from December 1998 to May 1999. One method of the research included deep interviews with elders, those who are in their 50's. 40's or 30's. and the adolescent. 183 Q-Populations taken from literary works such as poems or novels were also formed as another method. Finally. 36 Q-cards were made after consultation with Professors of the nursing department. The subjects of the P- sample were 30 high sohoolboys/girls - who were in first, second, and third years. The result showed that 3 factors provided an explanation for 59.14% of the whole variables: the first factor, 41.37%; the second factor. 11.49%, and the third factor. 6.28%. These three factors were analyzed and categorized as three types. Twenty subjects out of the 30 were included in Type 1: Respecting Elders. The statements which showed the most positive consent were as follows: 'The declining age is a perfect time to prosper completing a worthy life' ; 'Getting old. one needs financial stability' and 'Elders wish the best for their children' The statements showing the most negative response were as follows: 'It is better to die than to live as an older person' ; 'Elders are insignificant' ; and 'Getting old is the worst unhappiness that tortures human.' Four subjects were included in Type 2. Resenting Elders. The statements which showed the most positive consent were as follows: 'Aging is a process of dying that nobody can escape from'. 'Elders should be concerned about his health and try to maintain their health' ; and 'When you set older. you regret about the life in the Past.' The statements showing the most negative response were as follows: 'When You get older. You should stand aloof greed and worldly things' 'When You got older, You become generous and gentle' ; and 'When You set he gets old. You change to become a comfortable and warm person.' Six out of 30 subject were included in Type 3 Caring Elders. The statements which showed the most positive consent were as follows: 'Elders should be concerned about his health and try to maintain their health' ; 'Elders wish the best for their children' ; and 'Elders deserve to be treated with filial respects.' The statements showing the most negative response were as follows 'Elders are insignificant' ; 'Elders have freedom and plenty of free time.' and 'Elders are alienated form and drove out of the society.' The above-mentioned results show that most adolescents in Korea recognize aging as the time of fruition and development: it is a time of benefiting and giving back to society. Aging can also be seen as a time of generosity and magnanimity and the time of respect and favorable treatment from society. despite the change of modern society and the ostensible transformation of a family system. Their recognition seems deeply rooted in the traditional confucian values and the dual family system which is Peculiar especially to the Korea - one which maintains both the superficial form of nuclear family and the substantial mode of the enlarged family system. In sum, many Korean adolescents attribute the meaning of the elderly and aging to the type of the respect with the elderly and the type of the elderly's caretaking.

• Korean Journal of Human Ecology
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• v.14 no.3
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• pp.491-504
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• 2005

This research studies the residential environment of the elderly and its trend. Our main focus is on the residential condition and its type between parents and their child/ren in korea which has already entered the aging society. The results are as follows: (1) This paper finds that the residence type of the households with elderly people becomes multifarious, as in a two-generation household, a couple and their single child, a couple family, etc. (2) The parents living separately from their child/ren account for 63.3%, which is becoming predominant in the residence type of the elderly. On the other hand, those living with their child/ren take up merely 24.5%. Thus, we can infer that the number of the parents with the former type is on the increase. (3) The residence type in reality is different from the one intended by elderly people, so we can estimate future change in the residence type. (4) The residence type varies, as in living together with young family, living separately from young family, separation at a distance, etc. In conclusion, we need appropriate living programs for each various residence type between elderly people and their children.