• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2006년도 정기학술발표대회 논문집
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• pp.332-337
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• 2006

플랜트 기술은 산업의 종합기술로서 관련 산업으로의 파급효과가 큰 반면, 기술력을 갖추기 위해서는 장기간에 걸친 투자가 필요하며, 업계공동 혹은 국가적인 차원에서 플랜트 산업의 장기 발전전략을 수립하여 지속적으로 추진할 필요가 있다. 또한 플랜트분야 고급기술자의 노하우를 축적하고 교육할 수 있는 플랜트 교육프로그램을 서둘러 구축할 필요가 있다. 이를 위해 플랜트 교육 프로그램을 구축하여 정부기관과의 정책에 적극 부응하는 플랜트 정보제공, 기술개발 지원 등 전문적인 교육을 제공할 수 있는 교육 프로그램 개발이 필요할 것이다. 이러한 현실에서 본 연구는 건설 분야에서의 플랜트 교육 프로그램을 조사하여 국내와 국외의 플랜트 교육 현실을 파악하고 향후 국내 플랜트 기술력의 향상을 위해 필요한 교육 프로그램 개발을 위한 기초 조사로써 연구를 수행하고자 한다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권8호
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• pp.235-242
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• 2020

4차 산업혁명 시대를 맞아 우리 농업·농촌의 디지털 전환을 추진하고 다가오는 인공지능 시대를 대비하기 위하여, 필요한 양질의 데이터를 수집하고 분석해서 활용할 수 있는 체계와 시스템 구축이 필요하다. 이를 위해 농업인이나 농정담당자 등 다양한 이해 관계자들이 느끼는 문제점이나 이슈들을 조사·분석하여, 공동 활용을 위한 빅데이터 플랫폼 확충, 지속 가능한 빅데이터 거버넌스 구축 그리고 수요자 기반의 빅데이터 활용 기반 활성화 등 우리 농업·농촌의 디지털 전환을 추진하기 위해서 반드시 선결되어야 할 빅데이터 활성화를 위한 전략적 방안들을 제시하고자 한다.

• Biomolecules & Therapeutics
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• 제23권5호
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• pp.414-420
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• 2015

Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the exact anti-inflammatory mechanism of fisetin is not understood. In this study, the pharmacological action modes of fisetin in lipopolysaccharide (LPS)-stimulated macrophage-like cells were elucidated by using immunoblotting analysis, kinase assays, and an overexpression strategy. Fisetin diminished the release of nitric oxide (NO) and reduced the mRNA levels of inducible NO synthase (iNOS), tumor necrosis factor (TNF)-${\alpha}$, and cyclooxygenase (COX)-2 in LPS-stimulated RAW264.7 cells without displaying cytotoxicity. This compound also blocked the nuclear translocation of p65/nuclear factor (NF)-${\kappa}B$. In agreement, the upstream phosphorylation events for NF-${\kappa}B$ activation, composed of Src, Syk, and I${\kappa}B{\alpha}$, were also reduced by fisetin. The phospho-Src level, triggered by overexpression of wild-type Src, was also inhibited by fisetin. Therefore, these results strongly suggest that fisetin can be considered a bioactive immunomodulatory compound with anti-inflammatory properties through suppression of Src and Syk activities.

• 스마트미디어저널
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• 제2권3호
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• pp.34-38
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• 2013

상품권을 이용한 상거래에는 인쇄 및 관리를 포함한 여러 비용이 추가된다. 상품권을 디지털화하여 모바일 폰을 통해 유통할 경우, 이러한 비용이 많이 감소된다. 또한, 스마트폰 활성화에 따라 모바일 거래가 증가하고 있기에 근거리 통신기능을 갖춘 NFC 기술이 주목받고 있다. 그리하여, 모바일 전자결제를 위해 NFC 기반의 전자상품권을 이용한 방법이 연구되고 있다. 마케팅 전략에 도움이 될 수 있는 전자상품권의 유통경로를 분석하기 위해, 본 논문에서는 전자상품권에 유용한 데이터를 저장하기 위한 방법을 제안한다. 제안한 방법은 객체메모리모델을 활용한다. 제안된 전자상품권은 상품권 자체 정보뿐만 아니라, 유통이력정보 블록을 포함한다. 향후에는 제안한 전자상품권을 구현하고 테스트한다.

• 복식문화연구
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• 제22권2호
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• pp.258-272
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• 2014

This study aims at comprehending the characteristics of fashion communications through case study about an art marketing that Prada develops in the field of modern fashion and providing theoretical materials on creativity-based art marketing and communication spread as expression strategy for brand philosophy and personality. For its research method, theoretical study was reviewed about art marketing and Prada's fashion philosophy and then cases on Prada's art marketing were analyzed according to their types. Prada's types in their art marketing are classified into several groups: support of art foundation and artists, differentiation via flagship store, application of image fashion, exhibition project, and cooperative work with different realms. From the above marketing strategies, we can find the values in that the brand image imbedded in enterprises with culture and art was contributable to set up the brand identity, that they were much beneficial to continuous activation for fashion culture and art fields, and that fashion communications of artistic emotion based on challenge and innovation were proposed. This fashion communication in Prada via way of art marketing is not just expression of Prada's luxury fashion brand but willingness to make their unique style from different facades. This also suggests the orientation that modern fashion should look forward to in finding a new way through cooperative relationship with other fields.

• 지역사회간호학회지
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• 제24권3호
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• pp.332-345
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• 2013

Purpose: This study was attempted to provide quality improvement and revitalization of visiting nurse services by Importance-Performance Analysis of persons being provided with the services. Methods: The subjects were 350 people being provided with visiting nurse services from a long term home care institution in the kangwon Province during the period of data collection between Aug. 16 and Sep. 15, 2011. Data analysis was conducted through t-test, ANOVA, and IPA by using the SPSS/WIN 12.0 program. Results: As a result of the Importance-Performance Analysis of visiting nurse services, it turned out that the strength on reliability, assurance, and empathy should be maintained with good work and the aspects of responsiveness appeared to be intensively improved, and the tangibility proved to be subject to improvement. Conclusion: For the activation of visiting nurse services, methods for improving the performance in the intensive care area and management strategy establishment which highlights the advantages of strength maintenance area are needed.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제13권2호
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• pp.53-60
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• 2007

Various changes in medical environments including growing elderly population, chronic diseases, deepening competition among hospitals since opening to foreign medical service, economic strategy for improvement of profit system have caused hospitals to be specialized. In this backgrounds, the purpose of this study is to receive basic data for architectural planning on the spatial organization of outpatient department in general hospital. The results of this study were as follows; First, major changes of outpatient department in general hospital are composed of 'co-work in medical examination and treatment', 'decentralization of diagnosis and treatment(D/T)' and 'patient-oriented medical service'. Changes by co-work system include appearance of medical offices for co-work, activation of specialized clinics, grouping of E/T section for outpatient and various types of specialized centers. Second, the grouping of E/T sections means the modification of E/T system and organization in general hospitals, and a new spatial organization will be needed. Third, the types of specialized centers are getting varied. they are classified into several types including disease-resource, social stratum-resource, human organ-resource, health-resource, rehabilitation-resource, alternative medical center and so on.

• ETRI Journal
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• 제33권4호
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• pp.528-536
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• 2011

In this paper, we analyze the location accuracy of real-time locating systems (RTLSs) in multipath environments in which the RTLSs comply with the ISO/IEC 24730-2 international standard. To analyze the location error of RTLS in multipath environments, we consider a direct path and indirect path, in which time and phase are delayed, and also white Gaussian noise is added. The location error depends strongly on both the noise level and phase difference under a low signal-to-noise ratio (SNR) regime, but only on the noise level under a high SNR regime. The phase difference effect can be minimized by matching it to the time delay difference at a ratio of 180 degrees per 1 chip time delay (Tc). At a relatively high SNR of 10 dB, a location error of less than 3 m is expected at any phase and time delay value of an indirect signal. At a low SNR regime, the location error range increases to 8.1 m at a 0.5 Tc, and to 7.3 m at a 1.5 Tc. However, if the correlation energy is accumulated for an 8-bit period, the location error can be reduced to 3.9 m and 2.5 m, respectively.

• 대한의생명과학회지
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• 제25권4호
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• pp.293-301
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• 2019

Combination chemotherapy is more effective than mono-chemotherapy and is widely used in clinical practice for enhanced cancer treatment. In this study, we investigated the potential synergistic effects of acetaminophen, a common component in many cold medicines, and romidepsin, a histone deacetylase (HDAC) inhibitor, in the A549 non-small cell lung cancer (NSCLC) cell line. The combination of acetaminophen and romidepsin also exerted significant cytotoxicity and apoptosis induced by activation of caspase-3 on tumor cells in vitro. Moreover, combination therapy significantly induced increased production of chemokines that stimulate migration of activated T-cells into tumor cells. This mechanism can lead to active T-cell mediated anti-tumor immunity in addition to the direct cytotoxic chemotherapeutic effect. Activated T-cells led to enhanced cytotoxicity in drug-treated A549 cells through interaction with tumor cells. These results suggested that the interaction between the two drugs is synergistic and significant. In conclusion, our data showed that the use of romidepsin and low concentrations acetaminophen could induce effective anti-tumor effects via enhanced tumor immune and direct cytotoxic chemotherapeutic responses. The combination of acetaminophen with romidepsin should be considered as a promising strategy for the treatment of lung cancer.

• 약학회지
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• 제52권6호
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• pp.500-506
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• 2008

Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. In this study we found that apigenin stimulated melanin synthesis in a dose-dependent manner in B16 murine melanoma cells. Since in our previous study $K^+$-$Cl^-$-cotransport (KCC) has been shown to mediate the mechanism of action of apigenin in neuronal cells, we further investigated the role of KCC in the melanogenesis-stimulating effect of apigenin in B16 cells. At nontoxic concentrations apigenin induced $Cl^-$-dependent $K^+$ efflux, a hallmark of KCC activity, which was markedly prevented by a specific KCC inhibitor R-(+)-[(2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid (DIOA). These results indicate that KCC is functionally present, and activated by apigenin in the B16 cells. In addition, the apigenin-induced stimulation of melanogenesis was also significantly inhibited by DIOA. NEthylmaleimide (NEM), a known KCC activator, induced $Cl^-$ efflux and stimulated melanogenesis in a concentration-dependent fashion. Both effects of NEM were significantly inhibited by DIOA. Taken together, these results suggest that apigenin can modulate melanogenesis through the activation of a membrane ion transporter, KCC in B16 cells. These results further suggest that apigenin may be a good candidate in the therapeutic strategy for hypopigmentation disorders, such as vitiligo.