• 대한한의학회지
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• 제23권2호
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• pp.1-18
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• 2002

Objectives : The objective of this study was to examine the academic informationseeking behavior and demand of the oriental medical researcher and to create the base data for establishing a library environment providing a high-quality information service which would aid the activity of such researchers, Methods : We distributed a questionnaire to the one hundred professors of the college of oriental medicine on the method of acquisition of information data, the environment of the library belonging to the college, and the like. Results : $\circled1$ The main class using the academic information service of oriental medicine was revealed to be researchers having a career of 10 to 15 years who had a domestic doctorate in oriental medicine. $\circled2$ When accessing information, the primary information resource used was academic journals. $\circled3$ Of the data forms mentioned in the study, periodicals was used most in number of printed data; computer databases among non-printed data. $\circled4$ The purpose of using an information resource was for performing a research project. $\circled5$ The path of acquisition of information was usually through the materials in their possession. $\circled6$ The greatest difficulty in gathering information was first of all the lack of information owned by the library, and next a lack of time and insufficient knowledge of information search and use. $\circled7$ More than 90% of respondents on the necessity of an expert library answered as "necessary" or "certainly necessary", indicating that the foundation of an expert library is very urgent. Conclusions : This study is beneficial for researchers engaged in oriental medicine to activate the use of information and also it will form a base of data for researchers to establish an environment of expert library in oriental medicine.

• 대한물리치료과학회지
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• 제28권1호
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• pp.33-45
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• 2021

Background: Children with cerebral palsy have difficulty acquiring motor skills through motor learning due to lack of motor planning of the central nervous system and musculoskeletal dysfunction. Motor learning is the acquisition or modification of movements with the aim of developing skilled movements and behaviors. Cerebral palsy improve motor function through motor learning, and effective motor learning mainly depends on practice parameters such as learning feedback. Therefore, we investigate the effect of motor learning in children with cerebral palsy and try to present the possibility of clinical application. Design: A systemic review. Methods: Research papers were published from Jan, 2010 to Dec, 2020 and were searched using PubMed and Medline. The search terms are 'task specific training' OR 'motor learning' OR 'feedback(Mesh term)' OR 'goal activity' AND 'cerebral palsy(Mesh term)'. A total of eight papers were analyzed in this study. The paper presented the quality level based on the research evidence, and also presented PEDro (Physiotherapy Evidence Database) scores to evaluate the quality of design studies in randomized clinical trials. Results: The results showed that motor learning coaching in children with cerebral palsy improved motor function in post and follow up tests. Also, self-control feedback of motor learning is more effective than external control feedback. 100% external control feedback of motor learning is effective in the acquisition phase and 50% external feedback of motor learning is effective in the retain phase. Conclusion: These results suggest that it will be an important data for establishing evidence on the effect of motor learning arbitration methods in children with cerebral palsy to develop clinical applicability and protocols.

• 정보보호학회논문지
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• 제22권1호
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• pp.67-80
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• 2012

최근 안드로이드 모바일 기기의 사용자가 증가함에 따라 디지털 포렌식 분야에서도 안드로이드에 대한 관심이 높아지고 있다. 하지만 해당 플랫폼 및 기기의 고유한 특성을 이용한 증거수집 및 분석에 대한 연구는 부족한 실정이다. 안드로이드 시스템의 특징 중 하나인 안드로이드 로그는 기기의 휘발성 저장매체로부터 수집될 수 있는 휘발성 데이터로서, 안드로이드 하부 시스템에서부터 애플리케이션에 이르기까지 최근의 모든 구동 내역과 관련한 기록이 저장되기 때문에 포렌식적으로 매우 중요한 정보가 될 수 있다. 본 논문에서는 안드로이드 로그의 고유한 특성을 사용자 행위와 연계하여 유의미한 정보를 이끌어내는 안드로이드 로그 수집 분석 시스템을 제안하고 나아가 로그 분석의 효율성을 극대화하여 현장에서 실시간 증거 분석이 가능하도록 해주는 효율적 분석 기법을 제안한다. 실험에서는 제안하는 로그 수집 분석 시스템을 이용함으로써 다양한 사용자 행위 정보를 수집하여 구체적이고 직관적으로 표현 가능함을 보이고, 제안하는 로그 분석 기법이 일반 정규식 검색 방법에 비해 10배 이상 검색시간을 단축함을 보인다.

• 핵의학기술
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• 제18권2호
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• pp.22-27
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• 2014

PET/CT검사는 장비의 발전과 더불어 환자의 피폭을 줄이기 위하여 저 선량을 사용하는 추세에 있다. 이에 PET/CT scanner의 영상의 질을 유지하기 위하여 주입선량의 변화에 따른 적정한 bed당 획득시간을 평가하고자 한다. 모형 실험은 NEMA NU2-1994 phantom으로 hot cylinder의 농도를 3, 4.3, 5.5, 6.7 MBq/kg 으로 증가시키고 bed당 획득시간을 30 sec, 1 min, 1 min 30 sec, 2 min, 2 min 30 sec, 3 min, 3 min 30 sec, 4 min, 4 min 30sec, 5 min, 5 min 30 sec 10 min, 20 min, 30 min로 늘려가며 영상을 획득 후 hot cylinder의 농도와 배후 방사능에 4개의 ROI (Region of Interest)을 설정하고 hot cylinder의 농도 와 bed당 획득시간에 따른 변화를 최대 표준섭취계수(Standard Uptake Value maximum, $SUV_{max}$)를 측정 후 신호 대 잡음비(Signal to Noise Ratio, SNR), BKG (Background)의 표준편차를 계산하여 비교해 보았다. 또한 4.3 MBq phantom을 이용하여 검사 대기시간의 변화(15분과 1시간)에 따른 각각의 $SUV_{max}$, SNR, BKG의 표준편차를 비교하였다. 단위 질량당 방사능의 농도가 3, 4.3, 5.5, 6.7 MBq으로 증가하고 또한 각 농도의 time/bed을 1분30초에서 30분까지 늘렸을 때 hot cylinder의 $SUV_{max}$ 값은 bed당 획득시간이 각 방사능의 농도에 따라 30초에서 2분까지는 최대 18.3에서 최소 7.3까지 변화가 심했고 2분 30초에서 30분까지는 최대 8에서 최소 5.6으로 일정한 $SUV_{max}$ 값을 나타내었다. 단위 질량당 방사능의 변화에 따른 SNR은 3 MBq에서는 최소 0.41에서 최대 0.49까지 일정하였고 4.3 MBq과 5.5 MBq에서는 각각 최소 0.23, 0.39에서 최대 0.59, 0.54로 bed당 획득시간이 늘수록 상승하였다. 방사능 농도 6.7 MBq에서는 30초에서 최대 0.59로 높았지만 이후 0.43에서 0.53으로 일정하게 유지하였다. BKG (Background)의 표준편차는 3 MBq에서 2분 30초 후부터 0.38에서 0.06으로 낮아졌고 4.3 MBq과 5.5 MBq에서는 1분 30초 후부터 0.38에서 0으로 낮아졌고 6.7 MBq에서는 30초에서 30분 전 구간에서 낮은 0.33에서 0.05이었다. 4.3 MBq 팬텀으로 검사대기시간을 15분과 1시간으로 변화시킨 결과에서는 bed당 획득시간이 2분 30초부터 $SUV_{max}$값이 서로 일정한 값을 보였고 SNR은 1분 30초부터 비슷한 값을 보였다. 위 결과와 같이 단위 질량당 주입된 방사능의 농도를 3, 4.3, 5.5, 6.7 MBq으로 증가시켰을 때 bed당 획득시간이 2분 30초 이상에서는 $SUV_{max}$와 SNR의 값이 서로 일정하게 유지되고 검사 대기시간의 변화(15분과 1시간)에서도 bed당 획득시간이 2분 30초 이상에서는 $SUV_{max}$와 SNR의 값이 일정하게 유지되는 것을 알 수 있었다. 이 NEMA NU2-1994 phantom 실험의 결과에서 주입되는 방사능의 농도의 변화에도 일정한 $SUV_{max}$와 SNR의 값을 구하기 위한 최소 bed당 획득시간은 2분 30초이라는 것을 알 수 있었다. 하지만 이 획득시간은 장비의 사양과 특성에 따라 차이가 있을 수 있다.

• Environmental Analysis Health and Toxicology
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• 제18권2호
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• pp.145-153
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• 2003

The goal of this study is to develop a biomarker used in monitoring abnormal behaviors of Japanese medaka (Oryzias latipes) as a model organism caused by hazardous chemicals. Japanese medaka was treated by copper of appropriate sublethal concentrations after starvation for 48 hr. The untreated individuals showed common behavioral characteristics (i.e. , smooth and linear movements). Locomotive activity of the fish was monitored using an image processing and automatic data acquisition system. When treated with copper (100 ppb), the fish showed shaking patterns more frequently. As the concentration of copper increased to 1,000 ppb, activity decreated, and the fish showed an erratic movement. Fish were exposed to copper at various concentrations (0,100 and 1,000 ppb) for 24 hrs, and acetylcholine esterase (AChE) activity was observed. When fish were exposed to 1,000 ppb of copper, the body AChE activities appeared to decrease but the head AChE activities showed little change. Expressions of tyrosine hydroxylase (TH) protein in the different organs from both head (brain) and body (kidney) portions affected by the copper treatment were analyzed using immunohistochemical technique compared with control. Five organs of the fish (olfactory bulb, hyothalamus, optic lobe, pons and myelencephalon regions) showed a relatively strong TH protein expression in the control experiment. A differential expression of TH, however, was observed in the treatment (100 ppb and 1,000 ppb). The treatment (1,000 ppb) significantly suppressed TH protein production in the brain regions. In kidney, however, the same treatment caused little suppression compared with the control. Copper appeared to be less effective in suppression of TH than diazinon, a known TH suppressor. It was concluded that TH could be used at a potential biomarker to monitor the acute copper toxicity in Japanese medaka.

• Environmental Analysis Health and Toxicology
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• 제30권sup호
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• pp.7.1-7.10
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• 2015

Objectives For successful adoption of legislation controlling registration and assessment of chemical substances, it is important to obtain sufficient toxicological experimental evidence and other related information. It is also essential to obtain a sufficient number of predicted risk and toxicity results. Particularly, methods used in predicting toxicities of chemical substances during acquisition of required data, ultimately become an economic method for future dealings with new substances. Although the need for such methods is gradually increasing, the-required information about reliability and applicability range has not been systematically provided. Methods There are various representative environmental and human toxicity models based on quantitative structure-activity relationships (QSAR). Here, we secured the 10 representative QSAR-based prediction models and its information that can make predictions about substances that are expected to be regulated. We used models that predict and confirm usability of the information expected to be collected and submitted according to the legislation. After collecting and evaluating each predictive model and relevant data, we prepared methods quantifying the scientific validity and reliability, which are essential conditions for using predictive models. Results We calculated predicted values for the models. Furthermore, we deduced and compared adequacies of the models using the Alternative non-testing method assessed for Registration, Evaluation, Authorization, and Restriction of Chemicals Substances scoring system, and deduced the applicability domains for each model. Additionally, we calculated and compared inclusion rates of substances expected to be regulated, to confirm the applicability. Conclusions We evaluated and compared the data, adequacy, and applicability of our selected QSAR-based toxicity prediction models, and included them in a database. Based on this data, we aimed to construct a system that can be used with predicted toxicity results. Furthermore, by presenting the suitability of individual predicted results, we aimed to provide a foundation that could be used in actual assessments and regulations.

• Journal of Astronomy and Space Sciences
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• 제31권4호
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• pp.317-323
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• 2014

Odyssey, one of the NASA's Mars exploration program and SELENE (Kaguya), a Japanese lunar orbiting spacecraft have a payload of Gamma-Ray Spectrometer (GRS) for analyzing radioactive chemical elements of the atmosphere and the surface. In these days, gamma-ray spectroscopy with a High-Purity Germanium (HPGe) detector has been widely used for the activity measurements of natural radionuclides contained in the soil of the Earth. The energy spectra obtained by the HPGe detectors have been generally analyzed by means of the Window Analysis (WA) method. In this method, activity concentrations are determined by using the net counts of energy window around individual peaks. Meanwhile, an alternative method, the so-called Full Spectrum Analysis (FSA) method uses count numbers not only from full-absorption peaks but from the contributions of Compton scattering due to gamma-rays. Consequently, while it takes a substantial time to obtain a statistically significant result in the WA method, the FSA method requires a much shorter time to reach the same level of the statistical significance. This study shows the validation results of FSA method. We have compared the concentration of radioactivity of $^{40}K$, $^{232}Th$ and $^{238}U$ in the soil measured by the WA method and the FSA method, respectively. The gamma-ray spectrum of reference materials (RGU and RGTh, KCl) and soil samples were measured by the 120% HPGe detector with cosmic muon veto detector. According to the comparison result of activity concentrations between the FSA and the WA, we could conclude that FSA method is validated against the WA method. This study implies that the FSA method can be used in a harsh measurement environment, such as the gamma-ray measurement in the Moon, in which the level of statistical significance is usually required in a much shorter data acquisition time than the WA method.

• Plant Biotechnology Reports
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• 제5권1호
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• pp.45-51
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• 2011

A low acid phosphatase 3 (lap3) mutant was identified and characterized from an Arabidopsis activation-tagged (Weigel) population. The roots of the lap3 plants showed lower acid phosphatase (APase) activity compared to wild-type ones under low-Pi conditions ($10{\mu}M\;Pi$). Plasmid rescue experiments revealed that the activation-tagging vector was inserted into the intergenic region between At4g31540 and At4g31550 in the Arabidopsis genome. The genotypic segregation of the lap3 mutation was tightly linked with the phenotypic segregation of root APase activity in the prgeny of lap3. The transcript level of the At4g31520 (SDA1: SEVERE DEPOLYMERIZATION OF ACTIN 1), located 7.4 kb from the CaMV 35S enhancers in the lap3 mutant, was significantly reduced compared to that in the wild type. It was speculated that cellular actin polymerization may be involved in Pi acquisition in higher plants.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.604-614
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• 2013

본 연구는 초등학생의 긍정적 심리 향상을 위하여 연극과 마음챙김을 주요 활동으로 하는 방학 중 단기활동 프로그램을 구성하고 그 효과를 검증하였다. 양적분석과 질적분석을 함께 사용하여 프로그램 효과를 다각적으로 검증하였는데, 본 연구를 통해 확인된 결과는 다음과 같다. 첫째, 본 프로그램에 참여한 학생들은 자발적이기보다는 부모 등의 권유에 의해 참여한 경우가 대부분이었다. 둘째, 프로그램 실시 후 자아존중감, 행복감이 유의하게 향상되었으며 스트레스, 우울은 유의하게 감소된 것으로 나타났다. 셋째, 약 65~70%대의 학생들이 재밌었다, 도움이 되었다, 배우는 게 있었다, 다른 친구에게도 추천하고 싶다는 의사를 보였으며, 학생들이 긍정적 정서의 지각과 경험적 지식의 습득을 많이 경험한 것으로 보고되었다. 이상의 결과를 바탕으로 본 연구의 시사점과 제언을 논하였다.

• Journal of Korean Biological Nursing Science
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• 제21권3호
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• pp.217-223
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• 2019

Purpose: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. Methods: The animals were divided into three groups: a "vehicle" group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a "Day 1" group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a "Day 14" group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function. Results: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. Conclusion: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.