• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.191-199
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• 2000

Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.

• Journal of Conservation Science
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• v.32 no.4
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• pp.491-500
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• 2016

Fog is atmospheric in which tiny drops of water vapor are suspended in the air near the ground. Its form, occurrence, etc., change according to the temperature, relative humidity, wind and geographical features of the space around it. In particular, fog tends to occur near a source of water because of temperature and relative humidity difference. These days, climate change is increasingly affecting the occurrence of fog. Therefore the purpose of this study was to investigate how fog affects materials that are part of our cultural properties through outdoor exposure tests and artificial degradation. The degradation evaluation of materials as a function of fog occurrence frequency, showed that the color of metals changed noticeably, whereas dyed silk and Dancheong showed degradation on the surface and color differences but no particular tendencies. Therefore, damage prediction by color differences as a function of fog occurrence frequency was based on metal samples, which showed constant color differences. Through a comparison of the predictive value and color difference by outdoor exposure, the accuracy and applicability of the damage prediction formula was confirmed. If a more complex damage prediction formula is created, it is expected that prediction of the degree of material damage in the field would be possible.

• Magazine of the Korean Society of Agricultural Engineers
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• v.37 no.3_4
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• pp.34-47
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• 1995

It is experienced fact as a regular annual event that the structure to he designed on unreasonable flood for the agricultural structures including reservoirs have been brought not only loss of lives, but also enormous property damage. For the solution of this problem at issue, this study was conducted to develop an optimal runoff hydrograph model by comparison of the peak flows and time to peak between observed and simulated flows derived by linear time-invariant and linear time-variant models under the condition of having a short duration of heavy rainfall with uniform rainfall intensity at nine small watersheds which are within the range of 55.9 to 140.7 square kilometers in area in Han, Geum, Nagdong and Yeongsan Rivers. The results obtained through this study can be summarized as follows. 1. Storage constants and Gamma function arguments were calculated within the range of 1.2 to 6.42 and of 1.28 to 8.05 respectively by the moment method as the parameters for the analysis of runoff hydrograph based on linear time-invariant model. 2. Parameters for both linear time-invariant and linear time-variant models were calibrated with nine gaged watershed data, using a trial and error method. The resulting parameters including Gamma function argument, N and storage constant, K for linear time-invariant model were related statistically to watershed characteristic variables such as area, slope, length of main stream and the centroid length of the basin. 3. Average relative errors of the simulated peak discharge of calibrated runoff hydrographs by using linear time-variant and linear time-invariant models were shown to be 0.75 and 5.42 percent respectively to the peak of observed runoff hydrographs. Correlation coefficients for the statistical analysis in the same condition were shown to be 0.999 and 0.978 with a high significance respectively. Therefore, it can be concluded that the accuracy of a linear time-variant model is approaching more closely to the observed runoff hydrograph than that of a linear time-invariant model in the applied watersheds. 4. Average relative errors of the time to peak of calibrated runoff hydrographs by using linear time-variant and linear time-invariant models were shown to be 16.44 and 19.89 percent respectively to the time to peak of observed runoff hydrographs. Correlation coefficients in the same condition were also shown to be 0.999 and 0.886 with a high significance respectively. 5. It can be seen that the shape of simulated hydrograph based on a linear time- variant model is getting closer to the observed runoff hydrograph than that of a linear time-invariant model in the applied watersheds. 6. Two different models were verified with different rainfall-runoff events from data for the calibration by relative error and correlation analysis. Consequently, it can be generally concluded that verification results for the peak discharge and time to peak of simulated runoff hydrographs were in good agreement with those of calibrated runoff hydrographs.

• Journal of Astronomy and Space Sciences
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• v.26 no.1
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• pp.75-88
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• 2009

The main purpose of the current research is to introduce the alternative algorithm of the non-recursive batch filter based on the unscented transformation in which the linearization process is unnecessary. The presented algorithm is applied to the orbit determination of a low earth orbiting satellite and compared its results with those of the well-known Bayesian batch least squares estimation and the iterative UKF smoother (IUKS). The system dynamic equations consist of the Earth's geo-potential, the atmospheric drag, solar radiation pressure and the lunar/solar gravitational perturbations. The range, azimuth and elevation angles of the satellite measured from ground stations are used for orbit determination. The characteristics of the non recursive unscented batch filter are analyzed for various aspects, including accuracy of the determined orbit, sensitivity to the initial uncertainty, measurement noise and stability performance in a realistic dynamic system and measurement model. As a result, under large non-linear conditions, the presented non-recursive batch filter yields more accurate results than the other batch filters about 5% for initial uncertainty test and 12% for measurement noise test. Moreover, the presented filter exhibits better convergence reliability than the Bayesian least squares. Hence, it is concluded that the non-recursive batch filter based on the unscented transformation is effectively applicable for highly nonlinear batch estimation problems.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.10 no.4
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• pp.11-23
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• 2011

The objective of this paper is to develop a daily pattern clustering algorithm using historical traffic data that can reliably detect under various traffic flow conditions in urban streets. The developed algorithm in this paper is categorized into two major parts, that is to say a macroscopic and a microscopic points of view. First of all, a macroscopic analysis process deduces a daily peak/non-peak hour and emphasis analysis time zones based on the speed time-series. A microscopic analysis process clusters a daily pattern compared with a similarity between individuals or between individual and group. The name of the developed algorithm in microscopic analysis process is called "Two-step speed clustering (TSC) algorithm". TSC algorithm improves the accuracy of a daily pattern clustering based on the time-series speed variation data. The experiments of the algorithm have been conducted with point detector data, installed at a Ansan city, and verified through comparison with a clustering techniques using SPSS. Our efforts in this study are expected to contribute to developing pattern-based information processing, operations management of daily recurrent congestion, improvement of daily signal optimization based on TOD plans.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.4
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• pp.77-87
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• 2004

It is important for hydrographers to extract the accurate cross section of a river for the hydrographical analysis of the topography. Aerial photographs were used to extract the cross section of a river for the advantages of the accuracy and economical efficiency in this study, while the direct measurement has been used in existing studies. An ortho-rectified photo map using imageries taken by the PKNU 2 (High-resolution, multi-spectral, aerial photographic system developed by our laboratory) was generated using the surveyed data and a digital map. The cross section of a river that was obtained from the ortho-rectified by the surveyed Kinematic data of GPS was compared with the result using ImageStation stereo-plotter of corp. Z/I Imaging. As a result of this study, the RMSE in the ortho-rect process using the surveyed GPS data was lowered as from 5.5788 pixels (about 2m) to 2.84 (about 1m) in comparison with it in the process using a digital map. The surveyed kinematic GPS in extraction of the cross section of a river was excellent as 6.6cm of the planimetric and precision in the confidence level of 95%. The correlation coefficient between the result from the using stereo-plotter and the extraction of cross section of a river using aerial photos was 0.8 hydrographical acquisition of it using PKNU 2 imagery will be possible.

• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1041-1052
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• 2013

In this study, we estimate parameters of a distributed hydrologic model, GRM (grid based rainfall-runoff model), using a model-independent parameter estimation tool, PEST. We implement auto calibration of model parameters such as initial soil moisture, multipliers of overland roughness and soil hydraulic conductivity in the Geumho River Catchment and the Gamcheon Catchment using radar rainfall estimates and ground-observed rainfall represented by Thiessen interpolation. Automatic calibration is performed by GRM-MP (multiple projects), a modified version of GRM without GUI (graphic user interface) implementation, and "Parallel PEST" to improve estimation efficiency. Although ground rainfall shows similar or higher cumulative amount compared to radar rainfall in the areal average, high spatial variation is found only in radar rainfall. In terms of accuracy of hydrologic simulations, radar rainfall is equivalent or superior to ground rainfall. In the case of radar rainfall, the estimated multiplier of soil hydraulic conductivity is lower than 1, which may be affected by high rainfall intensity of radar rainfall. Other parameters such as initial soil moisture and the multiplier of overland roughness do not show consistent trends in the calibration results. Overall, calibrated parameters show different patterns in radar and ground rainfall, which should be carefully considered in the rainfall-runoff modelling applications using radar rainfall.

• Journal of the Korea Concrete Institute
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• v.17 no.6 s.90
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• pp.955-962
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• 2005

Still no accurate theory exists for predicting ultimate shear strength of deep reinforced concrete beams because of the structural and material non-linearity after cracking. Currently, the load capacity assesment is performed for the upper structure of the bridges and containing non-reliability in the applications and results. The purpose in this study is to evaluate analytically the complex shear behaviors and normal strength for the reinforced concrete deep beams and to offer the accuracy load capacity assesment method based on the reliability theories. This paper presents a method for the load capacity assesment of reinforcement concrete deep beams using nonlinear finite element analysis. A computer program named RCAHEST (Reinforced Concrete Analysis in Higher Evaluation System Technology), for the analysis of reinforced concrete structures was used. Material non-linearity is taken Into account by comprising tensile, compressive and shear models of cracked concrete and a model of reinforcing steel. From the results, determine the reliability index for the failure base on the Euro Code. Then, calculate additional reduction coefficient to satisfy the goals from the reliability analysis. The proposed numerical method for the load capacity assesment of reinforced concrete deep beams is verified by comparison with the others methods.

• Journal of Periodontal and Implant Science
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• v.36 no.1
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• pp.147-154
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• 2006

Surgical intervention in the posterior maxillary region requires detailed knowledge of maxillary sinus anatomy and the possible anatomical variations. This study evaluated the incidence, location of maxillary sinus septa by using radiographic (panoramic radiography and computed tomography) findings and comparison of panoramic radography with CT in antral anatomical variation. This study was based on data from 70 sinuses in partial dentate maxilla. The sample consisted of 61 patients(25 women and 36 men, with ages ranging between 19 and 77 years and a mean age of $49.4{\pm}11.3$ years) who were being treatment-planned to receive implant-supported restorations. First, the panoramic images were examined for the presence of antral septa by radiologist and examiner who don't know about CT findings. And incidence of antral septa was evaluated using an axial plane of CT image. The incidence of septa was compared between panoramic radiography and CT. The accuracy of the incidence was compared between radiologists and dentists. A total of 20 septa were found in 70 sinuses on CT image and the prevalence of one or more septa per sinus was found to be 28.6%. The assumed incidence of septa on panoramic radiography was $27.6%{\pm}2.2%$ in radiologist and $31.9%{\pm}5.8%$ in dentists. Erroneous diagnosis rate was 11.42% in radiologist and 15.96% in dentists. 40% of antral septa were located in the anterior(premolar) region, 30% of septa were located in the middle(first molar) and posterior(second molar) region separately. Prior to implant placement, it seems appropriate to consider panoramic radiography as a standard radiographic examination and periapical radiographs may be used to complete the findings in regions not sharply depicted in the panoramic radiograph. And cross-sectional imaging should be used in sites with severe bone loss and close proximity of the maxillary sinus.

• Journal of the Korean GEO-environmental Society
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• v.11 no.5
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• pp.35-43
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• 2010

Partially saturated permeability should be defined by the function of suction (or degree of saturation) and porosity. However, commercial software and most researchers' model often describe as the function of suction. The stability of a soil slope can be affected by both hydraulic and shear strength properties of partially saturated soils. For both studies, we generally use an uncoupled seepage analysis program Seep/W(Geo-Slope, 2007) and a series stress-deformation analysis program Sigma/W, or slope stability analysis program Slope/W. Seep/W is performed for simulations of partially saturated flow problems in non-deformable soil media. However, under real situations, the water flow processes in a deformable soil are influenced by soil skeleton movement and the pore water pressure changed due to seepage will lead to changes in stresses and to deformation of a soil. Many researchers are currently developing their models for solving coupled hydro-mechanical problems to simulate slope stability during a rainstorm. For a proper implementation in the field, the developed model should be still needed in order to achieve appropriate accuracy of the solution for coupled hydro-mechanical problems in soil slope stability. Thus, the paper presents the comparison of slope stability between uncoupled and coupled analyses of seepage and stress deformation problems.