• BMB Reports
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• 제40권1호
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• pp.1-6
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• 2007

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

• IMMUNE NETWORK
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• 제8권1호
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• pp.1-6
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• 2008

Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.

• Journal of Dental Anesthesia and Pain Medicine
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• 제24권1호
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• pp.57-65
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• 2024

Background: The objective of behavioral guidance is to establish effective communication that aligns with a child's requirements to manage disruptive behavior. This study aimed to evaluate the effectiveness of the Tell-Show-Do and Ask-Tell-Ask techniques in managing dental anxiety in children during their initial appointment. Methods: The study included 50 children (28 boys and 22 girls) without any prior experience between the ages of 7 and 11 at their first dental visit. The children were randomly categorized into two groups: Group 1, Tell Shows Do, and Group 2, Ask-Tell-Ask. Subsequently, all children underwent noninvasive treatment procedures such as restorations, sealants, and oral prophylaxis. Furthermore, behavioral management techniques were employed based on the allocated group. Finally, anxiety levels for all children were assessed using the Raghavendra, Madhuri, and Sujata Pictorial Scale (RMS-PS) and heart rate at three different intervals (before, during, and after). The obtained data were entered into Microsoft Excel, and statistical analysis was performed using SPSS software. A paired t-test and Mann-Whitney U-test were used to compare the mean and median values of the two groups and determine their effectiveness. Results: Children in the TSD group exhibited statistically significant heart rates and RMS-PS scores in intra-group comparisons. However, children in the ask-tell-ask group showed a significant reduction only in the RMS-PS scores (P < 0.001) but not in the measures used to assess heart rate (P < 0.001). Conclusion: Tell-Show-Do was more effective than ask-tell-ask in alleviating dental anxiety in children. The simultaneous application of these two strategies can synergistically alleviate dental anxiety during a child's initial dentist appointment.

• 한국통신학회논문지
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• 제18권11호
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• pp.1607-1617
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• 1993

Manchester-Coded ASK 광 파장 분할 다중화(WDM) 시스템의 성능이 산탄잡음과 광섬유 비선형성에 의해 야기되는 four wave mixing(FWM)을 고려하여 평가된다. 그 결과는 non-return-to zero(NRZ)를 사용한 ASK 변조방식과 비교된다. 더구나, 최대 입력 파우어(FWM에 의해 제한)와 최소 입력 파우어(수신감도에 의해 제한)의 비로서 정의되는 동적범위(dynamic range)가 평가된다. 1.55 rm 16채널 WDM 시스템에 대해 ASK Manchester-Coded시스템의 동적범위는 NRZ보다 2.OdB 개선된다. 이 결과는 10 GHz 채널 간격과 1 Gbps/channel 비트율을 갖는 시스템에서 분산-이 동(dispersion-shifed) 광섬유와 기존의 광섬유의 경우 같다.

• 정보관리연구
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• 제37권1호
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• pp.57-81
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• 2006

본 논문에서는 공공도서관의 새로운 서비스 영역인 ASK_a 서비스 운영모형을 제안하였다. 제안한 모형이 갖는 기능을 입력과 처리, 출력과정으로 구분하여 설계하였다. 최적의 입력 형식은 웹 폼형식을 제안하였고, 처리과정은 공공도서관의 혼합형(수평형, 계층형) 협력모델을 제안하였고, 출력 과정은 제공된 질문-해답정보에 대한 아카이빙 정책을 제안하였다. 특히 ASK_a 서비스가 성공적으로 운영되도록 하기 위해서 제안한 모형의 핵심을 공공도서관의 협력연계를 통한 외부 인력과 자원활용으로 하였다. 이러한 협력의 최종목표는 고도의 전문정보 서비스를 공공도서관 이용자에게 제공하는 것이다.

• 한국통신학회논문지
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• 제26권11B호
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• pp.1595-1599
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• 2001

본 논문에서는 ITS 서비스를 위해 개발된 5.8 GHz대역 근거리 전용 무선 통신을 이용한 자동게이트통관시스템의 차량탑재장치(OBE) 구성요소 중 ASK 변조기를 설계 및 제작하였다. 제안된 ASK 변조기는 인접채널간섭을 줄이기 위하여 3 V 단일전압 드레인 제어 변조회로로 설계되었으며 0.7 - 3 V의 넓은 선형변조영역과 40 dB 이상의 On/off Ratio 특성을 얻었다. 회로의 Layout과 공정은 ETRI 0.5$\mu\textrm{m}$ MESFET Library를 사용하였고 칩 면적은 1.0mm $\times$ 1.0mmn로 제작하였다.

• Biomolecules & Therapeutics
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• 제32권4호
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• pp.451-459
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• 2024

Apoptosis signal-regulating kinase 1 (ASK1) is an upstream signaling molecule in oxidative stress-induced responses. Because oxidative stress is involved in asthma pathogenesis, ASK1 gene deficiency was investigated in animal models of allergic asthma. However, there is no study to investigate whether ASK1 inhibitors could be applied for asthma to date. Selonsertib, a potent and selective ASK1 inhibitor, was applied to BALB/c mice of an ovalbumin (OVA)-induced allergic asthma model. Selonsertib suppressed antigen-induced degranulation of RBL-2H3 mast cells in a concentration-dependent manner. The administration of selonsertib both before OVA sensitization and OVA challenge significantly reduced airway hyperresponsiveness, and suppressed eosinophil numbers and inflammatory cytokine levels in the bronchoalveolar lavage fluid. Histopathologic examination elucidated less inflammatory responses and reduced mucin-producing cells around the peribronchial regions of the lungs. Selonsertib also suppressed the IgE levels in serum and the protein levels of IL-13 in the bronchoalveolar lavage fluid. These results suggest that selonsertib may ameliorate allergic asthma by suppressing immune responses and be applicable to allergic asthma.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 I
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• pp.194-197
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• 2003

We proposed Binary ASK system for 1Giga bit Modem. The Binary ASK system has a high speed shutter transmitter and no IF receiver only by symbol synchronization. The advantage of proposed system is that circuitry is very simple without IF process. The disadvantage of proposed system are that line spectrum occurs unordinary interference to other channels, and enhancement to 4-level system is impossible due to its large SNR degradation.

• 한국정보과학회논문지:정보통신
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• 제33권1호
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• pp.1-8
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• 2006

지금까지의 많은 보안프로토콜들은 비정형화된 설계 및 검증 방법을 통해 개발되었다. 그 결과 유.무선 네트워크 분야에서 보안상 안전하다고 여겨왔던 많은 보안 프로토콜들의 보안 취약점들이 하나둘씩 발견되어오고 있다. 이에 따라, 통신 프로토콜을 개발하기 이전에 설계단계에서부터, 수학적인 기호 및 의미에 바탕을 둔 설계 언어로, 프로토콜의 안전성을 분석하기 위한 정형적 설계 및 검증 방법의 중요성이 점차 증대되고 있다. 현재, 모바일 통신 네트워크의 확산과 더불어 다양한 모바일 프로토콜들이 제안되고 있다. 본 논문에서는 정형적 검증 방법을 이용해서 ASK 모바일 프로토콜의 보안 취약점을 지적한다. 또한, 보안 취약점을 개선한 새로운 ASK 모바일 프로토콜을 제안하고 검증하였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 하계종합학술대회 논문집(2)
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• pp.233-236
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• 2001

We have designed and fabricated ASK modulator MMIC operating at 5.8GHz for OBE used in AGPS (Automatic Gate Passing System). ASK modulator MMIC was designed to apply a sing1e supply voltage of 3V to the drain in order to decrease ACP (Adjacent Channel Power). The measurement result of this chip exhibits on/off characteristic over 30dB. The design parameters are optimized through ADS simulation tool. The layouts and fabrication o( ASK Modulator MMIC were designed and fabricated by using ETRI 0.5${\mu}{\textrm}{m}$ MESFET library. The chip sizes were 1mm $\times$1mm. The performance analysis of the implemented ASK Modulator based on the design parameters is accomplished.