• BMB Reports
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• v.40 no.1
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• pp.1-6
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• 2007

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

• IMMUNE NETWORK
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• v.8 no.1
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• pp.1-6
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• 2008

Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.

• Journal of Dental Anesthesia and Pain Medicine
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• v.24 no.1
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• pp.57-65
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• 2024

Background: The objective of behavioral guidance is to establish effective communication that aligns with a child's requirements to manage disruptive behavior. This study aimed to evaluate the effectiveness of the Tell-Show-Do and Ask-Tell-Ask techniques in managing dental anxiety in children during their initial appointment. Methods: The study included 50 children (28 boys and 22 girls) without any prior experience between the ages of 7 and 11 at their first dental visit. The children were randomly categorized into two groups: Group 1, Tell Shows Do, and Group 2, Ask-Tell-Ask. Subsequently, all children underwent noninvasive treatment procedures such as restorations, sealants, and oral prophylaxis. Furthermore, behavioral management techniques were employed based on the allocated group. Finally, anxiety levels for all children were assessed using the Raghavendra, Madhuri, and Sujata Pictorial Scale (RMS-PS) and heart rate at three different intervals (before, during, and after). The obtained data were entered into Microsoft Excel, and statistical analysis was performed using SPSS software. A paired t-test and Mann-Whitney U-test were used to compare the mean and median values of the two groups and determine their effectiveness. Results: Children in the TSD group exhibited statistically significant heart rates and RMS-PS scores in intra-group comparisons. However, children in the ask-tell-ask group showed a significant reduction only in the RMS-PS scores (P < 0.001) but not in the measures used to assess heart rate (P < 0.001). Conclusion: Tell-Show-Do was more effective than ask-tell-ask in alleviating dental anxiety in children. The simultaneous application of these two strategies can synergistically alleviate dental anxiety during a child's initial dentist appointment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.11
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• pp.1607-1617
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• 1993

The performance of Manchester-coded ASK optical wavelength division multiplexing(WDM) systems is evaluated laking into account the shot noise and the four wave mixing(FWM) caused by fiber nonlinearities. The result is compared to conventional non-return-to-zero(NRZ) systems for ASK modulation formats. Further, the dynamic range, defined as the ratio of the maximum input power(limited by the FWM), to the minimum input power(limited by receiver sensitivity), is evaluated. For 1.55 rm 16 channel WDM systems, the dynamic range of ASK Manchester coded systems shows a 2.0 dB improvement with respect to the NRZ. This result holds true for both dispersion-shifted fiber and conventional fiber it has been obtained for 10 GHz channel spacing, 1 Gbps/channel bit rate.

• Journal of Information Management
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• v.37 no.1
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• pp.57-81
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• 2006

The new service of Korean public library, ASK_a service model suggests a new management practice in collaborative digital reference services. The model has three functions: input transaction, process transaction, and output transaction. The best form for input is the web form. The best form for process is a model with a hybrid type of public libraries(hierarchical and lateral type). The output suggests the archiving policy for gathering the query-answer data. The core of this model is providing an advanced information service to its users through cooperation with public libraries and external manpower.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.11B
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• pp.1595-1599
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• 2001

In this paper, we have desired and implemented of ASK modulator MMIC operating at 5.8 GHz for OBE used in AGPS(Automatic Gate Passing System). The proposed ASK modulator MMIC was implemented to apply a single supply voltage of 3 V to the drain in order to decrease ACP(Adjacent Channel Power). As a result, it is exhibits a broad linear modulation range from 0.7 V to 3 V and an On/off characteristic over 40 dB. The layouts of ASK modulator MMICs was designed and fabricated by using ETRI 0.57m MESFET library The chip size was 1.0mm $\times$x1.0mm.

• Biomolecules & Therapeutics
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• v.32 no.4
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• pp.451-459
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• 2024

Apoptosis signal-regulating kinase 1 (ASK1) is an upstream signaling molecule in oxidative stress-induced responses. Because oxidative stress is involved in asthma pathogenesis, ASK1 gene deficiency was investigated in animal models of allergic asthma. However, there is no study to investigate whether ASK1 inhibitors could be applied for asthma to date. Selonsertib, a potent and selective ASK1 inhibitor, was applied to BALB/c mice of an ovalbumin (OVA)-induced allergic asthma model. Selonsertib suppressed antigen-induced degranulation of RBL-2H3 mast cells in a concentration-dependent manner. The administration of selonsertib both before OVA sensitization and OVA challenge significantly reduced airway hyperresponsiveness, and suppressed eosinophil numbers and inflammatory cytokine levels in the bronchoalveolar lavage fluid. Histopathologic examination elucidated less inflammatory responses and reduced mucin-producing cells around the peribronchial regions of the lungs. Selonsertib also suppressed the IgE levels in serum and the protein levels of IL-13 in the bronchoalveolar lavage fluid. These results suggest that selonsertib may ameliorate allergic asthma by suppressing immune responses and be applicable to allergic asthma.

• Proceedings of the IEEK Conference
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• 2003.07a
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• pp.194-197
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• 2003

We proposed Binary ASK system for 1Giga bit Modem. The Binary ASK system has a high speed shutter transmitter and no IF receiver only by symbol synchronization. The advantage of proposed system is that circuitry is very simple without IF process. The disadvantage of proposed system are that line spectrum occurs unordinary interference to other channels, and enhancement to 4-level system is impossible due to its large SNR degradation.

• Journal of KIISE:Information Networking
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• v.33 no.1
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• pp.1-8
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• 2006

Security protocols have usually been developed using informal design and verification techniques. However, many security protocols thought to be secure was found to be vulnerable later. Thus, the importance of formal specification and verification for analyzing the safely of protocols is increasing. With the rise of mobile communication networks, various mobile security protocols have been proposed. In this paper, we identify the security weakness of the ASK mobile Protocol using formal verification technique. In addition, we propose a new ASK protocol modifying its vulnerability and verify its robustness.

• Proceedings of the IEEK Conference
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• 2001.06b
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• pp.233-236
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• 2001

We have designed and fabricated ASK modulator MMIC operating at 5.8GHz for OBE used in AGPS (Automatic Gate Passing System). ASK modulator MMIC was designed to apply a sing1e supply voltage of 3V to the drain in order to decrease ACP (Adjacent Channel Power). The measurement result of this chip exhibits on/off characteristic over 30dB. The design parameters are optimized through ADS simulation tool. The layouts and fabrication o( ASK Modulator MMIC were designed and fabricated by using ETRI 0.5${\mu}{\textrm}{m}$ MESFET library. The chip sizes were 1mm $\times$1mm. The performance analysis of the implemented ASK Modulator based on the design parameters is accomplished.