• 한국전자거래학회지
• /
• 제18권3호
• /
• pp.69-92
• /
• 2013

본 연구는 정보시스템 기능 설계와 활동원가기준 예산, 그리고 IT 프로젝트 타당성을 확보하기 위해 개발된 활동패턴분석방법론을 소개하고, 2010년 종합건강검진센터에 적용한 사례를 통해 활동패턴분석의 유용성을 제시하였다. 활동패턴분석은 분석대상 범위 내 행위자들의 활동 분리, 활동 조정, 활동가치산출을 핵심 논리로 하며, 자원기반이론과 행위자 네트워크 이론을 중심 이론으로 한다. 본 연구에서 제시한 G검진센터는 활동패턴분석 진단을 통해 (1) IT 전략, (2) IT구축 목표, (3) 새로운 비즈니스 프로세스, (4) 정보시스템 설계도(기능 명세), (5) 정보시스템 구축 예산 및 타당성을 확보하였다. 활동패턴분석은 분석범위와 분석시기 결정이 유연하며, 분석대상을 분석목적에 적합하도록 확장할 수 있다는 점에서 유용하다. 궁극적으로는 정보시스템 도입 조직의 IS자원 관리능력의 내부화를 위한 방법론으로 활용될 수 있다.

• 대한화학회지
• /
• 제58권1호
• /
• pp.92-99
• /
• 2014

The pH sensitive hydrogels composed of N-isopropylacrylamide (NIPA) and acryloyl phenylalanine (APA) were prepared by redox polymerization using N,N'-methylenebisacrylamide (MBA) as a crosslinker. Anti-inflammatory and analgesic agent, Keterolac Tromethamine (KT), was loaded successfully into poly(NIPA-co-APA) copolymeric hydrogels by swelling equilibrium method. To understand the nature of drug in the polymeric matrix, the newly synthesized drug loaded poly(NIPA-co-APA) copolymeric hydrogels were characterized by using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The scanning electron microscopy (SEM) technique result indicates the spherical smooth surface of the hydrogels. The drug (KT) releasing nature of the poly(NIPA-co-APA) hydrogels was studied in pH 1.2 and 7.4. Effects of drug loading, crosslinking agent, pH and the ionic strength of the external medium on swelling of hydrogels were also investigated.

• 한국도서관정보학회지
• /
• 제30권3호
• /
• pp.233-254
• /
• 1999

The forth edition of the Publication Manual of the American Psychological Association (1994) provides documentation advice for writers in the social sciences. This style of citation briefly identifies the source for readers and enables them to locate the source of information in the alphabetical reference list at the end of an article. Although the APA publication manual gives recommendations for citing some kinds of electronic resources, it acknowledges that at the time of writing this edition, a standard had not yet emerged for referencing on-line information. Because the manual was published before the development of the Internet as we know it, it does not have guidelines for citing www sites, web discussion forum posting, and other Internet resources,. Therefore this study aims to extend the principles and conventions of APA citation style to electronic resources.

• BMB Reports
• /
• 제50권4호
• /
• pp.201-207
• /
• 2017

Alternations in usage of polyadenylation sites during transcription termination yield transcript isoforms from a gene. Recent findings of transcriptome-wide alternative polyadenylation (APA) as a molecular response to changes in biology position APA not only as a molecular event of early transcriptional termination but also as a cellular regulatory step affecting various biological pathways. With the development of high-throughput profiling technologies at a single nucleotide level and their applications targeted to the 3'-end of mRNAs, dynamics in the landscape of mRNA 3'-end is measureable at a global scale. In this review, methods and technologies that have been adopted to study APA events are discussed. In addition, various bioinformatics algorithms for APA isoform analysis using publicly available RNA-seq datasets are introduced.

• Molecules and Cells
• /
• 제39권4호
• /
• pp.281-285
• /
• 2016

Almost all of eukaryotic mRNAs are subjected to polyadenylation during mRNA processing. Recent discoveries showed that many of these mRNAs contain more than one polyadenylation sites in their 3' untranslated regions (UTR) and that alternative polyadenylation (APA) is prevalent among these genes. Many biological processes such as differentiation, proliferation, and tumorigenesis have been correlated to global APA events in the 3' UTR of mRNAs, suggesting that these APA events are tightly regulated and may play important physiological roles. In this review, recent discoveries in the physiological roles of APA events, as well as the known and proposed mechanisms are summarized. Perspective for future directions is also discussed.

• The Korean Journal of Pain
• /
• 제33권1호
• /
• pp.60-65
• /
• 2020

Background: Anatomic changes in the acromion have been considered a main cause of shoulder impingement syndrome (SIS). To evaluate the relationship between SIS and the acromion process, we devised a new morphological parameter called the acromion process cross-sectional area (APA). We hypothesized that the APA could be an important morphologic diagnostic parameter in SIS. Methods: We collected APA data from 95 patients with SIS and 126 control subjects who underwent shoulder magnetic resonance imaging (MRI). Then we measured the maximal cross-sectional area of the bone margin of the acromion process on MRI scans. Results: The mean of APAs were 136.50 ± 21.75 ㎟ in the male control group and 202.91 ± 31.78 ㎟ in the male SIS group; SIS patients had significantly greater APAs (P < 0.001). The average of APAs were 105.38 ± 19.07 ㎟ in the female control group and 147.62 ± 22.90 ㎟ in the female SIS group, and the SIS patients had significantly greater APAs (P < 0.001). The optimal APA cut-off in the male group was 165.14 ㎟ with 90.2% sensitivity, 91.4% specificity, and an area under the curve (AUC) of 0.968. In the female group, the optimal cut-off was 122.50 ㎟ with 85.2% sensitivity, 84.9% specificity, and an AUC of 0.928. Conclusions: The newly devised APA is a sensitive parameter for assessing SIS; greater APA is associated with a higher possibility of SIS. We think that this result will be helpful for the diagnosis of SIS.

• International Journal of Control, Automation, and Systems
• /
• 제2권2호
• /
• pp.256-262
• /
• 2004

Conventionally, profile non-uniformity has been characterized by relying on approximated profile with angle or anisotropy. In this study, a new non-uniformity model for etch profile is presented by applying a discrete wavelet to the image obtained from a scanning electron microscopy (SEM). Prediction models for wavelet-transformed data are then constructed using a back-propagation neural network. The proposed method was applied to the data collected from the etching of tungsten material. Additionally, 7 experiments were conducted to obtain test data. Model performance was evaluated in terms of the average prediction accuracy (APA) and the best prediction accuracy (BPA). To take into account randomness in initial weights, two hundred models were generated for a given set of training factors. Behaviors of the APA and BPA were investigated as a function of training factors, including training tolerance, hidden neuron, initial weight distribution, and two slopes for bipolar sig-moid and linear function. For all variations in training factors, the APA was not consistent with the BPA. The prediction accuracy was optimized using three approaches, the best model based approach, the average model based approach and the combined model based approach. Despite the largest APA of the first approach, its BPA was smallest compared to the other two approaches.

• 정보관리학회지
• /
• 제28권1호
• /
• pp.123-144
• /
• 2011

본 연구는 학문의 지적 구조를 분석하는 새로운 분석기법인 저자프로파일링분석과 전통적인 분석기법인 저자동시인용분석을 비교하여 분석함으로써 국내 연구환경에 맞는 지적 구조 분석 방법을 제안하는 데 목적을 두고 있다. 이를 위하여 본 연구에서는 인용색인을 이용하지 않고 학문의 지적 구조를 분석할 수 있는 텍스트마이닝을 이용한 저자프로파일링분석을 통하여 새로운 지적 구조 방법의 유용성을 확인하 고자 하였다. 분석대상 학술지는 "대한건축학회 논문집 - 계획계"를 대상으로 하였다.

• 한국도서관정보학회지
• /
• 제33권3호
• /
• pp.87-108
• /
• 2002

본 연구의 목적은 인터넷을 통해 접근하고 입수가능한 전자정보원을 대상으로 참고문헌 작성기준에 관한 스타일 메뉴얼들의 기술요소와 기재순서, 기술형식을 비교분석하여, 국내 연구자나 학협회, 출판사 등이 참고문헌을 작성하거나 작성지침을 제시할 때 포함할 수 있는 기술요소 및 형식에 관한 자료를 제공하는데 있다. 이를 위하여 최근에 수정보완된 MLA Style, APA Style, CBE Style, Chicago Style, ISO 690-2, SIST-02를 대상으로 그들의 요소와 순서, 표기방법 및 형식을 검토하고, 표기방법 및 형식에 따른 동일자료에 대한 기술사례를 제시하였다.

• Ocean and Polar Research
• /
• 제24권1호
• /
• pp.47-53
• /
• 2002

To evaluate the effect of reed population on the distribution and activities of microorganisms, vertical distribution of heterotrophic bacteria, degradation rate of cellulose, extracellular aminopeptidase activity (APA) and metabolic diversity based on GN2 Microlog plate were measured at two salt marsh stations in Hogok-ri, Namyang Bay, west coast of Korea. The number of heterotrophic bacteria at station 1 (reed population inhabited area) showed 2 to 6 times higher than that of station 2 (exposed area) with exception in the surface layer. Cellulose degradation rates in station 1 showed more than 50%. month-I and higher than that of station 2 (10.2 to 38.4%. $month^{-1}$). Yet the APA at two stations did not show difference except surface layer and suggested that APA might not be a significant factor in degrading marsh plant debris. Lipid class compounds, cell wall polymers and L-alanine were widely used by microorganisms. The number and activities of bacterial populations especially concerned in plant debris degradation seemed to be stimulated by the reed communities.