• Journal of Music and Human Behavior
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• v.13 no.2
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• pp.49-66
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• 2016

This study investigated the song-induced autobiographical memory of patients with early Alzheimer's Dementia (AD) by comparing the effects of patient-selected songs (M-AD) versus music therapist-selected songs (M-MT). A total of 19 patients with early AD participated in this study. In the M-AD and M-MT conditions, each participant listened to a song and was instructed to recall memory. The time to recall memory, the specificity of the memory, mood changes, and the type of recalled memory were measured. Perceived familiarity and preference of the used songs and association of the song with the recalled memory were also analyzed. The results of the study showed that the M-AD condition elicited more specific memory and positive mood change than the M-MT condition. In addition, AD patients reported a higher level of familiarity with and preference of songs in the M-AD condition, compared to the M-MT condition. These results indicate that patient-selected songs, which have a personal meaning to an individual, could be effectively used for intervening with memory of this population, which would support music therapists to make better decision with regard to song selection. Further studies would be needed to deepen the understanding of autobiographical memory in older population with cognitive impairment and to propose more effective music therapy strategies for intervening with memory.

• 한국노년학
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• v.32 no.3
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• pp.747-758
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• 2012

Detecting probable Alzheimer's disease (AD) at an early stage is crucial in slowing the progression of the disease and initiating drug therapy for more effective symptom management. Therefore, this study aimed to identify linguistic features that allow us to distinguish between patients with AD and normal controls. This paper reports on characteristics of spontaneous speech in subjects in three stages of AD (questionable, mild, moderate) compared with education- and age-matched normal controls. Four components of speech were measured in Korean native speakers with AD and normal aging: speech tempo, hesitation (measured in seconds), rate of articulation errors, and rate of grammatical errors. The results revealed significant differences in most of these speech components among the four groups, including significant differences between normal controls and the questionable AD group in the areas of speech tempo and rate of grammatical errors. Phonological? articulatory ability was preserved in questionable AD, and grammatical ability was preserved in questionable and mild AD. Subjects with moderate AD were severely impaired in grammatical ability. Prospective assessments of spontaneous speech skills using a dialogue and picture-description task are useful in detecting the subtle, spontaneous speech impairments that AD causes even in its early stage.

• Korean Journal of Community Nutrition
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• v.16 no.6
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• pp.627-635
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• 2011

The prevalence of Atopic Dermatitis (AD), a non-infective chronic inflammatory skin disease, is increasing worldwide. Avoiding the allergen is the basic principle in the treatment of AD. However, when the allergen is food, excessive restriction can lead to nutrition deficiency. The objective of the study was to examine the status of the dietary restriction and compare the caregiver's restriction practice with doctor's recommendation in Korean children with AD. A total of 158 children diagnosed with Atopic Dermatitis were recruited for this study. Information about foods that aggravate AD symptoms and food restriction were collected from the mothers of 158 children aged 6 month-5 year with AD using questionnaires. Food restriction recommendation by doctor was collected through medical chart. McNemar and Margianl homogeneity tests were used to detect a relationship between food restriction recommended by doctor and current practice by mother. There were significant proportion differences of food restriction for each food between by doctor and mother. We found 75.9% of children were avoiding eggs although only 61.4% were recommended for egg restriction by a doctor. Children with restriction of more than 4 kinds of food were 53.2% compared to 13.3% by doctor. Excessive restrictors tended to be younger and diagnosed at younger age. The caregivers of excessive restrictors had trends of "being older" and "having higher income". Avoidance of common foods in children without food allergy could result in malnutrition or impaired growth. Nutrition education is needed for sound practice and nutrition care in children with Atopic Dermatitis as well as interactive communication between caregivers and experts.

• Korean Journal of Radiology
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• v.24 no.11
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• pp.1131-1141
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• 2023

Objective: Cortical iron deposition has recently been shown to occur in Alzheimer's disease (AD). In this study, we aimed to evaluate how cortical gray matter iron, measured using quantitative susceptibility mapping (QSM), differs in the clinical cognitive impairment spectrum. Materials and Methods: This retrospective study evaluated 73 participants (mean age ± standard deviation, 66.7 ± 7.6 years; 52 females and 21 males) with normal cognition (NC), 158 patients with mild cognitive impairment (MCI), and 48 patients with AD dementia. The participants underwent brain magnetic resonance imaging using a three-dimensional multi-dynamic multi-echo sequence on a 3-T scanner. We employed a deep neural network (QSMnet+) and used automatic segmentation software based on FreeSurfer v6.0 to extract anatomical labels and volumes of interest in the cortex. We used analysis of covariance to investigate the differences in susceptibility among the clinical diagnostic groups in each brain region. Multivariable linear regression analysis was performed to study the association between susceptibility values and cognitive scores including the Mini-Mental State Examination (MMSE). Results: Among the three groups, the frontal (P < 0.001), temporal (P = 0.004), parietal (P = 0.001), occipital (P < 0.001), and cingulate cortices (P < 0.001) showed a higher mean susceptibility in patients with MCI and AD than in NC subjects. In the combined MCI and AD group, the mean susceptibility in the cingulate cortex (β = -216.21, P = 0.019) and insular cortex (β = -276.65, P = 0.001) were significant independent predictors of MMSE scores after correcting for age, sex, education, regional volume, and APOE4 carrier status. Conclusion: Iron deposition in the cortex, as measured by QSMnet+, was higher in patients with AD and MCI than in NC participants. Iron deposition in the cingulate and insular cortices may be an early imaging marker of cognitive impairment related neurodegeneration.

• Korean Journal of Applied Biomechanics
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• v.12 no.2
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• pp.279-293
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• 2002

In the study the subjects who 10 university golfers act, and the kinetic factors were analyzed by the ground reaction system. the conclusion are as follows. 1) In the golf putting swing, the ground reaction factors of sagital plane in aspect are showen that the left and right foot sufficient difference, in the level of p <.05. 2) In the golf putting swing, the ground reaction factors of frontal plane in aspect is showen that the left foot has no significant difference in AD BS in the level of p < .05. In success, IP, FS. It can show significant difference. In addition, the right foot is shown the success, There is significant difference. 3) In the golf putting swing, the ground reaction factors of the vertical plane in aspect are shown that the left foot has no significant difference in BS, FS in the level p < .05. In success, AD, IP. It can show significant difference. In addition, the right foot is shown the success, There is significant difference. 4) In the golf putting swing, the ground reaction factors of torque in aspect are shown that the left foot had no significant difference in BS in the level p < .05. In success, AD, IP, FS. It can show significant difference. In addition, the right foot has no significant difference in IP in the level p < .05. AD, BS, FS. There is significant difference. The summarized conclusions are as follows. The first that the power of sagital plane needs the motion which can get the good power change in the stabilized pose. The second is that the small motion can make good putting in stabilized pose. The third is that the body weight move to the direction of the ball. The fourth is that the putting which looks perfect oscillation is good motion.

• Bulletin of the Korean Chemical Society
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• v.30 no.7
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• pp.1579-1582
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• 2009

The reaction rates of 4-X-2,6-dinitrochlorobenzenes (X = $NO_2,\;CN,\;CF_3$) with Y-substituted pyridines (Y = 3-$OCH_3,\;H,\;3-CH_3,\;4-CH_3$) in methanol-acetonitrile mixtures were measured by conductometry at 25 ${^{\circ}C}$. It was observed that the rate constant increased in the order of X = 4-$NO_2\;>\;4-CN\;>\;4-CF_3$ and the rate constant also increased in the order of Y = 4-$CH_3\;>\;3-CH_3\;>\;H\;>\;3-OCH_3$. When the solvent composition was varied, the rate constant increased in order of MeCN > 50% MeOH > MeOH. The electrophilic catalysis by methanol may be ascribed to the formation of hydrogen bonds between alcoholic hydrogen and nitrogen of pyridines in ground state. Based on the transition parameters, ${\rho}_S,\;{\rho}_N,\;{\beta}_Y,\;{\rho}_{XY}$ and solvent effects, the reaction seems to proceed via $S_N$Ar-Ad.E mechanism. We also estimated the isokinetic solvent mixtures (${\rho}_{XY}$ = 0) based on cross-interaction constants, where the substituent effects of the substrate and nucleophile are compensated.

• Journal of the Korean Applied Science and Technology
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• v.41 no.1
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• pp.58-68
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• 2024

The purpose of this study was to investigate the effects of treadmill exercise treadmill exercise (TE) and environmental enrichment (EE) interventions on cognitive function, muscle function, and the expression of tight junction proteins in an Alzheimer's disease (AD) animal model. To create the AD animal model, aluminum chloride (AlCl₃) was administered for 90 days (40mg/kg/day), while simultaneously exposing the animals to TE (10-12m/min, 40-60min/day) or EE. The results showed that cognitive impairment and muscle dysfunction induced by AlCl₃ administration were alleviated by TE and EE. Furthermore, TE and EE reduced the increased expression of β-amyloid(Aβ), alpha-synuclein, and tumor necrosis factor-α (TNF-α) proteins observed in AD pathology. Additionally, TE and EE significantly increased the expression of decreased adhesive adjacent proteins (Occludin, Claudin-5, and ZO-1) induced by AlCl₃ administration. Lastly, correlation analysis between Aβ protein and tight junction proteins showed negative correlations (Occludin: r=-0.853, p=0.001; Claudin-5: r=-0.352, p=0.915; ZO-1: r=-0.424, p=0.0390). In conclusion, TE or EE interventions are considered effective exercise methods that partially alleviate pathological features of AD, improving cognitive and muscle function.

• Journal of Advanced Navigation Technology
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• v.18 no.3
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• pp.236-241
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• 2014

In a mobile ad hoc networks, multi-hop transmission is used to transfer data from source node to destination node and the routing protocol is the one of the important technical issues. The links between nodes can be unstable due to the changes of node location and channel conditions, and it can induce link error. To solve this problem, multipath routing was proposed. Multipath routing can reduce the data congestion and increase data throughput. In the multipath routing, however, each path can be interfered by the other path, and it can aggravate network performance. In this paper, we propose the multipath routing technique in the multi-rate MANET. The proposed multipath routing can avoid interference without the knowledge of node location. Simulation results show that the proposed multipath routing can reduce transmission delay and error.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.10a
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• pp.377-380
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• 2010

MANET(Mobile Ad-hoc Network) has been proposed as a infrastructure-less network using distributed algorithm for remote environment monitoring and control. The mobility of MANET would make the topology change frequently compared with a static network and a node is resource-constrained. Hence, to improve the routing protocol in MANET, energy efficient routing protocol is required as well as considering the mobility would be needed. In this paper, we extend RODMRP(Resilient Ontology-based Dynamic Multicast Routing Protocol) structure by a modifying the level of cluster. We call this network protocol CACH-RODMRP. Our contribution consists estimating the optimal level of clustering depth with considering node position and reducing the network residual energy. The simulation results of proposal algorithm show that the energy is significantly reduced compared with the previous clustering based routing algorithm for the MANET.

• Journal of Korean Biological Nursing Science
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• v.11 no.1
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• pp.77-84
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• 2009

Purpose: This study was performed to investigate outbreak, treatment, and lifestyle in children with atopic dermatitis (AD) for developing a health promotion education program. Method: Data were collected from 2,920 children with AD in preschool and elementary schools in K city. Result: The majority of children (43.75%) were onset in less than 1 yr after the birth. The locations of skin lesion were face, extension of extremities, and flextion of extremities, neck and trunk. The types of treatment were complement therapies, and medical treatment such as pediatrics and dermatology. Their parents chose a type of treatment for their children. Of complement therapies, the most common type was aroma oil. Herbal medicine was the most eating type among complement therapies. In lifestyle, the preferred bathing method was shower. In applying moisturizer, the most common time was within 3 min after bath. The highest frequency of taking instant/processed diet was 1-2 times per week and the most preferred type was pork. Conclusion: A Health promotion educational program with AD in preschool and elementary school children should included a specificity of disease, the recent treatment guideline, life therapy and evidenced complement therapy by child and family unit for the promotion of their health.