• Title/Summary/Keyword: ABM

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Anti-tumor and Anti-inflammatory Activity of the Methanol Extracts from Adlay Bran

  • Lee, Ming-Yi;Tsai, Shu-Hsien;Kuo, Yueh-Hsiung;Chiang, Wenchang
    • Food Science and Biotechnology
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    • v.17 no.6
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    • pp.1265-1271
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    • 2008
  • Adlay bran is a waste product previously thought to have no commercial value, Its methanolic extract was fractionated using n-hexane (ABM-Hex), ethyl acetate (ABM-EtOAc), 1-butanol (ABM-BuOH), and water (ABM-$H_2O$). The ABM-EtOAc fraction exhibited a strongest inhibition against growth of human lung cancer cell A549 and human colorectal carcinoma cells HT-29 and COLO 205. Inhibition of cell cycle progression at $G_0/G_1$ transition, increase of cells at the sub-$G_1$ phase, and DNA ladders were observed in cells treated with ABM-EtOAc. The ABM-BuOH fraction showed the strongest inhibition of proinflammatory cytokines tumor necrosis factor (TNF)-$\alpha$ and interlukin (IL)-$1{\beta}$ in stimulated RAW 264.7 macrophages. Further, ABM-EtOAc and ABM-BuOH inhibited cyclooxygenase (COX)-2 expression in A549 and HT-29 carcinoma cells, while COX-l expression was not affected. These results reveal that both ABM-EtOAc and ABM-BuOH may aid the prevention of cancers and the applications in cancer chemotherapy.

Comparative study on the cellular activities of osteoblast-like cells and new bone formation of anorganic bone mineral coated with tetra-cell adhesion molecules and synthetic cell binding peptide

  • Yu, Hyeon-Seok;Noh, Woo-Chang;Park, Jin-Woo;Lee, Jae-Mok;Yang, Dong-Jun;Park, Kwang-Bum;Suh, Jo-Young
    • Journal of Periodontal and Implant Science
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    • v.41 no.6
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    • pp.293-301
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    • 2011
  • Purpose: We have previously reported that tetra-cell adhesion molecule (T-CAM) markedly enhanced the differentiation of osteoblast-like cells grown on anorganic bone mineral (ABM). T-CAM comprises recombinant peptides containing the Arg- Gly-Asp (RGD) sequence in the tenth type III domain, Pro-His-Ser-Arg-Asn (PHSRN) sequence in the ninth type III domain of fibronectin (FN), and the Glu-Pro-Asp-Ilu-Met (EPDIM) and Tyr-His (YH) sequence in the fourth fas-1 domain of ${\beta}$ig-h3. Therefore, the purpose of this study was to evaluate the cellular activity of osteoblast-like cells and the new bone formation on ABM coated with T-CAM, while comparing the results with those of synthetic cell binding peptide (PepGen P-15). Methods: To analyze the cell viability, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed, andto analyze gene expression, northernblot was performed. Mineral nodule formations were evaluated using alizarin red stain. The new bone formations of each group were evaluated using histologic observation and histomorphometrc analysis. Results: Expression of alkaline phosphatase mRNA was similar in all groups on days 10 and 20. The highest expression of osteopontin mRNA was observed in the group cultured with ABM/P-15, followed by those with ABM/T-CAM and ABM on days 20 and 30. Little difference was seen in the level of expression of collagen type I mRNA on the ABM, ABM/T-CAM, and ABM/P-15 cultured on day 20. There were similar growth and proliferation patterns for the ABM/T-CAM and ABM/P-15. The halo of red stain consistent with $Ca^{2+}$ deposition was wider and denser around ABM/T-CAM and ABM/P-15 particles than around the ABM particles. The ABM/T-CAM group seemed to have bone forming bioactivity similar to that of ABM/P-15. A complete bony bridge was seen in two thirds of the defects in the ABM/T-CAM and ABM/P-15 groups. Conclusions: ABM/T-CAM, which seemed to have bone forming bioactivity similar to ABM/P-15, was considered to serve as effective tissue-engineered bone graft material.

Applications of Agent-Based Modeling (ABM) in Enhancing Facility Operation and Management

  • Khodabandelu, Ali;Park, JeeWoong
    • International conference on construction engineering and project management
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    • 2022.06a
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    • pp.393-400
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    • 2022
  • Agent-based modeling (ABM), as a relatively new simulation technique, has recently gained in popularity in the civil engineering domain due to its uniquely advantageous features. Among many civil engineering applications, ABM has been applied to facility operation and management, such as energy consumption management, as well as the enhancement of maintenance and repair processes. The former studies used ABM to manage energy consumption through simulating human energy-related behaviors and their interactions with facilities, as well as electrical, heating, and cooling systems and appliances, while the latter used ABM to enhance maintenance process through facilitating coordination, negotiation, and decision making between facility managers, service providers, and repair workers. The present study aims to provide a short qualitative review on the most recent applications of ABM in the above-mentioned areas. Based on the review and follow-up analysis, the study identifies the advantages, disadvantages, and limitations of ABM applications to facility operation and management, and offers several potential future research topics in the hope of filling the existing literature gaps.

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Fabrication and Vibration Characterization of a Partially Etched-type Artificial Basilar Membrane

  • Kang, Hanmi;Jung, Youngdo;Kwak, Jun-Hyuk;Song, Kyungjun;Kong, Seong Ho;Hur, Shin
    • Journal of Sensor Science and Technology
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    • v.24 no.6
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    • pp.373-378
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    • 2015
  • The structure of the human ear is divided into the outer ear, the middle ear, and the inner ear. The inner ear includes the cochlea that plays a very important role in hearing. Recently, the development of an artificial cochlear device for the hearing impaired with cochlear damage has been actively researched. Research has been carried out on the biomimetic piezoelectric thin film ABM (Artificial Basilar Membrane) in particular. In an effort to improve the frequency separation performance of the existing piezoelectric thin film ABM, this paper presents the design, fabrication, and characterization of the production and performance of a partially etched-type ABM material. $O_2$ plasma etching equipment was used to partially etch a piezoelectric thin film ABM to make it more flexible. The mechanical-behavior characterization of the manufactured partially etched-type ABM showed that the overall separation frequency range shifted to a lower frequency range more suitable for audible frequency bandwidths and it displayed an improved frequency separation performance. In addition, the maximum magnitude of the vibration displacement at the first local resonant frequency was enhanced by three times from 38 nm to 112 nm. It is expected that the newly designed, partially etched-type ABM will improve the issue of cross-talk between nearby electrodes and that the manufactured partially etched-type ABM will be utilized for next-generation ABM research.

An Asymmetric Buffer Management Policy for SSD (SSD를 위한 비대칭 버퍼 관리 기법)

  • Jung, Ho-Young;Kang, Soo-Yong;Cha, Jae-Hyuk
    • Journal of Digital Contents Society
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    • v.12 no.2
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    • pp.141-150
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    • 2011
  • Recently the Solid State Drive (SSD) is widely used for storage system of various mobile devices. In this case, existing buffer replacement algorithms based on the hard disk do not consider characteristics of flash memory, so it caused performance degradation of the system. This paper proposes a novel buffer replacement policy called ABM (Asymmetric Buffer Management) policy. ABM policy separates read and write buffer space and applies different replacement unit and replacement algorithm for each buffer. In addition, write buffer delay scheme and dynamic size adaptation algorithm is applied for better performance. ABM outperforms other replacement policies, especially ABM-LRU-CLC shows 32% better performance than normal LRU policy.

The Influence of Hotel Enterprise′s ABM on ERP System Satisfaction and Downsizing (호텔기업의 ABM이 ERP시스템만족과 다운사이징에 미치는 영향관계)

  • Kim Mun Su
    • Journal of Applied Tourism Food and Beverage Management and Research
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    • v.14 no.2
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    • pp.39-63
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    • 2003
  • Hotel Enterprises are coping with changing circumstances by utilizing ABM and are downsizing for the sake of Innovation Results by setting up ERP(Enterprise Resource Planning) system. This study is intended to explore the correlations between Activity Based Management(ABM) of Strategic Management and ERP System Satisfaction, and the relations between ERP System Satisfaction and Downsizing. And through this, the methods of effective Strategic Management Development and efficient Downsizing will be suggested The objectives of this study are as follows: (1) to research the definition of Tourist Hotels' ABM (2) to examine the correlations between AMB and ERP system Satisfaction (3) to study the relations between ERP System Satisfaction and Downsizing Study Hypotheses, referring to preceeding study of Doo-jin Kong(2002) and DeLone & McLean, were set up to verify the Study Model. Data Analyses include the questionnaire survey of the Hotels using ERP system, reliability analysis, and regression analysis: for these analyses was used SPSS 10.0, the statistics package program. The conclusions show: First, ABM influences ERP System Satisfaction. Second, ERP System Satisfaction influences Downsizing. Therefore, ABM of Tourist Hotels needs to systematically take advantage of the Information Factors from ERP system and to maximize results by executing Downsizing through System development.

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Development of Passive-Type Daylighting System for Large Space (대공간 적용을 위한 패시브형 자연채광시스템 개발)

  • Sung, Tae-Kyung;Park, Yeon-Min;Kim, Joung-Min;Lee, Chung-Sik;Lee, Euol-Young;Joung, Che-Bong;Kim, Byung-Chul
    • Journal of the Korean Solar Energy Society
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    • v.35 no.5
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    • pp.1-10
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    • 2015
  • Whereas recent domestic buildings and industrial facilities are being constructed as large as possible, the daylighting systems for the large space have rarely been developed. Domestic situation has been reported as only several small or medium sized daylighting systems have been developed, and the large scaled systems have entirely being imported from abroad. We have developed a large scaled daylighting system for the big space. The developed system have been evaluated in terms of the average system efficiency and daylighting factor. Each results are shown with tabulated experimental data.

Influence of Electrochemical Oxidation Potential on Biofilm Structure and Bacterial Dissimilation in Wastewater Treatment Bioreactor (오수처리 반응기에서 생물막 매개체에 부과한 전기화학적 산화전위가 생물막의 구조와 미생물의 대사에 미치는 영향)

  • Na, Byung-Kwan;Park, Doo-Hyun
    • Microbiology and Biotechnology Letters
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    • v.35 no.1
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    • pp.73-80
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    • 2007
  • Biofilm media was equipped in two-compartmented wastewater treatment bioreactor which was separated by porcelain septum. DC 2.0 volt of electric potential was charged to anodic (oxidative) biofilm media (ABM) to induce oxidation potential but not to that of carbon (neutral) biofilm media (CBM) that was used for control test. Biofilm structure, biomass variation, Off variation and wastewater treatment efficiency in the bioreactor equipped with ABM (ABM-bioreactor) and CBM (CBM-bioreactor). Time-coursed variation of biofilm structure forming on surface of ABM and CBM was observed by scanning electron microscopy. The biofilm growing on ABM was dispersed on surface and was not completely covered the media but the biofilm growing on CBM was continuously increased and finally covered the media. The ORP of CBM was decreased to 100 mV, which was reciprocally proportional to the biomass growth. However, the ORP of ABM was about 800 mV, which was maintained during operation for about 60 days. The treatment efficiency of COD in the ABM bioreactor was 2 times higher than those in the CBM bioreactor. From these results, we proposed that electrochemical oxidation potential charged to biofilm media may inhibit formation of biofilm extremely condensed and activate bacterial cell metabolism.

Comparative Analysis of ABM/P-15, Bone Morphogenic Protein and Demineralized Bone Matrix after Instrumented Lumbar Interbody Fusion

  • Sathe, Ashwin;Lee, Sang-Ho;Kim, Shin-Jae;Eun, Sang Soo;Choi, Yong Soo;Lee, Shih-min;Seuk, Ju-Wan;Lee, Yoon Sun;Shin, Sang-Ha;Bae, Junseok
    • Journal of Korean Neurosurgical Society
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    • v.65 no.6
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    • pp.825-833
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    • 2022
  • Objective : ABM/P-15 (anorganic bone matrix/15-amino acid peptide fragment) is a commercially available synthetically manufactured P-15 collagen peptide fragment, that is adsorbed on ABM. This study was done to investigate the efficacy of ABM/P-15 in achieving fusion in the lumbar spine and comparing it with that of recombinant bone morphogenic protein-2 (rhBMP-2) and demineralized bone matrix (DBM). Methods : A retrospective observational study of prospectively collected data of 140 patients who underwent lumbar spinal fusion surgeries in a single specialty spine hospital between 2016 and 2020, with a minimum 6-month follow-up was conducted. Based on the material used for the augmentation of the bone graft at the fusion site, the patients were divided into three categories namely ABM/P-15, rhBMP-2, and DBM group. Results : ABM/P-15, rhBMP-2, and DBM were used in 46, 44, and 50 patients, respectively. Patient characteristics like age, gender, bone mineral density, smoking history, and presence of diabetes mellitus were comparable amongst the three groups. Average follow-up was 16.0±5.2, 17.9±9.8, and 26.2±14.9 months, respectively in ABM/P-15, rhBMP-2, and DBM groups. The fusion was achieved in 97.9%, 93.2%, and 98% patients while the average time-to-union was 4.05±2.01, 10±4.28, and 9.44±3.49 months (p<0.001), respectively for ABM/P-15, rhBMP-2, and DBM groups. The average pre-operative Visual analogue scale score was 6.93±2.42, 7.14±1.97, 7.01±2.14 (p=0.900) for ABM/P-15, rhBMP-2 and DBM groups, respectively, which reduced to 1.02±0.80, 1.21±0.96, and 0.54±0.70 (p=0.112), respectively at the last follow up. Pre-operative Oswestry disability index scores were 52.7±18.02, 55.4±16.8, and 53.56±19.6 (p=0.751) in ABM/P-15, rhBMP-2, and DBM groups, which post-operatively reduced to 33.77±15.52, 39.42±16.47, and 38.3±15.89 (p=0.412) and further to 15.74±8.3, 17.41±10.45, and 16.76±9.81 (p=0.603), respectively at the last follow-up. Conclusion : ABM/P-15 appears to achieve union significantly earlier than rhBMP-2 and DBM in lumbar spinal fusion cases while maintaining a comparable clinical and complication profile.

Performance Evaluation of An Azimuth Tracking Prismatic Daylighting System (방위각 추적식 프리즘형 집광조명시스템 성능평가)

  • Sung, Tae-Kyung;Lee, Chung-Sik;Lee, Eul-Young;Park, Yeon-Min;Joung, Che-Bong;Kim, Byung-Chul
    • Journal of the Korean Solar Energy Society
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    • v.32 no.3
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    • pp.129-137
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    • 2012
  • This thesis introduced an azimuth tracking prismatic daylighting system. The system improved several issues of the previous passive prismatic daylighting system: low efficiency at sunrise and sunset, glare effect and polarized. The system was developed to track the movement of sun with azimuth tracking device, and it has its own power from the attached solar cells. We compared the with previous passive one in terms with system efficiency and daylighting factors(DF).