• Journal of the Institute of Electronics and Information Engineers
• /
• v.53 no.11
• /
• pp.66-70
• /
• 2016

This paper presents an 24 GHz I/Q LO generator for a heartbeat measurement radar system. In order to improve the mismatch performance between I and Q LO signals against process variation, a 24 GHz I/Q LO generator employing a low-pass phase shifter and a high-pass phase shifter composed of inductors and capacitors is proposed. The proposed 24 GHz I/Q LO generator consists of an LO buffer, a low-pass phase shifter and a high-pass phase shifter. It was designed using a 65 nm CMOS technology and draws 8 mA from a 1 V supply voltage. The proposed 24 GHz I/Q LO generator shows a gain of 7.5 dB, a noise figure of 2.3 dB, 0.1 dB gain mismatch and $4.3^{\circ}$ phase mismatch between I and Q-path against process and temperature variations for the operating frequencies from 24.05 GHz to 24.25 GHz.

• Neonatal Medicine
• /
• v.16 no.1
• /
• pp.76-80
• /
• 2009

A male baby with intrauterine growth retardation had a short neck, small hands and feet, hypospadia, both grade I hydronephrosis, type II atrial septal defect, and moderate valvular pulmonary stenosis. The routine chromosome and banding analyses revealed a 46,XY,rec(8)del(8)(p21)dup(8) (q24.1)inv(8)(p21q24.1)pat chromosome constitution. His mother has normal chromosomes, but the father had 46,XY,inv(8)(p21q24.n Also his uncle had an inv(8) chromosome constitution. We used lymphocytes and examined 40 mitotic cells. All mitotic cells showed deletion of 8p21-->pter and duplication of 8q24.1 -->qter. Because Sp21 involves secretion of macrophage and lymphocyte against cancer cells, long-term follow-up for cancer will be needed.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6733-6738
• /
• 2013

Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (PCa). As PCa risk SNPs may also influence disease outcome, we studied here eight 8q24 risk alleles, and evaluated their role in PCa clinical covariates in northern Chinese men. Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=289) and from age-matched normal controls (n=288). Eight 8q24 SNPs were genotyped by polymerase chain reaction-high- resolution melting analysis in 577 subjects. We examined the prevalence distribution of 8q24 risk alleles and analyzed the associations between the risk allele and PCa and clinical covariates to infer their impact on aggressive PCa. Three of the eight SNPs were associated with PCa risk in northern Chinese men, including rs16901966 (OR 1.31, 95% CI 1.01-1.70, p=0.042), rs1447295 (OR 1.47, 95% CI 1.09-1.98, p=0.011) and rs10090154 (OR 1.55, 95% CI 1.14-2.12, p=0.005). Haplotype analysis based association with the risk alleles revealed significant differences between cases and controls (OR 1.43, 95%CI 0.99-2.06, p=0.049). The risk alleles rs16901966, rs1447295 and rs10090154 were associated with age at diagnosis and tumor stage as compared with controls, while rs16901966 was associated with aggressive PCa (OR 1.43, 95% CI 1.01-2.03, p=0.042). The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates. The three SNPs at 8q24 could be PCa susceptible genetic markers in northern Chinese men.

• Korean Journal of Environment and Ecology
• /
• v.26 no.1
• /
• pp.74-81
• /
• 2012

Decay rate and nutrient dynamics during leaf litter decomposition of deciduous Quercus acutissima and evergreen Quercus mysinaefolia were studied for 24 months from December 2008 to December 2010 in Gongju, Chungnam Province, Korea. Percent remaining weight of Q. acutissima and Q. mysinaefolia leaf litter after 24 months elapsed was $46.3{\pm}5.4%$ and $37.8{\pm}2.5%$, respectively. Decomposition of evergreen Q. mysinaefolia leaf litter was significantly faster than that of deciduous Quercus acutissima leaf litter. Decay constant(k) of Q. acutissima and Q. mysinaefolia leaf litter after 24 months elapsed was 0.38 and 0.49, respectively. Initial C/N and C/P ratio of Q. mysinaefolia leaf litter was significantly lower than those of Q. acutissima leaf litter. Initial C/N and C/P ratio of Q. acutissima leaf litter was 46.8 and 270.9, respectively. After 24 months elapsed, C/N and C/P ratio of decomposing Q. acutissima leaf litter decreased to 22.5 and 104.2, respectively. Initial C/N and C/P ratio of Q. mysinaefolia leaf litter was 22.4 and 41.7, respectively. After 24 months elapsed, C/N and C/P ratio of decomposing Q. mysinaefolia leaf litter decreased to 16.7 and 89.7, respectively. Initial concentration of N, P, K, Ca and Mg in leaf litter was 8.31, 0.44, 4.18, 9.38, 1.37 mg/g in Q. acutissima, and 19.88, 2.73, 7.06, 8.24, 2.61 mg/g in Q. mysinaefolia, respectively. Initial concentration of N and P in Q. mysinaefolia leaf litter was significantly higher than those in Q. acutissima. After 24 month elapsed, remaining N, P, K, Ca and Mg were 100.91, 114.75, 32.99, 50.63, 15.51% in Q. acutissima, and 43.22, 11.35, 12.98, 82.22, 44.23% in Q. mysinaefolia, respectively. N and P in decomposing leaf litter was immobilized in Q. acutissima, and mineralized in Q. mysinaefolia.

• Honam Mathematical Journal
• /
• v.38 no.3
• /
• pp.507-552
• /
• 2016

For a complex number q and a divisor function ${\sigma}_1(n)$ we define $$C(q):=q{\prod_{n=1}^{\infty}}(1-q^n)^{16}(1-q^{2n})^4,\\D(q):=q^2{\prod_{n=1}^{\infty}}(1-q^n)^8(1-q^{2n})^4(1-q^{4n})^8,\\L(q):=1-24{\sum_{n=1}^{\infty}}{\sigma}_1(n)q^n$$ moreover we obtain the number of representations of $n{\in}{\mathbb{N}}$ as sum of 24 squares, which are possible for us to deduce $L(q^4)C(q)$ and $L(q^4)D(q)$.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.26 no.3
• /
• pp.245-253
• /
• 2000

The development and progression of oral cancer is associated with an accumulation of multiple genetic alterations through the multistep processes. Comparative genomic hybridization(CGH), newly developed cytogenetic and molecular biologic technique, has been widely accepted as a useful method to allow the detection of genetic imbalance in solid tumors and the screening for chromosome sites frequently affected by gains or losses in DNA copy number. The authors examined 19 primary oral squamous cell carcinomas using CGH to identify altered chromosome regions that might contain novel oncogenes and tumor suppressor genes. Interrelationship between these genetic aberrations detected and major oncogenes and tumor suppressor genes previously recognized in carcinogenesis of oral cancers was studied. 1. Changes in DNA copy number were detected in 14 of 19 oral cancers (78.9%, mean: 5.58, range: $3{\sim}13$). High level amplification was present in 4 cases at 9p23, $12p21.1{\sim}q13.1$, 3q and $8q24{\sim}24.3$. Fourteen cases(78.9%, mean: 3.00, range: $1{\sim}8$) showed gains of DNA copy number and 12 cases(70.5%, mean: 2.58, range: $1{\sim}9$) revealed losses of DNA copy number. 2. The most common gains were detected on 3q(52.6%), 5p(21.0%), 8q(21.0%), 9p(21.0%), and 11q(21.0%). The losses of DNA copy number were frequently occurred at 9p(36.8%), 17q(36.8%), 13q(26.3%), 4p(21.0%) and 9p(21.0%). 3. The minimal common regions of gains were repeatedly observed at $3q24{\sim}26.7$, $3q27{\sim}29$, $1q22{\sim}31$, $5p12{\sim}13.3$, $8q23{\sim}24$, and 11q13.1-13.3. The minimal common regions of losses were detected at $9q11{\sim}21.3$, 17p31, $13q22{\sim}34$, and 14p16. 4. In comparison of CGH results with tumor stages, the lower stage group showed more frequent gain at 3q, 5q, 9p, and 14q, whereas gains at 1q($1q22{\sim}31$) and 11q($11q13.1{\sim}13.3$) were mainly detected in higher stage group. The loss at $13q22{\sim}34$ was exclusively detected in higher stage. The results indicate that the most frequent genetic alterations in the development of oral cancers were gains at $3q24{\sim}26.3$, $1q22{\sim}31$, and $5p12{\sim}13.3$ and losses at $9q11{\sim}21.3$, 17p31, and 13q. It is suggested that genetic alterations manifested as gains at $3q24{\sim}26.3$, $3q27{\sim}29$, $5p12{\sim}13.3$ and 5p are associated with the early progression of oral cancer. Gains at $1q22{\sim}31$ and $11q13.1{\sim}13.3$ and loss at 13q22-34 could be involved in the late progression of oral cancers.

• Genomics & Informatics
• /
• v.1 no.2
• /
• pp.101-107
• /
• 2003

Loss of heterozygosity (LOH) has been used to detect deleted regions of a specific chromosome in cancer cells. LOH on chromosome 16q has been reported to occur frequently in progressed hepatocellular carcinoma (HCC). Liver tissues from 37 Korean HCC patients were analyzed for LOH by using 25 polymorphic microsatellite markers distributed along 16q. Out of the 37 HCC patients studied, 21 patients (56.8%) showed LOH in various regions of 16q with at least one polymorphic marker. Puring the analysis of these 21 LOH cases, 6 patients showed interstitial LOHs in which the boundary of the LOH region was defined. With two rounds of LOH analysis, five commonly occurring interstitial LOH regions were identified; 16q21-22.1, 16q22.2 - 22.3, 16q22.3, 16q23.2 and 16q23.3 - 24.1. Among the five LOH regions the 16q23.3 - 24.1 region has been reported to be related with chromosome instability. A complete physical map, which covers the 3.2 Mb region of 16q23.3 - 24.1 (D16S402 and D16S486), was constructed to identify novel candidate tumor suppressor genes. We provide the minimally tiling path map consisting of 28 BAC clones. There was one gap between NT_10422.11 and NT_019609.9 of the human genome sequence contig (NCBI sequence build 33, April 29, 2003). This gap can be filled by sequencing the R-1425M20 clone which bridges these sequence contigs.

• Journal of the Korean earth science society
• /
• v.22 no.6
• /
• pp.500-511
• /
• 2001

For the southeastern Korea aound the Yangsan fault we measured Q$_P^{-1}$ and Q$_S^{-1}$ simultaneously by using the extended coda-normalization method for seismograms registered at 9 stations deployed by KIGAM. We analyzed 707 seismograms of local earthquakes that occurred between December 1994 and February 2000. From seismograms, bandpass filtered traces were made by applying Butterworth filter with frequency-bands of 1${\sim}$2, 2${\sim}$4, 4${\sim}$8, 8${\sim}$16 and 16${\sim}$32 Hz. Estimated Q$_P^{-1}$ and Q$_S^{-1}$ values decrease from (7${\pm}$2)${\times}$10$^{-3}$ and (5${\pm}$4)${\times}$10$^{-4}$ at 1.5 Hz to (5${\pm}$4)${\times}$10$^{-3}$ and (5${\pm}$2)${\times}$10$^{-4}$ at 24 Hz, respectively. By fitting a power-law frequency dependent to estimated values over the whole stations, we obtained 0.009 (${\pm}$0.003)f$^{-1.05({\pm}0.14)$ for Q$_P^{-1}$ and 0.004 (${\pm}$0.001)f$^{-0.75({\pm}0.14)$) for Q$_S^{-1}$, where f is frequency in Hz.

• Journal of fish pathology
• /
• v.8 no.1
• /
• pp.31-36
• /
• 1995

Hc nuclear polyhedrosis virus DNA genome was digested with EcoRI endonuclease, these partial fragments were recombined into the pUC8 plasmid vector and transformed in E. coli JM 83 cell. The genome DNA has 24 EcoRI fragments and 12 fragments of them were subcloned. The four recombinants were named as eNP-O, eNP-Q, eNP-R and eNP-S. The expression of foregin gene of the recombinants was investigated by analysing protein patterns on the SDS-PAGE. The eNP-O, eNP-Q and eNP-R were expressed a different weight of protein as comparision with potypeptide bands of E. coli JM 83 host cell.

• Journal of the Korean earth science society
• /
• v.27 no.4
• /
• pp.475-485
• /
• 2006

The physical properties of the central and southwestern crust of South Korea were estimated by comparing values of ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ in the Kimcheon and Mokpo areas. In order to get ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ values, seismic data were collected from two stations of the KIGAM network (KMC and MUN) and four stations of the KMA network (CPN, KUC, MOP, and WAN). An extended coda-normalization method was applied to these data. Estimates of ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ show variations depending on frequency. As frequencies vary from 3 Hz to 24 Hz, the estimates decrease from $(1.4{\pm}3.9){\times}10^{-3}\;to\;(2.3{\pm}3.5){\times}10^{-4}\;for\;{Q_P}^{-1}\;and\;(1.8{\pm}1.3){\times}10^{-3}\;to\;(1.9{\pm}1.5){\times}10^{-4}\;for\;{Q_S}^{-1}$ in central South Korea, and $(5.9{\pm}4.8){\times}10^{-3}\;to\;(2.2{\pm}3.8){\times}10^{-4}\;for\;{Q_P}^{-1}\;and\;(0.5{\pm}2.8){\times}10^{-3}\;to\;(1.8{\pm}1.6){\times}10^{-4}\;for\;{Q_S}^{-1}$ in southwestern South Korea. According that a frequency-dependent power law is applied to the data, the best fits of ${Q_P}^{-1}\;and\;{Q_S}^{-1}\;are\;0.003f^{-0.49}\;and\;0.005f^{-1.03}$ in central South Korea, and $0.026f^{-1.47}$ and $0.001f^{-0.49}$ in southwestern South Korea, respectively. These values almost correspond to those of seismically stable regions although ${Q_P}^{-1}$ values of southwestern South Korea are a little high due to lack of data used.