• Investigative Magnetic Resonance Imaging
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• v.18 no.4
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• pp.290-302
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• 2014

Purpose : Susceptibility-weighted magnetic resonance (MR) sequence is three-dimensional (3D), spoiled gradient-echo pulse sequences that provide a high sensitivity for the detection of blood degradation products, calcifications, and iron deposits. This pictorial review is aimed at illustrating and discussing its main clinical applications. Materials and Methods: SWI is based on high-resolution, 3D, fully velocity-compensated gradient-echo sequences using both magnitude and phase images. To enhance the visibility of the venous structures, the magnitude images are multiplied with a phase mask generated from the filtered phase data, which are displayed at best after post-processing of the 3D dataset with the minimal intensity projection algorithm. A total of 200 patients underwent MR examinations that included SWI on a 3 tesla MR imager were enrolled. Results: SWI is very useful in detecting multiple brain disorders. Among the 200 patients, 80 showed developmental venous anomaly, 22 showed cavernous malformation, 12 showed calcifications in various conditions, 21 showed cerebrovascular accident with susceptibility vessel sign or microbleeds, 52 showed brain tumors, 2 showed diffuse axonal injury, 3 showed arteriovenous malformation, 5 showed dural arteriovenous fistula, 1 showed moyamoya disease, and 2 showed Parkinson's disease. Conclusion: SWI is useful in detecting occult low flow vascular lesions, calcification and microbleed and characterising diverse brain disorders.

• Journal of Broadcast Engineering
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• v.12 no.1 s.34
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• pp.41-52
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• 2007

The 3DTV services can be seen as a general case of the multi-view video that has been receiving a significant attention lately. However, the key factors that influence the success of 3DTV are the availability of content, the ease of use, the quality of contents, and the reduction of cost. This paper deals primarily with the perceptual improvement in image quality, especially based on human factors. An optimal asymmetrical coding method for binocular and multi-view images is presented. The quantitative value of asymmetrical rate to maintain optimized subjective image quality is explored. Also we analyze how edges of 2D images affect on 3D perceptions and propose an edge-preserving algorithm to perform perceptual improvements. Experimental results demonstrate that the proposed algorithm enhances subjective image quality much better than conventional methods.

• Tunnel and Underground Space
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• v.23 no.1
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• pp.54-65
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• 2013

The LCM (Linear Cutting Machine) test is one of the most powerful and reliable methods for designing the disc cutter and for predicting the TBM (Tunnel Boring Machine) performance. It has an advantage to predict the actual load on disc cutter from the laboratory test on the real-size large rock samples, however, it also has a disadvantage to transport and/or prepare the large rock samples and to need an extra cost for experiment. In order to overcome this problem, lots of numerical studies have been performed. In this study, the PFC3D (Particle Flow Code in 3 Dimension) has been adopted for numerical analysis on optimum cutter spacing and failure aspects of Busan Tuff. The optimum cutting condition with s/p ratio of 16 and minimum specific energy of $14MJ/m^3$ was derived from numerical analyses. The cutter spacing for Busan Tuff had the good agreements with those of LCM test and numerical analysis by finite element method.

• Journal of Hydrogen and New Energy
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• v.31 no.4
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• pp.387-394
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• 2020

A parametric study of a 2.5 kW class propeller type micro hydraulic turbine was performed. In order to analyze the internal flow characteristics in the hydraulic turbine, three dimensional Reynolds-averaged Navier-Stokes equations with shear stress transport turbulence model were used and the hexahedral grid system was used to construct computational domain. To secure the reliability of the numerical analysis, the grid dependency test was performed using the grid convergence index method based on the Richardson extrapolation, and the grid dependency was removed when about 1.7 million nodes were used. For the parametric study, the axial distance at shroud span (L) between the inlet guide vane and the runner, and the inlet and outlet blade angles (β₁, β₂) of the runner were selected as the geometric parameters. The inlet and outlet angles of the runner were defined in the 3 spans from the hub to tip, and a total of 7 geometric parameters were investigated. It was confirmed that the outlet angles of the runner had the most sensitive effect on the power and efficiency of the micro hydraulic turbine.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.379-385
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• 2015

The eye irritation potential of drug candidates or pharmaceutical ingredients should be evaluated if there is a possibility of ocular exposure. Traditionally, the ocular irritation has been evaluated by the rabbit Draize test. However, rabbit eyes are more sensitive to irritants than human eyes, therefore substantial level of false positives are unavoidable. To resolve this species difference, several three-dimensional human corneal epithelial (HCE) models have been developed as alternative eye irritation test methods. Recently, we introduced a new HCE model, MCTT HCE$^{TM}$ which is reconstructed with non-transformed human corneal cells from limbal tissues. Here, we examined if MCTT HCE$^{TM}$ can be employed to evaluate eye irritation potential of solid substances. Through optimization of washing method and exposure time, treatment time was established as 10 min and washing procedure was set up as 4 times of washing with 10 mL of PBS and shaking in 30 mL of PBS in a beaker. With the established eye irritation test protocol, 11 solid substances (5 non-irritants, 6 irritants) were evaluated which demonstrated an excellent predictive capacity (100% accuracy, 100% specificity and 100% sensitivity). We also compared the performance of our test method with rabbit Draize test results and in vitro cytotoxicity test with 2D human corneal epithelial cell lines.

• Smart Structures and Systems
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• v.2 no.2
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• pp.115-126
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• 2006

The Terra-Scope system is an affordable 4-D down-hole seismic monitoring system based on independent, microprocessor-controlled sensor Pods. The Pods are nominally 50 mm in diameter, and about 120 mm long. They are expected to cost approximately $6000 each. An internal 16-bit, extremely low power MCU controls all aspects of instrumentation, eight programmable gain amplifiers, and local signal storage. Each Pod measures 3-D acceleration, tilt, azimuth, temperature, and other parametric variables such as pore water pressure and pH. Each Pod communicates over a standard digital bus (RS-485) through a completely web-based GUI interface, and has a power consumption of less than 400 mW. Three-dimensional acceleration is measured by pure digital force-balance MEMS-based accelerometers. These accelerometers have a dynamic range of more than 115 dB and a frequency response from DC to 1000 Hz with a noise floor of less than $30ng_{rms}/{\surd}Hz$. Accelerations above 0.2 g are measured by a second set of MEMS-based accelerometers, giving a full 160 dB dynamic range. This paper describes the system design and the cooperative shared-time scheduler implemented for this project. Restraints accounted for include multiple data streams, integration of multiple free agents, interaction with the asynchronous world, and hardened time stamping of accelerometer data. The prototype of the device is currently undergoing evaluation. The first array will be installed in the spring of 2006.

• Radiation Oncology Journal
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• v.20 no.1
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• pp.24-33
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• 2002

Purpose : In order to improve dose homogeneity and to reduce acute toxicity in tangential whole breast radiotherapy, we evaluated two treatment techniques using multiple static fields or universal compensators. Materials and Methods : 1) Multistatic field technique : Using a three dimensional radiation treatment planning system, Adac Pinnacle 4.0, we accomplished a conventional wedged tangential plan. Examining the isodose distributions, a third field which blocked overdose regions was designed and an opposing field was created by using an automatic function of RTPS. Weighting of the beams was tuned until an ideal dose distribution was obtained. Another pair of beams were added when the dose homogeneity was not satisfactory. 2) Universal compensator technique : The breast shapes and sizes were obtained from the CT images of 20 patients who received whole breast radiation therapy at our institution. The data obtained were averaged and a pair of universal physical compensators were designed for the averaged data. DII (Dose Inhomogeneity Index : percentage volume of PTV outside $95\~105\%$ of the prescribed dose) $D_{max}$ (the maximum point dose in the PTV) and isodose distributions for each technique were compared. Results : The multistatic field technique was found to be superior to the conventional technique, reducing the mean value of DII by $14.6\%$ (p value<0.000) and the $D_{max}$ by $4.7\%$ (p value<0.000). The universal compensator was not significantly superior to the conventional technique since it decreased $D_{max}$ by $0.3\%$ (p value=0.867) and reduced DII by $3.7\%$ (p value=0.260). However, it decreased the value of DII by maximum $18\%$ when patients' breast shapes fitted in with the compensator geometry. Conclusion : The multistatic field technique is effective for improving dose homogeneity for whole breast radiation therapy and is applicable to all patients, whereas the use of universal compensators is effective only in patients whose breast shapes fit inwith the universal compensator geometry, and thus has limited applicability.

• Investigative Magnetic Resonance Imaging
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• v.16 no.1
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• pp.25-30
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• 2012

Purpose : To compare the enhancement pattern of normal facial nerves on 3D-FLAIR and 3D-T1-FFE-F) sequences at 3.0 T MR units. Materials and Methods: We assessed 20 consecutive subjects without a history of facial nerve abnormalities who underwent temporal bone MRI with contrast enhancement between January 2008 and March 2009. Two neuroradiologists independently reviewed pre-/post-enhanced 3D-T1-FFE-FS and 3D-FLAIR images respectively with 2-week interval to assess the enhancement of normal facial nerves divided into five anatomical segments. The degree of enhancement in each segment was graded as none, mild or strong, and the results of 3D-FLAIR and 3D-T1-FFE-FS image sets were compared. Results: On 3D-FLAIR images, one of the two reviewers observed mild enhancement of the genu segment in two (10%) subjects. On 3D-T1-FFE-FS images, at least one segment of the facial nerve was enhanced in 13 (65%) subjects. At least one reviewer found that 17 of the 100 segments showed enhancement on 3D-T1-FFE-FS images, with the mastoid segment being the most commonly enhanced. Interobserver agreement on 3D-T1-FFE-FS images was good for enhancement of the normal facial nerve (${\kappa}$= 0.589). Conclusion: In contrast to 3D-T1-FFE-FS, normal facial nerve segments rarely showed enhancement on 3D-FLAIR images.

• Journal of Veterinary Science
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• v.24 no.1
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• pp.4.1-4.16
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• 2023

Background: In vitro culture of preantral follicles is a promising technology for fertility preservation. Objectives: This study aims to investigate an optimized three-dimensional (3D) fetal bovine serum (FBS)-free preantral follicle culture system having a simple and easy operation. Methods: The isolated follicles from mouse ovaries were randomly divided in an ultra-low attachment 96-well plates supplement with FBS or bovine serum albumin (BSA) culture or encapsulated with an alginate supplement with FBS or BSA culture. Meanwhile, estradiol (E₂) concentration was assessed through enzyme-linked immunosorbent assay of culture supernatants. The diameter of follicular growth was measured, and the lumen of the follicle was photographed. Spindle microtubules of oocytes were detected via immunofluorescence. The ability of oocytes to fertilize was assessed using in vitro fertilization. Results: The diameters were larger for the growing secondary follicles cultured in ultra-low attachment 96-well plates than in the alginate gel on days 6, 8, and 10 (p < 0.05). Meanwhile, the E2 concentration in the BSA-supplemented medium was significantly higher in the alginate gel than in the other three groups on days 6 and 8 (p < 0.05), and the oocytes in the FBS-free system could complete meiosis and fertilization in vitro. Conclusions: The present study furnishes insights into the mature oocytes obtained from the 3D culture of the preantral follicle by using ultra-low attachment 96-well plate with an FBS-free system in vitro and supports the clinical practices to achieve competent, mature oocytes for in vitro fertilization.

• Geophysics and Geophysical Exploration
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• v.23 no.1
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• pp.22-37
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• 2020

We analyze the comprehensive three-dimensional (3D) magnetic structure characteristics from the seafloor to the deep layer of the Tofua Arc (TA) 12 seamount in the Tonga Arc, Southwestern Pacific, using bathymetric and geomagnetic data, and magnetization vector inversion (MVI) results. The seafloor features surrounding TA 12 highlight a NW-SE-oriented elliptical caldera at the summit of the seamount, two small cones in the depressed area. A large-scale sea valley is present on the western flank of the seamount, extending from these caldera cones to the southwestern base of the seamount. TA 12 seamount exhibits a low magnetic anomaly in the caldera depression, whereas a high magnetic anomaly is observed surrounding the low magnetic anomaly across the caldera summit. It is therefore presumed that there may be a strong magnetic material distribution or magma intrusion in the caldera. The 3D MVI results show that the high anomaly zones are mainly present in the surrounding slopes of the seamount from the seafloor to the -3,000 m (below the seafloor) level, with the magnetic susceptibility intensity increasing as the seafloor level increases at the caldera depression. However, small high anomaly zones are present across the study area near the seafloor level. Therefore, we expect that the magma ascent in TA 12 seamount migrated from the flanks to the depression area. Furthermore, we assume that the complex magnetic distribution near the seafloor is due to the remnant magnetization.