• Title/Summary/Keyword: 3D(three-dimensional)

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Simplified finite element modelling of non uniform tall building structures comprising wall and frame assemblies including P-Δ effects

  • Belhadj, Abdesselem Hichem;Meftah, Sid Ahmed
    • Earthquakes and Structures
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    • v.8 no.1
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    • pp.253-273
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    • 2015
  • The current investigation has been conducted to examine the effect of gravity loads on the seismic responses of the doubly asymmetric, three-dimensional structures comprising walls and frames. The proposed model includes the P-${\Delta}$ effects induced by the building weight. Based on the variational approach, a 3D finite element with two nodes and six DOF per node including P-${\Delta}$ effects is formulated. Dynamic and static governing equations are derived for dynamic and buckling analyzes of buildings braced by wall-frame systems. The influences of P-${\Delta}$ effects and height of the building on tip displacements under Hachinohe earthquake record are investigated through many structural examples.

Investigation of Binding Modes of the Verapamil and Curcumin into Human P-glycoprotein (P-gp)

  • Gadhe, Changdev G.;Cho, Seung Joo
    • Journal of Integrative Natural Science
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    • v.6 no.4
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    • pp.205-210
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    • 2013
  • Human P-gp is a protein responsible for the multidrug resistance (MDR) and causes failure of cancer chemotherapy. Till date no X-ray crystal structure is reported for this membrane protein, which hampers active research in the field. We performed homology modeling to develop three dimensional (3D) model of P-gp, and docking studies of the verapamil and curcumin have been performed to gain insight into the interaction mechanism between inhibitors and P-gp. It was identified that the inhibitors docked into the upper part of P-gp and interacted through the hydrophobic interactions.

3D stability of shallow cavity roof with arbitrary profile under influence of pore water pressure

  • Luo, W.J.;Yang, X.L.
    • Geomechanics and Engineering
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    • v.16 no.6
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    • pp.569-575
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    • 2018
  • The stability of shallow cavities with an arbitrary profile is a difficult issue in geotechnical engineering. This paper investigates this problem on the basis of the upper bound theorem of limit analysis and the Hoek-Brown failure criterion. The influence of pore pressure is taken into consideration by regarding it as an external force acting on rock skeleton. An objective function is constructed by equating the internal energy dissipation to the external force work. Then the Lagrange variation approach is used to solve this function. The validity of the proposed method is demonstrated by comparing the analytical solutions with the published research. The relations between shallow and deep cavity are revealed as well. The detaching curve of cavity roof with elliptical profile is obtained. In order to facilitate the application of engineering practice, the numerical results are tabulated, which play an important role in tunnel design and stability analysis of roof. The influential factors on potential collapse are taken into consideration. From the results, the impact of various factors on the extent of detaching is seen intuitively.

Reflective Fourier Ptychographic Microscopy Using Segmented Mirrors and a Mask

  • Ahn, Hee Kyung;Chon, Byong Hyuk
    • Current Optics and Photonics
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    • v.5 no.1
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    • pp.40-44
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    • 2021
  • In this paper, LED arrays with segmented mirrors and a mask are presented as a new dark-field illuminator for reflective Fourier ptychographic microscopy (FPM). The illuminator can overcome the limitations of the size and the position of samples that the dark-field illuminator using a parabolic mirror has had. The new concept was demonstrated by measuring a USAF 1951 target, and it resolved a pattern in group 10 element 6 (274 nm) in the USAF target. The new design of the dark-field illuminator can enhance competitiveness of the reflective FPM as a versatile measurement method in industry.

Current status and prospects of organoid-based regenerative medicine

  • Woo Hee Choi;Dong Hyuck Bae;Jongman Yoo
    • BMB Reports
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    • v.56 no.1
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    • pp.10-14
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    • 2023
  • Organoids derived from stem cells or organ-specific progenitors are self-organizable, self-renewable, and multicellular three-dimensional (3D) structures that can mimic the function and structure of the derived tissue. Due to such characteristics, organoids are attracting attention as an excellent ex vivo model for drug screening at the stage of drug development. In addition, since the applicability of organoids as therapeutics for tissue regeneration has been embossed, the development of various organoids-based regenerative medicine has been rapidly progressing, reaching the clinical trial stage. In this review, we give a general overview of organoids and describe current status and prospects of organoid-based regenerative medicine, focusing on organoid-based regenerative therapeutics currently under development including clinical trials.

Topological implications of DNA tumor viral episomes

  • Eui Tae, Kim;Kyoung-Dong, Kim
    • BMB Reports
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    • v.55 no.12
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    • pp.587-594
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    • 2022
  • A persistent DNA tumor virus infection transforms normal cells into cancer cells by either integrating its genome into host chromosomes or retaining it as an extrachromosomal entity called episome. Viruses have evolved mechanisms for attaching episomes to infected host cell chromatin to efficiently segregate the viral genome during mitosis. It has been reported that viral episome can affect the gene expression of the host chromosomes through interactions between viral episomes and epigenetic regulatory host factors. This mini review summarizes our current knowledge of the tethering sites of viral episomes, such as EBV, KSHV, and HBV, on host chromosomes analyzed by three-dimensional genomic tools.

USING WEB CAMERA TECHNOLOGY TO MONITOR STEEL CONSTRUCTION

  • Kerry T. Slattery;Amit Kharbanda
    • International conference on construction engineering and project management
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    • 2005.10a
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    • pp.841-844
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    • 2005
  • Computer vision technology can be used to interpret the images captured by web cameras installed on construction sites to automatically quantify the results. This information can be used for quality control, productivity measurement and to direct construction. Steel frame construction is particularly well suited for automatic monitoring as all structural members can be viewed from a small number of camera locations, and three-dimensional computer models of steel structures are frequently available in a standard electronic format. A system is being developed that interprets the 3-D model and directs a camera to look for individual members as regular intervals to determine when each is in place and report the results. Results from a simple lab-scale system are presented along with preliminary full-scale development.

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MicroSUCI: A Microsurgical Background That Incorporates Suction Under Continuous Irrigation

  • Theodora Papavasiliou;Stelios Chatzimichail;Ankur Khajuria;Joon-Pio Hong
    • Archives of Plastic Surgery
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    • v.50 no.1
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    • pp.96-100
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    • 2023
  • The microsurgical anastomosis is integral to the success of autologous-free tissue transfer. Successful performance of this procedure relies strongly on operator dexterity, which can be made more challenging when blood and edematous fluids obscure the field of view. Workflow is impeded by intermittent irrigation and suctioning, necessitating presence of an assistant, with risk of arterial thrombosis, from vessels being drawn into suction drains. To negate these current disadvantages and minimize the barrier of entry to microvascular operations, we designed, manufactured, and patented a novel three-dimensional printed microsurgical background device with microfluidic capabilities that allow continuous suction and irrigation as well as provide platforms that enable multiangle retraction to facilitate operator autonomy. This was validated in an ex vivo model, with the device found to be superior to the current standard. We believe that this will have major applicability to the improvement of microsurgeon

Free vibration behaviour of multi-directional functionally graded imperfect plates using 3D isogeometric approach

  • Lahdiri, Abdelhafid;Kadri, Mohammed
    • Earthquakes and Structures
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    • v.22 no.5
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    • pp.527-538
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    • 2022
  • In this paper the free vibration frequencies of tri-directional functionally graded materials imperfect plate is investigated for Several plate geometries with two types of porosity (even and uneven) and different type of material configuration. The effect of several parameters such as power law index and boundary conditions have been investigated. For this purpose, an efficient computational method is developed and written under Matlab environment, based on a three-dimensional modeling and the isogeometric method is used for the discretization of the structure based on NURBS (Nonuniform rational B-spline) basis functions. The results obtained by the present method are validated by the comparison with the results given by several authors in the literature.

Current Status and Development Direction of Advanced Air Mobility ICTs (Advanced Air Mobility ICT 기술 현황 및 발전 방향)

  • B.J. Oh;M.S. Lee;B.K. Kim;Y.J. Jeong;Y.J. Lim;C.D. Lim
    • Electronics and Telecommunications Trends
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    • v.38 no.3
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    • pp.1-10
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    • 2023
  • In this study, the status of global advanced air mobility (AAM) was investigated to derive information and communications technologies (ICTs) that should be prepared according to directions of domestic AAM development. AAM is an urban air traffic system for moving from city to city by electric vertical take-off and landing or personal aircraft. It is expected to establish a three-dimensional air traffic system that can solve ground traffic congestion caused by the rapid global urbanization. With the full-scale commercialization of AAM solutions, high-density air traffic is expected, and with the advent of the personal air vehicle (PAV), the flight space usage is expected to expand. Therefore, it is necessary to develop a safe AAM service through early research on core ICTs for autonomous flight.