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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Current status and prospects of organoid-based regenerative medicine

  • Woo Hee Choi (Department of Microbiology, CHA University School of Medicine) ;
  • Dong Hyuck Bae (Department of Microbiology, CHA University School of Medicine) ;
  • Jongman Yoo (Department of Microbiology, CHA University School of Medicine)
  • Received : 2022.11.10
  • Accepted : 2022.12.16
  • Published : 2023.01.31
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Abstract

Organoids derived from stem cells or organ-specific progenitors are self-organizable, self-renewable, and multicellular three-dimensional (3D) structures that can mimic the function and structure of the derived tissue. Due to such characteristics, organoids are attracting attention as an excellent ex vivo model for drug screening at the stage of drug development. In addition, since the applicability of organoids as therapeutics for tissue regeneration has been embossed, the development of various organoids-based regenerative medicine has been rapidly progressing, reaching the clinical trial stage. In this review, we give a general overview of organoids and describe current status and prospects of organoid-based regenerative medicine, focusing on organoid-based regenerative therapeutics currently under development including clinical trials.

Keywords

Acknowledgement

This work was supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program-3D-TissueChip Based Drug Discovery Platform Program) (2000 9773, Commercialization of 3D Multifunction Tissue Mimetics Based Drug Evaluation Platform) and the Technology Innovation Program (or Industrial Strategic Technology Development Program, 20018578, Production standardization and development of analysis to verify the quality and characterization of organoid based regeneration medicine) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea) and the Korean Fund for Regenerative Medicine (KFRM) grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (HH21C0010).

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