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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Aging of hair follicle stem cells and their niches

  • Hansaem Jang (Department of Life Sciences, Pohang University of Science and Technology (POSTECH)) ;
  • Yemin Jo (Department of Life Sciences, Pohang University of Science and Technology (POSTECH)) ;
  • Jung Hyun Lee (Division of Dermatology, Department of Medicine, University of Washington) ;
  • Sekyu Choi (Department of Life Sciences, Pohang University of Science and Technology (POSTECH))
  • Received : 2022.10.25
  • Accepted : 2022.11.14
  • Published : 2023.01.31
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Abstract

Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. Research on hair follicle aging and age-related hair loss has demonstrated that a decline in hair follicle stem cell (HFSC) activity with aging can decrease the regeneration capacity of hair follicles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate ageassociated changes in HFSCs and their niches, thereby promoting hair regrowth.

Keywords

Acknowledgement

We thank members of the Choi laboratory for their helpful discussions and comments on the manuscript. This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (NRF-2022R1 C1C1011895 and NRF-2022M3A9D3016848) and Basic Science Research Institute Fund (NRF-2021R1A6A1A10042944). Y.J. was supported by a Genexine Research Fellowship Award. This work was also supported by a BK21 FOUR Research Fellowship funded by the Ministry of Education, Republic of Korea.

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