• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1119-1124
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• 2012

Background: The effect and possible mechanism of traditional Chinese medicine, baicalin, on the PI3K/Akt signaling pathway in drug-resistant human myeloid leukemia HL-60/ADR cells have been investigated in this current study. Methods: HL-60/ADR cells were treated by 20, 40, $80\;{\mu}mol/L$ baicalin followed by cell cycle analysis at 24h. The mRNA expression level of the apoptosis related gene, Bcl-2 and bad, were measured by RT-PCR on cells treated with $80\;{\mu}mol/L$ baicalin at 12, 24 and 48hr. Western blot was performed to detect the changes in the expression of the proteins related to HL-60/ADR cell apoptosis and the signaling pathway before and after baicalin treatment, including Bcl-2, PARP, Bad, Caspase 3, Akt, p-Akt, NF-${\kappa}B$, p-NF-${\kappa}B$, mTOR and p-mTOR. Results: Sub-G1 peak of HL-60/ADR cells appeared 24 h after $20\;{\mu}mol/L$ baicalin treatment, and the ratio increased as baicalin concentration increased. Cell cycle analysis showed 44.9% G0/G1 phase cells 24 h after baicalin treatment compared to 39.6% in the control group. Cells treated with $80\;{\mu}mol/L$ baicalin displayed a trend in decreasing of Bcl-2 mRNA expression over time. Expression level of the Bcl-2 and PARP proteins decreased significantly while that of the PARP, Caspase-3, and Bad proteins gradually increased. No significant difference in Akt expression was observed between treated and the control groups. However, the expression levels of p-Akt, NF-${\kappa}B$, p-NF-${\kappa}B$, mTOR and p-mTOR decreased significantly in a time-dependent manner. Conclusions: We conclude that baicalin may induce HL-60/ADR cell apoptosis through the PI3K/AKT signaling pathway.

• The korean journal of orthodontics
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• v.34 no.5 s.106
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• pp.429-438
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• 2004

The purpose of this study was to compare the effects of different light direction exposure times and setting times when using plasma arc light on shear bond strength of metal brackets. 240 extracted human premolars were randomly assigned to one of 16 groups Standardized brackets were bonded to enamel using different light curing units (Plasma arc light and Halogen light), exposure times (Plasma arc light 2. 4, 6 seconds and Halogen light 20 seconds). and light directions [Vertical direction [V] and Oblique direction [O]). 8 groups were tested after 5 minutes and the remaining 8 groups after 24 hours. The metal brackets were bonded with Transbond XT. Shear bond strength was measured by a universal testing machine. The results were as fellows: There were as differences between the shear bond strengths of the Vertical groups (V) and Oblique groups (O). regardless of exposure times and types of light curing units (p>0.05). The shear bond strength of the group with 2 seconds of plasma light were significantly lower than other exposure time groups (P<0.05). The shear bond strength tested after 5 minutes was lower than after 24 hours (p<0.05) The Adhesive Remment Index (ARI) score showed no statistically significant difference among the different groups. The results of this study suggested that the light direction of plasma arc light had no influence on the shear bond strength of metal brackets to enamel. and exposure times more than 4 seconds produced shear bond strengths similar to those Produced with a conventional halogen curing light.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.393-403
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• 2018

This study was conducted to evaluate the effects of a Motivation Enhancement for Smoking Cessation Program on middle school students' knowledge regarding smoking, self-efficacy, and daily amount of smoking. The study used a nonequivalent control group pre-post-test design and included 47 students who smoke from two middle schools located in city U as subjects. Subjects were separated into two groups, an experimental group with 23 students and a control group with 24 students. Data were collected from February 19, 2018 to May 11, 2018 and analyzed using the IBM SRSS/win 24.0 program to conduct a t-test, ${\chi}^2$-test, Fisher's exact test, and a paired t-test. After subjects went through the Motivation Enhancement for Smoking Cessation Program, their knowledge regarding smoking (t= 3.38, p=0.002), self-efficacy (t= -3.37, p=0.002), and their daily amount of smoking (t=3.38, p=0.002) showed significant changes. The results indicate that the Motivation Enhancement for Smoking Cessation Program is effective at increasing subjects' knowledge regarding smoking and self- efficacy while decreasing their daily amount of smoking. Therefore, to induce cessation of adolescent smoking, Motivation Enhancement for Smoking Cessation Programs tailored to each student should be held.

• Toxicological Research
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• v.13 no.4
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• pp.385-391
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• 1997

Inductive effects of cytochrome P450 2B1 by $\alpha$- and $\beta$-ionone were characterized in individual liver lobes of male Sprague Dawley rats. When rats were administered ionones orally at 100, 300, and 600 mg/kg for 24 hr, cytochrome P450 2B1 was induced dose-dependently in liver S-9 fractions as measured by P450 2B-specific monooxygenases and Western immunoblotting. The activity of P450 1A- and P450 2B-specific monooxygenases was differentially expressed in each lobe of normal liver. In addition, the monooxygenase activity was induced by $\alpha$- and $\beta$-ionone with different potency in each lobe of the liver. Our present results indicate that the different induction of P450s by $\alpha$- and $\beta$-ionone in each lobe may explain different susceptibilities of rat liver lobes to certain hepatotoxicants which require metabolic activation for their toxicity and that $\alpha$- and $\beta$-ionone may be useful model inducers of P450 2B1 in studying the toxic mechanism of certain toxicants which may require the metabolic activation by P450.

• Journal of dental hygiene science
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• v.10 no.5
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• pp.329-334
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• 2010

This study was performed to identify the relationship between scaling behaviors and knowledge about scaling and oral health belief of worker, and to provide baseline data for developing industry oral health policy. The survey had conducted self-administered questionnaires by 326 workers in Gyeongsan and Yeongcheon areas in Gyeongbuk province. Their scaling behaviors, knowledge and oral health belief were measured. The results were as follow; The average score of knowledge about scaling was 6.44. The average oral health belief was 2.72. In detail, 'usefulness' was 3.24 as the highest and 'seriousness' was 2.25 as the lowest. The periodic scaling and scaling cycle were associated with 'seriousness' and 'barrier' as positive correlation(p<.05, .01). On the other hand, they were associated with knowledge and 'usefulness' as negative correlation(p<.01). Meanwhile, scaling motive showed positive correlation with 'cue of action'(p<.01), showed negative correlation with knowledge(p<.01). In the correlation between knowledge about scaling and oral health belief, knowledge showed negative correlation with 'barrier'(p<.01) and showed positive correlation with 'usefulness'(p<.01). Finally, we need to advertise and manage the importance of scaling politically and makes people do the voluntary scaling in six-month intervals in order to keep the periodontal health of worker.

• The Bulletin of The Korean Astronomical Society
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• v.32 no.2
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• pp.24.2-24.2
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• 2007

• Communications of the Korean Mathematical Society
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• v.28 no.3
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• pp.433-447
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• 2013

In this paper, we calculate the number of points on elliptic curves $y^2=x^3+Ax$ over $F_{p^r}$ modulo 24. This is a generalization of [8], [9] and [16].

• Journal of Korean Biological Nursing Science
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• v.24 no.1
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• pp.58-66
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• 2022

Purpose: The purpose of this study was to identify the level of psychological insulin resistance and self-care activities and to evaluate the factors affecting self-care activities in patients with type 2 diabetes mellitus undergoing insulin therapy to provide basic data for the development of educational programs. Methods: Data were collected through the interviews using a structured questionnaire from August 29 to October 20, 2017, from the patients with type 2 diabetes mellitus visiting the Diabetes Mellitus Center at H-General Hospital in J-city. The subjects were 168 patients who had been being treated via self-injection for at least three months after the start of insulin therapy. Data analyses were conducted using t-test, ANOVA, Pearson's correlation coefficients, and stepwise multiple regression using the SAS WIN 9.2 program. Results: The mean score of psychological insulin resistance was 61.25 (range 19-95) and the mean score of self-care activities was 53.19 (range 18-90). Self-care activities were significantly different by gender (t = -2.94, p= .004), perceived health status (F= 7.00, p< .001), and hypoglycemia during the last three months (t= -2.47, p= .015). Negative correlation was observed between psychological insulin resistance and self-care activities (r= -.33, p< .001). Self-care activities were significantly predicted by psychological insulin resistance, perceived health status, gender, and hypoglycemia during the last three months, and 19.0% of the variance in self-care activities was explained (F= 9.01, p< .001). Conclusion: Psychological insulin resistance in patients undergoing insulin therapy and its effects on self-care activities identified in this study will be useful in starting and maintaining insulin therapy in the future.

• Journal of the Korean Dietetic Association
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• v.24 no.4
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• pp.283-297
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• 2018

The purpose of this study was to examine the relationships between the nutrient intake and level of depressive symptoms. A total of 5,761 subjects with depression were selected for the main data analysis from a Korean National Health and Nutrition Examination Survey, KNHANES (2016), and were divided into low depressed and high depressed groups. The data were analyzed by descriptive analysis, ${\chi}^2-test$, logistic regression, and t-test using SPSS 24.0 statistics. The results revealed significant differences in the prevalence of depression according to sex (P<0.001), age (P<0.001), income (P<0.001), and education (P<0.001). Regarding the health behavior, higher stress levels (P<0.001) and smoking habit (P<0.001) appeared to be strongly associated with high levels of depression. On the other hand, the possibility of experiencing depressive symptoms was lower when the number of walking days per week was more than 3 days (P<0.05), when the number of working days per week was more than 5 days (P<0.01), and the rate of aerobic physical activity was higher. Based on the 'Dietary Reference Intakes for Koreans 2015', the subjects in the low depression group showed better intake of energy and 22 nutrients than the high depression group.

• Journal of Korean Academy of Nursing
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• v.13 no.2
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• pp.70-86
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• 1983

The purpose of study carried out to determine the effect of informativeness influeucing the state-Anxiety of Hysterectomy patient, the relationship between Hysterectomy patient's general characteristics on State-Anxiety. and to investigation the cause of hysterectomy patient's Anxiety, the relationship between the cause of Anxiety and State-Anxiety. This stuad carried out between April 14. to May 24. 1983. This study sample consisted of 104 Hysterectomy patient who admitted to department of obstetrics of Seoul National University Hospital, Korea University Hospital, Han Yang University Hospital and Seung Nam Hospital. The Sample were divided into two groups; fifty two of experimental and fifty two of control group. The method used for the collection of data were set of information prepared by reseacher and state-Anxiety Inventory, The Questionnaire of state-Anxiety Inventory was made up 20 items. The data was analyzed by computer program. The results of the study were as follows. 1. There was shown state Anxiety to be alleviated by experimental group and control group. 2. There was significant relation between experimental group and control group. (p<0.01) 3. There was relation of state-Anxiety by education Level: Experimental group (p＜0.05) control group (p<0.05) religion : only control group (p＜0.05)economic state : only control group (p<0.05) The people who encouraged hysterectomy: Experimental group (p<0.05) control group (p＜0.0001) 4. The cause of preoperative anxiety about hysterectomy were as follows: 1) destruction of body image(=loss of uterus) 2) husband's attitude 3) Expactation that hysterectomy will adversely affect sexual relation 5. Among the cause of Anxiety, R²for state-Anxiety were as follows: 1) economic state 17.3% 2) deatch 21.6% 3) Expactation that hysterectomy will adversely affect sexual relation 24.5%.