• Journal of Korean Neurosurgical Society
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• v.46 no.4
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• pp.385-388
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• 2009

Objective : We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter in World Health Organization (WHO) grade III gliomas in association with other molecular markers to evaluate their prevalence. Methods : The samples of a total of 36 newly WHO grade III glioma patients including 19 anaplastic oligodendrogliomas (AO), 7 anaplastic oligoastrocytomas (AOA), and 10 anaplastic astrocytomas (AA) were analyzed. The methylation status of the MGMT gene promoter was confirmed by methylation-specific polymerase chain reaction. The 1p/19q chromosomal deletion status and EGFR amplification were assessed by Fluorescence In-Situ Hybridization. MGMT, EGFR, EGFRvlll, and p53 expression were analyzed by immunohistochemical staining. Results : The MGMT gene promoter was methylated in 32 (88.9%) and unmethylated in 4 (11.2%) Among them, all of the AO and AOA had methylated MGMT gene promoter without exception. Significant associations between MGMT gene promoter hypermethylation and 1p/19q deletion was observed (p=0.003). Other molecular markers failed to show significant associations between MGMT gene promoter statuses. Conclusion : There was extensive epigenetic silencing of MGMT gene in high grade gliomas with oligodendroglial component. Together with frequent 1p/19q co-deletion in oligodendroglial tumors, this may add plausible explanations supporting the relative favorable prognosis in oligodendroglial tumors compared with pure astrocytic tumors.

• Journal of Korean Neurosurgical Society
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• v.48 no.1
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• pp.14-19
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• 2010

Objective : Allelic losses or loss of heterozygosity (LOH) at many chromosomal loci have been found in the cells of meningiomas. The objective of this study was to evaluate LOH at several loci of different chromosomes (1p32, 17p13, 7q21, 7q31, and 22q13) in different grades of meningiomas. Methods : Forty surgical specimens were obtained and classified as benign, atypical, and anaplastic meningiomas. After DNA extraction, ten polymorphic microsatellite markers were used to detect LOH. Medical and surgical records, as well as pathologic findings, were reviewed retrospectively. Results : LOH at 1p32 was detected in 24%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. Whereas LOH at 7q21 was found in only one atypical meningioma. LOH at 7q31 was found in one benign meningioma and one atypical meningioma. LOH at 17p13 was detected in 4%, 40%, and 80% in benign, atypical, and anaplastic meningiomas, respectively. LOH at 22q13 was seen in 48%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. LOH results at 1p32 and 17p13 showed statistically significant differences between benign and non-benign meningiomas. Conclusion : LOH at 1p32 and 17p13 showed a strong correlation with tumor progression. On the other hand, LOH at 7q21 and 7q31 may not contribute to the development of the meningiomas.

• Journal of applied mathematics & informatics
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• v.12 no.1_2
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• pp.143-154
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• 2003

A finite group G is called (l, m, n)-generated, if it is a quotient group of the triangle group T(l, m, n) = 〈$\chi$, y, z│$\chi$$\^$l/ = y$\^$m/ = z$^n$ = $\chi$yz = 1〉. In [19], the question of finding all triples (l, m, n) such that non-abelian finite simple group are (l, m, n)-generated was posed. In this paper we partially answer this question for the sporadic group Ru. In fact, we prove that if p, q and r are prime divisors of │Ru│, where p < q < r and$.$(p, q) $\neq$ (2, 3), then Ru is (p, q, r)-generated.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.92-101
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• 2019

This study used the Q-method to derive the structure of subjective opinions and perceptions of university students about the behavior of food delivery agency service provided by staff not directly employed in restaurants. For this purpose, the Q factor analysis was performed using the PC QUANL program for the Q-sort, which consists of a statement card, a P-sample, and a classification process. The results were classified into three types. The factor names were set as the first type (N = 7): efficiency seeking type, the second type (N = 19): benefit seeking type, and the third type [(N = 6): cost-effectiveness seeking type. The characteristics of each type are Type 1:Types that recognize aspects that are efficient for both consumers and restaurants, Type 2: Types of recognizing aspects of being benefited from speed, convenience and benefit, Type 3: Although it contributes to labor cost savings, it appears to recognize price and quality aspects in the initial market, which is burdened by consumers. The purpose of this study is to derive the problems of food delivery agency service business according to the three types and to provide strategic implications for the development direction and improvement plan.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.57-60
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• 2020

순위다중패턴매칭문제는 길이가 n인 텍스트 T와 패턴들의 집합 P' = {P₁,P₂…,P_k}가 주어졌을 때, P'에 속하는 패턴들과 상대적인 순위가 일치하는 T의 모든 부분문자열들의 위치를 찾는 문제이다. P'에서 가장 짧은 패턴의 길이가 m, 가장 긴 패턴의 길이를 $\bar{m}$, 모든 패턴들의 길이의 합을 M, q개의 연속된 문자들을 q-그램이라 할 때, 기존에 텍스트의 핑거프린트를 이용하여 순위다중패턴매칭문제를 $O(q!+nqlogq+Mlog\bar{m}+nM)$ 시간에 해결하는 알고리즘이 제시되었다. 본 논문에서는 텍스트의 핑거프린트를 활용하여 O(max(q!,M,n))개의 스레드를 이용하여 순위다중패턴매칭문제를 평균적으로 $O(\bar{m}+qlogq+n/q!)$ 시간에 해결하는 병렬 구현 방법을 제시한다. 실험 결과, n = 1,000,000, k = 1,000, m = 5, q = 3일 때, 본 논문에서 제시하는 병렬 구현 방법은 기존의 순차 알고리즘보다 약 19.8배 빠르게 수행되었다.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.1
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• pp.40-43
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• 2005

This paper presents the minimization of the fuel cost by optimal allocation of P-Q generation in a three-bus sample system. Derivation of the system loss sensitivities by optimization technique is introduced. The loss sensitivities are substituted into the optimality conditions and the optimal P-Q allocation is computed to obtain the minimal fuel cost.

• Korean Journal of Radiology
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• v.22 no.2
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• pp.233-242
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• 2021

Objective: To evaluate the association of MRI features with the major genomic profiles and prognosis of World Health Organization grade III (G3) gliomas compared with those of glioblastomas (GBMs). Materials and Methods: We enrolled 76 G3 glioma and 155 GBM patients with pathologically confirmed disease who had pretreatment brain MRI and major genetic information of tumors. Qualitative and quantitative imaging features, including volumetrics and histogram parameters, such as normalized cerebral blood volume (nCBV), cerebral blood flow (nCBF), and apparent diffusion coefficient (nADC) were evaluated. The G3 gliomas were divided into three groups for the analysis: with this isocitrate dehydrogenase (IDH)-mutation, IDH mutation and a chromosome arm 1p/19q-codeleted (IDHmut1p/19qdel), IDH mutation, 1p/19q-nondeleted (IDHmut1p/19qnondel), and IDH wildtype (IDHwt). A prediction model for the genetic profiles of G3 gliomas was developed and validated on a separate cohort. Both the quantitative and qualitative imaging parameters and progression-free survival (PFS) of G3 gliomas were compared and survival analysis was performed. Moreover, the imaging parameters and PFS between IDHwt G3 gliomas and GBMs were compared. Results: IDHmut G3 gliomas showed a larger volume (p = 0.017), lower nCBF (p = 0.048), and higher nADC (p = 0.007) than IDHwt. Between the IDHmut tumors, IDHmut1p/19qdel G3 gliomas had higher nCBV (p = 0.024) and lower nADC (p = 0.002) than IDHmut1p/19qnondel G3 gliomas. Moreover, IDHmut1p/19qdel tumors had the best prognosis and IDHwt tumors had the worst prognosis among G3 gliomas (p < 0.001). PFS was significantly associated with the 95th percentile values of nCBV and nCBF in G3 gliomas. There was no significant difference in neither PFS nor imaging features between IDHwt G3 gliomas and IDHwt GBMs. Conclusion: We found significant differences in MRI features, including volumetrics, CBV, and ADC, in G3 gliomas, according to IDH mutation and 1p/19q codeletion status, which can be utilized for the prediction of genomic profiles and the prognosis of G3 glioma patients. The MRI signatures and prognosis of IDHwt G3 gliomas tend to follow those of IDHwt GBMs.

• Journal of Korea Entertainment Industry Association
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• v.15 no.8
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• pp.411-421
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• 2021

The purpose of the study was to identify the untact medical services campaign awareness in COVID-19 era using Q methodology. We used subjective analysis for this purpose and examined 1) what are the types of untact medical services campaign awareness? and 2) what are the homogeneous characteristics and implications between each type? We composed a Q concourse through interviews with university students to write Q statements, selected a P sample, and used Q-sort obtained from the sorting process to analyze it through Q-factor analysis in the PC QUANL program. Q methodology was used to examine the subjective tendency of untact medical services campaign awareness in COVID-19 era. As a result of the analysis, four types were identified. 1) Type 1 (N=7): Belief & official announcement type, 2) Type 2 (N=4): Governmental notice type, 3) Type 3 (N=3): Medical information public notice type, 4) Type 4 (N=2): Sympathetic information type. An insightful analysis was derived in that the analysis could identify factors in the schema of respondents related to untact medical services in COVID-19 era.

• Journal of Nutrition and Health
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• v.49 no.5
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• pp.367-377
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• 2016

Purpose: This study analyzed the degree of job stress and caffeine intake in workers in industrial positions in order to determine the relationships between job stress and caffeine intake. Methods: For this purpose, this study conducted a survey targeting 361 blue collar workers working for K manufacturing company, Gwangju. Results: The total score for job stress in subjects was $72.7{\pm}6.8points$/100points. According to job stress, subjects were categorized as follows: Q1 for the group who had the least stress; Q2 for the group who had little stress; Q3 for the group who had a lot of stress, and Q4 for the group who had the most stress. As for the effects of caffeine on health, 57.1% thought that caffeine is helpful and not harmful if taken properly while 17.3% responded that less caffeine consumption is better. Daily intake of caffeine according to stress was presented as: $172.0{\pm}85.3mg$ in Q1, $179.0{\pm}83.7mg$ in Q2, $187.9{\pm}81.4mg$ in Q3, and $214.2{\pm}147.3mg$ in Q4 (p < 0.05). The percentages of caffeine consumption compared to the daily safe limit in subjects were: $43.0{\pm}21.3$, $44.8{\pm}20.9$, $47.1{\pm}20.4$, and $53.6{\pm}36.8%$ in Q1, Q2, Q3, and Q4, respectively (p < 0.05). Adverse effects such as nausea or vomiting from caffeine were most common in Q4 (p < 0.05). Conclusion: As a result, higher stress in blue collar workers working for K manufacturing company was associated with more caffeine consumption. Groups with a lot of stress (Q4) consumed approximately 50% of daily safe limit of caffeine. Considering the results above, this study suggests that further research on more precise caffeine intake and its effects is needed.

• Journal of Internet Computing and Services
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• v.19 no.4
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• pp.107-121
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• 2018

The purpose of this study is to explore the present US consumer behavioral trends and various cognitive schema types for sharing economy frame and shared service. For this, by applying Q methodology, this paper theoretically defines three differentiated typologies of US consumer in a interpretive perspective. This study is in-depth focused on discovering and categorizing characteristics of a respondent's thinking structure called 'schemata'. According to the entire procedures of Q methodology, this paper analyzed Q-sorted data from twenty-four people in the basis of forty Q-samples (statements). Consequently, we discovered four consumer groups named as Type 1 'Socialsumer', Type 2 'Smarsumer', Type 3 'Researsumer'.