Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지
DOI QR코드

DOI QR Code

Loss of Heterozygosity at 1p, 7q, 17p, and 22q in Meningiomas

  • Chang, In-Sok (Department of Neurosurgery, Hallym University College of Medicine) ;
  • Cho, Byung-Moon (Department of Neurosurgery, Hallym University College of Medicine) ;
  • Moon, Seung-Myung (Department of Neurosurgery, Hallym University College of Medicine) ;
  • Park, Se-Hyuck (Department of Neurosurgery, Hallym University College of Medicine) ;
  • Oh, Sae-Moon (Department of Neurosurgery, Hallym University College of Medicine) ;
  • Cho, Seong-Jjn (Department of Pathology, Hallym University College of Medicine)
  • Received : 2010.02.03
  • Accepted : 2010.06.21
  • Published : 2010.07.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Allelic losses or loss of heterozygosity (LOH) at many chromosomal loci have been found in the cells of meningiomas. The objective of this study was to evaluate LOH at several loci of different chromosomes (1p32, 17p13, 7q21, 7q31, and 22q13) in different grades of meningiomas. Methods : Forty surgical specimens were obtained and classified as benign, atypical, and anaplastic meningiomas. After DNA extraction, ten polymorphic microsatellite markers were used to detect LOH. Medical and surgical records, as well as pathologic findings, were reviewed retrospectively. Results : LOH at 1p32 was detected in 24%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. Whereas LOH at 7q21 was found in only one atypical meningioma. LOH at 7q31 was found in one benign meningioma and one atypical meningioma. LOH at 17p13 was detected in 4%, 40%, and 80% in benign, atypical, and anaplastic meningiomas, respectively. LOH at 22q13 was seen in 48%, 60%, and 60% in benign, atypical, and anaplastic meningiomas, respectively. LOH results at 1p32 and 17p13 showed statistically significant differences between benign and non-benign meningiomas. Conclusion : LOH at 1p32 and 17p13 showed a strong correlation with tumor progression. On the other hand, LOH at 7q21 and 7q31 may not contribute to the development of the meningiomas.

Keywords

References

  1. Akagi K, Kurahashi H, Arita N, Hayakawa T, Monden M, Mori T, et al. : Deletion mapping of the long arm of chromosome 22 in human meningiomas. Int J Cancer 60 : 178-182, 1995 https://doi.org/10.1002/ijc.2910600208
  2. Arrieta O, Garcia E, Guevara P, Garcia-Navarrete R, Ondarza R, Rembao D, et al. : Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Cancer 94 : 3210-3218, 2002 https://doi.org/10.1002/cncr.10594
  3. Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, et al. : Scatter factor and hepatocyte growth factor : activities, properties, and mechanism. Cell Growth Differ 3 : 11-20, 1992
  4. Bozzetti C, Bortesi B, Merisio C : Loss of heterozygosity (LOH) in ovarian cancer. Int J Gynaecol Obstet 85 : 294-295, 2004 https://doi.org/10.1016/j.ijgo.2004.01.002
  5. Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, et al. : Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311 : 29-33, 1984 https://doi.org/10.1038/311029a0
  6. Hollstein M, Sidransky D, Vogelstein B, Harris CC : p53 mutations in human cancers. Science 253 : 49-53, 1991 https://doi.org/10.1126/science.1905840
  7. Jeffers M, Rong S, Vande Woude GF : Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16 : 1115-1125, 1996
  8. Karamitopoulou E, Perentes E, Diamantis I : p53 protein expression in central nervous system tumors : an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies. Acta Neuropathol (Berl) 85 : 611-616, 1993 https://doi.org/10.1007/BF00334670
  9. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW : Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51 : 6304-6311, 1991
  10. Kim JH, Lee SH, Rhee CH, Park SY, Lee JH : Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas. J Neurooncol 40 : 101-106, 1998 https://doi.org/10.1023/A:1006110812240
  11. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. : The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61 : 215-225; discussion 226-219, 2002
  12. Lee JY, Finkelstein S, Hamilton RL, Rekha R, King JT Jr, Omalu B : Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 55 : 1163-1173, 2004 https://doi.org/10.1227/01.NEU.0000141081.07086.A0
  13. Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Choi KS : Loss of heterozygosity on chromosome 10, 13, 17, and p53 gene mutation in human brain gliomas. J Korean Neurosurg Soc 22 : 537-550, 1993
  14. Leuraud P, Marie Y, Robin E, Huguet S, He J, Mokhtari K, et al. : Frequent loss of 1p32 region but no mutation of the p18 tumor suppressor gene in meningiomas. J Neurooncol 50 : 207-213, 2000 https://doi.org/10.1023/A:1006400723490
  15. Liu Y : The human hepatocyte growth factor receptor gene : complete structural organization and promoter characterization. Gene 215 : 159-169, 1998 https://doi.org/10.1016/S0378-1119(98)00264-9
  16. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. : The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 : 97-109, 2007 https://doi.org/10.1007/s00401-007-0243-4
  17. Martinez-Rumayor A, Arrieta O, Guevara P, Escobar E, Rembao D, Salina C, et al. : Coexpression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor cMET predict recurrence of meningiomas. Cancer Lett 213 : 117-124, 2004 https://doi.org/10.1016/j.canlet.2004.04.026
  18. Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K : Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 6 : 1313-1318, 1991
  19. Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R : Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev 13 : 41-59, 2002 https://doi.org/10.1016/S1359-6101(01)00029-6
  20. Moriyama T, Kataoka H, Kawano H, Yokogami K, Nakano S, Goya T, et al. : Comparative analysis of expression of hepatocyte growth factor and its receptor, c-met, in gliomas, meningiomas and schwannomas in humans. Cancer Lett 124 : 149-155, 1998 https://doi.org/10.1016/S0304-3835(97)00469-2
  21. Niedermayer I, Feiden W, Henn W, Steilen-Gimbel H, Steudel WI, Zang KD : Loss of alkaline phosphatase activity in meningiomas : a rapid histochemical technique indicating progression-associated deletion of a putative tumor suppressor gene on the distal part of the short arm of chromosome 1. J Neuropathol Exp Neurol 56 : 879-886, 1997 https://doi.org/10.1097/00005072-199708000-00006
  22. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, et al. : Mutations in the p53 gene occur in diverse human tumour types. Nature 342 : 705-708, 1989 https://doi.org/10.1038/342705a0
  23. Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P : p53 mutations in nonastrocytic human brain tumors. Cancer Res 51 : 6202-6205, 1991
  24. Park M, Dean M, Cooper CS, Schmidt M, O'Brien SJ, Blair DG, et al. : Mechanism of met oncogene activation. Cell 45 : 895-904, 1986 https://doi.org/10.1016/0092-8674(86)90564-7
  25. Patil SR, Merrick S, Lubs HA : Identification of each human chromosome with a modified Giemsa stain. Science 173 : 821-822, 1971 https://doi.org/10.1126/science.173.3999.821
  26. Pykett MJ, Landers J, George DL : Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas. J Neurooncol 32 : 39-44, 1997 https://doi.org/10.1023/A:1005779406636
  27. Riemenschneider MJ, Perry A, Reifenberger G : Histological classification and molecular genetics of meningiomas. Lancet Neurol 5 : 1045-1054, 2006 https://doi.org/10.1016/S1474-4422(06)70625-1
  28. Simon M, von Deimling A, Larson JJ, Wellenreuther R, Kaskel P, Waha A, et al. : Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas : a genetic model of meningioma progression. Cancer Res 55 : 4696-4701, 1995
  29. Sulman EP, Dumanski JP, White PS, Zhao H, Maris JM, Mathiesen T, et al. : Identification of a consistent region of allelic loss on 1p32 in meningiomas : correlation with increased morbidity. Cancer Res 58 : 3226-3230, 1998
  30. Ueki K, Wen-Bin C, Narita Y, Asai A, Kirino T : Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas. Cancer Res 59 : 5995-5998, 1999
  31. Weber RG, Bostrom J, Wolter M, Baudis M, Collins VP, Reifenberger G, et al. : Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas : toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A 94 : 14719-14724, 1997 https://doi.org/10.1073/pnas.94.26.14719
  32. Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, et al. : A second-generation linkage map of the human genome. Nature 359 : 794-801, 1992 https://doi.org/10.1038/359794a0
  33. Zankl H, Zang KD : Cytological and cytogenetical studies on brain tumors. 4. Identification of the missing G chromosome in human meningiomas as no. 22 by fluorescence technique. Humangenetik 14 : 167-169, 1972 https://doi.org/10.1007/BF00273305
  34. Zhou CZ, Qiu GQ, Zhang F, He L, Peng ZH : Loss of heterozygosity on chromosome 1 in sporadic colorectal carcinoma. World J Gastroenterol 10 : 1431-1435, 2004

Cited by

  1. The role of radiotherapy following gross-total resection of atypical meningiomas : Clinical article vol.117, pp.4, 2012, https://doi.org/10.3171/2012.7.jns112113
  2. Long-term survival analysis of atypical meningiomas: survival rates, prognostic factors, operative and radiotherapy treatment vol.156, pp.8, 2010, https://doi.org/10.1007/s00701-014-2156-z
  3. Masked hypodiploidy in anaplastic meningiomas by duplication of the original clone found in atypical meningiomas: Illustration of the evolution of genetic alterations vol.34, pp.4, 2014, https://doi.org/10.1111/neup.12112
  4. The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences vol.50, pp.6, 2010, https://doi.org/10.1016/j.pjnns.2016.07.001
  5. Genomic analysis of synchronous intracranial meningiomas with different histological grades vol.138, pp.1, 2018, https://doi.org/10.1007/s11060-018-2772-1