• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3304-3308
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• 2010

Condensation of 4-amino-5-mercapto-3-($\alpha$-naphthyl)-s-triazole (1) with cyanogen bromide gives 6-amino-3-($\alpha$-naphthyl)-s-triazolo[3,4-b]-1,3,4-thiadiazole (2) which on condensation with chloranil yields 3,9-di-($\alpha$-naphthyl)-6,14-dioxo-bis-(s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]cyclohexane]-5a,6a-diene) (3). 3-($\alpha$-naphthyl)-s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]quinoxaline (4) is obtained by a similar condensation of (2) with 2,3-dichloroquinoxaline. The reaction of (2) with $\alpha$-haloketones followed by bromination affords 7-aryl-3-($\alpha$-naphthyl)-imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles (5) and their 6-bromo analogues 6 respectively. The structures of all newly synthesized compounds were established on the basis of elemental analyses, IR, $^1H$-NMR. The antibacterial and antifungal activities of all newly synthesized compounds have also been evaluated.

• 한국동물위생학회지
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• 제23권1호
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• pp.1-8
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• 2000

This study was carried out to simultaneous determination of penicillin G and chloramphenicol in livestock products by HPLC. The results obstained were as follows; 1. Penicillin G and chloramphenicol were analyzed by HPLC on symmetry $C_{18}$ column with acetonitrile-0.1 M phosphate buffer containing 0.0157 M thiosulfate (25 : 75) as mobile phase at UV 325nm and 280nm, respectively. 2. Samples were applied to a SeP-Pak $C_{18}$ cartridge, from which eluted penicillin derivatized with 2 M 1,2,4-triazole containing 0.001 M mercuric chloride. 3. The average recovery rates of penicillin G and chloramphenicol were 81.8% and 80.3%, respectively, and the detection limits were 5 ppb (5$\mu\textrm{g}$/kg: 7.9IU/kg) for penicillin G and chloramphenicol in porcine and bovine muscle.

• 대한화학회지
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• 제57권6호
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• pp.755-760
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• 2013

The present study is synthesis of derivatives of N'-(4-amino-5-sulfanyl-4H-1,2,4-triazole-3-yl)-2-(1H-benzimidazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted by disc diffusion method. Compound $2MB_1$, $2MB_3$, $2MB_5$ inhibit the appreciable microbial growth while rest of the compound possess the moderate activities. Anti-inflammatory activity tested by reduces local edema induced in the rat paw by injection of phlogestic agent. Compound $2MB_1$, $2MB_8$, $2MB_5$, $2MB_3$ and $2MB_6$ exhibit satisfying anti-inflammatory activity while analgesic activity conducted by acetic acid induced writhing effect in mice while compound $2MB_1$, $2MB_4$ and $2MB_7$ having the good analgesic activity. The chemical structures of all newly synthesized compounds were confirmed by their IR, $^1H$ NMR and mass spectral data.

• Transactions on Electrical and Electronic Materials
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• 제12권2호
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• pp.80-83
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• 2011

We have fabricated phosphorescent white organic light-emitting devices (WOLEDs) with a spin-coated poly(Nvinylcarbazole) [PVK] host layer. Iridium(III) bis[(4,6-difluorophenyl)-pyridinato-N,$C^{2'}$]picolinate (FIrpic), tris(2-phenylpyridine)iridium(III) [$Ir(ppy)_3$], and tris(2-phenyl-1-quinoline)iridium(III) [$Ir(phq)_3$], were used as the blue, green, and red guest materials, respectively. The PVK was mixed with FIrpic, $Ir(ppy)_3$, and $Ir(phq)_3$ molecules in a chlorobenzene solution and spin-coated in order to prepare the emission layer; 3-(4-biphenylyl)-4-phenyl-5-(4-tertbutylphenyl)-1,2,4-triazole (TAZ) was used as an electron transport material. The resultant device structure was ITO/PVK:FIrpic:$Ir(ppy)_3:Ir(phq)_3$/TAZ/LiF/Al. The electroluminescence, efficiency, and electrical conduction characteristics of the WOLEDs based on the doped PVK host layer were investigated. The maximum current efficiency of the three wavelength WOLED with the doped PVK host was 19.2 cd/A.

• 한국작물학회지
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• 제33권3호
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• pp.292-297
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• 1988

기계이앙묘의 도장을 방지하고 묘소질의 향상을 꾀하며 이앙후 초기생육을 촉진시킬 수 있는 가능성을 검토하기 위하여 triazole 계의 GA생합성 억제제인 Uniconazole과 Pochlobutrazol 의 처리시험을 수행하였다. 각기 다른 처리시기 및 약량하에서 묘소질에 미치는 영향을 구명하고져 온실에서 검토한 결과를 요약하면 다음과 같다. 1. 초장단축효과로 본 약제간 활성은 Uniconazole이 높았으며, 초장단축요인은 주로 엽초의 신장억제에 기인되었다. 2. 파종전 토양혼화처리에서 파종후 30일까지 초장단축율이 경시적으로 증가하였으나 30일 후로는 감소하였으며 두 약제가 비슷한 양상을 나타내었다. 3. 처리시기별 초장단축효과는 처리시기가 빠를수록, 동일 처리시기에서는 약량이 증가할수록 높았다. 4. 건물중비율은 약제처리에 의해 낮아졌으며, 초장단축율과 묘충실도는 정의 상관관계가 있었다.

• Weed & Turfgrass Science
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• 제1권4호
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• pp.69-75
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• 2012

설부소립균핵병 방제를 위한 살균제 반응을 조사하기 위하여 Typhula incarnata 균주를 2012년 용평에 3곳 골프장에서 채집하여 propiconazole, tebuconazole 및 azoxystrobin 살균제에 대하여 감수성을 평가하였다. 50개의 균주에 대한 실내에서 감수성을 평가를 위하여 4개의 다른 농도로 수행하였다. 균사생장을 효과적으로 50%까지 억제하는 농도인 $EC_{50}$은 tebuconazole이 가장 낮았다. Triazole 계인 tebuconazole의 평균 $EC_{50}$은 0.0048 ${\mu}g\;ml^{-1}$이며, 최소 $EC_{50}$은 0.0005 ${\mu}g\;ml^{-1}$ 농도이며, 최대 $EC_{50}$의 농도는 0.014 ${\mu}g\;ml^{-1}$이었다. 반면, Propiconazole의 평균 $EC_{50}$은 0.5825 ${\mu}g\;ml^{-1}$이고, $EC_{50}$의 범위는 0.078 ${\mu}g\;ml^{-1}$에서 1.651 ${\mu}g\;ml^{-1}$이었다. Strobilurin 계인 azoxystrobin은 평균 $EC_{50}$은 0.0278 ${\mu}g\;ml^{-1}$이고, 최소와 최대 $EC_{50}$은 범위는 0.0017 ${\mu}g\;ml^{-1}$에서 0.131 ${\mu}g\;ml^{-1}$이었다. Propiconazole, azoxystrobin 및 tebuconazole 살균제간의 $EC_{50}$ 사이에 상관 관계가 나타나지 않았으며, 이들 균주와 이들 살균제 간에 교차저항성도 없었다. 이 연구 결과 용평에서 채집한 T. incarnata 균주는 3종의 살균제에 대하여 실내감수성 시험에서 저항성 균주가 없다는 것을 확인할 수 있었다.

• 한국재료학회지
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• 제18권4호
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• pp.199-203
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• 2008

High-efficiency phosphorescent organic light emitting diodes using TCTA-TAZ as a double host and $Ir(ppy)_3$ as a dopant were fabricated and their electro-luminescence properties were evaluated. The fabricated devices have the multi-layered organic structure of 2-TNATA/NPB/(TCTA-TAZ) : $Ir(ppy)_3$/BCP/SFC137 between an anode of ITO and a cathode of LiF/AL. In the device structure, 2-TNATA[4,4',4"-tris(2-naphthylphenyl-phenylamino)-triphenylamine] and NPB[N,N'-bis(1-naphthyl)-N,N'-diphenyl-1,1'-biphenyl-4,4'-diamine] were used as a hole injection layer and a hole transport layer, respectively. BCP [2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline] was introduced as a hole blocking layer and an electron transport layer, respectively. TCTA [4,4',4"-tris(N-carbazolyl)-triphenylamine] and TAZ [3-phenyl-4-(1-naphthyl)-5-phenyl-1,2,4-triazole] were sequentially deposited, forming a double host doped with $Ir(ppy)_3$ in the [TCTA-TAZ] : $Ir(ppy)_3$ region. Among devices with different thickness combinations of TCTA ($50\;{\AA}-200\;{\AA}$) and TAZ ($100\;{\AA}-250\;{\AA}$) within the confines of the total host thickness of $300\;{\AA}$ and an $Ir(ppy)_3$-doping concentration of 7%, the best electroluminescence characteristics were obtained in a device with $100\;{\AA}$-think TCTA and $200\;{\AA}$-thick TAZ. The $Ir(ppy)_3$ concentration in the doping range of 4%-10% in devices with an emissive layer of [TCTA ($100\;{\AA}$)-TAZ ($200\;{\AA}$)] : $Ir(ppy)_3$ gave rise to little difference in the luminance and current efficiency.

• 분석과학
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• 제16권6호
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• pp.483-487
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• 2003

Triazole 계의 대표적인 농약 중 하나인 amitrole (3-amino-1,2,4-triazole)은 널리 사용되고 있는 제초제로, 환경 중에 유입될 경우 지하수 및 지표수를 오염시킴으로써 궁극적으로 음용수의 오염까지 일으킬 수 있다. 이 물질은 물에 대한 용해도가 높은 반면, 유기 용매에 대한 용해도가 낮고 극성이 강하기 때문에 수질 시료로부터 추출하기 매우 어렵다. 본 연구에서는 수질 시료중의 amitrole을 GC/MS를 이용하여 ppb 수준 이하의 극미량까지 분석하기 위한 방법을 조사하였다. 10 mL의 수질 시료를 진공회전증발기로 완전히 증발시킨 후, isobutyl chloroformate (iso-BCF)를 사용하여 실온에서 15~20분간 반응시켜 유도체화 하였다. 그 결과, N-isobutoxycarbonyl amitrole derivative를 생성함으로써 GC/MS에서의 감도가 향상됨을 확인할 수 있었다. $1.0{\mu}g/L$, $10.0{\mu}g/L$ 및 $100.0{\mu}g/L$ 농도의 수질에서 본 분석방법의 회수율은 각각 98.0%, 94.9% 및 105.3%였고, RSD는 2.4%, 2.8% 및 1.5%였다. 10 mL의 수질 시료로부터 얻어진 검량선의 상관계수는 $0.1{\sim}100.0{\mu}g/L$의 농도 범위에서 0.997로 나타나 직선성이 우수하였으며, 검출한계는 $0.1{\mu}g/L$로 나타났다.

• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2491-2494
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• 2013

The effect of additives in an electrolyte solution on the conversion efficiency of a dye sensitized solar cell was investigated. A density functional theory (DFT) method was used to examine the physical and chemical properties of nitrogen-containing additives adsorbed on a $TiO_2$ surface. Our results show that additives which cause lower partial charges, higher Fermi level shifts, and greater adsorption energies tend to improve the performance of DSSCs. Steric effects that prevent energy losses due to electron recombination were also found to have a positive effect on the conversion efficiency. In this work, 3-amino-5-methylthio-1H-1,2,4-triazole (AMT) has been suggested as a better additive than the most popular additive, TBP, and verified with experiments.

• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.3943-3949
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• 2012

A series of aromatic hydrazides 3a-j were prepared by refluxing esters 2a-j with hydrazine hydrate in methanol, which were prepared by the esterification of 1a-j. Acetohydrazides 3a-j upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazate salts 4a-j, which on refluxing with hydrazine hydrate yielded substituted 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-j. The target compounds 6a-j were synthesized by condensing furan-3-carboxylic acid in the presence of polyphosphoric acid under reflux. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their urease, acetylcholine esterase inhibition, antioxidant and alkaline phosphatase inhibition activity. Almost all of the compounds 6a-j showed good to excellent activities against urease and acetylcholine esterase more than the reference drugs. Compounds 6f and 6g were more potent scavenger of free radicals than the reference n-propyl gallate. Compound 6b and 6h showed excellent activities of alkaline phosphatase as compare to the reference $KH_2PO_4$.