• Radiation Oncology Journal
• /
• v.21 no.2
• /
• pp.149-157
• /
• 2003

Purpose: The purpose of this study was to determine if there were prognostic differences between BRCA related and BRCA non-related Korean patients with early-onset breast carcinomas. Materials and Methods: Sixty women who had developed breast cancers before the age of 40, and who were treated at the Soonchunhyang University Hospital, were studied independently of their family histories. The age range was 18 to 40 with a median of 34.5 years. Lymphocyte specimens from peripheral blood were studied for the heterozygous mutations of BRCA1 and BRCA2 using direct sequencing methods. Immunohistochemistry was peformed on the paraffin-embedded tissue blocks that were available. Results: Eleven deleterious mutations (18.3%, 6 in BRCA1 and 5 in BRCA2) and 7 missense mutations of unknown significance (11.7%), were found among the 60 patients. More than half of the mutation were novel, and were not reported in the database. Most of the BRCA-associated patients had no history of breast cancer. No treatment related failures were observed in the BRCA carriers, with the exception of one patient that had experienced a new primary tumor of the contralateral breast. The seven year relapse free survival rate were 50 and 79% In the BRCA carrier and BRCA negative patients, respectively. Although the expression of estrogen and progesterone receptors were less common, and histological features more aggressive, in the BRCA associated tumors, the outcome of the patients with BRCA mutations was not poorer than that on the patients without deleterious mutations. Conclusion.: Despite the BRCA mutation carriers having adverse prognostic features, the recurrence rate was relatively lower than that in the BRCA non-carrying Korean patients wi4h early-onset breast carcinomas. In addition, although the prevalence of the BRCA mutation in Korean patients was higher than that in white patients, the penetrance of the cancer seemed to be relatively low in Korean women carrying BRCA mutations. A large population based study of the BRCA mutation, with a long-term follow-up of the study patients will be required to confirm these results.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.27 no.3
• /
• pp.419-430
• /
• 2000

The purpose of this study was to compare the microleakage pattern of preventive resin restoration using conventional composite resin and flowable composite resin that recently developed. 60 sound premolar teeth were allocated to three groups. Flowable composite resin was used for the experimental groups(Group I and II) and conventional resin for the control group(Group III). After composite filling and sealant application, all teeth were thermocycled and evaluated for microleakage under light microscope. Additionally, a variety of voids formed inside restorations were also evaluated. Data were analyzed statistically using Kruskal-Wallis test and/or Mann-Whitney U-test. The results of the present study were as follows. 1. Microleakage found in all samples was only limited to the interface of restoration margin and enamel. 2. The flowable composite resin groups (Group I, II) generally showed less microleakage than control groups (conventional preventive resin restoration) (p<0.05) 3. Various types of voids were observed in most specimens. Especially, there was a tendency for more and larger voids to be found in group I, II than group III (p<0.05).

• Journal of Korean Home Economics Education Association
• /
• v.18 no.3 s.41
• /
• pp.41-60
• /
• 2006

The system of teaching culinary practice needs drastic modification to catch up with dietary life and education curriculum changes. To reflect such changes, it is necessary to instill a strong will and interest as well as educational environment improvement in teachers. In this sense, this study researched the teachers' stages of concerns, levels of use, innovation configuration, and intervention demands, based on the CBAM(Concerns Based Adoption Method) developed by Hord et. al. For the survey, 500 questionnaires sent by mail and 187 were analyzed by SPSS/win 10.0 program. The results are summarized as follows. 1) The teachers stages of concerns on culinary practice is assessed to be in the lowest level of perceptual stage, which indicates a state of indifference. 2) In terms of the levels of use, routine use was the highest, followed by refinement use, integrated use, research use, and reinvent use in descending order. Mechanical use posted the lowest level. Even though the stages of concern showed the beginning stage, the Level of use was relatively high. 3) About the innovation configuration, approximately 30% of the teachers were not accomodate the culinary practice referred to the 7th National Education Curriculum. 4) According to the intervention demands on culinary practice education, it was found that teachers generally wanted more interventions in every component. Among the intervention components, the highest demand was on the support for facility. Demand on the financing is the second highest. Teachers in the level of routine use demanded more information and materials supply and individual encouragement, but teachers in the level of preparation needed study opportunity for training on operation skills more.

• Korean Journal of Environment and Ecology
• /
• v.27 no.1
• /
• pp.99-112
• /
• 2013

This study aims to show the changes of characteristics of vegetation structure for 20 years(1991~2010) in Naejangsan National Park. As a result of analysis of actual vegetation, the mixed community of Quercus variabilis and Quercus serrata was distributed with 56.1%, and Q. variabilis community showed in southern steep slope with 17.6%. Pinus densiflora community(5.8%) was observed on the ridge and Carpinu tschonoskii community distributed in the slope of the valley with 6.6%. Zelkova serrata and Prunus sargentii community were distributed in valley. The classification by TWINSPAN, ordination by DCA considering importance percentage and property of vegetation class were divided into 4 communities, which are community I(P. densiflora-Q. variabilis community), community II(Q. variabilis community), community III(C. tschonoskii community) and community IV(Mixed deciduous broad-leaved trees community). The age of Pinus densiflora was 32years old and Q. serrata was 36 years old in the community I, that of Q. variabilis was 64 years old in the community II, Q. serrata was 46 years old and C. tschonoskii was 45 years old in the community III, and Acer palmatum was 54 years old and Cornus controversa was 47 years old in the community IV. As the result of Shannon's index of species diversity, the community Iwas ranged from 0.9751 to 1.4199, community II was ranged from 1.0765 to 1.3278, community III was ranged from 1.0353 to 1.2881, and community IV was ranged from 1.1412 to 1.3807. The change of vegetation structure analyzed through the comparison with results of studies carried out 20 years ago were natural selection of P. densiflora, expansion of Quercus spp. and increase of C. tschonoskii. Especially, A. palmatum is dominated by Q. variabilis in canopy layer like the result of study 20 years ago. A. palmatum was analysed by 14.6% in the canopy layer of only mixed deciduous broad-leaved trees community. As a result of analysis of habitat property of Q. variabilis and A. palmatum, Q. variabilis was distributed in dry area with the low value of pH, O.M., exchangeable cations and Avail. P, and A. palmatum was located in the wet valley with huge value of nourishment. The tendency of reduction of bio-diversity by Sasa borealis is same as previous study but, the distributed areas were reduced in Naejangsan area.

• Journal of Sericultural and Entomological Science
• /
• v.14 no.2
• /
• pp.125-154
• /
• 1972

The major purpose of this survey is to collect the related information on technical aspects for solving the problems which are facing producing farmers and regions, provide scientific facts to farmers related personals and institutions and aimed at contributing the development of sericultural sector in Korea. The results are as follows; (1) The area of mulberry field per a farmer which was selected as sample ranges from 3.0 to 370a with its average 45. 1a. And yet, the average of new cultivated areas is above than that of ordinary ones by 56.3 to 33.8a. The largest area is Honam hill area with 101. 1a and e smallest is Muzinzang with 20.8a. Shortly, a large number of farmer belongs to 11 to 50a with 66.5 per cent. (2) The ratio of clay and loam soils which are inadequte for growing of mulberry trees is 28.3 per cent and particulary high in new cultivated area with 36.2 per cent. And yet, base soil is occupied with 45 per cent of heavy clay and particularly even 54.2 per cent in new cultivated area. On the other hand, the number of areas which the contents of organic matters is relatively low, with 48.2 per cent is near the half, but the ratio of mulberry fields which seems to contain organic matters abundantly is only 7.2 per cent. (3) The varieties of mulberry trees are Ilgirae, Gaeryangseoban, Suwonsang No.4 and Nosang. The ,ratio of the varieties are 33.3%, 25.7%, 18.0% and 10.5%, respectively. Consequently the four varieties enumerated above occupies 93.5 per cent. (4) The mulberry fields are almost composed of exclusive mulberry fields and its ratio was 92.3 per cent. The number of planted trees per 10a arrange from 480 to 1,390 and its average is 846. But most of them nearly belong to 701 to 1,000 with 91.3per cent. (5) The second year's autumn after planting is generally adopted as the first harvesting season, and its ratio is 73.0 per cent, but autumn of the years and next spring are not few, and its ratio are 12.7 and 8.7 per cent. The first harvesting method is relatively normal with 88.8 per cent of ratio. From the viewpoint of harvesting method, picking leaves was applied with 97.7 per cent of ratio in young larvae rearing and picking shoot and picking shoot after harvest with branches were applied with 80.0 per cent of ratio in grown larvae rearing. The ratio of applying the harvesting method of picking leaves were 97.7 and 91.7 per cent in young larva and grown larva in autumn rearings. But there was also picking leaves absolutely with 7.1 per cent of ratio(Chunwon was 47 per cent) and yet, the farmers applying cutting before shooting in spring was no more than 17.8 percent.

• Journal of Nutrition and Health
• /
• v.50 no.3
• /
• pp.246-256
• /
• 2017

Purpose: This study aimed to investigate the association of total dietary antioxidant capacity (TAC) with oxidative stress and metabolic markers among patients with metabolic syndrome according to gender. Methods: A total of 346 subjects aged 30~59 years with two or more risk factors of metabolic syndrome were recruited from a general hospital near Seoul in South Korea between 2010 and 2012 based on data from the medical checkup. Biochemical indices for oxidative stress and metabolic markers were measured. Food consumption data from 3-day food records were linked with the antioxidant capacity database for commonly consumed Korean foods to estimate individual's TAC. Results: Average dietary TAC of the study subjects was 132.0 mg VCE/d/1,000 kcal in men and 196.4 mg VCE/d/1,000 kcal in women. Levels of ${\gamma}$-glutamyltransferase (GGT), systolic blood pressure, diastolic blood pressure, and blood triglycerides were reduced significantly according to increasing TAC in men, but there was no significant trend in women. Intakes of total flavonoids and carotenoids were significantly negatively correlated with GGT (p < 0.05) and d-ROMs (p < 0.01) in men, whereas those of ${\alpha}$-tocopherol (p < 0.05) and ${\gamma}$-tocopherol (p < 0.05) were positively correlated with biological antioxidant potential (BAP) in women. The odds ratio of high oxidative stress indices and abnormal metabolic markers according to TAC level were not significant in either men or women. Conclusion: The results show that dietary TAC was partially associated with oxidative stress and metabolic markers among patients with metabolic syndrome. Further research is required for elucidating the association between dietary TAC and incidence of metabolic syndrome and chronic diseases within a large population in prospective studies.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.20 no.4
• /
• pp.348-356
• /
• 2018

Most of fires were human-caused fires in Korea, but meteorological factors are also big contributors to fire behavior and its spread. Thus, meteorological factors as well as topographical and forest factors were considered in the fire danger rating systems. This study aims to develop an advanced national integrated daily weather index(DWI) using weather data in the spring and fall to support forest fire prevention strategy in South Korea. DWI represents the meteorological characteristics, such as humidity (relative and effective), temperature and wind speed, and we integrated nine logistic regression models of the past into one national model. One national integrated model of the spring and fall is respectively $[1+{\exp}\{-(2.706+(0.088^*T_{mean})-(0.055^*Rh)-(0.023^*Eh)-(0.014^*W_{mean}))\}^{-1}]^{-1}$, $[1+{\exp}\{-(1.099+(0.117^*T_{mean})-(0.069^*Rh)-(0.182^*W_{mean}))\}^{-1}]^{-1}$ and all weather variables significantly (p<0.01) affected the probability of forest fire occurrence in the overall regions. The accuracy of the model in the spring and fall is respectively 71.7% and 86.9%. One integrated national model showed 10% higher accuracy than nine logistic regression models when it is applied weather data with 66 random sampling in forest fire event days. These findings would be necessary for the policy makers in the Republic of Korea for the prevention of forest fires.

• Journal of Korea Foundry Society
• /
• v.41 no.2
• /
• pp.144-152
• /
• 2021

Based on the analysis of the current state of the world's foundry industry, we looked at the international competitiveness of Korea's foundry industry for the past 20 years. Korea's total foundry production is 2.52 million tons, and the production per company (so-called productivity) is 2,831 tons, which is the eighth largest in the world and down one position for the case of total foundry production, while productivity remains its position compared to three years ago. Korea is the only one of the top 10 foundry to see a decline in production. Similar to the global situation, Korean products consist of 38% of grey csat iron, 31% of ductile cast iron, 15% of aluminum, and 9% of cast steel. In order to obtain statistics on Korea's foundry industry, the survey conducted a service project for approximately nine months from April 2020. Various statistical surveys and sample in-depth surveys by the Korean standard industry class were evaluated for various contents of the domestic casting industry. We also looked at the number of companies, the distribution by region, the number of workers and the percentage of foreigners, and the distribution of each job, as well as the R&D investment status according to the size of the enterprise. Together, sales, exports, sales and various profit ratios were analyzed to measure the earning power of foundry industry. In addition, the classification by grouping the foundry industry according to the process utilized by focusing on each company, and to determine the sales, exports, and yield status for each process was also investigated on the basis. Based on these data, the domestic foundry industry has presented a variety of offers for the following issues for sustainable growth; global ranking, marginal corporate restructuring, training of domestic technical people, differentiated support policies by company size and process.

• Korean Journal of Psychosomatic Medicine
• /
• v.28 no.2
• /
• pp.143-154
• /
• 2020

Objectives : The purpose of this study was to examine cognitive and psychological characteristics of patients with military service suitability issues compared to the general psychiatric outpatients. Methods : 108 patients who visited psychiatric clinic center due to military service suitability issues and 80 general psychiatric patients were recruited from the Department of Psychiatry of university hospital. ANCOVA and chi-equare test were used to examine differences between two groups. Furthermore, we utilized paired t-test to compare the scrore within military group depending on when they performed the psychological assessment. Results : There were no significant differences between military group and general outpatient group in WAIS-IV scores. However, military group scored remarkably higher than control group on validity scales, F-r and Fp-r whereas they scored lower on validity scale, K-r. Furthermore, military group showed significantly higher on BDI and MMPI-2-RF, EID, RCd, RC2, RC3, COG, HLP, SFD, NFC, STW, SAVE, SHY, DSF, NEGE-r, INTR-r. As a result of comparison within the military group following the periods of assessment, military group did not show the significant differences on the overall scales of MMPI-2-RF. Conclusions : The present study showed that military group tends to report their psychological distress more exaggeratedly. In addition, they had significantly elevated not only emotional distress such as depression and anxiety but interpersonal problem. The implications and limitations were discussed along with some suggestions for the future studies.

• Journal of Practical Agriculture & Fisheries Research
• /
• v.20 no.2
• /
• pp.57-72
• /
• 2018

In order to extract meaningful information from the excellent farming settlement cases of young farmers published by KNCAF, we studied the key words with text mining and created a word cloud for visualization. First, in the text mining results for the entire sample, the words 'CEO', 'corporate executive', 'think', 'self', 'start', 'mind', and 'effort' are the words with high frequency among the top 50 core words. Their ability to think, judge and push ahead with themselves is a result of showing that they have ability of to be managers or managers. And it is a expression of how they manages to achieve their dream without giving up their dream. The high frequency of words such as "father" and "parent" is due to the high ratio of parents' cooperation and succession. Also 'KNCAF', 'university', 'graduation' and 'study' are the results of their high educational awareness, and 'organic farming' and 'eco-friendly' are the result of the interest in eco-friendly agriculture. In addition, words related to the 6th industry such as 'sales' and 'experience' represent their efforts to revitalize farming and fishing villages. Meanwhile, 'internet', 'blog', 'online', 'SNS', 'ICT', 'composite' and 'smart' were not included in the top 50. However, the fact that these words were extracted without omission shows that young farmers are increasingly interested in the scientificization and high-tech of agriculture and fisheries Next, as a result of grouping the top 50 key words by crop, the words 'facilities' in livestock, vegetables and aquatic crops, the words 'equipment' and 'machine' in food crops were extracted as main words. 'Eco-friendly' and 'organic' appeared in vegetable crops and food crops, and 'organic' appeared in fruit crops. The 'worm' of eco-friendly farming method appeared in the food crops, and the 'certification', which means excellent agricultural and marine products, appeared only in the fishery crops. 'Production', which is related to '6th industry', appeared in all crops, 'processing' and 'distribution' appeared in the fruit crops, and 'experience' appeared in the vegetable crops, food crops and fruit crops. To visualize the extracted words by text mining, we created a word cloud with the entire samples and each crop sample. As a result, we were able to judge the meaning of excellent practices, which are unstructured text, by character size.