• Journal of Life Science
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• v.33 no.10
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• pp.767-775
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• 2023

Sulfasalazine is a disease-modifying antirheumatic abiotic agent. It is a derivative of aminosalicylic acid and has been used for the treatment of various inflammatory diseases, such as rheumatoid arthritis, ulcerative colitis, and Crohn's disease, since it was first synthesized in 1941 and approved as a medicine in the United States in 1950. However, its mechanism of action has not yet been clearly identified. In this study, the effects of sulfasalazine on cell survival, apoptosis, and cell cycle progression in macrophages, which are major immune cells that regulate inflammatory responses, were investigated using mouse macrophage RAW 264.7 cells. Sulfasalazine inhibited the viability of RAW 264.7 cells in a dose-dependent manner, starting at a concentration of 0.25 mM. Annexin-V staining was used to confirm that the decrease in cell viability was due to apoptosis, and the number of Annexin-V-positive cells increased significantly at a concentration of 0.25 mM or higher. The effect of sulfasalazine on the expression of key proteins that regulate the G0/G1 phase of the cell cycle was also investigated. Sulfasalazine treatment significantly increased the expression of the cyclin-dependent kinase inhibitors p21 and p27 in RAW 264.7 cells. Although sulfasalazine is frequently used as a control drug in studies on inflammatory diseases, such as inflammatory colitis and rheumatoid arthritis, studies on its effect on macrophages are very limited. Therefore, the results of this study are expected to provide vital information on the use of sulfasalazine as a disease treatment.

• Journal of Preventive Medicine and Public Health
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• v.22 no.4 s.28
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• pp.578-590
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• 1989

This study was conducted to assess the equity in the regional insurance scheme through analysis of the computerized data from one regional insurance society and National Federation of Medical Insurance. We analysed the insurance contribution and benefit by the classes based on total and income-related contribution per household. The major findings of this study are as follows : 1. The average proportion of income-related contribution among the total was 39.2% and the upper classes show higher proportion of the income-related contribution. 2. The upper classes show higher health care utilization rate than the lower classes. It suggests that the lower classes have relatively large unmet medical needs. 3. The analysis through the Lorenz curve reveals that there exists transference of contributions from the upper to lower classes. But the cumulative percentage of insurance benefit is smaller than that of the number of the insured. It implies that regional medical insurance scheme in Korea has still some inequity in the context of social security principles.

• Korean Journal of Environmental Agriculture
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• v.28 no.2
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• pp.194-201
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• 2009

To evaluate the exposure of non-point source pesticide pollution in agricultural watershed and to investigate pesticide distribution and runoff from agricultural land, paddy field, upland and orchard, this experiment was carry out during crop growing seasons. The pesticide were detected twenty pesticides fungicide 4, insecticide 10, herbicide 6) in water of Neungchon agricultural watershed and detection concentrations were range 0.008${\sim}$7.59 ppb. Most of the detection pesticides were using pesticides to rice paddy fields to control fungi, insects, weeds. During the crop cultivation, the pesticide were detected total thirty pesticides by pepper field soil 6, orchard soil 4, sesame field soil 3 and rice paddy field soil 5, and pesticide concentrations were range 0.001${\sim}$0.109 ppm. Especially the herbicides were detected mainly in May and June in the stream water. The pesticide were detected thirty pesticides by fungicide 2, insecticide 6, herbicide 5 in water of Jungam Koseong agricultural watershed and detection concentrations were range 0.01${\sim}$7.21 ppb. In regard to the detected pesticides, the concentration of individual pesticides measured in surface water of the study areas never exceeded guidelines for agriculture chemicals concerning water quality-effluent from paddy fields in Japan (Katayama, 2003). Runoff rate of pesticides was range 0.07${\sim}$3.06 % from Kongju agricultural land to watershed after applied pesticides.

• Archives of design research
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• v.16 no.3
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• pp.15-22
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• 2003

At public spaces, signs have purposes of communicating their information clearly. Especially directional signs point out the proper route showing our surroundings. The present directional signs which are indicating 3-dimensional direction in a 2-dimensional mode seem to be difficult to understand as we are moving. This study has the purpose of investigating the role of present signs and suggesting visually effective directional signs, in particular arrows. Firstly, this study surveyed the user's attitude on directional signs in case of subway station. The research shows that the present directional signs hardly perform their roles to communicate the directional information, which means the need of newly expressed arrows. In this study we consider a new effective expression on the viewpoint of human cognition mechanism. So it is thought that those trials are helpful to efficient sign system.

• Journal of Energy Engineering
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• v.5 no.2
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• pp.123-130
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• 1996

Reduction, sulfidation, and regeneration reactions were performed using domestic and Australian iron ore in order to develop a desulfurizing sorbent for the high temperature desulfurization process that is one of major processes in the integrated coal gasification combined cycle (IGCC) system. A TGA (Thermogravimetric Analysis) reactor and a fixed-bed reactor were used. Some basic kinetic information was obtained from BET surface area measurements, SEM photos, cyclic reactions, reaction temperature changes and TGA curves of the sorbents. The rates of both desulfurization and regeneration increased with increasing reaction temperature in the range of 500-700$^{\circ}C$.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.593-597
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• 2003

As construction projects are complicated and large in scale, a collaboration between project participants is getting more emphasized over the last few years. The collaboration tools for participants are various. but traditionally drawings and specifications have played an important role. Especially, though storage form in drawings vary in entire construction lifecycle, drawings are still important as the core factor in latest information technology streams in regard to usefulness and reusability of information. As an attempt to standardize drawings in the public construction based on CALS/EC, this study analyzes user's requirements for drawings qualitatively, and looks into drawings standards in Korea, America and Japan, and each kind of ISO standard for drawings. And this study predicts future-oriented user's requirement for drawings based on Construction CALS/EC, and presents future-oriented direction of development applicable in domestic drawing standard in construction.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.05a
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• pp.115-128
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• 2017

국가연구개발사업은 35개 부처, 약 18.9조 원(미래부 KISTEP, 2016)에 달하며, 이러한 규모의 R&D 활동을 위해 대부분의 국가연구개발사업은 연구관리전문기관에 의한 위탁관리 형태로 추진되고 있다. 위탁관리 형태 중 하나로 볼 수 있는 사업단은 신규 대형 사업의 경우 거의 관행적으로 설립하는 경향이 있어 그 수가 증가 중인 것으로 추정되나, 그나마 드물게 수행되고 있는 국가연구개발사업 관리체계에 대한 조사나 정책 수립은 연구관리전문기관 위주로 이루어지고 있다. 이에 따라 국가연구개발사업에서 주요한 역할을 수행 중인 사업단의 현황과 운영 실태를 파악하고자 사업단의 설립형태와 기능 등 설치현황, 운영비와 인력 등 운영현황, 사업단 운영의 애로사항 등을 조사 분석 하였다. 2014년 기준으로 조사가 가능한 사업단은 모두 63개였으며, 사업단 총 인력규모와 관리하는 사업의 전체 예산 규모는 연구관리혁신협의회 11개 회원 연구관리전문기관 대비 인력규모는 2번째(17.8%), 예산은 5번째(8%) 수준이었다. 사업단의 독립법인 여부, 연구수행 여부 등 형태 기능의 특징은 다양하게 나타났으며, 사업단 기획평가관리비는 평균 5.6억 원으로 사업비 대비 비중의 평균은 6.3% 수준이었다. 사업단 운영의 애로사항으로는 계획된 예산의 적기 지원과 운영비 규정의 혼란 등이 대표적으로 도출되었다. 본고에서는 그간 선행연구와 조사 분석이 거의 이루어지지 않았던 국가연구개발사업 사업단에 대한 기본적인 실태와 현황, 이들이 직면하고 있는 다양한 문제점과 애로사항에 대해 파악하였다. 조사 분석 결과 효과적인 사업단 설립과 운영을 위해서는 적절한 가이드라인과 제도개선이 필요할 것으로 보인다. 다양한 사업단 운영 사례 분석과 연구를 통해 효율적인 사업단 조직체계와 설립형태, 적절한 운영비 제도 등을 제시해 줄 수 있다면 향후 사업단 체제와 대형 국가연구개발사업의 효과적인 추진과 관리에 도움이 될 것이다.

• Tuberculosis and Respiratory Diseases
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• v.65 no.5
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• pp.426-429
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• 2008

Neurogenic tumors are common in posterior mediastinal tumors and neurilemmoma represents approximately 40% of neurogenic tumors arising in the mediastinum. It is usually asymptomatic, and is generally diagnosed incidentally. In some cases, they presented with symptoms of nerve or airway compression. However, a solitary neurilemmoma, particularly not associated with von Recklinghausen disease, with spontaneous hemothorax is quite rare. We report a case of spontaneous massive hemothorax associated with a solitary neurilemmoma.

• The Korean Journal of Food And Nutrition
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• v.33 no.3
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• pp.322-330
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• 2020

The purpose of this study was to investigate the comparison of nutrient intake and metabolic syndrome between single person households and non-single person households in elderly subjects. We analyzed data from 2,903 subjects ≥ age 65 who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) 2013~2015. As a result, single-person households had lower income and economic ability, overall nutrient intake was deteriorated, and the proportion of high-carbohydrate intake was high, compared to non-single person households. After adjusting for potential confounders (sex, age, education, household income, economic activity, smoking status, alcohol consumption, walking frequency, health status, depression status, and dietary factors), the single-person household showed a tendency of 1.22-fold higher ORs of metabolic syndrome and 1.3-fold higher ORs of hypertriglyceridemia than the non-single-person household. We suggest that the single-person household may be associated with increased prevalence of metabolic syndrome and hypertriglyceridemia in the elderly subjects.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.4
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• pp.312-317
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• 2005

The objectives of this paper are to study the absorption characteristics of $NH_3$ bubbles in the binary nanofluids and to quantify the effects of surfactants and nano-particles on the bubble absorption performance. 2-Ethyl-1-Hexanol, n-Octanol, and 2-Octanol are used as the surfactants and nano-sized $Al_{2}O_3$ and Cu particles are added to make the binary nanofluids into $NH_3/H_{2}O$ solution. The concentration of $NH_3$ solution ($x_s$), the concentration of surfactants ($x_{SA}$), and the mass fraction of nano-particles ($w_{np}$) are considered as key parameters. The experimented ranges of $x_s,\;x_{SA},\;and\;w_{np}$ are $0{\sim}17.92\%,\;0{\sim}1,500\;ppm\;and\;0{\sim}0.2\%$, respectively. The absorption rates are calculated by measuring initial and final weights of test section and exposed time. In addition, the bubble absorption processes are visualized using the shadow graphic method. The results show that the absorption performance is significantly enhanced up to 4 times by adding the surfactants and up to 3 times in the binary nanofluids.