• Journal of Life Science
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• v.24 no.3
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• pp.323-328
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• 2014

MicroRNAs comprise a family of small noncoding RNAs that modulate physiological processes, including adipogenesis. MicroRNA-17 (miR-17) promotes adipocyte differentiation and enhances lipid accumulation. The transcriptional regulation of miR-17 during adipogenesis remains unknown. In this study, we investigated whether miR-17 is a target of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), which is a key regulator of adipogenesis. The levels of miR-17 and the expression of $PPAR{\gamma}$ increased after the induction of adipocyte differentiation. Three putative peroxisome proliferator response elements (PPREs) were identified in the miR-17 promoter region. Using chromatin immunoprecipitation and luciferase reporter assays, we observed the interaction of $PPAR{\gamma}$ with the miR-17 promoter. Mutagenesis experiments showed that the -677/-655 region of the miR-17 promoter could function as a PPRE site. These results suggest that $PPAR{\gamma}$ is essential for transcriptional activation of the miR-17 gene, thereby contributing to understanding the molecular mechanism of adipogenesis in adipocytes.

• Korean Journal of Heritage: History & Science
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• v.56 no.2
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• pp.12-26
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• 2023

Recently, 『Gyeongja(庚子)/Daetongryeok(大統曆)』(1600), a memorandum record of Yu Seong-ryong during the reign of King Seonjo(宣祖) of the Joseon Dynasty, was returned to Korea from Japan, and about 4,000 letters in cursive characters have been interpreted by Ro Seung-suk. The contents for 203 days written in the margin of 『Gyeongja(庚子)/Daetongryeok(大統曆)』 are mostly new, and are meaningful in understanding Yu's life and social association circumstances. There are daily routines of each day, contemporary figures, diseases and oriental medicine prescriptions. In particular, the combat record of Admiral Yi Sun-shin in 83 letters on the cover is very important to understand the situation in those days. It seems that the reason for writing the combat situations a year and a few months after Admiral Yi died in war was to honor his distinguished military service for a long time by King Seonjo's order according to the public opinion of the royal court. The record can be classified into two categories. First, Admiral Yi sighed when he heard about Yu's dismissal from the office in Gogeumdo, and was always alert with clear water on the boat after the Battle of Waekyo Castle. Second, he was killed by bullets shot by the enemy while directly encouraging battle, not listening to his men who tried to dissuade him from leading the naval battle at Noryang. This only contained contents of devoting his life desperately, which is an important proof of the theory of his death in war. It also contains nine methods for making liquor and another method that wasn't known to the public, and seems to include popular alcohol brewing methods or newly devised ones. In addition, there is a detail that Heo Jun, the author of 『Donguibogam』, introduced medicine to Yu, along with being unable to attend ancestral rites and relieving the poor written in red. There are also stories about Kang Hang(姜沆) returning to Korea after being captured by Japan and Lee Deok-hong(李德弘)'s son, who introduced Gugapseondo(龜甲船圖, the first picture of the Turtle Ship in Korea) to King Seonjo. In the light of the above, 『Gyeongja(庚子)/Daetongryeok(大統曆)』is an important historical record to empirically research not only figures related to Yu but also the circumstances of those days since it contains new facts that are not in the existing literature. In particular, the big accomplishment of this study is to correct the mistakenly known theory of Admiral Yi's suicide and to find out the new fact that Heo Jun provided medical information. In this respect, this book is expected to serve as a testament to the future study of the history and characters related to Yu in the mid-Joseon period.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.1
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• pp.49-58
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• 2011

Among the various ERP solutions, SAP R/3 solution has been chosen because SAP system follows global standard processes which include most of business solutions for various industries. The ERP education is limited by learning theory only and they are not sufficient for understanding wide scale of business processes. Real world scenarios with hands on experience approach will be the core aspect of this article. As per real world scenarios, "ChungBuk Motors. Corp." has been created and students are asked to create the organization structure and the procurement process for this virtual enterprise. As a result, students attending this class showed better understanding of overall ERP system comparing to the students attended other ERP classes. The hands-on experience with real-world scenarios proved that it is most practical and efficient solution for educating ERP system.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.235-239
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• 2010

MicroRNA는 RNA로 전사된 유전자와의 상보결합을 통해 유전자 발현을 억제하는 조절인자이다. MicroRNA 생성과정에서 pre-microRNA의 3' 또는 5' 부근의 strand가 선택되어 mature 시퀀스가 되고 유전자 조절에 직접 작용하게 된다. 하지만 어떤 특징을 가진 strand가 선택 되는지에 대한 정확한 메커니즘은 아직 연구되어 있지 않다. 본 논문에서는 microRNA 시퀀스 정보를 바탕으로 하이퍼망을 구성하여 strand 선택 예측 모델을 구축하였다. 실험 결과 하이퍼망 학습을 통해 microRNA strand 선택에 중요한 영향을 미치는 시퀀스 특징을 찾을 수 있었고, strand 선택을 높은 정확도로 예측할 수 있음을 확인하였다.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.05b
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• pp.163-166
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• 2003

현재 XML은 전자상거래와 기업간 정보유통 및 전사적 기업 관리 시스템에 주로 적용되고 있으며 이를 위해서 XML 데이터를 효율적으로 처리할 수 있는 XML DBMS 관련 제품들이 시장에 빠르게 구현되고 있다. 이러한 XML 문서의 이용은 Mobile 환경으로 이동하면서 온라인 비즈니스와 동일한 환경 구축을 위해 모바일 비즈니스에서의 사용범위가 확대되어 가고 있으며, 많은 XML 문서의 효율적 관리를 위해서 모바일 전용의 DBMS에 XML 문서의 저장이 요구되고 있다. 본 논문은 이동 단말기에 XML 문서를 저장하기 위한 XML DBMS를 개발하였다. 기존의 모바일 DBMS에 대해 XML Adapter를 탑재하여 이동 단말기에 직접 XML 문서를 저장할 수 있도록 함으로써 표준 언어인 XML 문서의 활용을 극대화 하도록 하였으며, 이에 따라 기존의 Mobile DBMS를 이용하여 XML 데이터를 쉽게 조작할 수 있고, 이동 단말기에 대한 활용도를 극대화 할 수 있다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.158-161
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• 2023

스마트팩토리는 기존 제조산업과 ICT(Information & Communication Technology)가 융합된 지능형 공장이다. 이는 직접적인 제조공정 과정이 수행되는 OT(Operational Technology) 영역(0~3계층)과 전사업무 관리를 수행하는 IT(Information Technology) 영역(4~5계층)으로 구분되며, 각 영역과 계층이 연결되어 제조·물류·유통 과정의 자동화 및 지능화를 제공한다. 그러나 각 영역과 계층이 연결됨에 따라 보안위협 벡터가 증가하고 있으며, 다영역·다계층 환경인 스마트팩토리에 적합한 대응체계 연구를 위해 영역별 보안위협 관련 데이터를 통합하여 처리 및 관리하는 아키텍처 연구가 필요한 실정이다. 이에 따라 본 논문에서는 스마트팩토리 환경 내 IT 및 OT 영역 장치를 식별하고 보안위협 관련 데이터 통합 처리 및 관리를 위한 아키텍처를 제안한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.333-336
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• 2024

스마트팩토리는 기존 제조산업에 ICT 기술이 융합된 지능형 공장이다. 이는 IT(Information Technology)영역과 OT(Operation Technology)으로 구분되고, 영역 간 연결을 통해 제조공정 자동화 및 지능화를 수행한다. IT영역은 외부 네트워크와 연결되어 스마트팩토리의 전사업무 관리를 수행하며, OT영역은 폐쇄망 네트워크로 구성되어 직접적인 제조과정을 수행한다. 이는 2개의 영역으로 구분되어 자동화 및 지능화된 제조공정 과정을 수행함에 따라 구조가 복잡해지고 있으며, 이로 인해 스마트팩토리 보안위협이 발생 가능한 공격 표면이 증가하고 있다. 이에 대응하기 위해서는 스마트팩토리 IT영역과 OT영역의 특징을 분석하고, 영역별 적합한 보안위협 대응체계를 수립해야 한다. 이에 따라, 본 논문에서는 다수의 장치에 대한 학습이 용이하고, 세부적으로 학습기법을 구분할 수 있는 연합학습을 활용하여 스마트팩토리 영역별 적합한 보안위협 대응방안을 제안한다.

• Korean Journal of Environmental Agriculture
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• v.38 no.4
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• pp.296-306
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• 2019

BACKGROUND: Temperature is known to be the main factor affecting development, growth and reproduction of organisms and also a physical factor directly related to insect survival. Insects as ectothermal species should be responsive to climate changes for their survival and develop various survival strategies under the unfavorable temperature such as low temperature. The purpose of this study is to identify genes contributing to adaptation of low temperature. METHODS AND RESULTS: To identify genes contributing to adaptation of low temperature, the transcriptomic data were obtained from fat body in Plutella xyostella larvae via next generation sequencing. We identified structural proteins, heat shock proteins, antioxidant enzymes, detoxification proteins, and cryoprotectant mobilization and biosynthesis-related proteins. Genes encoding chitinase, cuticular protein, Hsp23, chytochrome protein, Glutathione S transferase, and phospholipase 2 were up-regulated under low temperature. Proteins related to energy metabolism such as UDP-glycosy ltransferase, trehalase and trehalose transporter were down-regulated. CONCLUSION: When insect pests were exposed to low temperature, changes in gene expression of fat body could provide some hints for understanding temperature adaptation strategies.

• The Journal of the Korea Contents Association
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• v.13 no.8
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• pp.466-473
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• 2013

Gene expression is regulated by a wide range of mechanisms at the DNA sequence level. In addition, gene expression is also regulated by epigenetic mechanisms through DNA methylation, histone modification, and ncRNA. To understand the regulation of gene expression at the epigenetic level, we constructed aging related gene database and analyzed epigenetic properties that are focused on DNA methylation. The DNA methylation of promoter or upstream region of the genes induces to repress the gene expression. We compared and analyzed distribution between whole human genes and aging related genes in the epigenetic properties such as CGI distribution, methylation motif pattern, and TFBS (transcription factor binding site) distribution. In contrast to methylation motif pattern, CGI and TFBS distributions are positively correlated with epigenetic regulation of aging related gene expression. In this study, the epigenetic data about DNA methylation of the aging genes will provide us to understand phenomena of the aging and epigenetic mechanism for regulation of aging related genes.

• The Journal of Information Technology
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• v.5 no.3
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• pp.81-96
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• 2002

Recently business reengineering is the most attractive management reforming skill. Many of the Korean firms are paying attention to business reengineering and many of them have initiated it. The major purposes of this study are; (1) to investigate the relationship between each variable and success or failure of business reengineering, and (2) to examine interaction effects of measurement and performation variables. Two hundred eighteen questionaires were used for analysis. In order to throughout studies that I executed earlier. To look for dependence of critical success factors on analysis was performed to examine patterns between measurement and performance variables. In conclusion, the hypothesized relationships in the research model are supported by the empirical findings of this study. Additionally it is possible to establish theoretical reference system on the basis of critical success factors.