• Journal of Life Science
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• v.23 no.4
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• pp.471-478
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• 2013

Human adipose tissue-derived mesenchymal stem cells (hADSCs) have therapeutic potential, including the ability to self-renew and differentiate into multiple lineages. Understanding of molecular mechanisms of stem cell differentiation is important for improving the therapeutic efficacies of stem cell transplantation. In this study, we determined the role of nuclear factor of activated T cells (NFAT5) in the osteogenic differentiation of hADSCs. The down-regulation of NFAT5 expression by the transfection of a specific siRNA significantly inhibited osteogenic differentiation of hADSCs and decreased the activity of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$) promoter without affecting their proliferation and adipogenic differentiation. The inhibition of NFAT5 expression inhibited the basal and Tumor Necrosis Factor ${\alpha}$ (TNF-${\alpha}$) induced activation of NF-${\kappa}B$, but it did not affect TNF-${\alpha}$-induced degradation of the $I{\kappa}B$ protein. These findings indicate that NFAT5 plays an important role in the osteogenic differentiation of hADSCs through the modulation of the NF-${\kappa}B$ pathway.

• Science of Emotion and Sensibility
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• v.26 no.3
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• pp.41-52
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• 2023

The purpose of this study was to determine the effects of resilience on information processing. Thirty-nine male high school students were randomly selected and assigned to one of the three experimental groups: (1) high group (n = 13), (2) middle group (n = 13) and low group (n = 13) according to their resilience scale (KRQ-53) scores. The tasks were simple reaction time, choice reaction time-1, and choice reaction time -2. Electroencephalogram (EEG) was measured at Fp1, Fp2, F3, F4, Fz, Cz and Pz. A 3 × 8 × 4 (groups × areas × times) ANOVA with repeated measures on the last factor was calculated to determine resilience effects on EEG. P300 was analyzed using a 3 × 3 × 8 (groups × tasks × areas) ANOVA. The results showed that the theta waves of the middle group were higher than those of the high and low groups. Second, as a result of analyzing alpha waves, the high group demonstrated higher alpha waves than the middle and low groups. Third, the mid-beta waves of the middle and low groups were higher than those of the high group. Lastly, the result of this study showed that the P300 amplitude of the middle group was higher than that of the high and low groups. These results indicated that the middle group processed cognitive information more efficiently than the other two groups. The findings of this study demonstrated that cognitive information processing ability varies depending on the degree of resilience.

• Pediatric Infection and Vaccine
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• v.26 no.1
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• pp.42-50
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• 2019

Purpose: We investigated the clinical features and epidemiology of staphylococcal scalded skin syndrome (SSSS) from year 2006 to 2015 in Changwon city, Korea. Methods: We reviewed medical records of 69 patients diagnosed with SSSS from year 2006 to 2015. Antibiotic susceptibility testing was performed by agar dilution method. Methicillinresistant Staphylococcus aureus (MRSA) was phenotypically identified by oxacillin susceptibility testing and genotypically confirmed by the existence of the mecA gene. Results: The median age of patients was 2.0 years (range 0.2-6 years). Three (4.3%), 53 (76.8%), and 13 (18.9%) patients showed the generalized type, the intermediate type, and the abortive type, respectively. Patients occurred throughout the year, but most patients occurred between July and October. MRSA was isolated from 54 of the 60 patients regardless of the clinical types. All patients recovered without any complications. Conclusions: There was a constant occurrence of SSSS patients caused by MRSA in Changwon area during 2006 and 2015. It is needed to constantly monitor the occurrence of patients with SSSS.

• Aerospace Engineering and Technology
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• v.1 no.2
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• pp.83-90
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• 2002

This paper describes the development of scientific payload system onboard the KSR-III. The ozone detector(UVR), Langmuir electron probe(LEP), airglow photometer(AGP), and magnetometer(MAG) constitute this system. The purpose of the ozone detector is to measure the ozone density profile and the LEP measures the electron density and temperature in the ionosphere over the Korean Peninsula. The AGP detects airglow in the mesosphere over the Korean Peninsular. The MAG provides rocket attitude and the magnetic fluctuation information during the flight. With the developed payloads, the ground calibration tests and the environmental tests have been performed.

• The Magazine of the IEIE
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• v.28 no.3
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• pp.30-42
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• 2001

초소형의 전자 부품, 의료기기 및 광부품 등의 핵심부품들에 관한 산업계와 소비자의 욕구에 발맞추어 과학 기술의 진보가 요구되고 있다. 전통적인 금속 가공 방법과 MEMS와 같은 미세 부품 성형 방법의 중간적인 형태의 Milli-Structure 생산 기술은 근간의 추이에 발맞추어 차세대 국가경쟁력 강화를 위한 핵심기술로 주목받고 있다. 본 논문에서는 미세 부품 성형에 관련하여 국외 개발 동향을 검토하고 국내의 연구 상황을 본 연구팀의 연구를 위주로 하여 미세 소성 가공과 미세 기계 가공으로 분류하여 검토해 보기로 한다.

• Defense and Technology
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• no.1 s.263
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• pp.22-29
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• 2001

국방부는 기초연구의 체계적이고 효율적인 수행을 위해 대학 및 정부출연연구소에 5개의 특화연구센터를 지정하여 운용하고 있다. 특화연구센터의 운영은 날로 심화되는 선진국의 기술패권주의를 극복하고 미래의 첨단 방산장비 소요에 대비할 수 있는 핵심기술의 신속한 개발에 결정적인 촉매가 될 것으로 기대된다. 더욱이 1994년 설립된 자동제어, 전자광학, 전자파 특화연구센터는 지난해 2단계 연구개발 목표를 마치고 올해부터 3단계 목표를 수행하게 된다. 따라서 창간 기념 특별 기획으로 그 동안 특화연구센터의 활동을 중간 점검해 보고 앞으로의 추진 일정을 살펴보는 기회를 마련하였다.

• Bulletin of the Korean Space Science Society
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• 2007.04a
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• pp.63-63
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• 2007

• 발명특허
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• v.5 no.11 s.57
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• pp.18-20
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• 1980

코페르니쿠스의 보수적요소를 거부하고 근본적으로 태양중심체계를 바꾸어 놓은 것은 케플러 (Gohannes Kepler, 1571-1630)였다. 그는 튀빙엔에서 신학을 공부했으나 천문학으로 관심을 돌렸다. 그에게 천문학을 가르친 매스틀린(Mastlin)은 지구중심우주체계를 강의했지만 사석에서는 코페르니쿠스가 맞는다고 했다. 그래서 케플러는 이미 학생시절에 열렬한 코페르니쿠스주의자가 되어 있었다. 케플러는 루터파 신교도로서 우주에서 삼위일체를 보았다. 즉 태양은 성교, 별들은 성자, 중간의 공간은 성신이었다. 그는 우주가 살아 있으며 행성들과 지구는 영혼을 가지고 있다고 믿었다. 이것은 아마도 당시에 크게 유행한 루터파 신비주의의 영향인 듯하다. 케플러는 철저한 피타고라스${\cdot}$플라톤주의자였다. 그는 우주가 수학적 조화를 이루고 있고, 신은 위대한 기하학자이며, 인간은 신의 이미지를 따서 만들어졌다고 보았다. 따라서 인간은 수학을 통해 우주를 이해할 수 있다는 생각이었다.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.45.4-45.4
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• 2019

각국의 인구와 국민총생산 등에 대한 천문학 및 천체물리학 관련 박사 연구자수의 상관관계를 구하였다. 그 결과, 국가별 상황에 따라 몇 개의 그룹으로 나뉨을 발견하였고, 신흥 선진국과 전통적 선진국 사이의 상관관계가 차이가 있음을 발견하였다. 이를 바탕으로 각국의 과학이나 경제 정책 등과의 관련성을 논의할 것이며, 특히 한국 천문학의 현주소에 대해 정량적으로 논의하고자 한다. 이를 통해 한국은 후발국과 선진국 사이의 중간자적인 입장임을 밝혔고, 한국 천문학을 선진국 수준으로 발전시키기 위한 투자 규모를 정량적 수치로 제공한다.

• Journal of Life Science
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• v.31 no.2
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• pp.209-218
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• 2021

This study aimed to evaluate the anti-obesity effects of Cudrania tricuspidata leaf extract in the order of leaf development on the shoot (L0, L1, L2, L3, L4, and L5). The leaves at the apex of a Cudrania tricuspidata shoot were classified as L0; the next leaves of the apex were classified as L1, L2, L3, and L4 from highest to lowest; and the lowest leaf was classified as L5. A series of 70% ethyl alcohol leaf extracts were screened for the inhibitory effects of adipogenesis in 3T3-L1 preadipocytes. We found that the apical leaf extract of Cudrania tricuspidata (CTL0) was the most effective. Next, a study was conducted on the inhibitory action mechanism of CTL0. Treatment with CTL0 significantly suppressed the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner, as confirmed by the decrease in lipid droplet content observed with Oil Red O staining. Treatment with 12.5 ㎍/ml, 25 ㎍/ml, and 50 ㎍/ml of CTL0 significantly reduced the lipid droplet content. Glucose and cellular triglyceride concentrations were reduced in the 3T3-L1 cells on the CTL0-treated medium compared to the differentiation medium (DM control, DMEM + insulin + dexamethasone + rosiglitazone). Compared with DM, CTL0 significantly inhibited the expression of key pro-adipogenic transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ), LPL, A-FABP, and Glut4. These findings show that CTL0 extract has potent anti-obesity effects.