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Epidemiology and clinical characteristics of headache comorbidity with epilepsy in children and adolescents (소아청소년 간질 환자에서 동반된 두통의 역학과 임상적 특징)

  • Rho, Young Il
    • Clinical and Experimental Pediatrics
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    • v.50 no.7
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    • pp.672-677
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    • 2007
  • Purpose : To assess the prevalence and characteristics of headache comorbidity with epilepsy in children and adolescents in a specialty epilepsy clinic. Methods : Two hundred twenty nine consecutive patients attending the Chosun University Hospital Pediatric Epilepsy Clinic (mean age $10.0{\pm}4.1\;years$, range 4-17, M:F ratio 1.1:1.0) were interviewed with a standardized headache questionnaire. Headache was classified according to the International Classification of Headache Disorders, 2nd Edition and epilepsy was classified according to the International League Against Epilepsy. Disability was assessed using pediatric migraine disability assessment (PedMIDAS). Results : Of the 229 epilepsy patients, 86 (37.6%) had co-morbid headache. Of the headache patients, 64 (74.4%) had migraine (65.6%- migraine without aura, 20.3% - migraine with aura, 14.1% - probable migraine). The mean headache frequency was $7.2{\pm}8.4$ per month, mean duration was $2.2{\pm}4.0$ hours, mean severity was $5.2{\pm}2.2$ out of 10, and mean PedMIDAS score was $13.0{\pm}35.4$. The proportion of females was not higher in epilepsy with headache patients (48.8%) compared to epilepsy patients alone (48.0%). In the patients with migraine, 48.4% had complex partial seizures, 17.2% had simple partial seizures, and 34.4% had generalized seizures (P=0.368). A postictal association of migraine was reported in 18.8% with 17.2% reporting a preictal headache, and 7.8% reporting an ictal headache. Conclusion : The prevalence of headache in pediatric epilepsy is higher than that in general pediatric population, suggesting a co-morbidity of headache in epilepsy patients with migraine being the most frequent headache disorder. Altered cerebral excitability resulting in an increased occurrence of spreading depression may explain the headache comorbidity with epilepsy. Further studies are needed to assess the etiology of this co-morbidity as well as assess the frequency, duration, severity and disability response to antiepileptic drugs.

Esophageal Reconstruction for Hypopharyngeal Stricture After Severe Corrosive Injury (부식성 하인두 협착시 식도재건술)

  • 변정욱;구본일
    • Journal of Chest Surgery
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    • v.30 no.1
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    • pp.48-54
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    • 1997
  • Between 1987 and 1995, eleven patients with severe chronic corrosive stenosis of the hypopharynx and esophagus underwent surgical restoration of digestive continuity at Inje University Seoul Palk Hospital. There were 7 male and 4 female patients aged from 21 to 47 years (mean, 34 years). The caustic material was acid in 6 patients and alkali in 5 patients. The esophagus was reconstructed using the right colon In 9 and left colon in 2. The cervical approach and the side of proximal anastomosis depended on the status of the pyriform slnus of the hypopharynx. In the neck, J-formed incision was made along the sternocleidomastoid muscle. The sternohyoid and thyrohyoid muscles were divided transversely to expose the thyroid cartilage. Hypopharyngeal opening for proximal anastomosis was made by reverse triangular formed resection of the thyroid cartilage after elevation of perichondrium. Immediately after operation, dysphagia and aspiration into trachea were common, so training of swallowing was required. Feeding gastrostomy was usually maintained for 3 months until restoration of swallowing function was confirmed . There was graft necrosis in 3 patients, who were treated with jejunal free graft. Revisional procedures for stenosis of cervical anastomosis in B patients consisted of widening of pharyngocecostomy site in 2 and resection of adhesive band in one. Return of normal swallowing assuring normal nutrition was obtained in 10 of 11 cases.

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A numerical study on the analysis of behavior characteristics of inclined tunnel considering the optimum direction of steel rib (강지보재 최적 설치방향을 고려한 경사터널의 거동특성에 대한 수치해석적 연구)

  • Park, Sang-Chan;Kim, Sung-Soo;Shin, Young-Wan;Shin, Hyu-Soung;Kim, Young-Geun
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.10 no.3
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    • pp.245-256
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    • 2008
  • The steel rib, one of the main support of tunnel, plays a very important role to stabilize tunnel excavation surface until shotcrete or rockbolt starts to perform a supporting function. In general, a steel rib at the horizontal funnel is being installed in the direction of gravity which is known favorable in terms of constructability and stability. However, as the direction of principal stress at the inclined tunnel wall is different from that of gravity, the optimum direction of steel rib could be different from that at the horizontal tunnel. In this study, a numerical method was used to analyze the direction of force that would develope displacement at the inclined tunnel surface, and that direction could be the optimum direction of steel rib. The support efficiency of steel rib could be maximized when the steel rib was installed to resist the displacement of the tunnel. Three directions which were recommended for the inclined tunnels in the Korea Tunnel Design Standard were used for the numerical models of steel rib direction. In conclusion, the results show that all displacement angle of the models are almost perpendicular to the tunnel surface regardless of face angle. So if the steel rib would be installed perpendicular to the inclined tunnel surface, the support efficiency of steel rib could be maximized.

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Bone reaction to bovine hydroxyapatite grafted in the mandibular defects of beagle dogs. (성견의 하악 골 결손부에 이식한 생체 유래 골 이식재 (OCS-B)에 대한 치조골의 반응)

  • Byun, Yu-Kyung;Park, Jun-Beom;Kim, Tea-Il;Seol, Yang-Jo;Lee, Yong-Moo;Ku, Young;Lee, Hye-Ja;Chung, Chong-Pyoung;Han, Soo-Boo;Rhyu, In-Chul
    • Journal of Periodontal and Implant Science
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    • v.36 no.1
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    • pp.39-49
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    • 2006
  • 1. 목 적 이 연구의 목적은 성견의 하악 골 결손부에 이식한 생체 유래 골 이식재에 대한 치조골의 반응을 알아보는 것이다. 2. 연구방법 및 재료 생후 1년 이상 된 성견 4마리의 하악 제2소구치 및 제 4 소구치를 발거하고 발치와에 금원심 폭경 8mm, 협설 폭경 5mm, 치조정에서의 깊이 6mm인 결손부를 형성하였다. 4주간의 자연 치유 후 판막을 형성하여 결손부의 크기를 확인하였다. 각각의 결손부 크기가 일정하도록 수정한 후 '이식재+차폐막'군에는 OCS-B을 이식하고 Bio-gide을 차단막으로 사용한 후 봉합하고 '이식재군'은 OCS-B 이식 후 차폐막 없이 봉합하였으며 '비이식'군은 아무런 처치없이 일차봉합하였다. 수술 4, 6주에 실험동물을 각각 희생시켜 실험부위를 적출하고 비탈회 연마 표본을 제작하여 골 치유 양성을 조직학적 및 조직계측학적으로 관찰하였다. 3. 연구결과 이식재 비이식군 및 이식군 모돼서 별다른 부작용없이 잘 치유되었다. 세 실험군 모두에서 술후 4주에 비교하여 술 후 6주에서의 결손부 산생골 형성량이 증가하였다. 술후 4주 소견에서 비이식군은 결손부 주변부위에서 골이 생성되어 나오는 양상을 보였으며 이식군은 이식재 주변으로 골침착 시작되는 것을 관찰할 수 있었다. 술후 6주 소견에서 비이식군은 결손부 경계부로부터의 지속적인 골 생성을 관찰할 수 있었으며 이식군은 이식재 주변으로 침착된 골의 양이 많아지고 신생골이 가교를 형성하는 것을 관찰할 수 있었다. 4. 결 론 차폐막 유무와 상관없이 OCS-B는 염증반응을 전혀 일으키지 않았으며 우수한 골 전도성을 보였다. 또한 결손부의 형태를 잘 유지하여 골재생을 위한 공간을 확보할 수 있었다. 이는 OCS-B가 골이식재로서의 필요조건을 갖추었음을 확인한 결과이며 보다 장기적인 관찰에서 OCS-B의 흡수 가능성을 확인하는 것이 필요할 것으로 보인다.

A Study on Competency Modeling of Micro Entrepreneurs Recovering From Failure (재도전 소상공인의 역량모델링에 관한 연구)

  • Im, jinhyuk;Park, Seonghee;Kim, JaeHyoung;Chae, yeonhee
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.17 no.6
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    • pp.71-88
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    • 2022
  • The purpose of this study is to develop the competencies to help micro entrepreneurs who have experienced failure to successfully re-challenge. To this end, relevant literature published from 1977 to 2022 was analyzed, behavioral event interviews (BEI) were conducted with 7 successful micro entrepreneurs, and focus group interviews (FGI) were conducted three times by inviting competency development and HRD experts. Based on these research activities, the draft about competencies for micro entrepreneurs who had have failure was derived. And then inviting 12 experts in related field for Delphi Analysis, the final competency model that helps micro entrepreneurs successfully recover were developed as follows : Competency Groups(small business owners, recovery from failure), 8 detailed competencies(seize business opportunities, business planning, business differentiation, operation management, market exploration, research and development of products and services, positive self-regulation, overcoming and coping with failure experiences), 22 competency factors, and 72 behavioral indicators. This study has an academic significance in that it developed the competencies required for micro entrepreneurs recovering from failure. In addition, the results of this study can be used to develop a competency-based education program for micro entrepreneurs and to select suitable candidates for support programs.

A Study on the Antifungal Properties of Ranunculaceae Herbal Medicines (미나리아재비과 한약재의 항진균성 검증 및 비교 연구)

  • Jae-yeoup Lim;Sang Ki Choi
    • Journal of Life Science
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    • v.34 no.6
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    • pp.393-398
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    • 2024
  • The purpose of this study was to verify the antifungal properties of various herbal medicines belonging to the Ranunculaceae family and to find an extraction method effective in inhibiting fungal growth. When antifungal activity was measured in a liquid medium with extracts obtained by either hot water extraction or organic solvent extraction of the herbal medicines Clematis apiifolia, Coptis chinensis, and Pusatilla chinensis, effective results were obtained from the chloroform extract. In addition, fungal growth inhibition experiments were performed on unicellular fungi, Candida albicans, Candida tropicalis, and Candida lusitaniae, and on filamentous fungi, such as Pythium ultimum, Aspergillus fumigatus, and Fusarium oxysporum, using disk diffusion experiments on solid media. It was confirmed that P. chinensis extract has excellent antifungal properties against Candida spp. and C. apiifolia extract against filamentous mold. Finally, GC-MS analysis was performed to explore the useful antifungal substances present in the extract. As a result of the study, thurbergenone from C. apiifolia and 16-hydroxycleroda-3, 13(14)-dien-15, 16-olide (16-HCDO) from C. chinensis were confirmed as antifungal candidates. In conclusion, it was confirmed that C. apiifolia, C. chinensis, and P. chinensis have antifungal activity against various fungi, and in GC-MS analysis, all herbal medicines were confirmed to have different antifungal candidates. These results indicate that the Ranunculaceae family has evolved in several directions for fungal resistance traits.

The Status of Soft Contact Lens Wear in College Students in Korea (한국 대학생들의 소프트 콘택트렌즈 착용에 대한 실태)

  • Kim, Douk-Hoon;Kim, Joung-Suk;Mun, Joung-Hak
    • Journal of Korean Ophthalmic Optics Society
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    • v.9 no.2
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    • pp.233-239
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    • 2004
  • This study investigated the status of soft contact lens wear in college students. The results were as follows: 1. The most prevalent age of initial contact lens wear was 19 years or 20 years, with an age distribution in females from as early as 10 years to 20 years. 2. For almost all subjects, the test clinic for the contact lens wear assessment and purchase of the contact lenses was an optical shop. 3. The main advantage for most male subjects was use for sports, whereas most female subjects used contact lenses for cosmetic reasons. 4. The most common side-effects experienced due to contact lens wear were red eye, foreign body sensation, and eye pain. 5. The most frequently reported eye disease caused by contact lens wear was conjunctivitis, with only few subjects experiencing keratitis. 6. Following treatment for the side effects of contact lens wear, most subjects hoped to re-use the previous contact lenses, some subjects wanted to change to new contact lenses, and others subjects refused further contact lens wear.

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Strength Evaluation of T-type Tubular Joints for Circular Section Multi-Column Wind Towers (원형단면 멀티기둥 풍력타워 적용 T형 강관조인트 강도 평가)

  • Kim, Kyung Sik;Park, Hyun Yong;Seo, Dong Hyuck
    • Journal of Korean Society of Steel Construction
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    • v.27 no.1
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    • pp.119-129
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    • 2015
  • Due to reduced self weight and alleviated wind effect, the multi-column wind towers that consist of a number of circular tubes as vertical members interconnected with horizontal brace members can be a substitute for the large-scale single cylinder wind towers. It is critical to guarantee strengths of tubular joints where vertical and horizontal members are structurally connected in order to make the whole multi-column system behave as a single tower structure. In this study, strength evaluation has been conducted for T-type tubular joints that are applicable in multi-column towers. Four of available design codes, i.e., AISC, Eurocode3, ISO 19902, CIDECT have been investigated and predictor equations in the considered design codes were validated and discussed through parametric numerical study on slenderness ratios of chords and braces at joints.

Clinical Analysis of Reoperation for Prosthetic Valve Replacement Report of 12 cases (인공판막 치환수술 재수술에 대한 임상적 고찰 -12예보고-)

  • 장진우;이연재
    • Journal of Chest Surgery
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    • v.30 no.4
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    • pp.390-395
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    • 1997
  • Between May 1986 and May 1996, 269 patients underwent prosthetic valve replacement. A bioprosthetic valve was replaced in 70 cases and mechanical valve was replaced in 232. Of this 12 patients performed reoperations for replacement, and the mean interval between primary valve operation and reoperation was 87.6 months for mitral valve and )7.7 months for aortic valve. There were 10 women and 2 me , agcd from 22 to 68 years(mean 45). A bioprosthetic valve was implanted in 8 cases and a mechanical valve was implanted in 4 cases for initial operation. llidications for reoperation were structural deterioration in 5 cases(42%), valve thrombus in 5 cases(42%) and endocarditis in 2 cases(17%). Operations performed included 3 aortic valve replacements(25%), 9 mitral valve replacements(75%). Wc used mechanical valve in llcases(92%) and tissue valve in 1 case(8%) for reoperation. There were 2 early operative deaths because of valve detachment and of acute respiratory failure. Among ten survivor's, there were no late deaths with follow up of 35.8 months.

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The Study on the User Behavioral Effects of Perception and Characteristics on the Common Essential Applications of Smartphones (스마트폰 공통 필수앱에 대한 이용자 인식과 특성이 이용 행동에 미치는 영향)

  • Youn, Bo Heum;Lee, Yoon Jae;Choi, Seong Jhin
    • Journal of Broadcast Engineering
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    • v.27 no.3
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    • pp.415-436
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    • 2022
  • This study was conducted by the customer survey of 15 to 65 years old in order to identify the user behavioral effects of perception and characteristics on the common essential applications of smartphones with the United Theory of Acceptance and Use of Technology (UTAUT) and Value-based Acceptance Model (VAM). As a result, it was found that performance expectancy, enjoyment, facilitating conditions, effort expectancy, and social influences, excluding information privacy concern, have a positive effect on use behavior. The moderating effect by age was found that the youth was higher between perceived value and behavioral intention, and the middle-aged was higher between enjoyment and perceived value. This study has significance in providing implications for establishing strategies on designing and pre-loading apps, and increasing usage rate.