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A Study on GHS Classification of 3-Methylpentane by Subacute Inhalation Toxicity (아급성흡입독성시험을 이용한 3-Methylpentane의 GHS 분류·표시)

  • Chung, Yong Hyun;Han, Jeong Hee;Shin, Seo Ho
    • Journal of the Korean Institute of Gas
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    • v.21 no.1
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    • pp.6-17
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    • 2017
  • Objectives : The purpose of this study was to obtain information regarding Globally Harmonized System(GHS) classification and health hazards that may result from a 4 weeks inhalation exposure of 3-Methylpentane in Sprague-Dawley rats. Methods : The testing method was conducted in accordance with OECD guidelines for the testing of chemicals No. 412(Subacute Inhalation Toxicity). The Rats were divided into 4 groups(5 male and 5 female rats in each group) and exposed to 0 ppm, 284 ppm, 1,135 ppm, 4,540 ppm 3-Methylpentane in each exposure chamber for 6 h/day, 5 days/week, for 4 weeks. After two weeks, the test animals were autopsied and carried out blood test and biochemical tests and histopathological examination. We used PRISTIMA (Toxicology data management system) to confirm the system and to have confidence of the raw data. Results : No death and particular clinical presentation including weight change and change of feed rate was observed. Relationship between dose, gender and response was also not significantly changed in hematologic examination, biochemical examination of blood and blood coagulation time. The histopathologic lesions caused by the test substance did not appear. Conclusions : NOAEL(No Observable Adverse Effect Level) of 3-Methylpentane is more than 4,540 ppm in male group and female group and the Ministry of Employment and Labor Guidance Announcement No. 2013-37(criteria for the classification marks and Safety of Chemicals) Specific target organ toxicity(repeated exposure) was determined with a substance that is not the separator material.

Comparative evaluation of renal size on radiography and ultrasonography in rabbits (토끼의 방사선 촬영상과 초음파 촬영상에 나타난 신장 크기의 비교평가)

  • Choi, Min-cheol;Yin, Xi-jun;Lee, Hyo-jong;Kang, Tae-young
    • Korean Journal of Veterinary Research
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    • v.36 no.4
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    • pp.991-995
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    • 1996
  • Renal size(length, width and height) of rabbits was measured by radiographs and nephrosonograms and compared with actual size. After measuring on the radiographs and nephrograms, both kidneys were removed from the body and actual size was also measured. On radiographs, right kidney was observed at the T13-L2 vertebrae and left kidney was at L2-L4 vertebrae. On nephrosonograms, the renal cortex was visible as small, homogenous echoes that were hypoechoic relative to the surrounding tissues, whereas the renal medulla was anechoic to slightly hypoechoic. The actual length, width and height of the left kidney were $35.84{\pm}3.12(mean{\pm}SD)$, $23.52{\pm}3.21$, $15.11{\pm}2.58cm$, respectively, whereas those of the right kidney were $36.02{\pm}3.42$, $23.69{\pm}3.50$ and $14.13{\pm}3.55cm$, respectively. On radiographs, the length and width of both kidneys were a little magnified(102-104%) when compared to actual size. On nephrosonograms, the length, width and height of bothkidneys were lessened(70-96 %) when compared to actual size. The length and width of kidney were 1.85 and 1.25 times the length of the second lumbar vertebrae on the ventrodorsal view. In correlation and correlation coefficient of body weight with the renal size, the body weight and renal size were significantly correlated with each other other(p<0.01) and the correlation coefficents of body weight with left, right and both Kindneys were 0.748, 0.794 and 0.859, respectively.

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Superoxide Dismutase and Peroxidase Activity of Transformed Callus in Tomato (형질전환된 토마토 캘러스의 Superoxide Dismutase와 Peroxidase 활성)

  • 유정민;정형진;김경민;곽상수
    • Korean Journal of Plant Tissue Culture
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    • v.25 no.3
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    • pp.177-181
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    • 1998
  • This study was carried out to investigate activity difference in the superoxide dismutase (SOD) and peroxidase (POD) of tomato callus transformed with Agrobacterium containing the GUS gene. Than those of other two tomato cultivars, the hypocotyl explant of JA101 was shown to have higher POD and SOD specific activity of 23 unit/mg protein and 2,156 unit/mg protein, respectively. Relatively high frequency of callus formation was obtained from the hypocotyl explant on MS medium containing 1 mg/L 2,4-D for 30 days and its POD(47 unit/mg protein) and SOD (95,786 unit/mg protein) specific activities were higher than other 2,4-D concentration. The hypocotyl explant and callus cocultivated with Agrobacterium for 72 hours were transferred to MS medium supplemented with 1 mg/L 2,4-D, 30 mg/L kanamycin, 30 g/L sucrose and 4 g/L Gelrite. The hypocotyl explants transferred to the medium formed callus with 45.5% effeciency after 8 weeks. The transformation efficiency confirmed by GUS assay was 21.6%. POD specific activity of the transformed callus (54 unit/mg protein) were somewhat lower than the non-transformed callus (64 unit/mgg protein) and SOD specific activity of the transformed callus (30,300 unit/mg protein) were also lower than the non-transformed callus (37,077 unit/mg protein). However there was no significant difference in POD and SOD isozyme patterns between the transformed and the non-transformed calluses. From these results, it revealed that there was no difference of antioxidant enzyme activities between the transformed callus and the non-transformed callus in tomato.

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A Study on the Development Lightweight Aggregate using Clink Ash for Reduction in Freezing Ground (지반의 동결저감 대책기술을 수립하기 위한 클링커애쉬 인공경량골재 개발에 관한 연구)

  • Moon, Jong-Wook
    • Fire Science and Engineering
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    • v.23 no.6
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    • pp.116-125
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    • 2009
  • This study is progressed function ratio, it's trued taste by an experiment to present data for human work light weight aggregate development that use clink ash progressed liquid limit, small success limit, wear loss in quantity, sand equivalent, sieve cutting examination. 80 : 20's match of function rain examination is 1.4, and that use rubble Goljae as ckink ash lightweight aggregate's capacity ratio increases by 1.0 increase of function rain many. Also, examination multiplied delicate flavor gradually according to increase of the mixing rate, and absorption coefficient increased. This is judged by phenomenon that appear by special quality upper clink ash of polystyrene bid and porosity's increase between lightweight aggregate. It is case that use aggregate of wear loss in quantity is 13.5 in sand equivalent and a wear loss in quantity experiment and although case that mix 20% increases by 14.4, this phenomenon by weak tissue of lightweight aggergate be judge. When it's as a these experiment, the statue prevention floor of a street improvement specifications is prescribing so that satisfy by sand equivalent 20, CBR 10. This is showed result that this satisfies in quality standard all in match experiment ago that see.

Oogenesis and Reproductive Cycle of Glossaulax didyma on the West Coast of Korea (한국 서해산 큰구슬우렁이, Glossaulax didyma의 난자형성과정 및 생식주기)

  • Kim, Dae-Gi;Chung, Ee-Young;Kim, Eun-Jong
    • The Korean Journal of Malacology
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    • v.22 no.1 s.35
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    • pp.13-22
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    • 2006
  • Gonadosomatic index (GSI), oogenesis and reproductive cycle of Glossaulax didyma were investigated by the cytological histological obserbations and morphometric data. Samples were collected monthly from the intertidal zone of Biin Bay, Seocheon, Korea, for one year. Monthly variations in the GSI showed similar patterns with gonadal development. In the early vitellogenic oocyte, the Golgi complex and mitochondria were invovled in the formation of lipid droplet and yolk precursor. In the late vitellogenic oocytes, the rough endoplasmic reticulum and multivesicular bodies were involved in the formation of profeid yolk granules in the cytoplasm. A mature yolk granule was composed of three components: main body (central core), superficial layer, and the limiting membrane. The spawning season was from early June to late August, and the main spawning occurred between July and August when the seawater temperature was above $19^{\circ}C$. The female reproductive cycle can be classified into five successive stages: early active stage (December to February), late active stage (February to March), ripe stage (April to July), spawning stage (June to August), recovery stage (August to November). Fully mature oocytes were approximately $250-270{\mu}m$ in diameter.

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Inhibitory Effects of Illicium verum Hooker fil. Dichloromethane Fractions on Adipocyte Differentiation (팔각회향 dichloromethane 분획물에 의한 지방세포 분화 억제 효과)

  • Jeong, Hyun Young;Jeong, In Kyo;Kim, Nam Ju;Yun, Hee Jung;Park, Jung Ha;Kim, Byung Woo;Kwon, Hyun Ju
    • Journal of Life Science
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    • v.29 no.4
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    • pp.447-454
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    • 2019
  • Fat accumulation in adipocytes occurs through the process of adipogenesis in which preadipocytes differentiate into adipocytes. Obesity is a metabolic disorder caused by excessive accumulation of fat in the body, which increases the incidence of cardiovascular diseases, hypertension, type 2 diabetes, hyperlipidemia, and various cancers. Recently, inhibition of adipocyte differentiation was shown to be a potential antiobesity strategy. In this study, the inhibitory effect of dichloromethane fractions from Illicium verum Hooker fil. water extract on the differentiation of 3T3-L1 preadipocytes to adipocytes was investigated. Dichloromethane fractions from I. verum Hooker fil. significantly inhibited adipocyte differentiation when applied during the adipocyte differentiation process, as assessed by measuring fat accumulation using Oil-red O staining. In addition, dichloromethane fractions from I. verum Hooker fil. reduced important adipogenic transcription factors, such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$, and peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$). The expression of FAS and LPL, which are terminal differentiation markers of mature adipocytes, was also reduced in the 3T3-L1 adipocytes treated with dichloromethane fractions from I. verum Hooker fil. In addition, the treatment significantly inhibited mitotic clonal expansion, which is essential for adipocyte differentiation, by arresting the G1 phase of the cell cycle. Taken together, these results suggest that dichloromethane fractions from I. verum Hooker fil. may be a natural material with antiobesity effects.

A Composite Study on the Writing Characteristics of Korean Learners - Focused on Syntax Production, Syntax Complexity and Syntax Errors (한국어 학습자의 쓰기 특성에 관한 융복합적 연구 - 구문산출성, 구문복잡성 및 구문오류를 중심으로)

  • Lee, MI Kyung;Noh, Byungho
    • Journal of the Korea Convergence Society
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    • v.9 no.11
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    • pp.315-324
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    • 2018
  • For Korean learners, writing is a harder part than any other areas in Korean languages. But in the future, the ability to organize and write systematically is essential for future koran languages learners to take classes, do assignments and presentations at school, and then adapt to job situations. Therefore, there is a need to devise a direction for this. In general, writing characteristics are viewed in many ways, including writing productivity, writing complexity, and writing errors. Accordingly, the study provided drawings and A4 paper for Vietnamese Korean learners, Chinese Korean learners, and Korean university students, before writing freely. Based on the their writing results, we looked at syntax factors (total C-units, total number of words), syntax complexity (number of words per C-unit and clause density), and writing errors (postposition, spell errors, and connective suffix, space errors) According to the study, Vietnamese and Chinese Korean language learners showed significantly lower syntax productivity and complexity than Korean university students, and showed more writing errors than Korean students in postposition and clause density. Based on the results of the study, we discussed writing guidelines for Korean languages learners. However, this study did not validate the differences in writing characteristics according to the Korean language level and length of residences for the study subjects. Therefore, it is necessary to consider this in future research.

The Impact of Social Identity and Social Alliance on Economic Performance in Social Enterprises (사회적 기업의 사회적 정체성과 사회적 협업 관계가 경제적 성과에 미치는 요인분석)

  • Kang, Hye Young
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.14 no.3
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    • pp.47-58
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    • 2019
  • The present study investigates the relationship between social competence and economic performance in social enterprises. Social enterprises simultaneously pursue social value creation and economic value creation, two of which are not easily compatible each other. This study explores the conditions under which these two values can synergize with each other and thereby, positively affect each other's performance. In particular, I examine how two important social competences, that is, social identity and social alliance, influence economic performance of social enterprises. Using the secondary data on social enterprises from Korea Social Enterprise Promotion Agency, I run OLS regression analyses to test hypotheses. I find that investment on social value creation, only when it aligns with social identity, has a statistically significant and positive relationship with economic performance of social enterprises. Further, the study finds evidence that social alliance in and of itself does not affect economic performance of social enterprises. However, social alliance does have a positive influence on social enterprises' economic performance, only when taking into account social alliance partners' organizational attributes and a focal social enterprise's degree of readiness to absorb expected gains from social alliance altogether. The present study improves our understanding on social entrepreneurship research by suggesting how social enterprises can enhance two seemingly incompatible values in a simultaneous manner. I also discuss potentially fruitful future research agenda based on the present paper's findings.

Some Suggestions for the improvement of preservation and management of diplomatic records (외교문서 관리제도의 개선 방향)

  • Jeon, Hyun-Soo
    • The Korean Journal of Archival Studies
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    • no.13
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    • pp.205-231
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    • 2006
  • My suggestions in this paper come out of the review of the records on the Korean-Japanese negotiations(1952-1965). Before January 2002, the enforcement of the public records law, we had a poor management system of the diplomatic records. For a long time the diplomatic records of Korean government has not been preserved and managed according to the international and professional standards. So many important records have been probably lost and unsuitably classified, preserved for the future use. By the coming of public records law this deplorable situation in the management of diplomatic records has been much improved. However the registration, classification, compilation, based on the principle of provenance were not so sufficiently realized. It is now very urgent to employ more archivists in the relevant governmental institutions and organizations, and to introduce the concept of record group for the management of diplomatic papers. Also at the preparatory work for the publication of the diplomatic papers it is strongly needed to make a room for the participation of the civil experts such as historians, archivists and political scientists. In the case of publication of the Korean-Japanese papers it is also necessary to take the relevant American and Japanese governmental records on Korean-Japanese negotiations and private records of the actors of the times into account. Moreover it must be also seriously considered to start a big project for the elaborate edition of the important records of the foreign policy of the nation.

A Study on the Obstacle Factors and the Development Strategy of High Value Occupational Training for Women (여성 고부가가치 직업훈련의 장애요인과 발전방안 연구)

  • Lee, Ji-Eun;Lim, Hee-Jeong
    • Journal of Digital Convergence
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    • v.17 no.3
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    • pp.181-189
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    • 2019
  • The purpose of this study is to derive obstacle factors to 'high value vocational training' and to suggest development strategies. The training aims to solve the quantitative and qualitative problems of female employment by providing professional training in high value areas such as ICT, SW and knowledge service. To verify the training to meet these objectives, 48 processes operated in 2018 were analyzed and field monitoring was conducted. As a result of the analysis, problems were identified and improvements were derived in terms of learners management, training course design, field practice operation, and performance evaluation. Based on these results, researchers suggested four ways to develop high value vocational training. First, select learners based on combined talent and second, strengthen the project of linking enterprises and structured field practices. Third, establish a performance evaluation system of its own and manage performance and fourth, expand support for excellent training courses and provide consulting for course development. The results of this study are expected to be used as a reference for establishing policies for high value occupational training. In the future, quantitative research should be conducted to clarify the performance and problems.