• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.spc1
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• pp.1-6
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• 2006

Rice is the most important crop in Korea and its annual production of 5.2 million ton is followed by over 0.5 million ton of bran as by-products of milling process. Although rice bran contains various nutritious and pharmaceutical compounds, rice brans are rarely utilized as functional food sources in Korea. In recent, tocotrienols are well known having distinctive pharmaceutical effectiveness. So tocotrienols extracted from rice bran oil were evaluated about Pharmaceutical function. The $IC_{50}$ of tocotrienols products against liver cancer, HepG2 cells were $149mg\;mL^{-1}$, indicating anticancer activity of final products. By animal feeding tests, the final products containing tocotrienols did not induce any toxicity signs in mortality, Incidence of clinical signs, body weight, etc. after a single oral administration, which proved safety of the tocotrienol products. In conclusion, tocotrienol extracted from rice bran has pharmaceutical activity without any toxic effects, which is also suggested tocotrienol products may be a good fortifying nutrition far the health and medical care.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.132-137
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• 1993

Several Prosapogenins and sapogenins obtained by acid hydrolysis or alkaline cleavage of Korean red ginseng saponins were separated and identified by spectral and physical methods. Some of these degradation products showed the cytotoxic activities against various cancer cell lines, that is, A549, SK - OV - 3, L121O, P388 and K562. The significant difference of activity between stereoisooers was not approved and the activity was inversely proportional to the number of sugars binding to sapogenins. It was clear that diol type prosapogenins and sapogenins were more cytotoxic than triol type ones.

• Journal of Food Hygiene and Safety
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• v.15 no.2
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• pp.151-166
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• 2000

The subacute toxicity of xylooligosaccharide (XO) was evaluated in SD rats. Groups of 60 male and 60 female rats were orally administered with 0, 333, 1000 or 3000 mg/kg of XO for 13 weeks. The changes of body weight, food and water consumption were investigated for 17 weeks, while heamatological values and histopathological findings were investigated at the end of the 13 weeks and 17 weeks including 4 weeks of recovery periods. No death and toxic effects were observed during the test periods. There were statistically significant changes in several parameters, but these change had no direct relationship to dosage. Clinical changes were general occurrence and no specific toxicity was related to XO. Gross necropsy and histopathology revealed that no target organs were found in the treated mouse with XO. According to the results, no-observed effect level of XO is estimated to be above 3000 mg/kg.

• Journal of Korean Society of Environmental Engineers
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• v.32 no.8
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• pp.795-801
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• 2010

The acute toxicity of arsenic compounds was assessed and compared using following four bioassays; bioluminescence activity of the recombinant strain RB1436, germination of four different seeds, ${\alpha}$-glucosidase activity produced by Bacillus lichemiformis, acute genetic revertant mutation using mutant strain Salmonella typhimurium. Different sensitivities were observed among tested bioassays, but generally the toxicity by arsenite was greater than that of arsenate. Among tested four seeds, sensitivities of Lactucus and Raphanus were greater than others, and these two seed types were appeared as proper type for bioassay. High revertant mutation ratio (5.1) was observed with 1 mg/L arsenite, indicating high mutagenicity. The sensitivity of ${\alpha}$-glucosidase activity on arsenic compounds was much lower than other methods. The evaluation of interactive toxic effects using various bioassays may comprise a useful tool for the bioassessment of environmental pollutants.

• Ecology and Resilient Infrastructure
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• v.8 no.4
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• pp.281-289
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• 2021

Commercially used disposable cups undergo fragmentation in the environment and become microplastics (MPs). These MPs can be ingested by aquatic organisms and cause a range of adverse effects. We assessed the acute and chronic toxicity of disposable cup-derived MP fragments in Daphnia magna. MP fragments were identified as a polyethylene terephthalate (PET) fragment with a size of 33.18 ± 7.76 ㎛. The presence of three additives including 1- Propanone. 1-phenyl-3-[2-(phenylmethoxy)phenyl]-, p-Xylene and ethylbenzene was analyzed from MP fragments. The 48 h acute toxicity revealed that 20 % of immobilization and mortality were found at the highest concentration of PET MP (200 mg L^-1). The 21 d chronic toxicity revealed that PET MP fragments significantly (p < 0.05) more reduced survival rate (31 %), total offspring (52 %) in D. magna compared with control group. The developmental abnormality of offspring (3.5%) by PET MP fragments was significantly (p < 0.05) higher than control groups (0.3%). These results are possibly induced by gut blocking by ingestion of MP fragments and their longer retention time. These findings indicate that the fragmentation of disposable cups (PET polymers) into small-sized MP fragments pose a significant ecological risk to aquatic organisms. Further studies are required to elucidate the underlying toxicity mechanisms.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2003.04a
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• pp.112-118
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• 2003

항균가공한 섬유제품은 건강하고 쾌적한 삶에 대한 욕구의 증가로 인해 점차 보편화되어 일반 의류는 물론이고 침구류, 인테리어 제품을 비롯하여 의료용에까지 확대되어 가고 있다. 현재 항균가공에 사용되고 있는 항균제는 합성항균제가 일반적이다. 합성항균제의 경우 기준치 이상의 독성을 가지지는 않지만 거의 대부분 자극성의 화합물로써 잠재적인 유해요인이 될 수 있는 것으로 보고되고 있으며, 또한 제조과정에서도 일반적인 합성화합물과 마찬가지로 환경오염을 유발하는 문제점도 피할 수 없다. (중략)

• Journal of Korean Society for Atmospheric Environment
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• v.12 no.1
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• pp.1-13
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• 1996

최근들어 발암성 혹은 돌연변이원성에 관련된 환경인의 영향에 관한 직접 혹은 간접적인 증거가 늘어감에 따라 대기환경에서 검출되는 화학적 발암성 물질에 많은 관심이 모아지고 있다. 수 많은 종류의 발암성 화학물질중 측히 독성 유기화합물은 주변환경에 널리 분포되어 있을 뿐만 아니라 그 종류가 매우 다양하여 적절한 관리가 어렵고 또한 일반적으로 대기중에 극미량 수준으로 존재하므로 측정, 분석이 어려워 그 위해성을 정확히 평가하기가 쉽지 않으므로 다른 물질보다 더 많은 연구와 관심의 대상이 되고 있다.(IARC, 1983; WHO, 1987; Calabrese & Kenyon, 1991; Field et al., 1992).

• Proceedings of the Korea Air Pollution Research Association Conference
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• 1999.10a
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• pp.47-49
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• 1999

월남전 고엽제 피해와 도시 폐기물 소각로 문제로 일반에게 알려진 다이옥신(Dioxins and Furans)은 기존의 연구결과 토양, 호수와 강의 바닥, 대기, 수계생물, 동식물 및 인체조직 등 거의 모든 자연환경에 존재하는 것으로 밝혀졌다. 특히 도시의 대기는 도시 폐기물 소각로나 자동차 등 화것 연료의 연소에 의해 배출되는 다이옥신, PCBs, PAH 등 많은 오염 물질을 함유하고 있는데 이 중 독성이 가장 높은 물질이 다이옥신이다.(중략)

• Biomolecules & Therapeutics
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• v.8 no.2
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• pp.179-183
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• 2000

To determine biosafety of fluorosilicic acid as a source of fluoride, we carried out acute toxicity and general pharmacological studies using mouse. Fluorosilicic acid had little effects on general behavior, pain response, convulsion, skeletal muscle function and intestinal mobility as compared to controls. It had either little adverse effects on alkaline phosphatase and collagen levels in osteoblast cells. This study supports the safety of fluorosilicic acid in animals.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2003.04a
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• pp.356-359
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• 2003

영화유기화합물의 제거에 있어서 일반적으로 이용되는 금속분말로는 아연, 주석, 니켈, 납, 철 등이 알려져 있으며, 경제성과 반응성이 좋고, 독성을 야기하지 않는다는 측면에서 영가 철이 가장 많이 연구·실용화되어 적용되고 있는 실정이다. 본 연구에서는 제철부산물들의 비표면적 측정, 화학적 구성성분 분석 및 pH의 변화를 통해 TCE, PCE 제거능력 평가 및 탈염소화반응을 확인하였으며, 제철부산물인 사상분진과 열연슬러지가 TCE 및 PCE의 제거효율적인 측면이나 산업폐기물의 재활용적인 측면에서 순수철보다 우수하다는 것을 확인하였다.