• Journal of Life Science
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• v.28 no.12
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• pp.1536-1544
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• 2018

Depression is a common, serious, and recurring mental disorder. The pathogenesis of depression involves many factors such as environmental factor, genetic factor and alteration of structure and function in neurobiological systems. Increasing evidence supports that epigenetic alteration may be associated with depression. The epigenetics is explained as the mechanisms by which environmental factor causes changes in chromatin structure and alters gene expression without changing DNA base sequence. DNA methylation and histone modification involving histone acetylation and methylation are the main epigenetic mechanisms. Animal studies have shown that stressful environment such as early life stress can leave persistent epigenetic marks in the genome, which alter gene expression and influence neural and behavioral function through adulthood. A potentially important gene in depression is brain-derived neurotrophic factor (BDNF). BDNF plays a central role in depression and antidepressant action. In studies of the rodent, exposure to stress at prenatal, postnatal, and adult stages alters BDNF expression through histone modification and DNA methylation of the BDNF gene which results in anxiety and depressive-like behavior. This review discusses recent advances in the study of the epigenetic mechanisms that contribute to depression, particularly histone modification and DNA methylation of the BDNF gene, that may help in the development of new targets for depression treatment.

• Journal of Service Research and Studies
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• v.8 no.3
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• pp.51-62
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• 2018

This study examines several evolutionary and alternative aspects of the system of existing education and suggests a more specific approach to the development of recent education that has evolved to the recent service economy era and a new approach to the human capacity of the World Economic Forum (WEF). We propose a stage of education system. We will change the meaning and choice of the job according to the rapid development of the 4th Industrial Revolution. Future occupational education also needs to be changed according to the expectation that job movement will happen frequently. The new education requires a model to prepare for the phenomenon of various convergence as technology collapses with the existing culture. And a higher-level educational philosophy is needed for human competence and the environment to actually connect industrial and social issues. The purpose of this study is to show the necessity of introduction of New Service Learning as a new system of education for super mobility. New Service Learning can be divided into five concepts: Innovation, Modernity, Sustainability, Humanity, and Technology. In future research, it is necessary to complement the research by empirically analyzing the concept of New Service Learning.

• Particle and aerosol research
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• v.14 no.4
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• pp.135-144
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• 2018

Based on a two-year measurement data, major sources for the ambient carbonaceous aerosols at the Anmyeon Global Atmosphere Watch (GAW) station were identified by using the Positive Matrix Factorization (PMF) model. The particulate matter less than or equal to $2.5{\mu}m$ in aerodynamic diameter (PM2.5) aerosols were sampled between June 2015 to May 2017 and carbonaceous species including ~80 organic compounds were analyzed. When the number of factors was 5 or 6, the performance evaluation parameters showed the best results, With 6 factor case, the characteristics of transported factors were clearer. The 6 factors were identified with various analyses including chemical characteristics and air parcel movement analysis. The 6 factors with their relative contributions were (1) anthropogenic Secondary Organic Aerosols (SOA) (10.3%), (2) biogenic sources (24.8%), (3) local biomass burning (26.4%), (4) transported biomass burning (7.3%), (5) combustion related sources (12.0%), and (6) transported sources (19.2%). The air parcel movement analysis result and seasonal variation of the contribution of these factors also supported the identification of these factors. Thus, the Anmyeon Island GAW station has been affected by both regional and local sources for the carbonaceous aerosols.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.2
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• pp.75-83
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• 2019

In this study, to propose the deterioration curves of urethane, ceramic, polysiloxane and fluorocarbon coating for the steel bridge, an accelerated corrosion tests were carried out. The each coating system wes applied on the top of the specimens, and circular initial defects were introduced with different diameters with 0.5, 1.0, 3.0, 5.0 mm. An accelerated corrosion test condition was used to simulate severe corrosive environment depending on ISO 20340. The deterioration curve of each coating type was evaluated based on deteriorated area from the circular defects. In order to evaluate the coating service life of installed steel bridge using deterioration curve, the acceleration coefficient was calculated at correlation between ISO 20340 and corrosivity categories by ISO 9223 based on field corrosion rate. From test results, the propagation rate of coating deterioration area was different to diameter of circular defects. In case of urethane coating, the coating service lifes of 3% deterioration area was evaluated in 31.8, 15.8, 9.9 and 3.9 years with C2, C3, C4 and C5 category.

• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.209-220
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• 2019

Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 mg/kg), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus. Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.

• The Korean Journal of Archival Studies
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• no.30
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• pp.175-204
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• 2011

Electronic records are generated not only in public sector but also in private sector. Records will be used across the public-private boundary. The Certified e-Document Authorities(CeDAs) may keep electronic documents in private sector for preservation and evidence, like the official Record Management Systems for Public sector. A CeDA is the Trusted Third Party (TTP) as a business to be entrusted and proof interchanging documents between parties. This CeDA system could be sustainable only if the CeDA earn the enough sales through enough uses. And yet, all the eight CeDA companies have not had enough users. How to utilize CeDAs is one of the hot issues in this area. In this paper, We analyze the threat to trustworthiness of CeDA due to payment of only one party among others, and describe the difficulty in use of CeDA for an individual user. These things make CeDAs cannot have enough users. To do address these, We expand the boundary of relevant parties for a document, present a delegate-establishing option under a joint name, show the needs of identifying and notifying minimum relevant parties, and suggest the proxy parties to help the individual users.

• Journal of Digital Convergence
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• v.17 no.1
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• pp.239-247
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• 2019

An accurate prediction of emotion is a very important issue for the sake of patient-centered medical device development and emotion-related psychology fields. Although there have been many studies on emotion prediction, no studies have applied the heart rate variability and neuro-fuzzy approach to emotion prediction. We propose ANFEP(Adaptive Neuro Fuzzy System for Emotion Prediction) HRV. The ANFEP bases its core functions on an ANFIS(Adaptive Neuro-Fuzzy Inference System) which integrates neural networks with fuzzy systems as a vehicle for training predictive models. To prove the proposed model, 50 participants were invited to join the experiment and Heart rate variability was obtained and used to input the ANFEP model. The ANFEP model with STDRR and RMSSD as inputs and two membership functions per input variable showed the best results. The result out of applying the ANFEP to the HRV metrics proved to be significantly robust when compared with benchmarking methods like linear regression, support vector regression, neural network, and random forest. The results show that reliable prediction of emotion is possible with less input and it is necessary to develop a more accurate and reliable emotion recognition system.

• Journal of The Korean Association For Science Education
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• v.39 no.2
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• pp.279-293
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• 2019

This study investigated the effects of national science leading school programs on students' positive experiences about science (PES) and teachers' perceptions of curriculum implementation factors affecting students' PES. For this study, Test for Indicators of Positive Experiences about Science (TIPES) was administered to a total of 11,488 students from 117 national science leading schools and 1,315 students from 50 normal counterpart schools. In addition, a total of 105 teachers were given a survey asking their curriculum implementation levels and perceptions on importance and performance levels of each identified factor that was known to influence students' PES. Students' total PES scores and scores in five sub-components of PES were widely varied across science leading school program types. In general, participating teachers reported common curriculum implementation factors that most positively affected students' PES including 'science-related activities out of school,' 'student-centered research projects,' 'ICT-related materials' and 'performance assessment.' Based on these results, implications for science education were discussed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.5
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• pp.189-203
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• 2021

Environmental changes, which are strongly requiring technological cooperation, such as technological development and strategic alliances according to industrial ecosystem change, have a significant impact on not only product quality but also services. Thus, there is a need for 'servitization' that can satisfy the needs of customers and the ecosystem of businesses through the convergence of manufacturing companies and services. This study uses the Expectation-Confirmation Model to examine the impact on user satisfaction and Continuance Usage Intention. Research(Study) was conducted on users who are using high-tech-based cars. For this, we used Expectation Confirmation(match expections for the user's pre-and post-use relationships), Perceived Ease, Perceived Usefulness, User Satisfaction and Habitual Use and using Continuance Usage Intention as a dependent variable. Their causation was examined with the spss 26.0 and smartpls 2.0 statistical programs. As implications of this study, Expectation Confirmation has been shown to have significant positive effects on Perceived Ease, Perceived Usefulness, User Satisfaction and Habitual Use. For this results, the expectations before and after the use of high-tech cars lead to improved daily lives convenience and(or) work efficiency, leading to user satisfaction and further Continuance Usage Intention. Motors consider it important to pursue the work improvements that consumers want and use it useful in daily lives in the production and sale of high-tech cars. It is expected that it will create natural habits for services that users are satisfied with, and that these habits will affect the continuous growth and understanding of the trend of change.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.38-47
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• 2021

This study is about a blockchain-based collective quarantine management system and its commercialization model. The configuration of this system includes a biometric information transmission unit that generates biometric information based on measured values generated from wearable devices, a biometric information transmission unit that transmits biometric information generated here from a quarantine management platform, and action information transmitted from the community server. is a system including an action information receiving unit for receiving from the quarantine management platform. In addition, a biometric information receiving unit that collects biometric information from the terminal, an encryption unit that encodes biometric information generated through the biometric information receiving unit based on blockchain encryption technology, and a database of symptoms of infectious diseases to store symptom information and an infection diagnosis database. The generated database includes a location information check unit that receives from the terminal of the user identified as a symptomatic person and determines whether the user has arrived in the community based on the location information confirmation unit and the location of the user after the location is confirmed. It includes a community arrival judgment unit that judges. And, the community server helps the interaction between the generated information. Such a blockchain based collective quarantine management system can help to advance the existing quarantine management system and realize a safer and healthier society.