• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2002.11a
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• pp.117-129
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• 2002

가. 부검 1. 부검시 주의 사항 ◇ 시험계획서와 표준작업수순(Standard Operating Procedure)를 충분히 숙지한다. ◇ 부검소견기록지를 준비한다. ◇ 부검은 정해진 장소(부검실)에서 보호구를 착용한 후 실시한다. ◇ 부검책임자의 감독하에 실시한다. ◇ 동물번호를 반복해서 확인하고 다른 동물과의 혼동을 피한다. ◇ 외모와 내부장기 및 조직을 잘 관찰한다. ◇ 이상부위는 소견을 상세히 기록한다 (위치, 크기, 모양, 색깔, 경도, 단면 등). ◇ 소견 기술(description)은 표준용어를 사용한다. ◇ 조직의 기계적 손상, 건조, 자가융해 등의 artifact를 최소화한다. ◇ 시험물질의 성질, 투여경로, 임상관찰 결과 등 필요한 정보를 파악하고 작업한다. 2. 육안관찰의 일반적인 원칙 ◇ 독성평가는 부검의 완벽함과 정확성에 의존한다. ◇ 부검은 병리에서 자료생산의 시작단계다. ◇ 육안관찰은 조직의 선택과 삭정에 대한 기초와 방향을 제공한다. ◇ 변화는 크기에 관계없이 진단의 가능성을 최대화한다. ◇ 시험계획서에 명시된 조직 및 기타 병변을 철저히 관찰하고 채취한다. ◇ 부검시 폐기된 조직은 영원히 사라짐을 명심한다. (중략)

• Journal of fish pathology
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• v.24 no.3
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• pp.225-236
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• 2011

This study was aimed to determine the fish physical status according to the gross and histopathological findings of liver in cultured black rock fish, Sebastes schlegeli. All 47 fish submitted had no marked abnormalities in the external findings. 42.55% of fish showed normal liver, 25.53% yellow liver, 25.53% atrophic brown liver, 4.26% yellowish-green liver and 2.13% fatty liver in gross examination. Grossly normal liver showed no remarkable change in lobular structure but many vacuoles were found in hepatic cell. Hepatic cells took normal roundish, polygonal shapes containing spherical nuclei. In group of yellow-brown liver, many brown pigments were seen in hepatic cells, MMCs and brown-colored hyaline droplets within cytoplasm of hepatocytes. Yellowish green pigments were seen in hepatic cells and MMCs of yellow green liver and green colored hyaline droplets within hepatocytes. The dilated central veins are highlighted with atrophy of hepatic cells. Outline of atrophic hepatocyte became ambiguous and nucleus frequently become small and pyknotic. Fatty liver showed prominent vacuolar structures in cells as clear spaces or foamy cytoplasm with degenerative nuclei. From these results, it was strongly suggested that hepatic gross and histological findings could be used as important and critical health parameters of fish prior to progression to substantial manifestation as clinical disease.

• Journal of Biomedical Engineering Research
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• v.20 no.5
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• pp.609-616
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• 1999

심폐바이패스시 발생할 수 있는 튜브 마모 및 파쇄는 롤러펌프의 반복되는 압박에 의해 롤러펌프에 장착된 튜브 내벽에 균열이 생기고 이로 인해 미세한 비생물적 조각들이 혈액중으로 떨어져 나가는 현상을 말하는데, 임상적으로 치명적인 색전증을 초래할 수 있다. 그러나 아직 롤러펌프 튜브로 사용되는 PVC 및 실리콘 튜브 중 어느 쪽이 마모 및 파쇄 관점에서 더 우수한지는 체계적으로 밝혀지지 않고 있다. 이에 본 연구는 두 종류의 튜브를각각 일정 기간 롤러펌프에 장착하여 작동시킨 뒤 튜브내외면을 육안 및 주사형 전자현미경으로 관찰하였다. 즉 PVC 및 실리콘 튜브 (내경 1/2 인치의)들을 미리 정해진 폐쇄도 조절에 의해 폐쇄 회로 심폐비이패스 롤러펌프 헤드에 장착시키고 4.500ml/min에서 각각 4차례씩 1,2,4,6 시간 작동시켰다. 파쇄에 의한 색전 관찰 실험에서는 회로 중간에 동맥여과기를 설치하고 각각 6,9시간 씩 롤러펌프를 작동시켰다. 실험 후 튜브 및 여과기들을 수거한 후 육안 및 주사형 전자현미경 분석을 시행하였다. 실험후 튜브 및 여과기들을 수거한 후 육안 및 주사형 전자현미경을 분석을 시행하였다. 튜브 외부의 육안 관찰 결과 일반적으로 실라스틱 튜브에서의 외부 마모가 PVC 튜브에 비해 현저하였다. 주사형 전자현미경 관찰에서 PVC 튜브에서의 홈은 좁으면서 경계선이 뚜렷한 특징을 보였고 3시간 이상 롤러와 접촉한 튜브들에게서는 깊은 균열이 간헐적으로 관찰되었다. 반면, 실라스틱에서의 홈은 좁으면서도 경계선이 뚜렷한 특징을 보였고 3시간 이상 롤러와 접촉한 튜브들에게서는 깊은 균열이 간헐적으로 관찰되었다.반면 실라스틱에서의 튜브들에서는 홈이 상대적으로 넓고 경계가 덜 명확했으며, 특징적으로 V 자 모양의 융기부들이 간헐적으로 관찰되었다. 실라스틱 및 PVC 튜브 모두에서 50u 전후의 Craters 가 간헐적으로 관찰되었다. 여과기의 여과망에 대한 주사형 전자현미경 분석 결과 실라스틱과 PVC 튜브 실험군 모두에서 색전입자로 의심되는조각들이 발견되었으나 두군간 정량적 비교는 어려웠다. 결론적으로 롤러펌프에 의한 튜브 마모 및 파쇄현상은 실리콘 및 PVC 튜브의 재질에 따라 그 양상에는 차이가 있으나 임상적인 측면에서는 어느 쪽도 상대적인 우수성이 입증되지 못하였다.

• Childhood Kidney Diseases
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• v.16 no.2
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• pp.146-149
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• 2012

Gross hematuria is uncommon, and rarely associated with hydronephrosis in healthy children. We describe a 3-year-old boy who complained of gross hematuria and dysuria. He was diagnosed as cystitis with bilateral hydronephrosis, and treated with antibiotics and conservative therapy. Our experience suggests that cystitis with hydronephrosis can occur in healthy children presenting with gross hematuria.

• 연구논문집
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• s.23
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• pp.141-153
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• 1993

본 연구는 국내의 플랜지 전문생산업체에서 제작하여 국외의 정유회사로 공급한 플랜지중 1개가 수압시험중 균열이 발생되어, 이에 대한 원인규명을 하고자 하였다. 먼저 균열이 간 플랜지와 동일재질의 건전한 플랜지를 입수하여 화학성분분석, 기계적 성질, 개재물, 경도측정 및 미세조직관찰을 통하여 비교조사하였고 파괴플랜지 용접부의 조직 및 경도측정으로 용접부의 영향을 조사하였다. 또한 파괴면의 육안관찰, SEM, EPMA 및 XRD분석으로써 균열발생 시기와 상태등을 추정하였다.

• Journal of the korean veterinary medical association
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• v.17 no.6
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• pp.34-38
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• 1981

• The Journal of Korean Academy of Prosthodontics
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• v.46 no.5
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• pp.443-454
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• 2008

Statement of problem: A clinically successful color match is one of the important factor to get an esthetic dental restoration. Dental shade guides are commonly used to evaluate tooth color in restorative procedure. But numerous reports have indicated that common shade guides do not provide sufficient spectral coverage of the natural tooth colors. To address issues associated with the shade guide, distinct avenues have been pursued objective spectrophotometric / colorimetric assessment. Purpose: This study compared the accuracy of tooth color selection of spectrophotometer with that of human visual determination. Three main factors were investigated, namely, the effect of light, the individual variation and the experience of the observer. Material and methods: At the first experiment, on ten patients, one operator independently selected the best matching shade to the unrestored maxillary central incisor, using a Vita Classical Shade Guide in the morning, at noon and in the afternoon. The same teeth were measured by means of a reflectance spectrophotometer. At the second experiment, on ten patients, ten operators (5 experts, 5 novices) selected and measured by the same method above at noon. At the third experiment, the results of the second experiment were divided into two groups, expert and novice, and analyzed. Results: 1. There was significant difference between visual and spectrophotometric assessment (mean ${\Delta}E$ values) in experiment 1, 2, 3 (P < .05). 2. There was no significant difference between experts and novices group, when comparing with each visual and spectrophotometric assessment (mean ${\Delta}E$ values). Conclusion: Spectrophotometer could be used to analyze the shade of natural tooth objectively. Thereby, this method offers the potential tominimize considerably the need for corrections or even remakesafter intraoral try-in of restoration. Furthermore, to achieve its advantage, both the shade-matching environment and communication between dentist and technician should be optimized with use of visual and instrumental shade-matching systems.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.85-91
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• 2004

In this study, we evaluated the crow's feet of 152 Korean women by using visual assessment established by our research group and mechanical assessment, Skin Visiometer SV 600. The volunteers were divided into 3 groups according to age; the group I of 30's was 43, the group II of 40's was 75, the group III of 50's was 34. The wrinkle score by visual assessment showed tendency to increase according to age and was statistically significant different among those three age groups (P 〈 0.05). But there was no significant difference between the left and the right of crow's feet. The 5 wrinkle parameters (RI, R2, R3, R4, R5) of mechanical assessment varied as age and the Rl, R4, and R5 showed statistically significant difference among three age groups (P 〈 0.05). However there was no significant difference between the left and the right of crow's feet. The volunteers were divided into 3 groups according to wrinkle score; (0-3 grade for group A, 4-6 grade for group B, 7-9 grade for group C). Only R4 and R5 showed significant difference between group A and group C (P 〈 0.05). It was suggested that visual scoring criteria applied in this study was related to R4 and R5 and was useful in investigating in fine wrinkles.

• Journal of Dental Rehabilitation and Applied Science
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• v.29 no.1
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• pp.81-93
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• 2013

The objectives were to evaluate the accuracy of shade selection by human visual system(VS) and 2 different colorimeters ($ShadeEye^{(R)}$(SE) and Shadepilot (SP)). Maxillary anterior teeth of 30 volunteers which had no caries or restorations were included in the study. Firstly, the accordance in shade selection by 3 dentists and 2 colorimeters was investigated. Secondly, the color of the teeth were measured by 1 observer's naked eye and 2 colorimeters under different illumination conditions (Sunny versus cloudy day). Additionally testing of inter-observer variability selected colors by 2 novice and 2 experienced dentists were compared. For comparing visual and 2 different colorimeters, SP(60%) showed significantly highest rate of accordance than the visual (23.3%) or SE (16.7%) and lowest mean ${\Delta}E$ ($2.62{\pm}0.74$ versus $3.83{\pm}1.38$;SE or $4.04{\pm}1.61$;VS)(p<0.001). If accuracy of shade selection were measured using VS, the mean ${\Delta}E$ value of cloudy day was higher than that of sunny day ($4.35{\pm}1.70$ versus $3.53{\pm}1.31$; p<0.001). There were no significant difference of the mean ${\Delta}E$ value between sunny and cloudy day in both SE and SP. Inter- observer repeatability was higher in 2 experienced group (73.3%) than novice group (36.7%). The mean ${\Delta}E$ of experienced group was lower than that of novice group ($3.60{\pm}1.47$ versus $4.70{\pm}1.67$; p<0.001). Colorimeters (SE or SP) is more accurate and more reproducible compared with human shade assessment. Using visual system may be limited by cloudy and inexperience of tester, then more experience and using colorimeters may be helpful of raising the accurate repeatability of shade selection.

• KSBB Journal
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• v.16 no.3
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• pp.302-306
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• 2001

The possibility of biomaterials prepared from natural polymer as a skin substitute was evaluated by measuring biocompatibility. Biodegradable films were prepared by solution blend method in the weight ratio of chitosan for the purpose of useful biomaterials. These films were inserted in the back of rat and their biodegradability was investigated by the film weight and hematology as a function of time for the biotransformation. The result of rat test showed that medium, high viscosity chitosan induced some suspects of inbiocompatibililty in the tissue by foreign body reaction 48 and 72 hours after implantation. Also, we prepared the official burn ointment which is made by low viscosity chitosan. This burn ointment was covered on the skin wound of artificial burn and their effect of healing was investigated by the evaluation of the naked eye and hematological change as a function of time. The result of rats test showed that burn ointments made from chitosan was effective reduction of inflammation than negative group.