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Coronary Arterial Lesions of Kawasaki Disease Observed in a Mouse Model of Sepsis: A Pilot Study and a Review of the Literature (패혈증 마우스 모델에서 가와사키병의 관상동맥 병변 관찰: 예비연구와 문헌고찰)

  • Kim, Joo-Hyun;Kim, Hyo-Jin;Shin, Jung-Ha;Choi, Ui-Yoon;Lee, Soo-Young;Han, Ji-Whan
    • Pediatric Infection and Vaccine
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    • v.24 no.2
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    • pp.102-107
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    • 2017
  • Purpose: Coronary arterial lesions (CALs) were reported to have developed in children with systemic inflammatory diseases, as well as those with Kawasaki disease (KD). The purpose of this study was to confirm that the CAL development in children with KD occurs in a mouse model of sepsis presenting typical systemic inflammatory response syndrome (SIRS). Methods: To induce the sepsis mouse model with SIRS, 6-week-old C57BL/6 mice were intraperitoneally injected with endotoxin. We compared histological findings of the major organs between the control and the sepsis groups and examined CAL in the heart of the septic mice. Results: Infiltrating inflammatory cells were relatively increased in the heart, liver, and kidneys of the sepsis group, compared with those of the control group. We confirmed lymphocytic infiltration in the myocardium (myocarditis) and the pericardial soft tissue of the heart. Furthermore, coronary artery of the septic mouse was identified, but CAL was not observed. Conclusions: In this study, we failed to confirm the existence of CAL in a mouse model of sepsis. However, it is well-known that CALs are seen in many kinds of diseases that cause SIRS. Our findings suggest further investigation into the clinical significance of CAL in various systemic inflammatory diseases, including KD.

대화방식(對話方式)의 특징(特徵)을 가진 SDI 시스팀의 성능(性能)

  • Saskova, V.;Kosik, J.
    • Journal of Information Management
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    • v.8 no.5
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    • pp.130-140
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    • 1975
  • 이용자(利用者) 중심(中心)의 대화방식(對話方式) 시스팀을 개발(開發)하고 시험(試驗)하였다. 2년(年)동안 280개의 프로파일로 CA - Condensates 데이터 베이스내에서 정보(情報)를 검색(檢索)해 보았다. 그 시스팀의 작업능률(作業能率)을 사용(使用)한 데이터 베이스와 하드웨어의 구조(構造), 소프트웨어 패키지, 이용자(利用者)의 수(數), 그리고 정보(情報)센터에서 제공(提供)한 보조(補助)에 따라 평가(評價)하였다. 대화식(對話式) 검색방법(檢索方法)이나 이용자(利用者)의 요구(要求)를 양화(量化)하는 것, 그리고 여러가지 분야별(分野別)로 검색(檢索)하는 방법(方法) 등 이용자(利用者)의 요구(要求)를 보다 충실(充實)하게 만족(滿足)시킬 수 있는 여러가지 방법(方法)들을 논의(論議)하였다. 모든 정보(情報)시스팀의 목적(目的)은 적시(適時)에 올바른 정(情)보를 적자(適者)에게 제공(提供)하는 것이라고 잘 알려져 있다. 다시 말해서, 정보(情報)시스팀의 주요목적(主要目的)은 이용자(利用者)의 요구(要求)를 충족(充足)시켜 주는 것이다. 이러한 관념(觀念)의 변화(變化)는 정보처리(情報處理)에 큰 변화(變化)를 가져와 정보(情報)시스팀의 적응성(適應性)을 증가(增加)시키기 위해 여러 가지 새로운 방법(方法)들이 개발(開發)되었다. 정보(情報)시스팀들 사이의 상호작용(相互作用), 사람과 컴퓨터와의 대화(對話), 그리고 컴퓨터의 조력(助力)으로 이용자(利用者)의 프로파일을 작성(作成)하는 것 등은 이용자(利用者)의 요구(要求)를 존중(尊重)하고, 필요(必要)한 정보(情報)를 쉽게 찾기 위해서 고안(考案)된 것이다. 한편, 우리들은 이용자(利用者)의 특성(特性)이나 배경(背景), 그리고 문헌(文獻)에 대한 그의 습성(習性) 등에 대해서 얼마나 모르고 있는가를 깨닫게 된다. 상기(上記)의 내용(內容)을 요약(要略)하면, 근대정보(近代情報) 시스팀은 다음의 필요조건(必要條件)을 만족(滿足)해야 한다. 1) 이용자(利用者)의 요구(要求)에 호응(呼應)하기 위해서 적합(適合)한 일련(一連)의 정보(情報)를 제공(提供)해야 한다. 2) 이용자(利用者)와의 관계(關系)에서 시스팀은 적극적(積極的)이어야 한다. 즉, 프로파일 검색공식(檢索公式)에서 유발(誘發)되는 잘못을 지시(指示)하고 지적(指適)할 수 있어 야 한다. 나아가서 컴퓨터의 조력(助力)으로 프로파일을 작성(作成)하고 쉽게 수정(修正)할 수 있는 바람직하다. 우리들은 상기(上記)한 필수조건(必須條件)에 일치(一致)하도록 노력(努力) 하고 Bratislava에 위치(位置)하고 있는 슬로박 과학원(科學院)의 무기화학연구소(無機化學硏究所)와 화학공업경제연구소(化學工業經濟硏究所)가 공동(共同)으로 개발(開發)한 시스팀이 상기(上記)의 특수성(特殊性) 최소(最少)한 몇가지 도입(導入)하였다. 시스팀은 CACS라는 작업명하(作業名下)에서 운영(運營)되었다. 대략 15개월동안 280여개의 프로파일로 CA- Condensates 데이터베이스에서 정보(情報)를 검색(檢索)하여 이용자(利用者)들에게 최신정보(最新情報) 주지사업(周知事業)을 해 보았다. 우리들은 시스팀의 작업능률(作業能率)을 평가(評價)하고 이용자(利用者)의 요구(要求)를 만족(滿足)시키는 최선(最善)의 방법(方法)을 모색(摸索)하였다. 우선 이용자(利用者)와 시스팀사이를 밀접(密接)하게 연결(連結)하는데 중점(重點)을 두었다. 작업능률(作業能率Z)을 분석(分折)해 보고 우리들은 효율(效率)에 영향(影響)을 주는 인자(因子)는 다음의 4가지 주요분류(主要分類)에 속한다는 결론(結論)을 얻었다. (1) 검색(檢索)하는 데이터 베이스 (2) 情報시스팀, 소프트웨어 패키지 그리고 하드웨어 구조(構造) (3) 이용자(利用者)의 특성(特性)과 그의 요구(要求) (4) 정보(情報)센터가 이용자(利用者)에게 제공(提供)하는 보조(補助)

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An Interconnection Method for Streaming Framework and Multimedia Database (스트리밍 프레임워크와 멀티미디어 데이타베이스와의 연동기법)

  • Lee, Jae-Wook;Lee, Sung-Young;Lee, Jong-Won
    • Journal of KIISE:Software and Applications
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    • v.29 no.7
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    • pp.436-449
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    • 2002
  • This paper describes on our experience of developing the Database Connector as an interconnection method between multimedia database, and the streaming framework. It is possible to support diverse and mature multimedia database services such as retrieval and join operation during the streaming if an interconnection method is provided in between streaming system and multimedia databases. The currently available interconnection schemes, however have mainly used the file systems or the relational databases that are Implemented with separated form of meta data, which deafs with information of multimedia contents, and streaming data which deals with multimedia data itself. Consequently, existing interconnection mechanisms could not come up with many virtues of multimedia database services during the streaming operation. In order to resolve these drawbacks, we propose a novel scheme for an interconnection between streaming framework and multimedia database, called the Inter-Process Communication (IPC) based Database connector, under the assumption that two systems are located in a same host. We define four transaction primitives; Read, Write, Find, Play, as well as define the interface for transactions that are implemented based on the plug-in, which in consequence can extend to other multimedia databases that will come for some later years. Our simulation study show that performance of the proposed IPC based interconnection scheme is not much far behind compared with that of file systems.

The Physicochemical Characteristics of Instant Nuroong-gi (즉석 누룽지의 이화학적 특성)

  • 박영희;오영준
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.26 no.4
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    • pp.632-638
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    • 1997
  • To develop the Instant Nuroong-gi in a short reconstitution time, we made puffed Instant Nuroong-gi samples and investigated their physicochemical characteristics. The Nuroong-gi was prepared using a Japonica variety with three different cooking conditions: steam cooker(process A), pressure cooker (process B) and cabinet cooker(process C). The Instant Nuroong-gi is produced by adding water to the Nuroong-gi which is broken into the size of 0.5~1.0cm. The amount of the added water is 40% of the weight of the broken Nuroong-gi. And it was puffed at 160~17$0^{\circ}C$ for 30 secands. The water binding capacity of Instant Nuroong-gi samples was 7.2 at process A, 6.5 at process B and 6.6 at process C. The total sugar content of Instant Nuroong-gi samples in hot water reached at the highest level at 3-minute cooking time. Through the sensory evaluation by a panelists, we discovered that Instant Nuroong-gi prepared by a steam cooker showed the highest roasted nutty taste, hardness, stickiness and overall acceptability. And Instant Nuroong-gi prepared by a pressure cooker showed the highest color, clearness, and roasted nutty flavor. Correlation coefficients between overall acceptability and other sensory attributes of Instant Nuroong-gi indicated that hardness had the most significant correlation to sensory evaluations. When we compared the results of color test with those of sensory evaluation of Instant Nuroong-gi prepared by three different cookers, we discovered that panelists preferred yellow Instant Nuroong-gi prepared by a pressure cooker. We found some morphological properties of Instant Nuroong-gi as a result of the comparison of the crystalization by a X-ray diffraction analysis and the observation of the shapes by a the scanning electron micrographs.

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Semantic Topic Selection Method of Document for Classification (문서분류를 위한 의미적 주제선정방법)

  • Ko, kwang-Sup;Kim, Pan-Koo;Lee, Chang-Hoon;Hwang, Myung-Gwon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.1
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    • pp.163-172
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    • 2007
  • The web as global network includes text document, video, sound, etc and connects each distributed information using link Through development of web, it accumulates abundant information and the main is text based documents. Most of user use the web to retrieve information what they want. So, numerous researches have progressed to retrieve the text documents using the many methods, such as probability, statistics, vector similarity, Bayesian, and so on. These researches however, could not consider both the subject and the semantics of documents. As a result user have to find by their hand again. Especially, it is more hard to find the korean document because the researches of korean document classification is insufficient. So, to overcome the previous problems, we propose the korean document classification method for semantic retrieval. This method firstly, extracts TF value and RV value of concepts that is included in document, and maps into U-WIN that is korean vocabulary dictionary to select the topic of document. This method is possible to classify the document semantically and showed the efficiency through experiment.

A study on flux characteristics from the submerged soils of Yeongju dam (영주댐 수몰지 토양의 용출 특성 분석)

  • Lee, Seungyoon;Shin, Cholong;Choi, Kwangsoon;Kim, Hojoon
    • Proceedings of the Korea Water Resources Association Conference
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    • 2018.05a
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    • pp.462-462
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    • 2018
  • 국내 신규댐 건설에 있어, 침수토양의 용출에 의한 호내 수질영향에 대해서는 현재까지 정량화된 사례는 찾기 어려우며, 댐 담수 초기에 증가되는 오염원에 대한 정확한 조사자료의 부족으로 담수이후의 수질변화에 대한 정확한 예측이 어려운 실정이다. 따라서 외부 오염부하의 강우시 유입과 퇴적물로부터의 영양염용출 등의 내부 오염부하가 함께 고려된 수질예측기법의 적용이 필요하다. 수몰지 토양 및 호내로부터의 내부부하에 있어서는 퇴적물 내의 다량 존재하는 오염물이 재용출 되거나 퇴적물 내의 화학적 생물학적 반응이 하천 수질에 악영향을 미치게 된다. 대부분 수몰지토양에서 수층으로 용출되는 유기물의 양은 수층에서 퇴적물로 흡수 또는 침강 되는 것보다 많은 경우도 있으며, 오염된 수계에서는 내부 부하량이 과다할 경우 수질 개선을 어렵게 하는 요인이 되고 있다. 따라서 본 연구에서는 2016년 시험담수 예정지인 신규댐 수몰지를 대상으로 토양에 포함된 유기물이 자연상태에서 수체로 용출되는 특성을 분석하여 수질에 미치는 영향을 검토하고자 한다. 댐 수몰지의 토양 시료는 시험담수전 2016년 7월, 토지이용 유형별로 5개지점(논, 밭, 대지, 임야, 하천)에서 시료를 채집하여 총 36일간 용출실험을 실시하였으며, 수층내 용존산소 조건을 호기성 조건과 혐기성 조건으로 나누어 실험하였다. 수질분석은 COD, T-N, T-P, $PO_4-P$등 9개 항목에 대해 실험기간 중 13회 실시하였다. 토양별 점유면적 대비 일 용출량은(kg/day) COD 63 kg/day, T-N 93.6 kg/day, T-P 5.8 kg/day, $PO_4-P$ 4.6 kg/day 였으며, 수몰지 내 토지이용현황별 오염원 기여율은 임야, 밭, 하천, 논, 대지 순 이었다. 본 실험은 수몰지토양의 순수용출량만을 담수개시~36일간 측정한 결과로서 실제 저수지환경에서는 실험값보다 낮을 것으로 판단되며, 수중 수질환경 변화 및 퇴적물의 퇴적 등으로 인하여 원토양으로부터의 용출로 인한 수질에의 영향은 시간의 경과와 함께 변화 또는 감소될 것으로 예상된다. 따라서 본 실험결과는 담수초기의 영향으로 국한하여 해석하는 것이 바람직하며, 보다 장기적인 영향파악을 위해서는 담수 후의 퇴적물의 거동(퇴적현황) 파악 및 담수 후 퇴적물의 장기용출실험을 통한 용출량 검토가 필요하다.

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Discovery of the Dmitri Donskoi ship near Ulleung Island(East Sea of Korea), using geophysical surveys (물리탐사기술을 이용한 침몰선 Dmitri Donskoi호 탐사)

  • Yoo, Hai-Soo;Kim, Su-Jeong;Park, Dong-Won
    • Geophysics and Geophysical Exploration
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    • v.8 no.1
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    • pp.104-111
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    • 2005
  • Dmitri Donskoi, the Russian cruiser launched in 1883, is known to have sunk near Ulleung Island (East Sea, Korea) on May 29, 1905, while it was participating in the Russo-Japanese War. In order to find this ship, information about its possible location was obtained from Russian and Japanese maritime historical records. The supposed location of the ship was identified, and we conducted a five-year geophysical survey from 1999 to 2003. A reconnaissance three-dimensional topographic survey of the sea floor was carried out using multi-beam echo sounder, marine magnetometer, and side-scan sonar. An anomalous body identified through the initial reconnaissance survey was identified by a detailed survey using a remotely operated vehicle, deep-sea camera, and the mini-submarine Pathfinder. Interpretation of the acquired data showed that the ship is hanging on the side of a channel, at the bottom of the sea 400 m below sea level. The location is about 2 km from Port Jeodong, Uleung Island. We discovered 152 mm naval guns and other war materiel still attached to the hull of the ship. In addition, the remnants of the steering gear and other machinery that were burnt during the final action were found near the hull. Strong magnetic fields, resulting from the presence of volcanic rocks in the survey area, affected the resolution of the magnetic data gathered; as a result, we could not locate the ship reliably using the magnetic method. Severe sea floor topography in the gully around the hull gave rise to diffuse reflections in the side-scan sonar data, and this prevented us from identifying the anomalous body with the side-scan sonar technique. However, the sea-floor image obtained from the multi-bean echo sounder was very useful in verifying the location of the ship.

Practitioners' Needs Analysis to Improve the Youth Theft Prevention Program (청소년 절도비행 재범방지 프로그램 개선을 위한 실무자 요구조사 연구)

  • Choi, Jaegwang;Jang, Heamin;Lee, Yu-Kyeong;Song, Wonyoung
    • Journal of Convergence for Information Technology
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    • v.11 no.9
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    • pp.145-156
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    • 2021
  • This study is aimed to improve the youth theft prevention program with rationality and practicality, based on the needs of practitioners who conduct these programs in fields. The survey questionnaire was prepared based on previous researches, and the survey was conducted on 72 probation officers and education instructors nationwide running a youth theft prevention program. As a result, practitioners reported the lack of self-control and high impulsivity as the main characteristics of the theft delinquent adolescents. And they recognized peer alignment and family problems as the causes of theft. As for the contents of the program, they reported that recidivism prevention skills such as understanding psychological problems, peer relationships, raising a sense of law compliance, anger, impulse control, dealing with negative emotions, and finding alternative behaviors, as well as moral development, are necessary. These results indicate that multi-dimensional interventions such as individuals, families, and peers are needed to prevent recidivism of juvenile theft. Implications of these results, future research directions, and limitations and significance of the study were discussed.

An Analysis of the Questions Presented in Chapters of Pattern Area in Elementary School Mathematics (초등수학의 규칙성 영역 단원에 제시된 발문의 특성 분석)

  • Do, Joowon
    • Education of Primary School Mathematics
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    • v.24 no.4
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    • pp.189-202
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    • 2021
  • The teacher's questions presented in the problem-solving situation stimulate students' mathematical thinking and lead them to find a solution to the given problem situation. In this research, the types and functions of questions presented in chapters of Pattern area of the 2015 revised elementary school mathematics textbooks were compared and analyzed by grade cluster. Through this, it was attempted to obtain implications for teaching and learning in identifying the characteristics of questions and effectively using the questions when teaching Pattern area. As a result of this research, as grade clsuter increased, the number of questions per lesson presented in Pattern area increased. Frequency of the types of questions in textbooks was found to be high in the order of reasoning questions, factual questions, and open questions in common by grade cluster. In chapters of Pattern area, relatively many questions were presented that serve as functions to help guess, invent, and solve problems or to help mathematical reasoning in the process of finding rules. It can be inferred that these types of questions and their functions are related to the learning content by grade cluster and characteristics of grade cluster. Therefore, the results of this research can contribute to providing a reference material for devising questions when teaching Pattern area and further to the development of teaching and learning in Pattern area.

Source rock investigation for the Gyeongju Seated Stone Buddha with Square Pedestals in the Blue House using nondestructive petrological analysis (청와대 소재 경주 방형대좌 석조여래좌상의 암석학적 비파괴분석을 통한 산지해석)

  • Lee, Myeong Seong;Yoo, Ji Hyun;Kim, Jiyoung
    • Journal of the Geological Society of Korea
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    • v.54 no.5
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    • pp.567-578
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    • 2018
  • A nondestructive petrological investigation was carried out to identify the original location and form of the Gyeongju Seated Stone Buddha with Square Pedestals in the Blue House (so-called Stone Buddha in the Blue House). The Statue is a representative stone Buddha statue of Silla (9th century) but its original location is controversial and some parts were missing. Based on the petrological observation, magnetic susceptibility and gamma spectrometry, its stone material was identified as medium-grained alkali feldspar granite. This kind of granites are widely found in the Namsan, Gyeongju. It is very likely that the Namsan granites are the source of rock of the Stone Buddha. The Yudeoksa (Igeosaji temple site) and Namsan are possible to be the original home of the Buddha Statue since there are petrologically identical alkali feldspar granite outcrop distributed in Namsan and stone heritage made of the same stone type in both places. An investigation on the square middle stone base in the Chuncheon National Museum reveals that it is less likely to be the missing part of the Buddha statue as the stone base is fine- to medium-grained pink feldspar granite and has different magnetic susceptibility from the Buddha statue. This study confirmed the contribution and significance of petrological investigation to identification of stone heritage in Korea.