• Journal of Hospice and Palliative Care
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• v.15 no.4
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• pp.193-204
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• 2012

Purpose: This correlation study was performed to examine Korean adults' perceptions and attitudes towards death with dignity and the withdrawal of life sustaining treatment and to identify factors that predict their attitude towards death with dignity. Methods: The study was conducted using convenience sampling of 291 adults from three towns of a metropolitan city in Korea. Data were collected using structured questionnaires which surveyed people's perception about and attitudes towards withdrawal of life sustaining treatment and scaled their attitude towards death with dignity. Data were analyzed by using descriptive statistics, Pearson correlation coefficients and multiple regression. Results: The attitude towards the withdrawal of life sustaining treatment and death with dignity showed a significant positive correlation (r=0.49, P<0.001). For attitudes towards death with dignity, significant predictors were attitudes towards the withdrawal of life sustaining treatment, age, religion, a proper withdrawal process and advanced medical directives, which explained 49.3% of total variance. Conclusion: The results of this study may contribute to development of a new medical decision-making system including nurses' appropriate roles in the process of withdrawing life sustaining treatment and advanced medical directives.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.6
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• pp.51-56
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• 2009

Safety and quality assessment systems are very important in manufacture, storage, transportation, and handling of hazardous materials(hazmat) to prevent hazmat disasters. At present, hazardous materials exist everywhere in our daily lives with various forms of plastics, household products of cleaning and washing detergents, fertilizers or petroleum-related products. However, hazardous materials are dangerous substances when they are released to human or environment. Hazardous materials become very widely used substances in the age of oil-based industrial economy. The Korean Ministry of Environment (KMOE) describes about one hundred thousand types of chemicals are produced and used worldwide. Over four hundred new chemicals are introduced in every year. A crucial question for the Korean hazardous material management may have been raised: Will you be safe from hazardous material incidents? The gas leak disaster at Union Carbide's Bhopal, India in 1984 that made over 6,400 people killed and 30,000 to 40,000 people seriously injured is the representative case for the safety of hazmat. Korea becomes vulnerable to hazmat disaster due to the development of high-tech industry. Thus, the risk assessment system is required to Korea for transferring abandoned hazmat management systems to self-correcting safety systems. This research analyzed characteristics of various hazmat incidents applying statistical analysis methods including frequency analysis or analysis of category data to hazmat incidents for ten years. All of three analyses of category data indicate the significance of causality between hazmat incident site groups and seasons, regional groups, and incident casualty groups.

• Economic and Environmental Geology
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• v.40 no.5
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• pp.705-711
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• 2007

We should treat carefully the one related to human rights among a large number of decision-making in our daily lives. As it is necessary to obtain physical evidences in the process of criminal investigation for solving a certain crime based on the principle of evidence, it leads to an increase in demand for forensic science and forensic geology. Forensic geology could be regarded as a fusion discipline of geology and forensic investigation and it is principally concerned to the study on the connection of a suspect and a crime scene with soil evidence which could be experimented using geological data and methods. So these results could be used as valuable information in a court. After its academic foundation has been builded since the last 1970s, its research objects have been expanded from soil evidence like rocks, minerals, soils, sediments to sociocultural, political, military and medical objects like ancient relics, mines, corpses. Its role is expanded from the simple finding of a particular location to the examination of archaeological theories and historical facts, the testimony of the cause of environmental pollution and the chronic demonstration of geological distribution of plants and anthropological origination. And these bring this discipline promptly to accept developed geological methodologies and to satisfy various forensic geological needs. Specialized forensic investigation institutes work actively for the R&D activities of forensic geology. In Korea, national institute of scientific investigation works a small part of forensic geological activities in total activities of forensic investigation. In conclusion, we concern to the importance of systematic discussion of building in proper position of forensic geology through its R&D methods, application cases of its performance and etc. based on geological characteristics in our country by a specialized geoscience institute.

• Science of Emotion and Sensibility
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• v.8 no.4
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• pp.423-433
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• 2005

The computer hardware development has provided many chances of emergence between art and technology. In many cases today's interactive artworks cannot be completed without audience's participation. The interactive production process with technical supplementation can be celled feedback. Mr. Nam Jun Paik showed 'Participant TV' that interacts with audience's response in real time. It means artwork changes with the constantly changing value from the data set from human visual perception. Dan Graham showed another feedback related work, which delays 5second playback in mirror that implies consequence of time. Today's media art has to sublimate coincidence, time ant audience into philosophical artwork through consonance that comes with video and sound as we can see from Bill Viola. Stelarc produced artworks. That use input data that is weak signals from brain, muscles. Through a terminal display with player, body expanded meaning of media. Jeffrey Shaw's 'Legible City' provided a fabrication of the reality with the interaction of bicycle's pedal speed and steering direction that is controlled by 4river. RE:MARK used microphone as input device as Edmond Couchot's 'Je same a la vent' and Nam Jun Paik's 'Participant TV' did. There is no communication without feedback between human being. The reality makes audience involved into artworks. That is the reason why feedback has to be natural. Through the feedback process, the originality of the idea is altered by audience. The feedback is not just part of flesh of artwork rather skeleton of it. Technological showoff cannot be art itself The perfection of technological application plan helps feedback that interacts with audience naturally in order that audience hoes not feel the feedback as artificial plan. Interactive media art has to be evolved into new media form with new integration feedback technology.

• Food Science of Animal Resources
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• v.26 no.2
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• pp.263-268
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• 2006

Probiotics including Lactobacillus acidophilus, refer to a group of nonpathogenic organisms that protect the human host against gastrointestinal(GI) infections by pathogenic bacteria such as Shiga toxin-producing E. coli(STEC). In the study, the inhibitory effects of STEC ATCC 43894 adhesion by L. acidophilus A4 was investigated on the HT-29 epithelial cells. Specific proteins regulated by cell Iysates of L. acidophilus A4 on STEC ATCC 43894 were also characterized by proteomic analysis. Both cell mass and Iysate of L. acidophilus A4 have exhibited the profound inhibitory activity on the HT-29 cells(about 1.5 log scale reduction). Two-dimensional gel electrophoresis(2-DE) revealed seven proteins that were up-regulated by cell Iysates of L. acidophilus A4 and three proteins that were down-regulated. In addition, three protein spots were only detected in the presence of cell Iysates. These results suggest that inhibitory effects of STEC adhesion by L. acidophilus may be due to the regulation of specific protein of STEC.

• Journal of Life Science
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• v.27 no.7
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• pp.834-839
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• 2017

Propolis is a natural product collected from plants by honey bees product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anti-cancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. Ovarian cancer is the second most common newly diagnosed cancer from all cancers among women in Korea and the leading cause of death from gynecological malignancies. While most ovarian cancer patients initially respond to surgical debulking and chemotherapy, patients later succumb to the disease. Thus, there is an urgent need to test novel therapeutic agents to counteract the high mortality rate associated with ovarian cancer. In this study, we investigated the anti-cancer properties and the active mechanism of Australian propolis in human epithelial ovarian cancer A2780 cells. Our data revealed that propolis showed a cytotoxic activity in a dose-dependent manner. Flow cytometric analysis for cell cycle arrest and apoptosis using propidium iodide staning and annexin V-FITC indicated that propolis could induce cycle arrest in the G0/G1 phase and apoptosis in a dose-dependent manner on human epithelial ovarian cancer cells. These results suggest that the Australian propolis is potential alternative agent on ovarian cancer prevention and treatment.

• Journal of Life Science
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• v.27 no.10
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• pp.1225-1231
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• 2017

Disruptive expression patterns of the circadian clock genes are highly associated with many human diseases, including cancer. Cell cycle and proliferation is linked to a circadian rhythm; therefore, abnormal clock gene expression could result in tumorigenesis and malignant development. The molecular network of the circadian clock is based on transcriptional and translational feedback loops orchestrated by a variety of clock activators and clock repressors. The expression of 10~15% of the genome is controlled by the overall balance of circadian oscillation. Among the many clock genes, Period 1 (Per1) and Period 2 (Per2) are clock repressor genes that play an important role in the regulation of normal physiological rhythms. It has been reported that PER1 and PER2 are involved in the expression of cell cycle regulators including cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors. In addition, correlation of the down-regulation of PER1 and PER2 with development of many cancer types has been revealed. In this review, we focused on the molecular function of PER1 and PER2 in the circadian clock network and the transcriptional and translational targets of PER1 and PER2 involved in cell cycle and tumorigenesis. Moreover, we provide information suggesting that PER1 and PER2 could be promising therapeutic targets for cancer therapies and serve as potential prognostic markers for certain types of human cancers.

• Journal of Life Science
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• v.27 no.11
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• pp.1269-1275
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• 2017

Tenebrio molitor samples were investigated as novel biomaterials and sources of food in several recent studies. However, the insects' effects on hair growth were not sufficiently researched. To develop novel and natural materials for preventing alopecia and promoting hair growth, this study investigated the antioxidant activities and hair-growth promotion effects of TMEs. To determine the antioxidant activities, the TMEs' DPPH radical- and nitrite-scavenging activities were examined. To determine hair-growth promotion effects, proliferations of human dermal papilla cells (DPCs) and the murine fibroblast cell line NIH3T3 were evaluated by using an MTS assay. In addition, estimations were made for cell viabilities against cell death induced by dihydrotesterone (DHT) in DPCs and inhibitory effects against potassium channel blocking induced by tolbutamide (TBM) in NIH3T3 cells. The DPPH radical scavenging activity was 81.17%, and the nitrite scavenging activity was 43.69%; the activities were similar to the activities of blueberry extracts. Moreover, the TMEs promoted the proliferation of human DPCs and NIH3T3 cells, which were concentrated dependently. The TMEs prevented not only DHT-induced DPC cytotoxicity but also TBM's action as a potassium channel blocker in NIH3T3 cells. The results suggested that TME could be used as a functional therapeutic alopecia reagent, to prevent hair loss and to promote hair growth.

• The Journal of the Korea Contents Association
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• v.8 no.8
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• pp.128-146
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• 2008

Cyworld has created a new social phenomenon that relationship between people and communities could be built by committing to digital writing. It has altered the way of people's writing attitudes from self-confessed to self-describing and self-broadcasting ways in which one regards oneself as the center of the cyber world. The purpose of this paper is to identify the shift in one's writing attitudes and how he/she develops technologies of the self in the Cyworld space. Quantitative and qualitative methods support the result; The analysis of 100 Cyworld users' mini-homepages show how the visual images in Cyworld affects their way of digital writing and the analysis of the change of writing habit due to sharing data how virtual 'family' that has been created by Cyworld. I categorize the characteristics of digital writing into three; 1)Visualization of technologies of the self 2)Networked technologies of the self 3)Sharing secretes. The aim of writing in Cyworld is not to keep the secrete but to share and, eventually, texts are circulated in the networked society where one is participated(Cyworld family). Therefore, the usage of images plays a significant role in Cyworld communities because the opened secretes are usually prepared to be presented on the basis of trustworthy toward other members.

• Journal of The Korean Association For Science Education
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• v.33 no.7
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• pp.1403-1417
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• 2013

In this study, we investigated scientists' perception of imagination and explored characteristics of scientific imagination. For this, we found out conceptions and characteristics based on literatures which related to imagination. We recruited eight distinguished Korean scientists who have rich research experiences by using Snowball sampling for in-depth interviews (60-90 minutes). All interviews were audio-recorded and transcribed. From the analysis of interview data, we identified their perceptions of imagination and the nature of scientific imagination which scientists reflect on during their research work. Semi-structured interview protocol was focused on: 1) how scientists perceive 'imagination' and 2) how scientists perceive the role of imagination in their scientific research. As results, we found out that scientists agreed that imagination plays an important role in scientific research process and they perceived imagination as an intrinsic part of human life. The study also indicated that participants have modern viewpoint about imagination. Moreover, we uncovered three characteristics of imagination in the research process. 1) Curiosity and interest have been a driving force for scientists' imagination. 2) When scientists use the imagination, they can be more creative during their research. 3) Imagination contemplated realistic possibilities based on the scientific knowledge, and produced the new ones. Educational implications for utilization of scientific imagination were also suggested.