• Journal of the Korean Chemical Society
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• v.54 no.2
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• pp.228-233
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• 2010

Recently, nanoparticles of gold and silver has been applied to various fields due to antimicrobial property. This study added Ag and Au nanoparticles in HEMA (2-hydroxyethylmethacrylate), NVP (N-vinyl pyrrolidone) and MMA (methylmethacrylate) and copolymerized the solution by heating at $70^{\circ}C$ for 40 minutes, $80^{\circ}C$ for 40 minutes, and finally, $100^{\circ}C$ for 40 minutes. Using the polymer produced through the copolymerization process, and measured the physical characteristics which showed water content of 28.43% ~ 35.27%, refractive index of 1.429 ~ 1.440, visible transmittance of 79.2% ~ 86.5% and tensile strength of 0.125 kgf ~ 0.201 kgf. We judged that we made the copolymer with antimicrobial and physical properties which is suitable for conventional contact lens.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.311-312
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• 2012

본 발표에서는 광학적 분석 시스템에 적용 가능한 발광소자(광원)과 수광소자(광센서)를 집적화시키는 모듈(수 발광 집적모듈) 기술을 제시하고자 한다. 이러한 수-발광 집적모듈은 다양한 응용 분야에 적용 될 수 있다. 예를 들어, 광신호 감지를 위한 광통신용 송-수신 모듈(optical communication), 의료/진단 분야에서 단백질/DNA/박테리아 등의 검출 및 분석에 관한 바이오 센서(bio-sensor), 그리고 대기(가스)/수질 모니터링에 관한 환경센서 등 매우 광범위한 분야에 해당되는 요소 기술이라 할 수 있다. 특히, 이들 분야들 중 바이오 물질을 분석하고 검출하는 광학적 바이오 센서 기술은 높은 경제적 가치와 산업적 성장 잠재력으로 인해 오랫동안 활발한 연구가 진행되어 오고 있다. 이러한 광학적 바이오 센서에서 가장 범용적인 방법 중 하나가 항온-항체 면역반응을 기반으로 하는 형광 검출(fluorescence detection) 기법이다. 이러한 시스템은 전체적으로 광원, 광학계, 그리고 센서로 구성되는데 기존에 일반적으로 사용되고 있는 형광 현미경의 경우는 민감도가 우수하다는 장점은 있으나 상당히 고가이고 부피가 크며 복잡한 광학구성으로 이루어져 있다는 한계점을 가지고 있다. 이러한 맥락에서 고민감도를 확보하면서 휴대성, 고속처리, 저가 등의 특성을 가진 시스템에 대한 요구가 갈수록 증가하고 있다. 이를 해결하기 위한 핵심기술 중의 하나가 수-발광 부분을 집적화 시키는 기술이라 할 수 있다. 본 연구에서는 바이오 센서 기술의 하나로서 형광을 측정하여 혈액내의 진단 지표인자를 검출할 수 있는 휴대용 혈액진단기기에 적용되는 소형 수 발광 집적 모듈을 개발하였다. 혈액내의 검출 성분의 양에 따라 형광의 세기가 변화하게 됨으로써 정량적인 검출이 가능한 원리이다. 모듈의 구조는 크게 광원(발광소자), 광학계, 그리고 광센서(수광소자) 세 영역으로 나누어 진다. 광원은 635 nm 적색 레이저다이오드로서 형광체(Alexa Fluor 647/발광파장: 668 nm)를 여기 시키는 기능을 하며 장착된 볼렌즈 의해 샘플의 형광체 영역으로 집광된다. 광학계는 크게 시준렌즈(collimating lens)와 광학필터로 구성됨으로써 샘플로부터 발생되는 광을 적절하게 수광소자로 전달하는 기능을 하게 된다. 여기서 광학필터의 경우는 기본적으로 Distributed Bragg's Reflector(DBR) 구조로써 실리콘(Si) 포토다이오드 상부에 모노리식(monolithic)하게 형성되며 검출 샘플로부터 진행되는 레이저 광(잡음의 주원인)은 차단하고 형광(광신호)만 통과 시키는 기능을 하게 된다. 따라서 신호 대 잡음비(S/N ratio)를 향상시키기 위해서는 정밀한 광 필터링 기능이 요구됨으로써 박막의 세밀한 공정 조건과 구조적-광학적 특성 분석이 수행되었다. 마지막으로 포토다이오드 소자는 일반적인 구조 이외에 중앙에 원형 구멍이 형성된 특별한 구조가 적용된다. 이것은 포토다이오드 구조에 변화를 줌으로써 모듈 구조를 효율적으로 응용할 수 있다는 의미를 갖는다. 또한 포토다이오드의 전기적-광학적 측정 분석을 통해 잡음 및 감도 특성이 세부적으로 조사되며 형광신호를 효과적으로 측정할 수 있음을 확인하였다. 최종적으로 제작된 모듈은 약 $1{\times}1{\times}1cm^3$ 내외 정도의 크기를 갖는다. 요약하자면 본 발표에서는 광학적 바이오센서에 적용할 수 있는 소형 수-발광 소자 집적모듈을 소개한다. 전체 모듈 설계는 최소한의 부피를 가짐과 동시에 측정의 정밀성을 향상시키는데 초점을 맞추어 진행하였다. 세부요소인 광학필터와 포트다이오드의 경우 잡음 및 민감도에 미치는 중요성 때문에 세밀한 공정 및 특성분석이 수행되었다. 결론적으로 독자적인 설계 및 공정을 통해 휴대성 및 정밀성 등의 목적에 부합한 경쟁력 있는 수-발광 소자 집적모듈 제작 기술을 확보하였다.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.111-117
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• 2003

We collected the domestic and foreign half-mirror coating lens for sunglasses. Their reflectance is measured using Spectrophotometer in order to analysis their optical property and the result which is calculated using Macleod program was compared with measured reflectance. In addition, we designed the new half-mirror coating lens with gold color using TiN material and investigated the optical property of the new half-mirror coating lens. The results obtained from analysis of half-mirror coating lenses are as follow : Two-tone half-mirror coating with silver color is fabricated with [air|$SiO_2$(or $Al_2O_3$)|Cr|glass]. The role of $SiO_2$(or $Al_2O_3$) on Cr improve the hardness of the lens and the thickness of the $Al_2O_3$ with 10 nm is good to show the lens silver color. Incase of color half-mirror coating lens. Blue system is designed by [air|$SiO_2$(66.3)|$TiO_2$(129.0)|$SiO_2$(62.9)|$SiO_2$(26.0)|$TiO_2$(120.3)|$SiO_2$(9.1)|glass], gold system [air|$SiO_2$(60.6)|$TiO_2$(86.2)|$SiO_2$(13.5)|$TiO_2$(86.8)|$SiO_2$(214.38)|glass], green system[air|$SiO_2$(74.3)|$TiO_2$(75.8)|$SiO_2$(44.3)|$TiO_2$(11.6)|$SiO_2$(160.8)|$TiO_2$(12.9)|$SiO_2$(183.3)|$TiO_2$(143.8)|glass], silver system[air|$SiO_2$(21.2)|$TiO_2$(49.7)|$SiO_2$(149.3)|glass]. White half-mirror coating lens has [air|$SiO_2$(17 nm)|$TiO_2$(43 nm)(or $ZrO_2$)|$SiO_2$(87 nm)|polysiloxane($4.46{\mu}m$|glass or CR-19]. It has half-mirror coaling lens which has about 19% reflectance and about 80% transmittance in the range of visible light(400~700nm). we designed the new half-mirror coating lens with gold color, the (x, y) value of the CIE is almost similar to the CIE value of [air|$SiO_2$(170 nm)|TiN(15 nm)|glass].

• Journal of Korea Society of Industrial Information Systems
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• v.20 no.3
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• pp.19-28
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• 2015

With the aim of developing a smartphone-based point-of-care device that is small, inexpensive, and easy to handle by non-expert, we designed a fluorescence smartscope for counting particles and a DC motor-controlled particle positioning system. Our smartscope can count the number of fluorescent particles and fluorescently-stained white blood cells through a phone camera with an adaptor containing a LED, a ball lens and optical filters and an application running on a smartphone. The motor was controlled wirelessly via Bluetooth with an Android smartphone. We found that axial spinning of a helical microfluidic channel allows arrangement of particles having size similar to the white blood cells. The motor-controlled particle positioning system can minimize time-consuming manual processes and automate sample preparation process and thus, if integrated with the smartscope, it can be used for a point-of-care testing device based on a smartphone.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.535-540
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• 2006

집적 영상(Integral Imaging) 시스템은 관찰자가 특수안경의 착용 없이 육안으로 3 차원 영상을 볼 수 있는 무안경식 양안시차 디스플레이 방식 중 하나로, 수직, 수평 시차와 총천연색의 영상을 제공한다. 집적영상 시스템은 3 차원 정보를 2 차원 엘리멘탈 이미지 (Elemental image)의 형태로 저장하는데, 엘리멘탈 이미지는 조금씩 다른 방향에서 제한된 크기로 촬영된 이미지이다. 엘리멘탈 이미지는 컴퓨터 그래픽으로 만들어질 수도 있는데, 이를 이용하는 집적 영상 방식을 CG 직접 영상 시스템이라 한다. 이와 같이 컴퓨터 계산에 의해 엘리멘탈 이미지를 얻는 과정을 이미지 매핑 (Image mapping)이라 부른다. 이제까지 제안된 이미지 매핑 방식에는 점대점 (Point to Point), MVR (Multi-Viewpoint Rendering), PGR (Parallel Group Rendering) 이 있다. 그러나 이런 방식들은 계산량이 많거나 렌즈 어레이 개수의 증가에 의해 속도에 영향을 받는 단점이 있어, 아직 가상현실 같은 실시간 CG 응용 분야에 사용하기 어려운 문제가 있다. 본 논문에서는 VVR (Viewpoint Vector Rendering)이라는 기존의 방법과 비교해 향상된 새로운 이미지 매핑 방법을 제안한다. 먼저 VVR 개념을 자세히 설명한 후 VVR 을 사용한 집적 영상 시스템을 구현하여 MVR 방법과 비교 분석한 실험결과와 개선되어야 할 방향을 제시한다.

• Korean Journal of Optics and Photonics
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• v.19 no.2
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• pp.140-143
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• 2008

The integrated external cavity laser has been fabricated with a 1550 nm FP-LD, an optical filter, a micro ball lens and accurate ceramic blocks using a micro-block stacking (MBS) technique. The integrated external cavity laser module whose size is only $2.0{\times}2.1{\times}0.7\;mm^3$ has been mounted on the TO-CAN package. For the case of the 1.8% transmission filter, the single mode characteristic has been obtained with the optical power of -27.1 dBm and the SMSR of 31.7 dB.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.2
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• pp.231-237
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• 2014

Purpose: This study is research of the conditions which causes difference between the refractive power of the measurement of autorefractometer and the prescription using phoropter. Methods: Autorefractometer (SR-7000) and phoroptor (AV-9000) were used to measure 60 eyes of 30 participants who had no eye diseases and wore the corrective lens due to Ametropia. To prevent the dependence of the prescription value of the refractive power on the testers, two testers measured the refractive power of the eyes of the participants at the same measuring conditions. Results: Statistically, the prescribed values of the refractive power by two testers were not significantly different. Most of the prescribed values of the refractive power were smaller than the refractive power by autorefractometer In case of myopic eyes, the difference between refractive powers by the measurement of autorefractometer and the prescription using phoropter showed the trend of increase as the spherical refractive power became larger. The result was analyzed by the range of the different cylindrical refractive power for the myopic astigmatic eyes. In this case, the difference between refractive powers showed the trend of decrease as the cylindrical refractive power became larger. Conclusions: No difference between the prescribed value by two testers was observed. In case of myopic or myopic astigmatic eyes, the difference between refractive powers by autorefractometer and the prescription were measured to be approximately proportional to the refractive powers of ametropic eyes. As the this difference become larger for the participant who needs the lens of larger refractive power, additional caution is needed in the prescription of the refractive power of the corrective lens.

• The KIPS Transactions:PartB
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• v.13B no.3 s.106
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• pp.295-300
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• 2006

The integral imaging system is an auto-stereoscopic display that allows users to see 3D images without wearing special glasses. In the integral imaging system, the 3D object information is taken from several view points and stored as elemental images. Then, users can see a 3D reconstructed image by the elemental images displayed through a lens array. The elemental images can be created by computer graphics, which is referred to the computer-generated integral imaging. The process of creating the elemental images is called image mapping. There are some image mapping methods proposed in the past, such as PRR(Point Retracing Rendering), MVR(Multi-Viewpoint Rendering) and PGR(Parallel Group Rendering). However, they have problems with heavy rendering computations or performance barrier as the number of elemental lenses in the lens array increases. Thus, it is difficult to use them in real-time graphics applications, such as virtual reality or real-time, interactive games. In this paper, we propose a new image mapping method named VVR(Viewpoint Vector Rendering) that improves real-time rendering performance. This paper describes the concept of VVR first and the performance comparison of image mapping process with previous methods. Then, it discusses possible directions for the future improvements.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.1
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• pp.1-17
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• 2020

Three-dimensional microscopic approaches in histopathology display multiplex properties that present puzzling questions for specimens as related to their comprehensive volumetric information. This information includes spatial distribution of molecules, three-dimensional co-localization, structural formation and whole data set that cannot be determined by two-dimensional section slides due to the inevitable loss of spatial information. Advancement of optical instruments such as two-photon microscopy and high performance objectives with motorized correction collars have narrowed the gap between optical theories and the actual reality of deep tissue imaging. However, the benefits gained by a prolonged working distance, two-photon laser and optimized beam alignment are inevitably diminished because of the light scattering phenomenon that is deeply related to the refractive index mismatch between each cellular component and the surrounding medium. From the first approaches with simple crude refractive index matching techniques to the recent cutting-edge integrated tissue clearing methods, an achievement of transparency without morphological denaturation and eradication of natural and fixation-induced nonspecific autofluorescence out of real signal are key factors to determine the perfection of tissue clearing and the immunofluorescent staining for high contrast images. When performing integrated laboratory workflow of tissue for processing frozen and formalin-fixed tissues, clear lipid-exchanged acrylamide-hybridized rigid imaging/immunostaining/in situ hybridization-compatible tissue hydrogel (CLARITY), an equipment-based tissue clearing method, is compatible with routine procedures in a histopathology laboratory.

• Journal of the Korean Vacuum Society
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• v.10 no.4
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• pp.396-402
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• 2001

MgO thin films with 1000 $\AA$ thickness were deposited on Cu substrates by using an electron gun evaporator at room temperature. A 1000 $\AA$ thick Al layer was deposited on the MgO for removing the charging effect of the MgO thin film during the measurements of the sputtering yields. A Ga ion liquid metal was used as the focused ion beam(FIB) source. The ion beam was focused by using double einzel lenses, and a deflector was employed to scan the ion beams into the MgO layer. Both currents of the secondary particle and the probe ion beam were measured, and they dramatically changed with varying the applied acceleration voltage of the source. The sputtering yield of the MgO layer was determined using the values of the analyzed probe current, the secondary particle current, and the net current. When the acceleration voltage of the FIB system was 15 kV, the sputtering yield of the MgO thin film was 0.30. The sputtering yield of the MgO thin film linearly increases with the acceleration voltage. These results indicate that the FIB system is promising for the measurements of the sputtering yield of the MgO thin film.